Publications Group Professor Hoogewijs


Query for publications at the National Center for Biotechnology Information



Schörg A, Santambrogio S, Platt J, Schödel J, Lindenmeyer MT, Cohen CD, Schrödter K, Mole DR, Wenger RH and Hoogewijs D (2015) Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping. Nucleic Acids Res. 43, 5810-5823.


Christensen AB, Herman JL, Elphick MR, Kober KM, Janies D, Linchangco G, Semmens D, Bailly X, Vinogradov SN and Hoogewijs D (2015) Phylogeny of echinoderm hemoglobins. PLoS ONE 10: e0129668.


Wenger RH, Kurtcuoglu V, Scholz CS, Marti HH and Hoogewijs D (2015) Frequently asked questions in hypoxia research. Hypoxia In press.


Müller-Edenborn K, Léger K, Glaus Garcon JF, Oertli C, Mirsaidi A, Richards PJ, Rehrauer H, Spielmann P, Hoogewijs D, Borsig L, Hottiger M and Wenger RH (2015) Hypoxia attenuates the proinflammatory response in colon cancer cells by regulating IkB. Oncotarget In press.

37. Tilleman L, Germani F, De Henau S, Helbo S, Desmet F, Van Doorslaer S, Hoogewijs D, Schoofs L, Braeckman BP, Fago A, Moens L and Dewilde S (2015) A globin domain in a neuronal transmembrane receptor of Caenorhabditis elegans and Ascaris suum: Molecular modeling and functional properties. J. Biol. Chem. 290, 10336-10352.



Storti F, Santambrogio S, Crowther L, Otto T, Abreu-Rodriguez I, Kaufmann M, Hu CJ, Dame C, Fandrey J, Wenger RH and Hoogewijs D (2014) A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression. Haematologica 99, e45-48.



Gardie B, Percy MJ, Hoogewijs D, Chowdhury R, Bento C,  Arsenault PR, Richard S, Almeida H, Ewing J, Lambert F, McMullin MF, Schofield CJ and Lee FS (2014) The role of PHD2 mutations in the pathogenesis of erythrocytosis. Hypoxia  2, 71-90.



Smith DR, Vinogradov SN and Hoogewijs D (2014) Hemoglobins in the genome of the cryptomonad Guillardia theta. Biol. Direct 9:7.



Fuady J, Bordoli MR, Abreu-Rodriguez I, Kristiansen G, Hoogewijs D, Stiehl DP and Wenger RW (2014) Hypoxia-inducible factor mediated induction of WISP-2 contributes to attenuated breast cancer progression. Hypoxia 2, 23-33.



Vinogradov SN, Bailly X, Smith DR, Tinajero-Trejo M, Poole RK and Hoogewijs D (2013) Microbial Eukaryote Globins. Adv. Microb. Physiol. 63, 391-446.



Anderson RT, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN and Lange CA (2013) Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res. 73, 5810-5820.



Vinogradov SN, Tinajero-Trejo M, Poole RK and Hoogewijs D (2013) Bacterial and Archaeal Globins – a Revised Perspective. Biochim. Biophys. Acta 1834, 1789-1800.



Ren C, Li Y, Han R, Gao D, Li W, Shi J, Hoogewijs D, Braeckman BP, De Henau S, Lu Y, Qu W, Gao Y, Wu Y, Li Z, Liu H, Wang Z and Zhang C (2013) GLB-13 is associated with oxidative stress resistance in Caenorhabditis elegans. IUBMB Life 65, 423-434.



Hoogewijs D, Dewilde S, Vierstraete A, Moens L and Vinogradov SN (2012) A phylogenetic analysis of the globins in Fungi. PLoS ONE 7:e31856.



Hoogewijs D, Ebner B, Germani F, Hoffmann FG, Fabrizius A,  Moens L, Burmester T, Dewilde S, Storz JF, Vinogradov SN and Hankeln T (2012) Androglobin: a chimeric globin in metazoans that is preferentially expressed in mammalian testes. Mol. Biol. Evol. 29, 1105-1114.



Ladroue C*, Hoogewijs D*, Gad S, Carcenac R, Storti F, Barrois M, Gimenez-Roqueplo A, Leporrier M, Casadevall N, Hermine O, Kiladjian J, Baruchel A, Fakhoury F, Bressac de Paillerets B, Feunteun J, Mazure N, Pouysségur J, Wenger RH, Richard S and Gardie B (2012) Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia and paraganglioma. Haematologica 97, 9-14. *joint first authors



Hoffmann FG, Opazo JC, Hoogewijs D, Hankeln T, Ebner B, Vinogradov SN, Bailly X and Storz JF (2012) Evolution of the globin gene family of deuterostomes: Lineage-specific patterns of diversification and attrition. Mol. Biol. Evol. 29, 1735-1745.



Vazquez-Limon C, Hoogewijs D, Vinogradov SN and Arredondo-Peter R (2012) The evolution of land plant hemoglobins. Plant Sci. 191-192, 71-81.



Vinogradov SN, Hoogewijs D and Arredondo-Peter R (2011) What are the origins and phylogeny of plant hemoglobins? Commun. Integr. Biol. 4, 443-445.



Hasgall PA, Hoogewijs D, Faza MB, Panse VG, Wenger RH and Camenisch G (2011) The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation. PLoS one 6:e22107.



Vinogradov SN, Fernandez I, Hoogewijs D and Arredondo-Peter R (2011) Phylogenetic relationships of plant 3/3 and 2/2 hemoglobins to bacterial and other eukaryotic hemoglobins Mol. Plant 4, 42-58.



Tilleman L, Germani F, De Henau S, Geuens E, Hoogewijs D, Braeckman BP, Vanfleteren JR, Moens L and Dewilde S (2011) Globins in Caenorhabditis elegans IUBMB Life 63, 166-174. 



Vinogradov S, Hoogewijs D, Vanfleteren J, Dewilde S, Moens L and Hankeln T (2011) Evolution of the globin superfamily and its function. In: Hemoglobin: Recent Developments and Topics. TRN Review, American Chemical Society (Ed. Nagai M), p. 232-254, Research Signpost, Kerala.   



Kiger L, Tilleman L, Geuens E, Hoogewijs D, Lechauve C, Moens L, Dewilde S and Marden MC (2011) Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom. PLoS one  6:e20478.



Wenger RH and Hoogewijs D (2010) Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells. Am. J. Physiol. Renal. Physiol. 298, F1287-F1296.



Geuens E*, Hoogewijs D*, Nardini M, Vinck E,  Pesce A, Kiger L, Fago A, Tilleman L, De Henau S, Marden M, Weber R, Van Doorslaer S, Vanfleteren JR, Moens L, Bolognesi M and Dewilde S (2010) Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties. BMC Biochem. 11:17. * joint first authors



Hoogewijs D, De Henau S, Dewilde S, Moens L, Couvreur M, Borgonie G, Vinogradov SN, Roy SW and Vanfleteren JR (2008) The Caenorhabditis globin gene family reveals extensive nematode-specific radiation and diversification. BMC Evol. Biol.  8:279.



Castelein N, Hoogewijs D, Devreese A, Braeckman B and Vanfleteren JR (2008) Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Biotechnol. J. 3, 803-812.



Hoogewijs D, Houthoofd K, Matthijssens F, Vandesompele J and Vanfleteren JR (2008) Selection and validation of a reliable set of candidate reference genes for quantitative sod gene expression analysis in C. elegans. BMC Mol. Biol.  9:9.



Hoogewijs D, Geuens E, Tilleman L, Vanfleteren JR, Moens L and Dewilde S (2008) Ever surprising nematode globins. In: Dioxygen Binding and Sensing Proteins, a tribute to Beatrice and Jonathan Wittenberg. Protein Reviews Series Vol. 9 (Eds. Bolognesi M, Di Prisco G, Verde C), p. 223-239, Springer, Milan.



Vinogradov SN, Hoogewijs D, Bailly X, Mizuguchi K, Dewilde S, Moens L and Vanfleteren JR (2007) A model of globin evolution. Gene 398, 132-142.



Hoogewijs D, Terwilliger NB, Webster KA, Powell-Coffman JA, Tokishita S, Yamagata H, Hankeln T, Burmester T, Rytkönen KT, Nikinmaa M, Abele D, Heise K,  Lucassen M, Fandrey J, Maxwell PH, Pahlman S and Gorr TA (2007) From critters to cancers: bridging trajectories between comparative and clinical research of oxygen sensing, HIF signaling and adaptations towards hypoxia. Integr. Comp. Biol. 47, 552-577. 



Thijs L, Vinck E, Wan X, Bolli A, Trandafir F, Hoogewijs D, Coletta M, Fago A, Weber R, Van Doorslaer S, Ascenzi P, Alam M, Moens L and Dewilde S (2007) Characterization of a globin coupled oxygen sensor with a gene regulating function. J. Biol. Chem. 282, 37325-37340.



Hoogewijs D, Geuens E, Dewilde S, Vierstraete A, Moens L, Vinogradov SN and Vanfleteren JR (2007) Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family. BMC Genomics 8:356.



Trandafir F, Hoogewijs D, Altieri F, Rivetti di Val Cervo P, Ramser K, Van Doorslaer S, Turano C, Vanfleteren JR, Moens L and Dewilde S (2007) Neuro- and cytoglobin as potential enzymes or substrates. Gene 398, 103-113.



Vinogradov SN, Hoogewijs D, Bailly X, Arredondo-Peter R, Gough J, Dewilde S, Moens L and Vanfleteren JR (2006) A phylogenomic profile of globins. BMC Evol. Biol. 6:31.



Pesce A, Nardini M, Dewilde S, Hoogewijs D, Ascenzi P, Moens L and Bolognesi M (2005) Modulation of oxygen binding to insect hemoglobins: the structure of hemoglobin from the botfly Gasterophilus intestinalis. Protein Sci. 14, 3057-3063.



Vinogradov SN, Hoogewijs D, Bailly X, Arredondo-Peter R, Guertin M, Gough J,  Dewilde S, Moens L and Vanfleteren JR (2005) Three globin lineages belonging to two structural classes in genomes from the three kingdoms of life. Proc. Natl. Acad. Sci. USA 102, 11385-11389.



Houthoofd K, Fidalgo MA, Hoogewijs D, Braeckman BP, Lenaerts I, Brys K, Matthijssens F, De Vreese A, Van Eygen S, Munoz MJ and Vanfleteren JR (2005) Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode C. elegans. Aging Cell 4, 87-95.



Hoogewijs D, Geuens E, Dewilde S, Moens L, Vierstraete A, Vinogradov SN and Vanfleteren JR (2004) Genome-wide analysis of the globin gene family of C. elegans. IUBMB Life 56, 697-702.



Geuens E, Dewilde S, Hoogewijs D, Pesce A, Nienhaus K, Olsen J, Vanfleteren JR, Bolognesi M and Moens L (2004) Nerve globins in invertebrates. IUBMB Life 56, 653-656.