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Universitätsprofessor/in, Zentrum für Kinder- und Jugendmedizin
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2015 SS
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2014 WS
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2014 SS
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2013 WS
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Efficacy of Brincidofovir in Pediatric Stem Cell Transplant Recipients With Adenovirus InfectionsIn: Journal of the Pediatric Infectious Diseases Society Jg. 10 (2021) Nr. 11, S. 987 - 993Online Volltext: dx.doi.org/
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Eye tumors in childhood as first sign of tumor predisposition syndromes : Insights from an observational study conducted in Germany and AustriaIn: Cancers Jg. 13 (2021) Nr. 8, S. 1876Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Hematopoietic stem cell transplantation in children and adolescents with GATA2-related myelodysplastic syndromeIn: Bone Marrow Transplantation Jg. 56 (2021) Nr. 11, S. 2732 - 2741Online Volltext: dx.doi.org/ (Open Access)
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N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastomaIn: Scientific Reports Jg. 10 (2020) Nr. 1, S. 7157Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressivenessIn: Scientific Reports Jg. 10 (2020) Nr. 1, S. 218Online Volltext: dx.doi.org/ (Open Access)
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Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4⁺ CAR T Cell EfficacyIn: Frontiers in Immunology Jg. 11 (2020) S. 531Online Volltext: dx.doi.org/ (Open Access)
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ALK positively regulates MYCN activity through repression of HBP1 expressionIn: Oncogene Jg. 38 (2019) Nr. 15, S. 2690 - 2705Online Volltext: dx.doi.org/
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Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in MiceIn: Thyroid Jg. 29 (2019) Nr. 10, S. 1438 - 1446Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastomaIn: Cancer Letters Jg. 455 (2019) S. 24 - 33Online Volltext: dx.doi.org/
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The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell linesIn: BMC Cancer Jg. 19 (2019) S. 243Online Volltext: dx.doi.org/ (Open Access)
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A mechanistic classification of clinical phenotypes in neuroblastomaIn: Science Jg. 362 (2018) Nr. 6419, S. 1165 - 1170Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Author Correction : The landscape of genomic alterations across childhood cancersIn: Nature Jg. 559 (2018) Nr. 7714, S. E10Online Volltext: dx.doi.org/ (Open Access)
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Circulating microRNA biomarkers for metastatic disease in neuroblastoma patientsIn: JCI Insight Jg. 3 (2018) Nr. 23, e97021Online Volltext: dx.doi.org/ (Open Access)
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The landscape of genomic alterations across childhood cancersIn: Nature Jg. 555 (2018) Nr. 7696, S. 321 - 327Online Volltext: dx.doi.org/ (Open Access)
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The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human diseaseIn: OncoTarget Jg. 9 (2018) Nr. 9, S. 8334 - 8349Online Volltext: dx.doi.org/ (Open Access)
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2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic TumorsIn: Klinische Pädiatrie Jg. 229 (2017) Nr. 3, S. 147 - 167Online Volltext: dx.doi.org/
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Accelerating drug development for neuroblastoma - New Drug Development Strategy : an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma projectIn: Expert Opinion on Drug Discovery Jg. 12 (2017) Nr. 8, S. 801 - 811Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expressionIn: OncoImmunology Jg. 6 (2017) Nr. 6, e1320626Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Overexpression of Lin28b in neural stem cells is insufficient for brain tumor formation, but induces pathological lobulation of the developing cerebellumIn: The Cerebellum Jg. 16 (2017) Nr. 1, S. 122 - 131Online Volltext: dx.doi.org/
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Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell linesIn: Clinical & Experimental Ophthalmology Jg. 45 (2017) Nr. 3, S. 288 - 296Online Volltext: dx.doi.org/
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RITA displays anti-tumor activity in medulloblastomas independent of TP53 statusIn: OncoTarget Jg. 8 (2017) Nr. 17, S. 27882 - 27891Online Volltext: dx.doi.org/ (Open Access)
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Targeting tachykinin receptors in neuroblastomaIn: OncoTarget Jg. 8 (2017) Nr. 1, S. 430 - 443Online Volltext: dx.doi.org/ (Open Access)
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The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma modelsIn: OncoTarget Jg. 8 (2017) Nr. 4, S. 6730 - 6741Online Volltext: dx.doi.org/ (Open Access)
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Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cellsIn: OncoTarget Jg. 7 (2016) Nr. 46, S. 74415 - 74426Online Volltext: dx.doi.org/ (Open Access)
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Development of Port-Site Metastases Following Thoracoscopic Resection of a NeuroblastomaIn: Pediatric Blood and Cancer Jg. 63 (2016) Nr. 1, S. 149 - 151Online Volltext: dx.doi.org/
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Immune response modulation by Galectin-1 in a transgenic model of neuroblastomaIn: OncoImmunology Jg. 5 (2016) Nr. 5, e1131378Online Volltext: dx.doi.org/ (Open Access)
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LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19In: Haematologica / The Hematology Journal Jg. 101 (2016) Nr. 6, S. e240 - e244Online Volltext: dx.doi.org/ (Open Access)
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MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastomaIn: OncoTarget Jg. 7 (2016) S. 66344 - 66359Online Volltext: dx.doi.org/ (Open Access)
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Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastomaIn: OncoTarget Jg. 7 (2016) Nr. 2, S. 1960 - 1972Online Volltext: dx.doi.org/
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Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot studyIn: European Journal of Cancer (EJC) Jg. 65 (2016) S. 91 - 101Online Volltext: dx.doi.org/
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Targeting MYCN-driven transcription by BET-bromodomain inhibitionIn: Clinical Cancer Research Jg. 22 (2016) Nr. 10, S. 2470 - 2781Online Volltext: dx.doi.org/ (Open Access)
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The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapseIn: OncoTarget Jg. 7 (2016) Nr. 6, S. 6620 - 6625Online Volltext: dx.doi.org/ (Open Access)
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Towards diagnostic application of non-coding RNAs in neuroblastomaIn: Expert Review of Molecular Diagnostics Jg. 16 (2016) Nr. 12, S. 1307 - 1313Online Volltext: dx.doi.org/
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A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studiesIn: Oncogene Jg. 34 (2015) Nr. 26, S. 3357 - 3368Online Volltext: dx.doi.org/ (Open Access)
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Absence of telomerase reverse transcriptase promoter mutations in neuroblastomaIn: Biomedical Reports Jg. 3 (2015) Nr. 4, S. 443 - 446Online Volltext: dx.doi.org/
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IGF2BP1 Harbors Prognostic Significance by Gene Gain and Diverse Expression in NeuroblastomaIn: Journal of Clinical Oncology (JCO) Jg. 33 (2015) Nr. 11, S. 1285 - 1293Online Volltext: dx.doi.org/
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MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosisIn: European Journal of Nuclear Medicine and Molecular Imaging Jg. 42 (2015) Nr. 2, S. 222 - 230Online Volltext: dx.doi.org/ (Open Access)
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MYCN and MicroRNAsIn: Pediatric and Adolescent Medicine Jg. 20 (2015) S. 35 - 46Online Volltext: dx.doi.org/
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MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastomaIn: Cancer Letters Jg. 366 (2015) Nr. 1, S. 123 - 132Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formationIn: OncoTarget Jg. 6 (2015) Nr. 7, S. 5204 - 5216Online Volltext: dx.doi.org/ (Open Access)
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MiR-34a deficiency accelerates medulloblastoma formation in vivoIn: International Journal of Cancer Jg. 136 (2015) Nr. 10, S. 2293 - 2303Online Volltext: dx.doi.org/ (Open Access)
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Mutational dynamics between primary and relapse neuroblastomasIn: Nature Genetics Jg. 47 (2015) Nr. 8, S. 872 - 877Online Volltext: dx.doi.org/
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Neoadjuvant/adjuvant treatment of high-risk retinoblastoma : a report from the German Retinoblastoma Referral CentreIn: British Journal of Ophthalmology (BJO) Jg. 99 (2015) Nr. 7, S. 949 - 953Online Volltext: dx.doi.org/
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NeuroblastomaIn: Critical Reviews in Oncogenesis Jg. 20 (2015) Nr. 3-4, S. 245 - 270Online Volltext: dx.doi.org/
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Relapsed neuroblastomas show frequent RAS-MAPK pathway mutationsIn: Nature Genetics Jg. 47 (2015) Nr. 8, S. 864 - 871Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumorsIn: OncoTarget Jg. 6 (2015) Nr. 17, S. 15425 - 15435Online Volltext: dx.doi.org/ (Open Access)
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Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastomaIn: Cancer Research Jg. 75 (2015) Nr. 15 Suppl., S. 4731Online Volltext: dx.doi.org/
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Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Nature Jg. 526 (2015) Nr. 7575, S. 700 - 704Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Cancer Research Jg. 75 (2015) Nr. 15 Suppl., S. LB - 210Online Volltext: dx.doi.org/
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Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiationIn: Science Signaling Jg. 8 (2015) Nr. 374,Online Volltext: dx.doi.org/
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Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : Implications for targeted treatmentIn: Clinical Cancer Research Jg. 21 (2015) Nr. 14, S. 3327 - 3339Online Volltext: dx.doi.org/ (Open Access)
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miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating SurvivinIn: International Journal of Cancer Jg. 136 (2015) Nr. 6, S. 1308 - 1320Online Volltext: dx.doi.org/ (Open Access)
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ALK pERKs up MYCN in neuroblastomaIn: Science Signaling Jg. 7 (2014) Nr. 349, S. pe27Online Volltext: dx.doi.org/
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BET protein inhibitor OTX015 has selective anti-tumoral activity in preclinical models of MYCN- amplified neuroblastomaIn: Cancer Research Jg. 74 (2014) Nr. 19 Suppl., S. 3967Online Volltext: dx.doi.org/
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CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patientsIn: PLoS ONE Jg. 9 (2014) Nr. 12, S. e114696Online Volltext: dx.doi.org/ (Open Access)
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Early Targets of miR-34a in NeuroblastomaIn: Molecular and Cellular Proteomics (MCP) Jg. 13 (2014) Nr. 8, S. 2114 - 2131Online Volltext: dx.doi.org/
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Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastomaIn: Pediatric Blood and Cancer Jg. 61 (2014) Nr. 10, S. 1867 - 1870Online Volltext: dx.doi.org/
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Neuroblastoma in dialog with its stroma : NTRK1 is a regulator of cellular cross-talk with Schwann cellsIn: OncoTarget Jg. 5 (2014) Nr. 22, S. 11180 - 11192Online Volltext: dx.doi.org/ (Open Access)
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Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsamplingIn: PLoS ONE Jg. 9 (2014) Nr. 10, S. e108818Online Volltext: dx.doi.org/ (Open Access)
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p19-INK4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in MYCN-amplified neuroblastomasIn: Human Molecular Genetics Jg. 23 (2014) Nr. 25, S. 6826 - 6837Online Volltext: dx.doi.org/
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BET bromodomain protein inhibition is a therapeutic option for medulloblastomaIn: OncoTarget Jg. 4 (2013) Nr. 11, S. 2080 - 2095Online Volltext: dx.doi.org/
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Chemoreduction improves eye retention in patients with retinoblastoma : a report from the German Retinoblastoma Reference CentreIn: British Journal of Ophthalmology (BJO) Jg. 97 (2013) Nr. 10, S. 1277 - 1283Online Volltext: dx.doi.org/
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Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cellsIn: International Journal of Cancer Jg. 133 (2013) Nr. 4, S. 908 - 919Online Volltext: dx.doi.org/
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Focal DNA copy number changes in neuroblastoma target MYCN regulated genesIn: PLoS ONE Jg. 8 (2013) Nr. 1, S. e52321Online Volltext: dx.doi.org/ (Open Access)
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Histone deacetylase 10 promotes autophagy-mediated cell survivalIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 110 (2013) Nr. 28,Online Volltext: dx.doi.org/
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Identifying transcriptional miRNA biomarkers by integrating high-throughput sequencing and real-time PCR dataIn: Methods: A Companion to Methods in Enzymology Jg. 59 (2013) Nr. 1, S. 154 - 163Online Volltext: dx.doi.org/
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Knock-down of lysine specific demethylase-1 drives hematopoietic stem cells into a CD41+myeloid biased phenotypeIn: Onkologie Jg. 36 (2013) Nr. Suppl. 7, S. 228 - 228
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LIN28B drives neuroblastoma oncogenesis through let7-MYCN signalingIn: Cancer Research Jg. 73 (2013) Nr. 8 Suppl. 1, S. 4596Online Volltext: dx.doi.org/
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Long-term follow-up of pediatric patients receiving total body irradiation before hematopoietic stem cell transplantation and post-transplant survival of >2 yearsIn: Pediatric Blood and Cancer Jg. 60 (2013) Nr. 11, S. 1792 - 1797Online Volltext: dx.doi.org/
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MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cellsIn: Oncogene Jg. 32 (2013) Nr. 8, S. 1059 - 1065Online Volltext: dx.doi.org/
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MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastomaIn: Nucleic Acids Research Jg. 41 (2013) Nr. 12, S. 6018 - 6033Online Volltext: dx.doi.org/ (Open Access)
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MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1AIn: International Journal of Cancer Jg. 133 (2013) Nr. 5, S. 1064 - 1073Online Volltext: dx.doi.org/
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Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAsIn: Oncogene Jg. 32 (2013) Nr. 24, S. 2927 - 2936Online Volltext: dx.doi.org/
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Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interactionIn: Scientific Reports Jg. 3 (2013) S. 1351Online Volltext: dx.doi.org/ (Open Access)
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Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-amplified neuroblastomaIn: International Journal of Cancer Jg. 132 (2013) Nr. 3, S. E106 - E115Online Volltext: dx.doi.org/
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Targeted Therapy for Neuroblastoma : ALK InhibitorsIn: Klinische Pädiatrie Jg. 225 (2013) Nr. 6, S. 303 - 308Online Volltext: dx.doi.org/
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The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemiaIn: BMC Cancer Jg. 13 (2013) S. 452Online Volltext: dx.doi.org/ (Open Access)
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The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastomaIn: Acta Neuropathologica Communications Jg. 1 (2013) Nr. 1, S. 19Online Volltext: dx.doi.org/ (Open Access)
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CD57(high) neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patientsIn: PLoS ONE Jg. 7 (2012) Nr. 8, S. e42025Online Volltext: dx.doi.org/ (Open Access)
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Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastomaIn: International Journal of Cancer Jg. 130 (2012) Nr. 11, S. 2591 - 2598Online Volltext: dx.doi.org/
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Die Vision der personalisierten Medizin : Neue Wege in der Diagnostik und Behandlung von Tumoren des zentralen Nervensystems im Kindes- und JugendalterIn: Unikate: Berichte aus Forschung und Lehre (2012) Nr. 42: Translationale Krebsforschung: Auf dem Weg zu neuen Therapien, S. 124 - 135Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcomeIn: British Journal of Cancer (BJC) Jg. 107 (2012) Nr. 8, S. 1409 - 1417Online Volltext: dx.doi.org/ (Open Access)
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Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkersIn: Genome Biology Jg. 13 (2012) Nr. 10, R 95Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomasIn: International Journal of Cancer Jg. 130 (2012) Nr. 11, S. 2599 - 2606Online Volltext: dx.doi.org/
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LIN28B drives neuroblastoma oncogenesis through let7-MYCN signalingIn: Klinische Pädiatrie Jg. 224 (2012) S. 222Online Volltext: dx.doi.org/
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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppressionIn: Nature Genetics Jg. 44 (2012) Nr. 11, S. 1199 - 1206Online Volltext: dx.doi.org/
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Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiationIn: Leukemia Jg. 26 (2012) Nr. 9, S. 2039 - 2051Online Volltext: dx.doi.org/
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Maßgeschneiderte Nager : Genetisch veränderte Mäuse helfen bei der Entwicklung zielgerichteter TherapienIn: Unikate: Berichte aus Forschung und Lehre (2012) Nr. 42: Translationale Krebsforschung: Auf dem Weg zu neuen Therapien, S. 42 - 50Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastomaIn: Oncogene Jg. 31 (2012) Nr. 12, S. 1571 - 1581Online Volltext: dx.doi.org/
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Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomasIn: Neuro-Oncology Jg. 14 (2012) Nr. 7, S. 859 - 869Online Volltext: dx.doi.org/ (Open Access)
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RITA-p53 activation in medulloblastoma as a new approach for treatment?In: Klinische Pädiatrie Jg. 224 (2012) S. 221Online Volltext: dx.doi.org/
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Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formationIn: Nature Cell Biology Jg. 14 (2012) Nr. 9, S. 958 - 965Online Volltext: dx.doi.org/
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Targeted expression of mutated ALK induces neuroblastoma in transgenic miceIn: Science Translational Medicine Jg. 4 (2012) Nr. 141, S. 141ra91Online Volltext: dx.doi.org/
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The JARID 1C histone demethylase is upregulated in aggressive neuroblastomas independent of MYCN amplificationIn: Klinische Pädiatrie Jg. 224 (2012) S. 221 - 222Online Volltext: dx.doi.org/
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Total body irradiation (TBI) in the conditioning regimens prior to hematopoietic stem cell transplantation (HSCT) : Long-term follow-up of 98 pediatric patientsIn: Strahlentherapie und Onkologie Jg. 188 (2012) Nr. Suppl. 1, S. 108Online Volltext: dx.doi.org/
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CAMTA1, a 1p36 Tumor Suppressor Candidate, Inhibits Growth and Activates Differentiation Programs in Neuroblastoma CellsIn: Cancer Research Jg. 71 (2011) Nr. 8, S. 3142 - 3151Online Volltext: dx.doi.org/
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High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary NeuroblastomaIn: Clinical Cancer Research Jg. 17 (2011) Nr. 15, S. 5082 - 5092Online Volltext: dx.doi.org/
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MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastomaIn: PLoS ONE Jg. 6 (2011) Nr. 9, S. e24584Online Volltext: dx.doi.org/ (Open Access)
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Molecular Targets in Embryonal TumorsIn: Klinische Pädiatrie Jg. 223 (2011) Nr. 1, S. 48Online Volltext: dx.doi.org/
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Neuroblastoma develops from neural crest stem cellsIn: Klinische Pädiatrie Jg. 223 (2011) Nr. 3, S. 198 - 198Online Volltext: dx.doi.org/
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Pharmacological activation of the p53 pathway by nutlin-3 inhibits medulloblastoma cell proliferation in vitro and in vivoIn: European Journal of Pediatrics Jg. 170 (2011) Nr. 2, S. 267 - 268Online Volltext: dx.doi.org/
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Polo-like kinase 1 is a therapeutic target in high-risk neuroblastomaIn: Clinical Cancer Research Jg. 17 (2011) Nr. 4, S. 731 - 741Online Volltext: dx.doi.org/
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Regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinomaIn: International Journal of Cancer Jg. 129 (2011) Nr. 10, S. 2390 - 2399Online Volltext: dx.doi.org/
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miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samplesIn: Clinical Cancer Research Jg. 17 (2011) Nr. 24, S. 7684 - 7692Online Volltext: dx.doi.org/
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A small kiss of death for cancerIn: Nature Medicine Jg. 16 (2010) Nr. 10, S. 1079 - 1081Online Volltext: dx.doi.org/
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Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signatureIn: Clinical Cancer Research Jg. 16 (2010) Nr. 5, S. 1532 - 1541Online Volltext: dx.doi.org/
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Accurate prediction of neuroblastoma outcome based on miRNA expression profilesIn: International Journal of Cancer Jg. 127 (2010) Nr. 10, S. 2374 - 2385Online Volltext: dx.doi.org/
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An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumoursIn: Oncogene Jg. 29 (2010) Nr. 24, S. 3583 - 3592Online Volltext: dx.doi.org/
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Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastomaIn: Clinical Cancer Research Jg. 16 (2010) Nr. 11, S. 2971 - 2978Online Volltext: dx.doi.org/
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Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastomaIn: Nucleic Acids Research Jg. 38 (2010) Nr. 17, S. 5919 - 5928Online Volltext: dx.doi.org/
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KDM 1A/LSD1 has a functional role in migration of medulloblastoma cells and their neuronal precursorsIn: Klinische Pädiatrie Jg. 222 (2010) Nr. 3, S. 221
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LSD1 is a novel therapeutic target in neuroblastoma (NB) and medulloblastoma (MB)In: European Journal of Pediatrics Jg. 169 (2010) Nr. 3, S. 381Online Volltext: dx.doi.org/
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MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumorsIn: Oncogene Jg. 29 (2010) Nr. 9, S. 1394 - 1404Online Volltext: dx.doi.org/
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Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplificationIn: Clinical Cancer Research Jg. 16 (2010) Nr. 17, S. 4353 - 4362Online Volltext: dx.doi.org/
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Plk1 is a novel target for high-risk neuroblastoma therapyIn: Klinische Pädiatrie Jg. 222 (2010) Nr. 3, S. 222 - A21Online Volltext: dx.doi.org/
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Production of chick embryo extract for the cultivation of murine neural crest stem cellsIn: JoVE Jg. 2010 (2010) Nr. 45,Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The DNA-binding protein YB-1 is a direct MYCN target and influences repair and resistance in neuroblastoma cell linesIn: Klinische Pädiatrie Jg. 222 (2010) Nr. 3, S. 219Online Volltext: dx.doi.org/
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The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in NeuroblastomaIn: Molecular Cell Jg. 40 (2010) Nr. 5, S. 762 - 773Online Volltext: dx.doi.org/
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ALK Mutation Analysis in Patients of the German Neuroblastoma StudyIn: Klinische Pädiatrie Jg. 221 (2009) Nr. 3, S. 195Online Volltext: dx.doi.org/
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Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressivenessIn: Oncogene Jg. 28 (2009) Nr. 19, S. 2015 - 2023Online Volltext: dx.doi.org/
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LSD 1 is a Potential Therapeutic Target in MedulloblastomaIn: Klinische Pädiatrie Jg. 221 (2009) Nr. 3, S. 203 - 204Online Volltext: dx.doi.org/
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Lysine-Specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : Implications for therapyIn: Klinische Pädiatrie Jg. 221 (2009) Nr. 3, S. A61Online Volltext: dx.doi.org/
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Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : implications for therapyIn: Cancer Research Jg. 69 (2009) Nr. 5, S. 2065 - 2071Online Volltext: dx.doi.org/ (Open Access)
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MicroRNAs 221 and 222 in the Pathogenesis of Solid Childhood TumorsIn: Klinische Pädiatrie Jg. 221 (2009) Nr. 3, S. 210Online Volltext: dx.doi.org/
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MicroRNAs in the pathogenesis of neuroblastomaIn: Cancer Letters Jg. 274 (2009) Nr. 1, S. 10 - 15Online Volltext: dx.doi.org/
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N-myc induces transformation of neural crest stem cells in vitro and in vivoIn: Klinische Pädiatrie Jg. 221 (2009) Nr. 3, S. 195Online Volltext: dx.doi.org/
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Pharmacologic activation of the p53 pathway using Nutlin-3 inhibits medulloblastoma cell proliferation in vitroIn: Klinische Pädiatrie Jg. 221 (2009) Nr. 3, S. 201Online Volltext: dx.doi.org/
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Prognostic role and functional analyses of miRNA expression in neuroblastomaIn: Klinische Pädiatrie Jg. 221 (2009) Nr. 3, S. 206Online Volltext: dx.doi.org/
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Proteomics of neuroblastoma master regulatorsIn: Klinische Pädiatrie Jg. 221 (2009) Nr. 3, S. 209Online Volltext: dx.doi.org/
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Reanalysis of neuroblastoma expression profiling data using improved methodology and extended follow-up increases validity of outcome predictionIn: Cancer Letters Jg. 282 (2009) Nr. 1, S. 55 - 62Online Volltext: dx.doi.org/
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Stabilization of N-Myc is a critical function of Aurora A in human neuroblastomaIn: Cancer Cell Jg. 15 (2009) Nr. 1, S. 67 - 78Online Volltext: dx.doi.org/
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The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivoIn: International Journal of Cancer Jg. 124 (2009) Nr. 10, S. 2488 - 2494Online Volltext: dx.doi.org/
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The miR-17-92 gene cluster is amplified and overexpressed in retinoblastomaIn: Klinische Pädiatrie Jg. 221 (2009) Nr. 3, S. 195Online Volltext: dx.doi.org/
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Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cellsIn: DNA Repair Jg. 7 (2008) Nr. 10, S. 1757 - 1764Online Volltext: dx.doi.org/
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Expression of the p75 neurotrophin receptor reduces tumorigenity of neuroblastoma cells in vivo and in vitroIn: Klinische Pädiatrie Jg. 220 (2008) Nr. 3, S. 206
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Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcomaIn: The Journal of Pathology Jg. 216 (2008) Nr. 4, S. 428 - 439Online Volltext: dx.doi.org/
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MYCN regulates oncogenic MicroRNAs in neuroblastomaIn: International Journal of Cancer Jg. 122 (2008) Nr. 3, S. 699 - 704Online Volltext: dx.doi.org/
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The LSD 1 histone demethylase is highly expressed in poorly differentiated neuroblastoma and is a novel therpeutic targetIn: Klinische Pädiatrie Jg. 220 (2008) Nr. 3, S. 208
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Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cellsIn: Cancer Letters Jg. 271 (2008) Nr. 1, S. 56 - 63Online Volltext: dx.doi.org/
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N-MYC regulates oncogenic micrornas in neuroblastomaIn: Pediatric Blood and Cancer Jg. 49 (2007) Nr. 4, S. 429 - 429Online Volltext: dx.doi.org/
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N-Myc regulates oncogenic micrortnas in neuroblastomaIn: European Journal of Pediatrics Jg. 166 (2007) Nr. 3, S. 278Online Volltext: dx.doi.org/
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Translating expression profiling into a clinically feasible test to predict neuroblastoma outcomeIn: Clinical Cancer Research Jg. 13 (2007) Nr. 5, S. 1459 - 1465Online Volltext: dx.doi.org/
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Expression of TrkA is a potential regulator of immunogenicity in neuroblastoma cellsIn: Klinische Pädiatrie Jg. 218 (2006) Nr. 3, S. 192 - 192
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MicroRNA expression analysis in neuroblastoma using pligonuclectide arraysIn: Klinische Pädiatrie Jg. 218 (2006) Nr. 3, S. 194
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Microarray analysis defines IPL/TSSC3 as a potential target mediating the synergistic effects of combined thermo-chemotherapy in neuroblastoma cellsIn: Klinische Pädiatrie Jg. 218 (2006) Nr. 3, S. 192 - 193Online Volltext: dx.doi.org/
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Biological effects of TrkA and TrkB receptor signaling in neuroblastomaIn: Cancer letters Jg. 228 (2005) Nr. 1-2, S. 143 - 153Online Volltext: dx.doi.org/
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Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomasIn: Oncogene Jg. 24 (2005) Nr. 1, S. 165 - 177
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Prediction of clinical outcome and biological characterization of neuroblastoma by expression profilingIn: Oncogene Jg. 24 (2005) Nr. 53, S. 7902 - 7912Online Volltext: dx.doi.org/
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The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasivenessIn: Carcinogenesis Jg. 26 (2005) Nr. 12, S. 2105 - 2115Online Volltext: dx.doi.org/
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NT-3 mediated signaling pathways in DAOY medulloblastoma cellsIn: Neuro-Oncology Jg. 6 (2004) Nr. 4, S. 409 - 409Online Volltext: dx.doi.org/
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Microarray-analysis : a new approach to study the molecular mechanisms of thermo-chemotherapyIn: Klinische Pädiatrie Jg. 215 (2003) Nr. 6, S. 298 - 302Online Volltext: dx.doi.org/
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Integrated Genomic Analysis Identifies Specific Alterations and Activation of Yap in Relapsed Neuroblastoma
47th Congress of the International Society of Paediatric Oncology (SIOP), October 8–11, 2015, Cape Town, South Africa,In: Pediatric Blood and Cancer Jg. 62 (2015) Nr. S4, S. S145 - S145Online Volltext: dx.doi.org/ -
ALK F1174L kinase activity as driver of cell proliferation in neuroblastoma cell line models and neuroblastoma tumorsIn: Cancer Research Jg. 72 (2012) Nr. 8, Suppl., S. 1683Online Volltext: dx.doi.org/
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Lysin-Specific Histone Dementhylase 1(LSD1) is a promising new Epigenetic Theapy target Crucially involved in the migration of Medulloblastoma Cells
15th International Symposium on Pediatric Neuro-Oncology, June 24-27 2012 Toronto, Ontario, Canada,In: Neuro-Oncology Jg. 14 (2012) Nr. Suppl. 1, S. i92Online Volltext: dx.doi.org/ -
miR-34a is dispensable for normal development but its loss Accelerates medulloblastoma formation
15th International Symposium on Pediatric Neuro-Oncology, June 24-27 2012 Toronto, Ontario, Canada,In: Neuro-Oncology Jg. 14 (2012) Nr. Suppl. 1, S. 89Online Volltext: dx.doi.org/ -
Long-term follow-up of patients receiving chemoreduction for intraocular rettinoblatoma in the German RB Center (1995-2004)
43rd Congress of the International Society of Paediatric Oncology (SIOP) 2011 ; 28th–30th October, 2011, Auckland, New Zealand,In: Pediatric Blood and Cancer Jg. 57 (2011) Nr. 5, S. 785Online Volltext: dx.doi.org/ -
Long-term follow-up of pediatric patients receiving total body irradiation before bone marrow transplantation
43rd Congress of the International Society of Paediatric Oncology (SIOP) 2011 ; 28th–30th October, 2011, Auckland, New Zealand,In: Pediatric Blood and Cancer Jg. 57 (2011) Nr. 5, S. 827Online Volltext: dx.doi.org/ -
Lysine-Specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : Implications for therapyIn: Klinische Pädiatrie / 13th Expert Meeting for Pediatric Oncology and Hematology ; Molecular Targeted Therapies for Childhood Cancers ; Günzburg, 28th-30th January 2010 Jg. 223 (2011) Nr. 1, S. A15Online Volltext: dx.doi.org/
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Accurate prediction of neuroblastoma outcome based on miRNA expression profiles
42nd Congress of the International Society of Pediatric Oncology (SIOP), October 21-24, 2010, Boston, USA,In: Pediatric Blood and Cancer Jg. 55 (2010) Nr. 5, S. 812Online Volltext: dx.doi.org/ -
Deep Sequencing Revals Differential Expression of Micrornas in Favourable Versus Unfavourable Neuroblastoma
42nd Congress of the International Society of Pediatric Oncology (SIOP) in Boston,In: Pediatric Blood and Cancer Jg. 55 (2010) Nr. 5, S. 826 - 827Online Volltext: dx.doi.org/ -
High Expression of the alk Receptor Tyrosine Kinase Precedes Mutation as a Determining Factor of Unfavourable Phenotype in Primary Neuroblastoma
42nd Congress of the International Society of Pediatric Oncology (SIOP), October 21-24, 2010, Boston, USA,In: Pediatric Blood and Cancer Jg. 55 (2010) Nr. 5, S. 827Online Volltext: dx.doi.org/ -
Pharmacologic Activation of the P53 Pathway by Nutlin-3 Inhibits Medulloblastoma Cell Proliferation in Vitro
42nd Congress of the International Society of Pediatric Oncology (SIOP), October 21-24, 2010, Boston, USA,In: Pediatric Blood and Cancer Jg. 55 (2010) Nr. 5, S. 918Online Volltext: dx.doi.org/ -
Development of Guidelines for Parents with Children Neuwly Diagnosed with Cancer : Nutrition, Personal and Oral Hygiene
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,In: Pediatric Blood and Cancer Jg. 53 (2009) Nr. 5, S. 757Online Volltext: dx.doi.org/ -
Exon-Level gene expression analysis of primary neuroblastomas improves risk prediction and identifies jaridic as a novel Therapeutic target
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,In: Pediatric Blood and Cancer Jg. 53 (2009) Nr. 5, S. 742 - 743Online Volltext: dx.doi.org/ -
LSD1 is a Potential Therapeutic Target in Medulloblastoma
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, October 5–9, 2009, Sao Paulo, Brazil,In: Pediatric Blood and Cancer Jg. 53 (2009) Nr. 5, S. 826Online Volltext: dx.doi.org/ -
Modeling Neuroblastomagenesis from neural crest Stem Cells in Vitro and in Vivo
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,In: Pediatric Blood and Cancer Jg. 53 (2009) Nr. 5, S. 703 - 704Online Volltext: dx.doi.org/ -
The MIR-17-92 Gene Cluster is Amplified an overexpressed in Rettinoblastoma
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,In: Pediatric Blood and Cancer Jg. 53 (2009) Nr. 5, S. 735Online Volltext: dx.doi.org/ -
Analysen molekularer und epigenetischer Veränderungen in neuroblastischen TumorenDuisburg, Essen (2011) 1 CD-ROM
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Analyse neurotrophinrezeptor-vermittelter Genregulationsmuster in neuroblastischen TumorenDuisburg, Essen (2007) 129 Bl. : Ill., graph. Darst.