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Dr. rer. nat. Johann Matschke

Funktionen

  • Wissenschaftliche/r Mitarbeiter/in, Institut für Zellbiologie (Tumorforschung)

Aktuelle Veranstaltungen

Keine aktuellen Veranstaltungen.

Vergangene Veranstaltungen (max. 10)

Keine vergangenen Veranstaltungen.

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Cihankaya, Hilal; Bader, Verian; Winklhofer, Konstanze F.; Vorgerd, Matthias; Matschke, Johann; Stahlke, Sarah; Theiss, Carsten; Matschke, Veronika
    Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS
    In: Cells Jg. 13 (2024) Nr. 12, 995
    Online Volltext: dx.doi.org/ (Open Access)
  • Dankó, Benedek; Hess, Julia; Unger, Kristian; Samaga, Daniel; Walz, Christoph; Walch, Axel; Sun, Na; Baumeister, Philipp; Zeng, Peter Y. F.; Walter, Franziska; Marschner, Sebastian; Späth, Richard; Gires, Olivier; Herkommer, Timm; Dazeh, Ramin; Matos, Thaina; Kreutzer, Lisa; Matschke, Johann; Eul, Katharina; Klauschen, Frederick; Pflugradt, Ulrike; Canis, Martin; Ganswindt, Ute; Mymryk, Joe S.; Wollenberg, Barbara; Nichols, Anthony C.; Belka, Claus; Zitzelsberger, Horst; Lauber, Kirsten; Selmansberger, Martin
    Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer
    In: npj Precision Oncology Jg. 8 (2024) Nr. 1, 116
    Online Volltext: dx.doi.org/ (Open Access)
  • Xiang, Kexu; Kunin, Mikhail; Larafa, Safa; Busch, Maike; Dünker, Nicole; Jendrossek, Verena; Matschke, Johann
    α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cells
    In: Cell Death Discovery Jg. 10 (2024) Nr. 1, 27
    Online Volltext: dx.doi.org/ (Open Access)
  • Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; Matschke, Johann; Jendrossek, Verena; Remke, Marc; Grüner, Barbara M.; Rösch, Alexander; Siveke, Jens; Herold-Mende, Christel; Blau, Tobias; Keyvani, Kathy; van Landeghem, Frank K H; Pietsch, Torsten; Felsberg, Jörg; Reifenberger, Guido; Weller, Michael; Sure, Ulrich; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn
    A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
    In: Clinical Cancer Research Jg. 29 (2023) Nr. 2, S. 488 - 500
    Online Volltext: dx.doi.org/ (Open Access)
  • Henning, Yoshiyuki; Willbrand, Katrin; Larafa, Safa; Weißenberg, Gesa; Matschke, Veronika; Theiss, Carsten; Görtz, Gina-Eva; Matschke, Johann
    Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia
    In: Cell Death Discovery Jg. 9 (2023) Nr. 1, 398
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Dellin, Maurice; Rohrbeck, Ina; Asrani, Purva; Schreiber, Julian A.; Ritter, Nadine; Glorius, Frank; Wünsch, Bernhard; Budde, Thomas; Temme, Louisa; Strünker, Timo; Stallmeyer, Birgit; Tüttelmann, Frank; Meuth, Sven G.; Spehr, Marc; Matschke, Johann; Steinbicker, Andrea; Gatsogiannis, Christos; Stoll, Raphael; Strutz-Seebohm, Nathalie; Seebohm, Guiscard
    The second PI(3,5)P₂binding site in the S0 helix of KCNQ1 stabilizes PIP₂-at the primary PI1 site with potential consequences on intermediate-to-open state transition
    In: Biological Chemistry Jg. 404 (2023) Nr. 4,
    Online Volltext: dx.doi.org/
  • Xiang, Kexu; Kalthoff, Christian; Münch, Corinna; Jendrossek, Verena; Matschke, Johann
    Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity
    In: Cell Death and Disease Jg. 13 (2022) Nr. 7, 641
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Henning, Yoshiyuki; Blind, Ursula Sarah; Larafa, Safa; Matschke, Johann; Fandrey, Joachim
    Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction
    In: Cell Death and Disease Jg. 13 (2022) Nr. 7, 662
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Junghans, Maya; John, Felix; Cihankaya, Hilal; Schliebs, Daniel; Winklhofer, Konstanze F.; Bader, Verian; Matschke, Johann; Theiss, Carsten; Matschke, Veronika
    ROS scavengers decrease γH2ax spots in motor neuronal nuclei of ALS model mice in vitro
    In: Frontiers in Cellular Neuroscience Jg. 16 (2022) 963169
    Online Volltext: dx.doi.org/ (Open Access)
  • Goetting, Isabell; Larafa, Safa; Eul, Katharina; Kunin, Mikhail; Jakob, Burkhard; Matschke, Johann; Jendrossek, Verena
    Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation
    In: Frontiers in Oncology Jg. 12 (2022) 920017
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Hansel, Christine; Hlouschek, Julian; Xiang, Kexu; Melnikova, Margarita; Thomale, Jürgen; Helleday, Thomas; Jendrossek, Verena; Matschke, Johann
    Adaptation to chronic-cycling hypoxia renders cancer cells resistant to mth1-inhibitor treatment which can be counteracted by glutathione depletion
    In: Cells Jg. 10 (2021) Nr. 11, 3040
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Stein, Jan; Walkenfort, Bernd; Cihankaya, Hilal; Hasenberg, Mike; Bader, Verian; Winklhofer, Konstanze F.; Röderer, Pascal; Matschke, Johann; Theiss, Carsten; Matschke, Veronika
    Increased ROS-Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis
    In: Oxidative Medicine and Cellular Longevity Jg. 2021 (2021) 6924251
    Online Volltext: dx.doi.org/ (Open Access)
  • Matschke, Johann; Larafa, Safa; Jendrossek, Verena
    Metabolic reprograming of antioxidant defense : A precision medicine perspective for radiotherapy of lung cancer?
    In: Biochemical Society Transactions Jg. 49 (2021) Nr. 3, S. 1265 - 1277
    Online Volltext: dx.doi.org/
  • Krysztofiak, Adam; Szymonowicz, Klaudia; Hlouschek, Julian; Xiang, Kexu; Waterkamp, Christoph; Larafa, Safa; Goetting, Isabell; Vega-Rubin-de-Celis, Silvia; Theiss, Carsten; Matschke, Veronika; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
    In: iScience Jg. 24 (2021) Nr. 11, 103366
    Online Volltext: dx.doi.org/ (Open Access)
  • Götting, Isabell; Jendrossek, Verena; Matschke, Johann
    A new twist in protein kinase b/akt signaling : Role of altered cancer cell metabolism in akt-mediated therapy resistance
    In: International Journal of Molecular Sciences (IJMS) Jg. 21 (2020) Nr. 22, S. 8563
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Xiang, Kexu; Jendrossek, Verena; Matschke, Johann
    Oncometabolites and the response to radiotherapy
    In: Radiation Oncology Jg. 15 (2020) S. 197
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Szymonowicz, Klaudia; Krysztofiak, Adam; van der Linden, Jansje; Kern, Ajvar; Deycmar, Simon; Oeck, Sebastian; Squire, Anthony; Koska, Benjamin; Hlouschek, Julian; Vüllings, Melanie; Neander, Christian; Siveke, Jens; Matschke, Johann; Pruschy, Martin; Timmermann, Beate; Jendrossek, Verena
    Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
    In: Cells Jg. 9 (2020) Nr. 4, S. 889
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Matschke, Veronika; Theiss, Carsten; Matschke, Johann
    Oxidative stress: the lowest common denominator of multiple diseases
    In: Neural Regeneration Research Jg. 14 (2019) Nr. 2, S. 238 - 241
    Online Volltext: dx.doi.org/ (Open Access)
  • Shannan, B.; Matschke, Johann; Chauvistré, Heike; Vogel, F.; Klein, Diana; Meier, Friedegund; Westphal, Dana; Bruns, Johannes; Rauschenberg, Ricarda; Utikal, Jochen; Forschner, Andrea; Berking, Carola; Terheyden, Patrick; Dabrowski, Evelyn; Gutzmer, Ralf; Rafei-Shamsabadi, David Ali; Meiss, Frank; Heinzerling, Lucie M.; Zimmer, Lisa; Livingstone, Elisabeth; Váraljai, Renáta; Hoewner, A.; Horn, Susanne; Klode, Joachim; Stuschke, Martin; Scheffler, Björn; Marchetto, Aruna; Sannino, Giuseppina; Grünewald, Thomas Georg Philipp; Schadendorf, Dirk; Jendrossek, Verena; Rösch, Alexander
    Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanoma
    In: European Journal of Cancer (EJC) Jg. 109 (2019) S. 137 - 153
    Online Volltext: dx.doi.org/
  • Hlouschek, Julian; Ritter, Violetta; Wirsdörfer, Florian; Klein, Diana; Jendrossek, Verena; Matschke, Johann
    Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
    In: Cancer Letters Jg. 439 (2018) S. 24 - 38
    Online Volltext: dx.doi.org/
  • Hlouschek, Julian; Hansel, Christine; Jendrossek, Verena; Matschke, Johann
    The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
    In: Frontiers in Oncology Jg. 8 (2018) S. 170
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Matschke, Johann; Wiebeck, Elisa; Hurst, Sebastian; Rudner, Justine; Jendrossek, Verena
    Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia
    In: Radiation Oncology Jg. 11 (2016) Nr. 1, S. 75 - 87
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Matschke, Johann; Riffkin, Helena; Klein, Diana; Handrick, René; Lüdemann, Lutz; Metzen, Eric; Shlomi, Tomer; Stuschke, Martin; Jendrossek, Verena
    Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia
    In: Antioxidants and Redox Signaling Jg. 25 (2016) Nr. 2, S. 89 - 107
    Online Volltext: dx.doi.org/
  • Matschke, Veronika; Piccini, Ilaria; Schubert, Janina; Wrobel, Eva; Lang, Florian; Matschke, Johann; Amedonu, Elsie; Meuth, Sven G; Strünker, Timo; Strutz-Seebohm, Nathalie; Greber, Boris; Scherkenbeck, Jürgen; Seebohm, Guiscard
    The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels
    In: Cellular Physiology and Biochemistry Jg. 40 (2016) Nr. 6, S. 1549 - 1558
    Online Volltext: dx.doi.org/ (Open Access)
  • Matschke, Johann; Riffkin, H.; Handrick, R.; Klein-Hitpaß, Ludger; Jendrossek, Verena
    Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell death
    In: European Journal of Cancer (EJC) Jg. 49 (2013) Nr. Suppl. 2, S. 101
    Online Volltext: dx.doi.org/

    • Abstracts

  • Hessenow, Razan; Behrends, Carina; Xixi, Lin; Mladenov, Emil; Matschke, Johann; Aashish, Soni; Stuschke, Martin; Iliakis, George; Jendrossek, Verena; Timmermann, Beate
    Defects in DNA Damage Response Reinforce Proton Beam Specific Radiosensitivity of Cancer Cells
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 199 (2023) Nr. Suppl. 1, S. S36 - S37
    Online Volltext: dx.doi.org/ (Open Access)
  • Matschke, Johann;
    Cross-talk of radiotherapy-induced mitochondrial impairment and resulting metabolic reprogramming impact DNA DSB repair capacity
    ESTRO 2022: Learning from every patient, 6-10 May 2022, Copenhagen,
    In: Radiotherapy and Oncology (The Green Journal) Jg. 170 (2022) Nr. Supplement 1: ESTRO 2022, 6-10 May 2022, Copenhagen. Onsite in Copenhagen and Online, S. S307
    Online Volltext: dx.doi.org/
  • Shannan, B.; Matschke, Johann; Larafa, S.; Schadendorf, Dirk; Jendrossek, Verena; Rösch, Alexander;
    KDM5B's role in creating radiation synthetic vulnerabilities and its effects on sequential therapy combinations
    48th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF): Virtual, Innsbruck, 23-26 February 2022,
    In: Experimental Dermatology Jg. 31 (2022) Nr. 2, S. e9 - e10
    Online Volltext: dx.doi.org/
  • Krysztofiak, A.; Szymonomicz, K.; Hlouschek, J.; Xiang, K.; Waterkamp, C.; Larafa, S.; Goetting, I.; Vega-Rubin-de-Celis, S.; Theiss, C.; Matschke, V.; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Ensuring fuels for DNA repair : Analysis of irradiated cancer cells reveals mitochondrial shutdown
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 197 (2021) Nr. Suppl. 1, S. 200
  • Krysztofiak, Adam; Szymonowicz, Klaudia A.; Hlouschek, Julian; Waterkamp, Christoph; Xiang, Kexu; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Modeling common aspects of the metabolic response of cancer cells to ionizing radiation
    In: Cancer Research Jg. 81 (2021) Nr. 13, 3065
  • Shannan, B.; Matschke, Johann; Jendrossek, Verena; Rösch, Alexander
    The Role of KDM5B in the Development of radiation-synthetic Vulnerability and its Effect on sequential Therapy Combinations
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 19 (2021) Nr. Suppl. 4, S. 74
  • Xiang, K.; Kalthoff, C.; Münch, C.; Hlouschek, J.; Jendrossek, Verena; Matschke, Johann
    The citrate carrier SLC25A1 acts as master regulator of metabolic reprogramming and offers an innovative strategy for metabolic induction of HRness and synthetic lethality approaches with radiotherapy
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 197 (2021) Nr. Suppl. 1, S. 48 - S49
  • Kalthoff, C.; Hlouschek, Julian; Koska, Benjamin; Vuellings, Manon; Timmermann, Beate; Jendrossek, Verena; Matschke, Johann;
    Inhibition of the mitochondrial citrate carrier SLC25A1 induces a DNA repair defect and increases cancer cell radiosensitivity
    26. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO) ; 24. - 28. Juni 2020, Wiesbaden, Germany,
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 196 (2020) Nr. 1 Supplement: Abstracts DEGRO 2020, S. S184
    Online Volltext: dx.doi.org/ (Open Access)
  • Hansel, C.; Hlouschek, J.; Helleday, T.; Jendrossek, Verena; Matschke, Johann
    Combined inhibition of GSH levels and sanitization of dNTPs is effective in eradicating cancer cells exposed to acute hypoxia or chronic cycling severe hypoxia
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 194 (2018) Nr. Suppl. 1, S. 172
    Online Volltext: dx.doi.org/ (Open Access)
  • Hlouschek, J.; Hansel, C.; Riffkin, H.; Jendrossek, Verena; Matschke, Johann;
    Targeting of antioxidant-associated mitochondrial transport systems overcomes chronic-cycling hypoxia-induced radioresistance
    33. Deutscher Krebskongress - Perspektiven verändern Krebs - Krebs verändert Perspektiven. Diagnose - Therapie - (Über-)Leben ; Berlin, 21.-24. Februar 2018,
    In: Oncology Research and Treatment Jg. 41 (2018) Nr. Suppl. 1, S. 150
    Online Volltext: dx.doi.org/ (Open Access)
  • Hlouschek, J.; Hansel, C.; Jendrossek, Verena; Matschke, Johann
    Targeting of the mitochondrial citrate carrier (SLC25A1) lowers antioxidant defense systems and increases radiosensitivity of hypoxic cancer cells
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 194 (2018) Nr. Suppl. 1, S. 30
    Online Volltext: dx.doi.org/ (Open Access)
  • Shannan, B.; Matschke, Johann; Hoewner, A.; Jendrossek, Verena; Schadendorf, Dirk; Rösch, Alexander
    Senescence-like responses in irradiated melanoma cells
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 13 (2015) Nr. Suppl.2, S. 34
    Online Volltext: dx.doi.org/
  • Matschke, Johann; Riffkin, H.; Handrick, R.; Klein-Hitpaß, Ludger; Jendrossek, Verena
    Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell death
    In: European Journal of Cancer (EJC) Jg. 50 (2014) Nr. Suppl. 5, S. 51
    Online Volltext: dx.doi.org/
  • Ontikatze, T.; Matschke, Johann; Grimm, F.; Brost, R.; Moscariello, M.; Iliakis, George; Jendrossek, Verena;
    Dihydroartemisinin exerts context-dependent lethal effects in combination with ionizing radiation
    19. Jahreskongress der Deutschen Gesellschaft für Radioonkologie; 9. bis 12. Mai 2013, Berlin,
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 189 (2013) Nr. SUPPL. 1, S. 128 - 129
    Online Volltext: dx.doi.org/

    • Habilitation

  • Matschke, Johann
    Metabolische Abhängigkeiten als molekulare Zielstruktur zur Überwindung der Strahlenresistenz
    Duisburg ; Essen (2024) 1 CD-ROM

    • Poster / Posterbeiträge

  • Goetting, I.; Larafa, S.; Eul, K.; Kunin, M.; Jakob, B.; Matschke, Johann; Jendrossek, Verena;
    Inhibierung der AKT-abhängigen Regulation der antioxidant defense erhöht die Radiosensitivität von Krebszellen
    28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 198 (2022) Nr. Supplement 1, S. S157
    Online Volltext: dx.doi.org/ (Open Access)
  • Xiang, K.; Kalthoff, C.; Jendrossek, Verena; Matschke, Johann;
    The citrate carrier SLC25A1 acts as regulator of metabolic reprogramming offering an innovative strategy for synthetic lethality approaches with radiotherapy
    28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 198 (2022) Nr. Supplement 1, S. S152 - S153
    Online Volltext: dx.doi.org/ (Open Access)
  • Kalthoff, Christian; Xiang, Kexu; Muench, Corinna; Hlouschek, Julian; Jendrossek, Verena; Matschke, Johann;
    Abstract PO-022: Inhibition of the citrate carrier SLC25A1 affects repair of radiation-induced DNA damage, increases radiosensitivity, and enhances lethality of IR in combination with DNA repair defects or DSB inhibitors
    AACR Virtual Special Conference on Radiation Science and Medicine; March 2-3, 2021, Online,
    In: Clinical Cancer Research Jg. 27 (2021) Nr. 8, Supplement, S. PO - 022
    Online Volltext: dx.doi.org/