• Zhang, Ruirui; Liu, Jie; Gasper, Raphael; Unger, Anke; Kaschani, Farnusch; Kaiser, Markus; Janning, Petra; Waldmann, Herbert

  Covalent modification of a glutamic acid inspired by HaloTag technology

  In: Nature Communications, Vol. 17, 2026, Nr. 1, 1257

  DOI (Open Access)
• Klink, Nikolas; Urban, Sebastian; Seier, Johanna A.; Adhikari, Bikash; Schwalm, Martin P.; Müller, Juliane; Dorsch, Madeleine; Steinbach, Philine; Jung, Jennifer; Vogt, Markus; Kaschani, Farnusch; Koch, Johannes; Führer, Siska; Kaiser, Markus; Schulze, Nina; Knapp, Stefan; Wolf, Elmar; Paschen, Annette; Grüner, Barbara M.; Gersch, Malte

  Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors

  In: Nature Communications, Vol. 17, 2026, Nr. 1, 4331

  DOI (Open Access)
• Brenner, Joel Cyrille; Zirden, Linda; Almeida-Hernandez, Yasser; Kaschani, Farnusch; Kaiser, Markus; Sanchez-Garcia, Elsa; Poepsel, Simon; Hellerschmied-Jelinek, Doris

  Conformational plasticity of a BiP-GRP94 chaperone complex

  In: Nature Structural & Molecular Biology, Vol. 32, 2025, Nr. 10, pp. 1947 – 1958

  DOI (Open Access)
• Katz, Liora S.; Visser, Emira J.; Plitzko, Kathrin F.; Pennings, Marloes A. M.; Cossar, Peter J.; Tse, Isabelle L.; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian; Scott, Donald K.

  Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 2110

  DOI (Open Access)
• Führer, Siska; Gallant, Kai; Kaschani, Farnusch; Kaiser, Markus; Janning, Petra; Waldmann, Herbert; Gersch, Malte

  Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome Analysis

  In: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 32, e202508916

  DOI (Open Access)
• Brenner, Joel Cyrille; Zirden, Linda; Almeida-Hernandez, Yasser; Kaschani, Farnusch; Kaiser, Markus; Sanchez-Garcia, Elsa; Poepsel, Simon; Hellerschmied-Jelinek, Doris

  Conformational plasticity of a BiP-GRP94 chaperone complex

  In: Nature Structural & Molecular Biology, Vol. 32, 2025, Nr. 10, pp. 1947 – 1958

  DOI (Open Access)
• Sanguankiattichai, Nattapong; Chandrasekar, Balakumaran; Sheng, Yuewen; Hardenbrook, Nathan; Tabak, Werner W.A.; Drapal, Margit; Kaschani, Farnusch; Grünwald-Gruber, Clemens; Krahn, Daniel; Buscaill, Pierre; Yamamoto, Suzuka; Kato, Atsushi; Nash, Robert; Fleet, George; Strasser, Richard; Fraser, Paul D.; Kaiser, Markus; Zhang, Peijun; Preston, Gail M.; van der Hoorn, Renier A.L.

  Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology

  In: Science, Vol. 388, 2025, Nr. 6744, pp. 297 – 303

  DOI
• Sewald, Leonard; Tabak, Werner W. A.; Fehr, Lorenz; Zolg, Samuel; Najdzion, Maja; Verhoef, Carlo J. A.; Podlesainski, David; Geiss-Friedlander, Ruth; Lammens, Alfred; Kaschani, Farnusch; Hellerschmied, Doris; Huber, Robert; Kaiser, Markus

  Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 3208

  DOI (Open Access)
• Katz, Liora S.; Visser, Emira J.; Plitzko, Kathrin F.; Pennings, Marloes A. M.; Cossar, Peter J.; Tse, Isabelle L.; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian; Scott, Donald K.

  Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 2110

  DOI (Open Access)
• Buscaill, Pierre; Sanguankiattichai, Nattapong; Kaschani, Farnusch; Huang, Jie; Mooney, Brian C.; Li, Yuge; Lyu, Joy; Sueldo, Daniela; Kaiser, Markus; van der Hoorn, Renier A. L.

  Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast

  In: Nature Communications, Vol. 15, 2024, Nr. 1, 10431

  DOI (Open Access)
• Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne-Wiechmann MN, van Ray O, Kaschani F, Kaiser M, Hänsel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S.

  Activation of automethylated PRC2 by dimerization on chromatin

  In: Mol Cell. 2024 Oct 17;84(20):3885-3898.e8.

  DOI
• Chen, Changlong; Buscaill, Pierre; Sanguankiattichai, Nattapong; Huang, Jie; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.

  Extracellular plant subtilases dampen cold-shock peptide elicitor levels

  In: Nature Plants, Vol. 10, 2024, Nr. 11, pp. 1749 – 1760

  DOI (Open Access)
• Präve, Leonard; Kuttenlochner, Wolfgang; Tabak, Werner W.A.; Langer, Chiara; Kaiser, Markus; Groll, Michael; Bode, Helge B.

  Bioengineering of syrbactin megasynthetases for immunoproteasome inhibitor production

  In: Chem, Vol. 10, 2024, Nr. 10, pp. 3212 – 3223

  DOI (Open Access)
• Huang, Jing; Jaekel, Andreas; van den Boom, Johannes; Podlesainski, David; Elnaggar, M.; Heuer-Jungemann, A.; Kaiser, Markus; Meyer, Hemmo; Saccà, Barbara

  A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway

  In: Nature Nanotechnology, Vol. 19, 2024, Nr. 10, pp. 1521 – 1531

  DOI (Open Access)
• Podlesainski, David; Adeniyi, Emmanuel T.; Gröner, Yvonne; Schulz, Florian; Krisilia, Violetta; Rehberg, Nidja; Richter, Tim; Sehr, Daria; Xie, Huzhuyue; Simons, Viktor E.; Kiffe-Delf, Anna-Lene; Kaschani, Farnusch; Ioerger, Thomas R.; Kaiser, Markus; Kalscheuer, Rainer

  The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113

  In: Cell Chemical Biology, Vol. 31, 2024, Nr. 10, pp. 1755 – 1771.e73

  DOI (Open Access)
• Ninck, Sabrina; Klaus, Thomas; Kochetkova, Tatiana V.; Esser, Sarah P.; Sewald, Leonard; Kaschani, Farnusch; Bräsen, Christopher; Probst, Alexander J.; Kublanov, Ilya V.; Siebers, Bettina; Kaiser, Markus

  Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities

  In: Environmental Microbiomes, Vol. 19, 2024, Nr. 1, 36

  DOI, Online Full Text (Open Access)
• Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik

  TopBP1 utilises a bipartite GINS binding mode to support genome replication

  In: Nature Communications, Vol. 15, 2024, Nr. 1, 1797

  DOI, Online Full Text (Open Access)
• Beaufort, Nathalie; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree; Podlesainski, David; Richter, Tim; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G.; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo Rodriguez, Kenny; Mieres-Perez, Joel; Beuck, Christine; Uebel, Stephan; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer; Todorov-Völgyi, Katalin; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt; Müller, Stephan A.; Wurst, Wolfgang; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu; Clausen, Tim; Huber, Robert; Lichtenthaler, Stefan F.; Schmuck, Carsten; Giese, Michael; Kaiser, Markus; Ehrmann, Michael; Dichgans, Martin

  Rational correction of pathogenic conformational defects in HTRA1

  In: Nature Communications, Vol. 15, 2024, Nr. 1, 5944

  DOI (Open Access)

All publications