S. Führer, K. Gallant, F. Kaschani, M. Kaiser, P. Janning, H. Waldmann, M. Gersch: 
Small molecule-induced alterations of protein polyubiquitination revealed by mass-spectrometric ubiquitome analysis. Angew. Chem. Int. Ed. 2025, early view.

J. C. Brenner, L. C. Zirden, L. Buzuk, Y. Almeida-Hernandez, L. Radzuweit, J. Diamantino, F. Kaschani, M. Kaiser, E. Sanchez-Garcia, S. Poepsel, D. Hellerschmied:
Conformational plasticity of a BiP-GRP94 chaperone complex. Nat Struct. Mol. Biol. 2025, accepted for publication.

N. Sanguankiattichai, B. Chandrasekar, Y. Sheng, N. Hardenbrook, W. W. A. Tabak, M. Drapal, F. Kaschani, C. Grünwald-Gruber, D. Krahn, P. Buscaill, S. Yamamoto, A. Kato, R. Nash, G. Fleet, R. Strasser, P. D. Fraser, M. Kaiser, P. Zhang, G. M. Preston, R. A. L. van der Hoorn:
Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology. Science 2025, 388, 297-302.

L. Sewald, W. W. A. Tabak, L. Fehr, S. Zolg, M. Najdzion, C. J. A. Verhoef, D. Podlesainski, R. Geiss-Friedlander, A. Lammens, F. Kaschani, D. Hellerschmied, R. Huber, M. Kaiser:
Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors. Nat. Commun. 2025, 16, 3208.

L. S. Katz, E. J. Visser, K. F. Plitzko, M. Pennings, P. J. Cossar, I. L. Tse, M. Kaiser^*, L. Brunsveld^*, D. K. Scott^*, C. Ottmann^*:
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Nat. Commun. 2025, 16, 2110. ^* corresponding authors.

P. Buscaill, N. Sanguankiattichai, F. Kaschani, J. Huang, B. C. Mooney, Y. Li, J. Lyu, D. Sueldo, M. Kaiser, R. A. L. van der Hoorn:
Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast. Nat. Commun. 2024, 15, 10431.

P.V. Sauer, E. Pavlenko, T. Cookis, L. C. Zirden, J. Renn, A. Singhal, P. Hunold, M. N. Hoehne-Wiechmann, O. van Ray, F. Kaschani, M. Kaiser, R. Hänsel-Hertsch, K. Y. Sanbonmatsu, E. Nogales, S. Poepsel:
Activation of automethylated PRC2 by dimerization on chromatin. Mol. Cell 2024, 84, 3885-3898.

C. Chen, P. Buscaill, N. Sanguankiattichai, J. Huang, F. Kaschani, M. Kaiser, R. A. L. van der Hoorn:
Extracellular plant subtilases dampen cold shock peptide elicitor levels. Nat. Plants 2024, 10, 1749-1760.

L. Präve, W. Kuttenlochner, W. W. A. Tabak, C. Langer, M. Kaiser, M. Groll, H. Bode:
Biosynthetic engineering of a syrbactin producing megasynthetase. Chem 2024, 10, 3212-3223.

J. Huang, A. Jaekel, J. van der Boom, D. Podlesainski, M. Elnagar, A. Heuer-Jungemann, M. Kaiser, H. Meyer, B. Saccà:
A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway. Nat. Nanotech. 2024, 19, 1521-1531.

D. Podlesainski, E. T. Adeniyi, Y. Gröner, F. Schulz, V. Krisilia, N. Rehberg, T. Richter, D. Sehr, H. Xie, V. E. Simons, A.-L. Kiffe-Delf, F. Kaschani, T. R. Ioerger, M. Kaiser^*, R. Kalscheuer^*:
The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113. Cell Chem. Biol. 2024, 31, 1-17. ^* corresponding authors.

S. Ninck, T. Klaus, T. V. Kochetkova, S. P. Esser, L. Sewald, F. Kaschani, C. Bräsen, A. J. Probst, I. V. Kublanov, B. Siebers, M. Kaiser:
Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities. Environ. Microbiome 2024, 19, 36.

M. Day, B. Tetik, M. Parlak, Y. Almeida-Hernández, M. Räschle, F. Kaschani, H. Siegert, A. Marko, E. Sanchez-Garcia, M. Kaiser, I. A. Barker, L. H. Pearl, A. W. Oliver, D. Boos:
TopBP1 utilises a bipartite GINS binding mode to support genome replication. Nat. Commun. 2024, 15, 1797.

N. Beaufort, L. Ingendahl, M. Merdanovic, A. Schmidt, D. Podlesainski, T. Richter, T. Neumann, M. Kuszner, I. R. Vetter, P. Stege, S. G. Burston, A. Filipovic, Y. B. Ruiz-Blanco, K. Bravo-Rodriguez, J. Mieres-Perez, C. Beuck, S. Uebel, M. Zobawa, J. Schillinger, R. Malik, K. Todorov-Völgyi, J. Rey, A. Roberti, B. Hagemeier, B. Wefers, S. A. Müller, W. Wurst, E. Sanchez-Garcia, A. Zimmermann, X.-Y. Hu, T. Clausen, R. Huber, S. F. Lichtenthaler, C. Schmuck, M. Giese, M. Kaiser, M. Ehrmann, M. Dichgans:
Rational correction of pathogenic conformational defects in HTRA1. Nat. Commun. 2024, 15, 5944.

S. Ninck, V. Halder, J. H. Krahn, D. Beisser, S. Resch, I. Dodds, R. Scholtysik, J. Bormann, L. Sewald, M. D. Gupta, G. Heilmann, D. D. Bhandari, K. Morimoto, P. Buscaill, B. Hause, R. A. L. van der Hoorn, F. Kaschani, M. Kaiser:
Chemoproteomics reveals the pan-HER kinase inhibitor Neratinib to target an Arabidopsis epoxide hydrolase related to phytohormone signaling. ACS Chem. Biol. 2023, 18, 1076-1088.

M. Blueggel, A. Kroening, M. Kracht, J. van den Boom, M. Dabisch, A. Goehring, F. Kaschani, M. Kaiser, P. Bayer, H. Meyer, C. Beuck:
The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase. Nat. Commun. 2023, 14, 3258.

D. M. Hoi, S. Junker, L. Junk, K. Schwechel, K. Fischel, D. Podlesainski, , J. Leodolter, P. M. E. Hawkins, L. van Geelen, F. Kaschani, J. Leodolter, F. E. Morreale, S. Kleine, S. Guha, K. Rumpel, V. M. Schmiedel, H. Weinstabl, A. Meinhart, R. J. Payne, M. Kaiser, M. Hartl, G. Boehmelt, U. Kazmaier, R. Kalscheuer, T. Clausen:
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival. Cell 2023, 186, 2176-2192.

B. Andlovic, G. Heilmann, S. Ninck, S. Andrei, F. Centorrino, Y. Higuchi, N. Kato, L. Brunsveld, M. Arkin, S. Menninger, A. Choidas, A. Wolf, F. Kaschani, M. Kaiser, J. Eickhoff, C. Ottmann:
IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Cell Chem. Biol. 2023, 30, 573-590.

C. Schmerling, L. Sewald, G. Heilmann, F. Witfeld, D. Begerow, K. Jensen, F. Kaschani, H. S. Overkleeft, B. Siebers, M. Kaiser:
Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling. Commun. Biol. 2022, 5, 1254.

L. A. R. Carvalho, B. Ross, L. Fehr, O. Bolgi, S. Wöhrle, K. M. Lum, D. Podlesainski, A. C. Vieira, R. Kiefersauer, R. Félix, T. Rodrigues, S. D. Lucas, O. Groß, R. Geiss-Friedlander, B. F. Cravatt, R. Huber, M. Kaiser^*, R. Moreira^*:
Chemoproteomics-enabled identification of 4-oxo-β-lactams as inhibitors of dipeptidyl peptidases 8 and 9. Angew. Chem. Int. Ed. 2022, 61, e202210498. ^* corresponding authors.

F. E. Morreale, S. Kleine, J. Leodolter, S. Junker, D. M. Hoi, S. Ovchinnikov, A. Okun, J. Kley, R. Kurzbauer, L. Junk, S. Guha, D. Podlesainski, U. Kazmaier, G. Boehmelt, H. Weinstabl, K. Rumpel, V. M. Schmiedel, M. Hartl, D. Haselbach, A. Meinhart, M. Kaiser^*, T. Clausen^*:
BacPROTACs mediate targeted protein degradation in bacteria. Cell 2022, 185, 2338-2353. ^* corresponding authors.

H. Chauvistré, B. Shannan, S. Daignault-Mill, R. Ju, D. Picard, S. Egetemaier, R. Varaljai, C. Gibhardt, A. Sechi, F. Kaschani, O. Keminer, S. Stehbens, Q. Liu, X. Yin, K. Jeyakumar, F. Vogel, C. Krepler, V. Rebecca, L. Kubat, S. Lueong, J. Forster, S. Horn, M. Remke, M. Ehrmann, A. Paschen, J. Becker, I. Helfrich, D. Rauh, M. Kaiser, S. Gul, M. Herlyn, I. Bogeski, J. N. Rodríguez-López, N. Haass, D. Schadendorf, A. Roesch:
Persister state-directed transitioning and vulnerability in melanoma. Nat. Commun. 2022, 13, 3055.

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