Publications

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Book

Ehrmann, Michael

The Periplasm

Washington, DC (2006) XVIII, 415 S., [11] Bl. : Ill., graph. Darst.
ISBN: 1-55581-398-4; 978-1-55581-398-7

Selected publications

All publications

    Journal articles

  • Merdanovic, Melisa; Burston, Steven G.; Schmitz, Anna Laura; Köcher, Steffen; Knapp, Stefan; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Activation by substoichiometric inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 117 (2020) Nr. 3, pp. 1414 - 1418
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Köcher, Steffen; Rey, Juliana; Bongard, Jens; Tiaden, André N.; Meltzer, Michael; Richards, Peter J.; Ehrmann, Michael; Kaiser, Markus
    Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, pp. 8555 - 8558
    ISSN: 1521-3773; 1433-7851
    Online Full Text: dx.doi.org/
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
    ISSN: 1552-4450; 1552-4469
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Beaufort, Nathalie; Scharrer, Eva; Kremmer, Elisabeth; Lux, Vanda; Ehrmann, Michael; Huber, Robert; Houlden, Henry H.; Werring, David John; Haffner, Christof; Dichgans, Martin
    Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 111 (2014) Nr. 46, pp. 16496 - 16501
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/
  • Malet, Hélène; Canellas, Flavia; Sawa, Justyna; Yan, Jun; Thalassinos, Konstantinos; Ehrmann, Michael; Clausen, Tim; Saibil, Helen R.
    Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ
    In: Nature Structural & Molecular Biology Vol. 19 (2012) Nr. 2, pp. 152 - 157
    ISSN: 1545-9993
    Online Full Text: dx.doi.org/
  • Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    HTRA proteases : regulated proteolysis in protein quality control
    In: Nature Reviews Molecular Cell Biology Vol. 12 (2011) Nr. 3, pp. 152 - 162
    ISSN: 1471-0072
    Online Full Text: dx.doi.org/
  • Merdanovic, Melisa; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Protein quality control in the bacterial periplasm
    In: Annual Review of Microbiology Vol. 65 (2011) pp. 149 - 168
    ISSN: 1545-3251; 0066-4227
    Online Full Text: dx.doi.org/
  • Kley, Juliane; Schmidt, Bastian; Boyanov, Boril; Stolt-Bergner, Peggy C.; Kirk, Rebecca; Ehrmann, Michael; Knopf, Ronit R.; Naveh, Leah; Adam, Zach; Clausen, Tim
    Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure
    In: Nature Structural & Molecular Biology Vol. 18 (2011) Nr. 6, pp. 728 - 731
    ISSN: 1545-9993
    Online Full Text: dx.doi.org/
  • Trübestein, Linda; Tennstaedt, Annette; Mönig, Timon; Krojer, Tobias; Canellas, Flavia; Kaiser, Markus; Clausen, Tim; Ehrmann, Michael
    Substrate induced remodeling of the active site regulates human HtrA1 activity
    In: Nature Structural & Molecular Biology Vol. 18 (2011) pp. 386 - 388
    ISSN: 1545-9993
    Online Full Text: dx.doi.org/
  • Merdanovic, Melisa; Mamant, Nicolette; Meltzer, Michael; Poepsel, Simon; Auckenthaler, Alexandra; Melgaard, Rie; Hauske, Patrick; Nagel-Steger, Luitgard; Clarke, Anthony R.; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Determinants of structural and functional plasticity of a widely conserved protease chaperone complex
    In: Nature Structural & Molecular Biology Vol. 17 (2010) Nr. 7, pp. 837 - 843
    ISSN: 1545-9993; 1545-9985
    Online Full Text: dx.doi.org/
  • Meltzer, Michael; Hasenbein, Sonja; Hauske, Patrick; Kucz, Nicolette; Merdanovic, Melisa; Grau, Sandra; Beil, Alexandra; Jones, Dafydd; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus
    Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control
    In: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 7, pp. 1332 - 1334
    ISSN: 0044-8249; 0932-2140
    Online Full Text: dx.doi.org/
  • Krojer, Tobias; Pangerl, Karen; Kurt, Juliane; Sawa, Justyna; Stingl, Christoph; Mechtler, Karl; Huber, Robert; Ehrmann, Michael; Clausen, Tim
    Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 22 (2008) pp. 7702 - 7707
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Krojer, Tobias; Sawa, Justyna; Schäfer, Eva; Saibil, Helen R.; Ehrmann, Michael; Clausen, Tim
    Structural basis for the regulated protease and chaperone function of DegP.
    In: Nature (2008) Nr. 453, pp. 885 - 890
    ISSN: 0028-0836; 1476-4687
    Online Full Text
  • Hasselblatt, Hanna; Kurzbauer, Robert; Wilken, Corinna; Krojer, Tobias; Sawa, Justyna; Kurt, Juliane; Kirk, Rebecca; Hasenbein, Sonja; Ehrmann, Michael; Clausen, Tim
    Regulation of the σE stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress
    In: Genes and Development Vol. 21 (2007) Nr. 20, pp. 2659 - 2670
    ISSN: 0890-9369; 1549-5477
    Online Full Text: dx.doi.org/
  • Grau, Sandra; Baldi, Alfonso; Bussani, Rossana; Tian, Xiaodan; Stefanescu, Raluca; Przybylski, Michael; Richards, Peter; Jones, Simon A.; Shridhar, Viji; Clausen, Tim; Ehrmann, Michael
    Implications of human HtrA1 in amyloid precursor protein processing.
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 102 (2005) Nr. 17, pp. 6021 - 6026
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Grau, Sandra; Baldi, Alfonso; Bussani, Rossana; Tian, Xiaodan; Stefanescu, Raluca; Przybylski, Michael; Richards, Peter; Jones, Simon A.; Shridhar, Viji; Clausen, Tim; Ehrmann, Michael
    Implications of the serine protease HtrA1 in amyloid precursor protein processing
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 102 (2005) Nr. 17, pp. 6021 - 6026
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Henrichs, Tanja; Mikhaleva, Natasha; Conz, Charlotte; Deuerling, Elke; Boyd, Dana; Zelasny, Adrian; Bibi, Eitan; Ban, Nenad; Ehrmann, Michael
    Target-directed proteolysis at the ribosome.
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 102 (2005) pp. 4246 - 4251
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Wilken, Corinna; Kitzing, Karina; Kurzbauer, Robert; Ehrmann, Michael; Clausen, Tim
    Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease
    In: Cell Vol. 117 (2004) Nr. 4, pp. 483 - 494
    ISSN: 0092-8674
    Online Full Text
  • Ehrmann, Michael; Clausen, Tim
    Proteolysis as a regulatory mechanism
    In: Annual Review of Genetics Vol. 38 (2004) pp. 709 - 724
    ISSN: 0066-4170; 0066-4197
    Online Full Text
  • Eser, Markus; Ehrmann, Michael
    SecA-dependent quality control of intracellular protein localization
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 100 (2003) Nr. 23, pp. 13231 - 13234
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Krojer, Tobias; Garrido-Franco, Marta; Hubert, Robert; Ehrmann, Michael; Clausen, Tim
    Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine
    In: Nature Vol. 416 (2002) Nr. 6879, pp. 455 - 459
    ISSN: 0028-0836; 1476-4687
    Online Full Text
  • Clausen, Tim; Southan, Chris; Ehrmann, Michael
    The HtrA family of proteases: Implications for protein composition and cell fate
    In: Molecular Cell Vol. 10 (2002) Nr. 3, pp. 443 - 455
    ISSN: 1097-2765
    Online Full Text
  • Spiess, Christoph; Beil, Alexandra; Ehrmann, Michael
    A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein
    In: Cell Vol. 97 (1999) Nr. 3, pp. 339 - 347
    ISSN: 0092-8674
    Online Full Text
  • Ehrmann, Michael; Bolek, Petra; Mondigler, Martin; Boyd, Dana; Lange, Roland
    TnTIN and TnTAP: Mini-transposons for site-specific proteolysis in vivo
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 94 (1997) Nr. 24, pp. 13111 - 13115
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Ehrmann, Michael; Boyd, Dana; Beckwith, Jonathan
    Genetic analysis of membrane protein topology by a sandwich gene fusion approach.
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 87 (1990) Nr. 19, pp. 7574 - 7578
    ISSN: 1091-6490; 0027-8424
    Online Full Text
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