Publications

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Book

Ehrmann, Michael

The Periplasm

Washington, DC (2006) XVIII, 415 S., [11] Bl. : Ill., graph. Darst.
ISBN: 1-55581-398-4; 978-1-55581-398-7

Selected publications

All publications

    Journal articles

  • Merdanovic, Melisa; Burston, Steven G.; Schmitz, Anna Laura; Köcher, Steffen; Knapp, Stefan; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Activation by substoichiometric inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 117 (2020) Nr. 3, pp. 1414 - 1418
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Köcher, Steffen; Rey, Juliana; Bongard, Jens; Tiaden, André N.; Meltzer, Michael; Richards, Peter J.; Ehrmann, Michael; Kaiser, Markus
    Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, pp. 8555 - 8558
    ISSN: 1521-3773; 1433-7851
    Online Full Text: dx.doi.org/
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
    ISSN: 1552-4450; 1552-4469
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Beaufort, Nathalie; Scharrer, Eva; Kremmer, Elisabeth; Lux, Vanda; Ehrmann, Michael; Huber, Robert; Houlden, Henry H.; Werring, David John; Haffner, Christof; Dichgans, Martin
    Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 111 (2014) Nr. 46, pp. 16496 - 16501
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/
  • Malet, Hélène; Canellas, Flavia; Sawa, Justyna; Yan, Jun; Thalassinos, Konstantinos; Ehrmann, Michael; Clausen, Tim; Saibil, Helen R.
    Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ
    In: Nature Structural & Molecular Biology Vol. 19 (2012) Nr. 2, pp. 152 - 157
    ISSN: 1545-9993
    Online Full Text: dx.doi.org/
  • Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    HTRA proteases : regulated proteolysis in protein quality control
    In: Nature Reviews Molecular Cell Biology Vol. 12 (2011) Nr. 3, pp. 152 - 162
    ISSN: 1471-0072
    Online Full Text: dx.doi.org/
  • Merdanovic, Melisa; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Protein quality control in the bacterial periplasm
    In: Annual Review of Microbiology Vol. 65 (2011) pp. 149 - 168
    ISSN: 1545-3251; 0066-4227
    Online Full Text: dx.doi.org/
  • Kley, Juliane; Schmidt, Bastian; Boyanov, Boril; Stolt-Bergner, Peggy C.; Kirk, Rebecca; Ehrmann, Michael; Knopf, Ronit R.; Naveh, Leah; Adam, Zach; Clausen, Tim
    Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure
    In: Nature Structural & Molecular Biology Vol. 18 (2011) Nr. 6, pp. 728 - 731
    ISSN: 1545-9993
    Online Full Text: dx.doi.org/
  • Trübestein, Linda; Tennstaedt, Annette; Mönig, Timon; Krojer, Tobias; Canellas, Flavia; Kaiser, Markus; Clausen, Tim; Ehrmann, Michael
    Substrate induced remodeling of the active site regulates human HtrA1 activity
    In: Nature Structural & Molecular Biology Vol. 18 (2011) pp. 386 - 388
    ISSN: 1545-9993
    Online Full Text: dx.doi.org/
  • Merdanovic, Melisa; Mamant, Nicolette; Meltzer, Michael; Poepsel, Simon; Auckenthaler, Alexandra; Melgaard, Rie; Hauske, Patrick; Nagel-Steger, Luitgard; Clarke, Anthony R.; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Determinants of structural and functional plasticity of a widely conserved protease chaperone complex
    In: Nature Structural & Molecular Biology Vol. 17 (2010) Nr. 7, pp. 837 - 843
    ISSN: 1545-9993; 1545-9985
    Online Full Text: dx.doi.org/
  • Meltzer, Michael; Hasenbein, Sonja; Hauske, Patrick; Kucz, Nicolette; Merdanovic, Melisa; Grau, Sandra; Beil, Alexandra; Jones, Dafydd; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus
    Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control
    In: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 7, pp. 1332 - 1334
    ISSN: 0044-8249; 0932-2140
    Online Full Text: dx.doi.org/
  • Krojer, Tobias; Pangerl, Karen; Kurt, Juliane; Sawa, Justyna; Stingl, Christoph; Mechtler, Karl; Huber, Robert; Ehrmann, Michael; Clausen, Tim
    Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 22 (2008) pp. 7702 - 7707
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Krojer, Tobias; Sawa, Justyna; Schäfer, Eva; Saibil, Helen R.; Ehrmann, Michael; Clausen, Tim
    Structural basis for the regulated protease and chaperone function of DegP.
    In: Nature (2008) Nr. 453, pp. 885 - 890
    ISSN: 0028-0836; 1476-4687
    Online Full Text
  • Hasselblatt, Hanna; Kurzbauer, Robert; Wilken, Corinna; Krojer, Tobias; Sawa, Justyna; Kurt, Juliane; Kirk, Rebecca; Hasenbein, Sonja; Ehrmann, Michael; Clausen, Tim
    Regulation of the σE stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress
    In: Genes and Development Vol. 21 (2007) Nr. 20, pp. 2659 - 2670
    ISSN: 0890-9369; 1549-5477
    Online Full Text: dx.doi.org/
  • Grau, Sandra; Baldi, Alfonso; Bussani, Rossana; Tian, Xiaodan; Stefanescu, Raluca; Przybylski, Michael; Richards, Peter; Jones, Simon A.; Shridhar, Viji; Clausen, Tim; Ehrmann, Michael
    Implications of human HtrA1 in amyloid precursor protein processing.
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 102 (2005) Nr. 17, pp. 6021 - 6026
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Grau, Sandra; Baldi, Alfonso; Bussani, Rossana; Tian, Xiaodan; Stefanescu, Raluca; Przybylski, Michael; Richards, Peter; Jones, Simon A.; Shridhar, Viji; Clausen, Tim; Ehrmann, Michael
    Implications of the serine protease HtrA1 in amyloid precursor protein processing
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 102 (2005) Nr. 17, pp. 6021 - 6026
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Henrichs, Tanja; Mikhaleva, Natasha; Conz, Charlotte; Deuerling, Elke; Boyd, Dana; Zelasny, Adrian; Bibi, Eitan; Ban, Nenad; Ehrmann, Michael
    Target-directed proteolysis at the ribosome.
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 102 (2005) pp. 4246 - 4251
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Wilken, Corinna; Kitzing, Karina; Kurzbauer, Robert; Ehrmann, Michael; Clausen, Tim
    Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease
    In: Cell Vol. 117 (2004) Nr. 4, pp. 483 - 494
    ISSN: 0092-8674
    Online Full Text
  • Ehrmann, Michael; Clausen, Tim
    Proteolysis as a regulatory mechanism
    In: Annual Review of Genetics Vol. 38 (2004) pp. 709 - 724
    ISSN: 0066-4170; 0066-4197
    Online Full Text
  • Eser, Markus; Ehrmann, Michael
    SecA-dependent quality control of intracellular protein localization
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 100 (2003) Nr. 23, pp. 13231 - 13234
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Krojer, Tobias; Garrido-Franco, Marta; Hubert, Robert; Ehrmann, Michael; Clausen, Tim
    Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine
    In: Nature Vol. 416 (2002) Nr. 6879, pp. 455 - 459
    ISSN: 0028-0836; 1476-4687
    Online Full Text
  • Clausen, Tim; Southan, Chris; Ehrmann, Michael
    The HtrA family of proteases: Implications for protein composition and cell fate
    In: Molecular Cell Vol. 10 (2002) Nr. 3, pp. 443 - 455
    ISSN: 1097-2765
    Online Full Text
  • Spiess, Christoph; Beil, Alexandra; Ehrmann, Michael
    A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein
    In: Cell Vol. 97 (1999) Nr. 3, pp. 339 - 347
    ISSN: 0092-8674
    Online Full Text
  • Ehrmann, Michael; Bolek, Petra; Mondigler, Martin; Boyd, Dana; Lange, Roland
    TnTIN and TnTAP: Mini-transposons for site-specific proteolysis in vivo
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 94 (1997) Nr. 24, pp. 13111 - 13115
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Ehrmann, Michael; Boyd, Dana; Beckwith, Jonathan
    Genetic analysis of membrane protein topology by a sandwich gene fusion approach.
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 87 (1990) Nr. 19, pp. 7574 - 7578
    ISSN: 1091-6490; 0027-8424
    Online Full Text

    Journal articles

  • Martinez-Rivas, Gemma; Ayala, Maria Victoria; Bender, Sebastien; Codo, Gilles Roussine; Swiderska, Weronika Karolina; Lampis, Alessio; Pedroza, Laura; Merdanovic, Melisa; Sicard, Pierre; Pinault, Emilie; Richard, Laurence; Lavatelli, Francesca; Giorgetti, Sofia; Canetti, Diana; Rinsant, Alexa; Kaaki, Sihem; Ory, Cécile; Oblet, Christelle; Pollet, Justine; Naser, Eyad; Carpinteiro, Alexander; Roussel, Muriel; Javaugue, Vincent; Jaccard, Arnaud; Bonaud, Amélie; Delpy, Laurent; Ehrmann, Michael; Bridoux, Frank; Sirac, Christophe
    A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils
    In: Nature Communications , Vol. 16 2025 , Nr. 1 , 2992
    DOI (Open Access)
  • Schillinger, Jasmin; Koci, Michelle; Bravo-Rodriguez, Kenny; Heilmann, Geronimo; Kaschani, Farnusch; Kaiser, Markus; Beuck, Christine; Luecke, Hartmut; Huber, Robert; Hellerschmied-Jelinek, Doris; Burston, Steven G.; Ehrmann, Michael
    High resolution analysis of proteolytic substrate processing
    In: The Journal of Biological Chemistry (JBC) , Vol. 300 2024 , Nr. 11 , 107812
    DOI (Open Access)
  • Beaufort, Nathalie; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree; Podlesainski, David; Richter, Tim; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G.; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo Rodriguez, Kenny; Mieres-Perez, Joel; Beuck, Christine; Uebel, Stephan; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer; Todorov-Völgyi, Katalin; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt; Müller, Stephan A.; Wurst, Wolfgang; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu; Clausen, Tim; Huber, Robert; Lichtenthaler, Stefan F.; Schmuck, Carsten; Giese, Michael; Kaiser, Markus; Ehrmann, Michael; Dichgans, Martin
    Rational correction of pathogenic conformational defects in HTRA1
    In: Nature Communications , Vol. 15 2024 , Nr. 1 , 5944
    DOI (Open Access)
  • Merle, David A.; Sen, Merve; Armento, Angela; Stanton, Chloe M.; Thee, Eric F.; Meester-Smoor, Magda A.; Kaiser, Markus; Clark, Simon J.; Klaver, Caroline C.W.; Keane, Pearse A.; Wright, Alan F.; Ehrmann, Michael; Ueffing, Marius
    10q26 – The enigma in age-related macular degeneration
    In: Progress in Retinal and Eye Research , Vol. 96 2023 , 101154
    DOI (Open Access)
  • Frantz, Renate; Gwozdzinski, Konrad; Gisch, Nicolas; Doijad, Swapnil Prakash; Hudel, Martina; Wille, Maria; Mraheil, Mobarak Abu; Schwudke, Dominik; Imirzalioglu, Can; Falgenhauer, Linda; Ehrmann, Michael; Chakraborty, Trinad
    A Single Residue within the MCR-1 Protein Confers Anticipatory Resilience
    In: Microbiology Spectrum , Vol. 11 2023 , Nr. 3 , e03592-22
    DOI (Open Access)
  • Rey, Juliana; Breiden, Maike; Lux, Vanda; Bluemke, Anika; Steindel, Maike; Ripkens, Kamilla; Möllers, Bastian; Bravo Rodriguez, Kenny; Boisguerin, Prisca; Volkmer, Rudolf; Mieres-Perez, Joel; Clausen, Tim; Sánchez-García, Elsa; Ehrmann, Michael
    An allosteric HTRA1-calpain 2 complex with restricted activation profile
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 119 2022 , Nr. 14 , e2113520119
    DOI (Open Access)
  • Romero-Molina, Sandra; Ruiz-Blanco, Yasser B.; Mieres-Perez, Joel; Harms, Mirja; Münch, Jan; Ehrmann, Michael; Sanchez-Garcia, Elsa
    PPI-Affinity : A Web Tool for the Prediction and Optimization of Protein-Peptide and Protein-Protein Binding Affinity
    In: Journal of Proteome Research , Vol. 21 2022 , Nr. 8 , pp. 1829 - 1841
    DOI (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications , Vol. 13 2022 , Nr. 1 , pp. 35 - 36
    DOI, Online Full Text (Open Access)
  • Malik, Rainer; Beaufort, Nathalie; Frerich, Simon; Gesierich, Benno; Georgakis, Marios K.; Rannikmäe, Kristiina; Ferguson, Amy C.; Haffner, Christof; Traylor, Matthew; Ehrmann, Michael; Sudlow, Cathie L. M; Dichgans, Martin
    Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities
    In: Brain: A Journal of Neurology , Vol. 144 2021 , Nr. 9 , pp. 2670 - 2682
    DOI (Open Access)
  • Merdanovic, Melisa; Burston, Steven G.; Schmitz, Anna Laura; Köcher, Steffen; Knapp, Stefan; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Activation by substoichiometric inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 117 2020 , Nr. 3 , pp. 1414 - 1418
    DOI (Open Access)
  • Kuusk, Ave; Neves, Joaõ Filipe; Bravo-Rodriguez, Kenny; Gunnarsson, Anders; Ruiz-Blanco, Yasser B.; Ehrmann, Michael; Chen, Hongming; Landrieu, Isabelle; Sánchez-García, Elsa; Boyd, Helen; Ottmann, Christian; Doveston, Richard G.
    Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ
    In: ACS Chemical Biology , Vol. 15 2020 , Nr. 1 , pp. 262 - 271
    DOI (Open Access)
  • Köcher, Steffen; Resch, Sarah; Kessenbrock, Till; Schrapp, Lukas; Ehrmann, Michael; Kaiser, Markus
    From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins : the chemical biology of Ahp-cyclodepsipeptides
    In: Natural Product Reports , Vol. 37 2020 , Nr. 2 , pp. 163 - 174
    DOI
  • Weil, Tatjana; Groß, Rüdiger; Röcker, Annika; Bravo-Rodriguez, Kenny; Heid, Christian; Sowislok, Andrea; Le, My-Hue; Erwin, Nelli; Dwivedi, Mridula; Bart, Stephen M.; Bates, Paul; Wettstein, Lukas; Müller, Janis A.; Harms, Mirja; Sparrer, Konstantin; Ruiz-Blanco, Yasser B.; Stürzel, Christina M.; von Einem, Jens; Lippold, Sina; Read, Clarissa; Walther, Paul; Hebel, Marco; Kreppel, Florian; Klärner, Frank-Gerrit; Bitan, Gal; Ehrmann, Michael; Weil, Tanja; Winter, Roland; Schrader, Thomas; Shorter, James; Sánchez-García, Elsa; Münch, Jan
    Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers
    In: Journal of the American Chemical Society: JACS , Vol. 142 2020 , Nr. 40 , pp. 17024 - 17038
    DOI (Open Access)
  • Bongard, Jens; Schmitz, Anna Laura; Wolf, Alex; Zischinsky, Gunther; Pieren, Michel; Schellhorn, Birgit; Bravo-Rodriguez, Kenny; Schillinger, Jasmin; Koch, Uwe; Nussbaumer, Peter; Klebl, Bert; Steinmann, Jörg; Buer, Jan; Sánchez-García, Elsa; Ehrmann, Michael; Kaiser, Markus
    Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action
    In: ChemMedChem , Vol. 14 2019 , Nr. 11 , pp. 1074 - 1078
    DOI
  • Nshanian, Michael; Lantz, Carter; Wongkongkathep, Piriya; Schrader, Thomas; Klärner, Frank-Gerrit; Blümke, Anika; Despres, Clément; Ehrmann, Michael; Smet-Nocca, Caroline; Bitan, Gal; Loo, Joseph A.
    Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator
    In: Journal of the American Society for Mass Spectrometry (JASMS) , Vol. 30 2019 , Nr. 1 , pp. 16 - 23
    DOI (Open Access)
  • Körver, Lisa; Papadopoulos, Chrisovalantis; Liu, Bin; Kravic, Bojana; Rota, Giulia; Brecht, Lukas; Veenendaal, Tineke; Polajnar, Mira; Blümke, Anika; Ehrmann, Michael; Klumperman, Judith; Jäättelä, Marja; Behrends, Christian; Meyer, Hemmo
    The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage
    In: EMBO Reports 2019 , pp. e48014
    DOI (Open Access)
  • Schillinger, Jasmin; Severin, Katharina; Kaschani, Farnusch; Kaiser, Markus; Ehrmann, Michael
    HTRA1-Dependent Cell Cycle Proteomics
    In: Journal of Proteome Research , Vol. 17 2018 , Nr. 8 , pp. 2679 - 2694
    DOI
  • Bongard, Jens; Lorenz, Marian; Vetter, Ingrid R.; Stege, Patricia; Porfetye, Arthur T.; Schmitz, Anna Laura; Kaschani, Farnusch; Wolf, Alex; Koch, Uwe; Nussbaumer, Peter; Klebl, Bert; Kaiser, Markus; Ehrmann, Michael
    Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes
    In: ACS Chemical Biology , Vol. 13 2018 , Nr. 5 , pp. 1307 - 1312
    DOI
  • Halder, Vivek; Oeljeklaus, Julian; Heilmann, Geronimo; Krahn, Jan; Liu, Yanlin; Xiong, Yan; Schlicht, Markus; Schillinger, Jasmin; Kracher, Barbara; Ehrmann, Michael; Kombrink, Erich; Kaschani, Farnusch; Kaiser, Markus
    Identification of the Natural Product RotihibinA as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling
    In: Chemistry - A European Journal , Vol. 24 2018 , Nr. 48 , pp. 12500 - 12504
    DOI
  • Klose, Ralph; Adam, M. Gordian; Weis, Eva-Maria; Moll, Iris; Wüstehube-Lausch, Joycelyn; Tetzlaff, Fabian; Oka, Chio; Ehrmann, Michael; Fischer, Andreas
    Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis
    In: Oncogene , Vol. 37 2018 , pp. 4260 - 4272
    DOI
  • Bravo-Rodriguez, Kenny; Hagemeier, Birte; Drescher, Lea; Lorenz, Marian; Rey, Juliana; Meltzer, Michael; Kaschani, Farnusch; Kaiser, Markus; Ehrmann, Michael
    Utilities for Mass Spectrometry Analysis of Proteins (UMSAP) : Fast post-processing of mass spectrometry data
    In: Rapid Communications in Mass Spectrometry , Vol. 32 2018 , Nr. 19 , pp. 1659 - 1667
    DOI
  • Ehrmann, Michael; Kaiser, Markus
    Small Molecules from Deep within the Gut
    In: ChemBioChem , Vol. 18 2017 , Nr. 11 , pp. 967 - 968
    DOI
  • Köcher, Steffen; Rey, Juliana; Bongard, Jens; Tiaden, André N.; Meltzer, Michael; Richards, Peter J.; Ehrmann, Michael; Kaiser, Markus
    Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors
    In: Angewandte Chemie International Edition , Vol. 56 2017 , Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute , pp. 8555 - 8558
    DOI
  • Sprengel, Andreas; Lill, Pascal; Stegemann, Pierre; Bravo-Rodriguez, Kenny; Schöneweiß, Elisa-Charlott; Merdanovic, Melisa; Gudnason, Daniel; Aznauryan, Mikayel; Gamrad, Lisa; Barcikowski, Stephan; Sánchez-García, Elsa; Birkedal, Victoria; Gatsogiannis, Christos; Ehrmann, Michael; Sacca, Barbara
    Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions
    In: Nature Communications , Vol. 8 2017 , pp. 14472
    DOI, Online Full Text (Open Access)
  • Rotan, Olga; Severin, Katharina; Pöpsel, Simon; Peetsch, Alexander; Merdanovic, Melisa; Ehrmann, Michael; Epple, Matthias
    Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles
    In: Beilstein Journal of Nanotechnology , Vol. 8 2017 , Nr. 1 , pp. 381 - 393
    DOI, Online Full Text (Open Access)
  • Papadopoulos, Chrisovalantis; Kirchner, Philipp; Bug, Monika; Grum, Daniel; Körver, Lisa; Schulze, Nina; Pöhler, Robert; Dressler, Alina; Fengler, Sven; Arhzaouy, Khalid; Lux, Vanda; Ehrmann, Michael; Weihl, Conrad C.; Meyer, Hemmo
    VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy
    In: The EMBO Journal , Vol. 36 2017 , Nr. 2 , pp. 135 - 150
    DOI (Open Access)
  • Schmidt, Nina; Irle, Inga; Ripkens, Kamilla; Lux, Vanda; Nelles, Jasmin; Johannes, Christian; Parry, Lee; Greenow, Kirsty; Amir, Sarah; Campioni, Mara; Baldi, Alfonso; Oka, Chio; Kawaichi, Masashi; Clarke, Alan R.; Ehrmann, Michael
    Epigenetic silencing of serine protease HTRA1 drives polyploidy
    In: BMC Cancer , Vol. 16 2016 , Nr. 1
    DOI (Open Access)
  • Ehrmann, Michael; Kaschani, Farnusch; Kaiser, Markus
    Chemical proteomics versus Leishmaniasis
    In: Chemistry and Biology , Vol. 22 2015 , Nr. 3 , pp. 309 - 310
    DOI (Open Access)
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology , Vol. 11 2015 , Nr. 11 , pp. 862 - 869
    DOI (Open Access)
  • Beaufort, Nathalie; Scharrer, Eva; Lux, Vanda; Ehrmann, Michael; Haffner, Christof; Dichgans, Martin
    Reply to Liu et al. : Loss of TGF-β signaling in CARASIL pathogenesis
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 112 2015 , Nr. 14 , pp. E1694
    DOI
  • Beaufort, Nathalie; Scharrer, Eva; Kremmer, Elisabeth; Lux, Vanda; Ehrmann, Michael; Huber, Robert; Houlden, Henry H.; Werring, David John; Haffner, Christof; Dichgans, Martin
    Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 111 2014 , Nr. 46 , pp. 16496 - 16501
    DOI
  • Thompson, Natalie J.; Merdanovic, Melisa; Ehrmann, Michael; van Duijn, Esther; Heck, Albert J.R.
    Substrate occupancy at the onset of oligomeric transitions of DegP
    In: Structure , Vol. 22 2014 , Nr. 2 , pp. 281 - 290
    DOI (Open Access)
  • Stolze, Sara C.; Meltzer, Michael; Ehrmann, Michael; Kaiser, Markus
    Ahp cyclodepsipeptides: The impact of the ahp residue on the "Canonical Inhibition" of S1 serine proteases
    In: ChemBioChem , Vol. 14 2013 , Nr. 11 , pp. 1301 - 1308
    DOI
  • Merdanovic, Melisa; Mönig, Timon; Ehrmann, Michael; Kaiser, Markus
    Diversity of allosteric regulation in proteases
    In: ACS Chemical Biology , Vol. 8 2013 , Nr. 1 , pp. 19 - 26
    DOI
  • Gloeckl, Sarina; Ong, Vanissa A.; Patel, Pooja; Tyndall, Joel D. A.; Timms, Peter; Beagley, Kenneth W.; Allan, John A.; Armitage, Charles W.; Turnbull, Lynne; Whitchurch, Cynthia B.; Merdanovic, Melisa; Ehrmann, Michael; Powers, James C.; Oleksyszyn, Jozef; Verdoes, Martijn; Bogyo, Matthew; Huston, Wilhelmina M.
    Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis
    In: Molecular Microbiology , Vol. 89 2013 , Nr. 4 , pp. 676 - 689
    DOI
  • Mastny, Markus; Heuck, Alexander; Kurzbauer, Robert; Heiduk, Anja; Boisguerin, Prisca; Volkmer, Rudolf; Ehrmann, Michael; Rodrigues, Christopher D.A.; Rudner, David Z.; Clausen, Tim
    XCtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in bacillus subtilis
    In: Cell , Vol. 155 2013 , Nr. 3 , pp. 647 - 658
    DOI
  • Weski, Juliane; Meltzer, Michael; Spaan, Lina; Mönig, Timon; Oeljeklaus, Julian; Hauske, Patrick; Vouilleme, Lars; Volkmer, Rudolf; Boisguerin, Prisca; Boyd, Dana; Huber, Robert; Kaiser, Markus; Ehrmann, Michael
    Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ Protease
    In: ChemBioChem , Vol. 13 2012 , Nr. 3 , pp. 402 - 408
    DOI
  • Tiaden, André N.; Klawitter, Marina; Lux, Vanda; Mirsaidi, Ali; Bahrenberg, Gregor; Glanz, Stephan; Quero, Lilian; Liebscher, Thomas; Wuertz, Karin; Ehrmann, Michael; Richards, Peter J.
    Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration
    In: The Journal of Biological Chemistry (JBC) , Vol. 287 2012 , Nr. 25 , pp. 21335 - 21345
    DOI
  • Stolze, Sara Christina; Meltzer, Michael; Ehrmann, Michael; Kaiser, Markus
    Development of a Solid-Phase Approach to the Natural Product Class of Ahp-Containing Cyclodepsipeptides
    In: European Journal of Organic Chemistry 2012 , Nr. 8 , pp. 1616 - 1625
    DOI
  • Lütticke, Christiane; Hauske, Patrick; Lewandrowski, Urs; Sickmann, Albert; Kaiser, Markus; Ehrmann, Michael
    E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe–Phe bonds
    In: Molecular BioSystems , Vol. 8 2012 , Nr. 6 , pp. 1775 - 1782
    DOI
  • Weski, Juliane; Ehrmann, Michael
    Genetic analysis of 15 protein folding factors and proteases of the Escherichia coli cell envelope
    In: Journal of Bacteriology , Vol. 194 2012 , Nr. 12 , pp. 3225 - 3233
    DOI
  • Tennstaedt, Annette; Pöpsel, Simon; Trübestein, Linda; Hauske, Patrick; Brockmann, Anke; Schmidt, Nina; Irle, Inga; Sacca, Barbara; Niemeyer, Christof M.; Brandt, Roland; Ksiezak-Reding, Hanna; Tirniceriu, Anca Laura; Egensperger, Rupert; Baldi, Alfonso; Dehmelt, Leif; Kaiser, Markus; Huber, Robert; Clausen, Tim; Ehrmann, Michael
    Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates
    In: The Journal of Biological Chemistry (JBC) , Vol. 287 2012 , Nr. 25 , pp. 20931 - 20941
    DOI
  • Tiaden, André N.; Breiden, Maike; Mirsaidi, Ali; Weber, Fabienne A.; Bahrenberg, Gregor; Glanz, Stephan; Cinelli, Paolo; Ehrmann, Michael; Richards, Peter J.
    Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein
    In: Stem Cells , Vol. 30 2012 , Nr. 10 , pp. 2271 - 2282
    DOI (Open Access)
  • Nigro, Annamaria; Menon, Ramesh; Bergamaschi, Andrea; Clovis, Yoanne M.; Baldi, Alfonso; Ehrmann, Michael; Comi, Giancarlo; De Pietri Tonelli, Davide; Farina, Cinthia; Martino, Gianvito; Muzio, Luca
    MiR-30e and miR-181d control Radial Glia cell proliferation via HtrA1 modulation
    In: Cell Death and Disease , Vol. 3 2012 , Nr. 8 , e360
    DOI (Open Access)
  • Malet, Hélène; Canellas, Flavia; Sawa, Justyna; Yan, Jun; Thalassinos, Konstantinos; Ehrmann, Michael; Clausen, Tim; Saibil, Helen R.
    Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ
    In: Nature Structural & Molecular Biology , Vol. 19 2012 , Nr. 2 , pp. 152 - 157
    DOI
  • Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    HTRA proteases : regulated proteolysis in protein quality control
    In: Nature Reviews Molecular Cell Biology , Vol. 12 2011 , Nr. 3 , pp. 152 - 162
    DOI
  • Sinha, Sharmistha; Lopes, Dahabada H. J.; Du, Zhenming; Pang, Eric S.; Shanmugam, Akila; Lomakin, Aleksey; Talbiersky, Peter; Tennstaedt, Annette; McDaniel, Kirsten; Bakshi, Reena; Kuo, Pei-Yi; Ehrmann, Michael; Benedek, George B.; Loo, Joseph A.; Klärner, Frank-Gerrit; Schrader, Thomas; Wang, Chunyu; Bitan, Gal
    Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins
    In: Journal of the American Chemical Society: JACS , Vol. 133 2011 , Nr. 42 , pp. 16958 - 16969
    DOI
  • Sawa, Justyna; Malet, Hélène; Krojer, Tobias; Canellas, Flavia; Ehrmann, Michael; Clausen, Tim
    Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope
    In: The Journal of Biological Chemistry (JBC) , Vol. 286 2011 , Nr. 35 , pp. 30680 - 30690
    DOI
  • Wu, Junchen; Zawistowski, Adam; Ehrmann, Michael; Yi, Tao; Schmuck, Carsten
    Peptide Functionalized Polydiacetylene Liposomes Act as a Fluorescent Turn-On Sensor for Bacterial Lipopolysaccharide
    In: Journal of the American Chemical Society: JACS , Vol. 133 2011 , Nr. 25 , pp. 9720 - 9723
    DOI
  • Merdanovic, Melisa; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Protein quality control in the bacterial periplasm
    In: Annual Review of Microbiology , Vol. 65 2011 , pp. 149 - 168
    DOI
  • Kley, Juliane; Schmidt, Bastian; Boyanov, Boril; Stolt-Bergner, Peggy C.; Kirk, Rebecca; Ehrmann, Michael; Knopf, Ronit R.; Naveh, Leah; Adam, Zach; Clausen, Tim
    Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure
    In: Nature Structural & Molecular Biology , Vol. 18 2011 , Nr. 6 , pp. 728 - 731
    DOI
  • Trübestein, Linda; Tennstaedt, Annette; Mönig, Timon; Krojer, Tobias; Canellas, Flavia; Kaiser, Markus; Clausen, Tim; Ehrmann, Michael
    Substrate induced remodeling of the active site regulates human HtrA1 activity
    In: Nature Structural & Molecular Biology , Vol. 18 2011 , pp. 386 - 388
    DOI
  • Hasenbein, Sonja; Meltzer, Michael; Hauske, Patrick; Kaiser, Markus; Huber, Robert; Clausen, Tim; Ehrmann, Michael
    Conversion of a regulatory into a degradative protease
    In: Journal of Molecular Biology (JMB) , Vol. 397 2010 , Nr. 4 , pp. 957 - 966
    DOI
  • Merdanovic, Melisa; Mamant, Nicolette; Meltzer, Michael; Poepsel, Simon; Auckenthaler, Alexandra; Melgaard, Rie; Hauske, Patrick; Nagel-Steger, Luitgard; Clarke, Anthony R.; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Determinants of structural and functional plasticity of a widely conserved protease chaperone complex
    In: Nature Structural & Molecular Biology , Vol. 17 2010 , Nr. 7 , pp. 837 - 843
    DOI
  • Sawa, Justyna; Heuck, Alexander; Ehrmann, Michael; Clausen, Tim
    Molecular transformers in the cell: lessons learned from the DegP protease-chaperone
    In: Current Opinion in Structural Biology , Vol. 20 2010 , Nr. 2 , pp. 253 - 258
    DOI
  • Stolze, Sara Christina; Meltzer, Michael; Ehrmann, Michael; Kaiser, Markus
    Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A
    In: Chemical Communications: ChemComm 2010 , Nr. 46 , pp. 8857 - 8859
    DOI
  • Campioni, Mara; Severino, Anna; Manente, Lucrezia; Tuduce, Ioana L; Toldo, Stefano; Caraglia, Michele; Crispi, Stefania; Ehrmann, Michael; He, Xiaoping; Maguire, Jacie; De Falco, Maria; De Luca, Antonio; Shridhar, Viji; Baldi, Alfonso
    The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein
    In: Molecular Cancer Research , Vol. 8 2010 , Nr. 9 , pp. 1248 - 1260
    DOI
  • Hauske, Patrick; Mamant, Nicolette; Hasenbein, Sonja; Nickel, Sabrina; Ottmann, Christian; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus
    Peptidic small molecule activators of the stress sensor DegS
    In: Molecular BioSystems , Vol. 5 2009 , Nr. 9 , pp. 980 - 985
    DOI
  • Hauske, Patrick; Meltzer, Michael; Ottmann, Christian; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus
    Selectivity profiling of DegP substrates and inhibitors
    In: Bioorganic and Medicinal Chemistry , Vol. 17 2009 , Nr. 7 , pp. 2920 - 2924
    DOI
  • Meltzer, Michael; Hasenbein, Sonja; Mamant, Nicolette; Merdanovic, Melisa; Poepsel, Simon; Hauske, Patrick; Kaiser, Markus; Huber, Robert; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael
    Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli
    In: Research in Microbiology , Vol. 160 2009 , Nr. 9 , pp. 660 - 666
    DOI
  • Meltzer, Michael; Hasenbein, Sonja; Hauske, Patrick; Kucz, Nicolette; Merdanovic, Melisa; Grau, Sandra; Beil, Alexandra; Jones, Dafydd; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus
    Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control
    In: Angewandte Chemie International Edition , Vol. 47 2008 , Nr. 7 , pp. 1332 - 1334
    DOI
  • Hauske, Patrick; Otmann, Christian; Meltzer, Michael; Ehrmann, Michael; Kaiser, Markus
    Allosteric regulation of proteases
    In: ChemBioChem , Vol. 9 2008 , Nr. 18 , pp. 2920 - 2928
    DOI
  • Launay, S.; Maubert, E.; Lebeurrier, N.; Tennstaedt, A.; Campioni, M.; Docagne, F.; Gabriel, C.; Dauphinot, L.; Potier, M. C.; Ehrmann, Michael; Baldi, A.; Vivien, D.
    HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival
    In: Cell Death and Differentiation , Vol. 15 2008 , Nr. 9 , pp. 1408 - 1416
    DOI
  • Krojer, Tobias; Pangerl, Karen; Kurt, Juliane; Sawa, Justyna; Stingl, Christoph; Mechtler, Karl; Huber, Robert; Ehrmann, Michael; Clausen, Tim
    Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 22 2008 , pp. 7702 - 7707
  • Krojer, Tobias; Sawa, Justyna; Schäfer, Eva; Saibil, Helen R.; Ehrmann, Michael; Clausen, Tim
    Structural basis for the regulated protease and chaperone function of DegP.
    In: Nature 2008 , Nr. 453 , pp. 885 - 890
  • Baldi, Alfonso; Mottolese, Marcella; Vincenzi, Bruno; Campioni, Mara; Mellone, Pasquale; Di Marino, Mariapia; di Crescenzo, Vincenzo G; Visca, Paolo; Menegozzo, Simona; Spugnini, Enrico P; Citro, Gennaro; Ceribelli, Anna; Mirri, Alessandra; Chien, Jeremy; Shridhar, Viji; Ehrmann, Michael; Santini, Mario; Facciolo, Francesco
    The serine protease HtrA1 is a novel prognostic factor for human mesothelioma
    In: Pharmacogenomics , Vol. 9 2008 , Nr. 8 , pp. 1069 - 1077
  • Hasenbein, Sonja; Merdanovic, Melisa; Ehrmann, Michael
    Determinants of regulated proteolysis in signal transduction
    In: Genes and Development , Vol. 21 2007 , Nr. 1 , pp. 6 - 10
    DOI
  • Severino, Anna; Campioni, Mara; Straino, Stefania; Salloum, Fadi N.; Schmidt, Nina; Herbrand, Ulrike; Frede, Stilla; Toietta, Gabriele; Rocco, Giuliana Di; Bussani, Rossana; Silvestri, Furio; Piro, Maddalena; Liuzzo, Giovanna; Biasucci, Luigi M.; Mellone, Pasquale; Feroce, Florinda; Capogrossi, Maurizio; Baldi, Feliciano; Fandrey, Joachim; Ehrmann, Michael; Crea, Filippo; Abbate, Antonio; Baldi, Alfonso
    Identification of Protein Disulfide Isomerase as a Cardiomyocyte Survival Factor in Ischemic Cardiomyopathy
    In: Journal of the American College of Cardiology (JACC) , Vol. 50 2007 , Nr. 11 , pp. 1029 - 1037
    DOI (Open Access)
  • Hasselblatt, Hanna; Kurzbauer, Robert; Wilken, Corinna; Krojer, Tobias; Sawa, Justyna; Kurt, Juliane; Kirk, Rebecca; Hasenbein, Sonja; Ehrmann, Michael; Clausen, Tim
    Regulation of the σE stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress
    In: Genes and Development , Vol. 21 2007 , Nr. 20 , pp. 2659 - 2670
    DOI
  • Eser, Markus; Henrichs, Tanja; Boyd, Dana; Ehrmann, Michael
    Target directed proteolysis in vivo.
    In: Methods in Enzymology , Vol. 421 2007 , pp. 68 - 83
  • Richards, P.J.; Nowell, Mari A.; Horiuchi, Sankichi; McLoughlin, Rachel M.; Fielding, Ceri A.; Grau, Sandra; Yamamoto, Naoki; Ehrmann, Michael; Rose-John, Stefan; Williams, Anwen S.; Topley, Nicholas; Jones, Simon A.
    Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
    In: Arthritis & Rheumatism , Vol. 54 2006 , Nr. 5 , pp. 1662 - 1672
    DOI
  • Chien, Jeremy; Aletti, Giovanni; Baldi, Alfonso; Catalano, Vincenzo; Muretto, Pietro; Keeney, Gary L.; Kalli, Kimberly; Staub, Julie; Ehrmann, Michael; Cliby, William; Lee, Yean Kit; Bible, Keith C.; Hartmann, Lynn C.; Kaufmann, Scott H.; Shridhar, Viji
    Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity
    In: The Journal of Clinical Investigation (JCI) , Vol. 116 2006 , Nr. 7 , pp. 1994 - 2004
    DOI
  • Grau, Sandra; Richards, Peter J.; Kerr, Briedgeen; Hughes, Clare; Caterson, Bruce; Williams, Anwen S.; Junker, Uwe; Jones, Simon A.; Clausen, Tim; Ehrmann, Michael
    The role of human HtrA1 in arthritic disease.
    In: The Journal of Biological Chemistry (JBC) , Vol. 281 2006 , Nr. 10 , pp. 6124 - 6129
  • Tian, Xiaodan; Cecal, Roxana; McLaurin, JoAnne; Manea, Marilena; Stefanescu, Raluca; Grau, Sandra; Harnasch, Mona; Amir, Sarah; Ehrmann, Michael; George-Hyslop, Peter St; Kohlmann, Markus; Przybylski, Michael
    Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry
    In: European Journal of Mass Spectrometry , Vol. 11 2005 , Nr. 5 , pp. 547 - 555
  • Grau, Sandra; Baldi, Alfonso; Bussani, Rossana; Tian, Xiaodan; Stefanescu, Raluca; Przybylski, Michael; Richards, Peter; Jones, Simon A.; Shridhar, Viji; Clausen, Tim; Ehrmann, Michael
    Implications of human HtrA1 in amyloid precursor protein processing.
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 102 2005 , Nr. 17 , pp. 6021 - 6026
  • Grau, Sandra; Baldi, Alfonso; Bussani, Rossana; Tian, Xiaodan; Stefanescu, Raluca; Przybylski, Michael; Richards, Peter; Jones, Simon A.; Shridhar, Viji; Clausen, Tim; Ehrmann, Michael
    Implications of the serine protease HtrA1 in amyloid precursor protein processing
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 102 2005 , Nr. 17 , pp. 6021 - 6026
  • Henrichs, Tanja; Mikhaleva, Natasha; Conz, Charlotte; Deuerling, Elke; Boyd, Dana; Zelasny, Adrian; Bibi, Eitan; Ban, Nenad; Ehrmann, Michael
    Target-directed proteolysis at the ribosome.
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 102 2005 , pp. 4246 - 4251
  • Harnasch, Mona; Grau, Sandra; Behrends, Christian; Dove, Simon L.; Hochschild, Ann; Iskandar, Maria-karnina; Xia, Weiming; Ehrmann, Michael
    Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins
    In: Molecular Membrane Biology , Vol. 21 2004 , Nr. 6 , pp. 373 - 383
    DOI
  • Wilken, Corinna; Kitzing, Karina; Kurzbauer, Robert; Ehrmann, Michael; Clausen, Tim
    Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease
    In: Cell , Vol. 117 2004 , Nr. 4 , pp. 483 - 494
  • Ehrmann, Michael; Clausen, Tim
    Proteolysis as a regulatory mechanism
    In: Annual Review of Genetics , Vol. 38 2004 , pp. 709 - 724
    DOI
  • Ehrle, Rainer; Mikhaleva, Natasha; Boyd, Dana; Davidson, Amy L.; Ehrmann, Michael
    Context-dependent effects of charged residues in transmembrane segments of MalF-PhoA fusions
    In: Research in Microbiology , Vol. 154 2003 , Nr. 9 , pp. 654 - 657
  • Eser, Markus; Ehrmann, Michael
    SecA-dependent quality control of intracellular protein localization
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 100 2003 , Nr. 23 , pp. 13231 - 13234
  • Krojer, Tobias; Garrido-Franco, Marta; Hubert, Robert; Ehrmann, Michael; Clausen, Tim
    Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine
    In: Nature , Vol. 416 2002 , Nr. 6879 , pp. 455 - 459
  • Clausen, Tim; Southan, Chris; Ehrmann, Michael
    The HtrA family of proteases : Implications for protein composition and cell fate
    In: Molecular Cell , Vol. 10 2002 , Nr. 3 , pp. 443 - 455
    DOI
  • Faber, Klaas Nico; Kram, Anita M.; Ehrmann, Michael; Veenhuis, Marten
    A Novel Method to Determine the Topology of Peroxisomal Membrane Proteins in Vivo Using the Tobacco Etch Virus Protease
    In: The Journal of Biological Chemistry (JBC) , Vol. 276 2001 , Nr. 39 , pp. 36501 - 36507
  • Steinke, Angelika; Grau, Sandra; Davidson, Amy; Hofmann, Eckhard; Ehrmann, Michael
    Characterization of transmembrane segments 3, 4, and 5 of Ma1F by mutational analysis
    In: Journal of Bacteriology , Vol. 183 2001 , Nr. 1 , pp. 375 - 381
  • Herskovits, Anat A.; Seluanov, Andrei; Rajsbaum, Ricardo; ten Hagen-Jongman, Corinne M.; Henrichs, Tanja; Bochkareva, Elena S.; Phillips, Gregory J.; Probst, Francis J.; Nakae, Taiji; Ehrmann, Michael; Luirink, Joen; Bibi, Eitan
    Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor Fts Y
    In: EMBO Reports , Vol. 2 2001 , Nr. 11 , pp. 1040 - 1046
  • Uhland, Kerstin; Mondigler, Martin; Spiess, Christoph; Prinz, Will; Ehrmann, Michael
    Determinants of translocation and folding of TreF, a trehalase of Escherichia coli
    In: The Journal of Biological Chemistry (JBC) , Vol. 275 2000 , Nr. 31 , pp. 23439 - 23445
  • Al-Masoudi, Najim A.; Al-Soud, Yaseen A.; Ehrmann, Michael; Clercq, Erik de
    Synthesis of acyclic 6,7-dihaloquinolone nucleoside analogues as potential antibacterial and antiviral agents.
    In: Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines , Vol. 8 2000 , Nr. 6 , pp. 1407 - 1413
  • Spiess, Christoph; Beil, Alexandra; Ehrmann, Michael
    A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein
    In: Cell , Vol. 97 1999 , Nr. 3 , pp. 339 - 347
  • Melchers, Klaus; Schuhmacher, Alexander; Buhmann, Anita; Weitzenegger, Thomas; Belin, Dominique; Grau, Sandra; Ehrmann, Michael
    Membrane topology of CadA homologous P-type ATPase of Helicobacter pylori as determined by expression of phoA fusions in Escherichia coli and the positive inside rule
    In: Research in Microbiology , Vol. 150 1999 , Nr. 8 , pp. 507 - 520
  • Guan, Lan; Ehrmann, Michael; Yoneyama, Hiroshi; Nakae, Taiji
    Membrane topology of the xenobiotic-exporting subunit, MexB, of the MexA,B-OprM extrusion pump in Pseudomonas aeruginosa
    In: The Journal of Biological Chemistry (JBC) , Vol. 274 1999 , Nr. 15 , pp. 10517 - 10522
  • Ehrmann, Michael
    Eine hochspezifische Protease zur Struktur-und Funktionsanalyse von Proteinen in vivo und in vitro.
    In: Biospektrum: das Magazin für Biowissenschaften , Vol. 3 1998 , pp. 53 - 56
  • Akiyama, Yoshinori; Ehrmann, Michael; Kihara, Akio; Ito, Koreaki
    Polypeptide binding of Escherichia coil FtsH (HflB)
    In: Molecular Microbiology , Vol. 28 1998 , Nr. 4 , pp. 803 - 812
  • Al-Masoudi, Najim A.; Al-Soud, Yaseen A.; Ehrmann, Michael; Clercq, Erik de
    Quinolone nucleosides: 6,7-dihalo-N-β- and α-glycosyl-1,4-dihydro-4- oxo-quinoline-3-carboxylic acids and derivatives. Synthesis, antimicrobial and antiviral activity
    In: Nucleosides and Nucleotides , Vol. 17 1998 , Nr. 12 , pp. 2255 - 2266
  • Ehrmann, Michael; Ehrle, Rainer; Hofmann, Eckhard; Boos, Winfried; Schlösser, Andreas
    The ABC maltose transporter
    In: Molecular Microbiology , Vol. 29 1998 , Nr. 3 , pp. 685 - 694
  • Prinz, William A.; Boyd, Dana H.; Ehrmann, Michael; Beckwith, Jon
    The protein translocation apparatus contributes to determining the topology of an integral membrane protein in Escherichia coli
    In: The Journal of Biological Chemistry (JBC) , Vol. 273 1998 , Nr. 14 , pp. 8419 - 8424
  • Spiess, Christoph; Happersberger, H. Peter; Glocker, Michael O.; Spiess, Eberhard; Rippe, Karsten; Ehrmann, Michael
    Biochemical characterization and mass spectrometric disulfide bond mapping of periplasmic α-amylase mals of Escherichia coli
    In: The Journal of Biological Chemistry (JBC) , Vol. 272 1997 , Nr. 35 , pp. 22125 - 22133
  • Ehrmann, Michael
    Biogenese, Struktur und Funktion integraler Membranproteine: die Membrankomponenten des ABC-Maltosetransporters von Escherichia coli.
    In: Biospektrum: das Magazin für Biowissenschaften , Vol. 2 1997 , pp. 46 - 47
  • Ehrmann, Michael; Bolek, Petra; Mondigler, Martin; Boyd, Dana; Lange, Roland
    TnTIN and TnTAP: Mini-transposons for site-specific proteolysis in vivo
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 94 1997 , Nr. 24 , pp. 13111 - 13115
  • Horlacher, Reinhold; Uhland, Kerstin; Klein, Wolfgang; Ehrmann, Michael; Boos, Winfried
    Characterization of a cytoplasmic trehalase of Escherichia coli
    In: Journal of bacteriology : JB , Vol. 178 1996 , Nr. 21 , pp. 6250 - 6257
  • Ehrle, Rainer; Pick, Charlotte; Ulrich, Regina; Hofmann, Eckhard; Ehrmann, Michael
    Characterization of transmembrane domains 6, 7, and 8 of MalF by mutational analysis
    In: Journal of bacteriology : JB , Vol. 178 1996 , Nr. 8 , pp. 2255 - 2262
  • Mondigler, Martin; Ehrmann, Michael
    Site-specific proteolysis of the Escherichia coli SecA protein in vivo
    In: Journal of bacteriology : JB , Vol. 178 1996 , Nr. 10 , pp. 2986 - 2988
  • Prinz, W.A.; Spiess, C.; Ehrmann, Michael; Schierle, C.; Beckwith, J.
    Targeting of signal sequenceless proteins for export in Escherichia coli with altered protein translocase
    In: The EMBO Journal , Vol. 15 1996 , Nr. 19 , pp. 5209 - 5217
  • Uhland, Kerstin; Zander, Thomas; Ehrmann, Michael
    Synthetic competition between cytoplasmic folding and translocation of a soluble membrane protein domain
    In: Research in Microbiology , Vol. 146 1995 , Nr. 2 , pp. 121 - 128
  • Uhland, Kerstin; Ehrle, Rainer; Zander, Thomas; Ehrmann, Michael
    Requirements for translocation of periplasmic domains in polytopic membrane proteins
    In: Journal of bacteriology : JB , Vol. 176 1994 , Nr. 15 , pp. 4565 - 4571
  • Whitley, P.; Zander, Thomas; Ehrmann, Michael; Haardt, M.; Bremer, E.; von Heijne, G
    Sec-independent translocation of a 100-residue periplasmic N-terminal tail in the E.coli inner membrane protein proW
    In: The EMBO Journal , Vol. 13 1994 , Nr. 19 , pp. 4653 - 4661
  • Hoffmann, Ralf; Jung, Stephan; Ehrmann, Michael; Hofer, Hans Werner
    The Saccharomyces cerevisiae gene PPH3 encodes a protein phosphatase with properties different from PPX, PP1 and PP2A
    In: Yeast , Vol. 10 1994 , Nr. 5 , pp. 567 - 578
    DOI
  • McGovern, Karen; Ehrmann, Michael; Beckwith, Jon
    Decoding signals for membrane protein assembly using alkaline phosphatase fusions
    In: The EMBO Journal , Vol. 10 1991 , Nr. 10 , pp. 2773 - 2782
  • Ehrmann, Michael; Beckwith, Jon
    Proper insertion of a complex membrane protein in the absence of its amino-terminal export signal
    In: The Journal of Biological Chemistry (JBC) , Vol. 266 1991 , Nr. 25 , pp. 16530 - 16533
  • Ehrmann, Michael; Boyd, Dana; Beckwith, Jonathan
    Genetic analysis of membrane protein topology by a sandwich gene fusion approach.
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 87 1990 , Nr. 19 , pp. 7574 - 7578
  • Reidl, Joachim; Römisch, Karin; Ehrmann, Michael; Boos, Winfried
    MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI.
    In: Journal of bacteriology : JB , Vol. 171 1989 , Nr. 9 , pp. 4888 - 4899
  • Gött, Peter; Ehrmann, Michael; Boos, Winfried
    Convenient transfer of lacZ-gene fusions to phage M13 by in vivo recombination and their use for nucleotide sequencing
    In: Gene : an international journal focusing on gene cloning and gene structure and function , Vol. 71 1988 , Nr. 1 , pp. 187 - 191
  • Ehrmann, Michael; Boos, Winfried; Ormseth, E.; Schweizer, Herbert P.; Larson, T.J.
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