E. coli Proteases - Metalloproteases

E. coli Proteases
Metalloproteases

Proteases of E. coli Metalloproteases

Proteases are listed according to their celluar localisation and in alphabetical order. MWs of periplasmic and outer membrane proteases are given for the unprocessed precursor proteins. Clicking on the protein name will open the latest UniProt file.

Metalloproteases localised in the

Cytoplasm
Cytoplasmic membrane
Periplasm
Outer membrane

Cytoplasm

Aminobenzoyl-glutamate utilization protein A (abgA)

Peptidase family M40 InterPro

Function

Structure

MW 46588 Da
436 aa
Leucine aminopeptidase LAP (ampA)

Peptidase family M17 InterPro

Function

Structure

MW 54879 Da
503 aa
Methionine aminopeptidase (ampM)

Peptidase family M24A InterPro

Function Removes the N-terminal methionine from nascent proteins

Structure PDB

MW 29331 Da
264 aa
Xaa-Pro aminopeptidase/AmpP (pepP)

Peptidase family M24B InterPro

Function Releases any N-terminal amino acid preceding proline, even from short peptides

Structure PDB

MW 49684 Da
440 aa

Dipeptidyl carboxypeptidase (dcp)

Peptidase family	M3 InterPro
Function	Removes dipeptides from the c-termini of oligopeptides, broad specificity, does not hydrolyse bonds in which p1' is Pro, or both p1 and p1' are Gly
Structure
MW	77384 Da 680 aa

D-alanyl-D-alanine dipeptidase (ddpX/vanX)

Peptidase family M45 InterPro

Function Hydrolyses Ala-Ala

Structure

MW 21213 Da
4002 aa
Putative frv operon protein FrvX (frvX)

Peptidase family M42/Glutamyl aminopeptidase (Lactococcus)

Function Unclear, homologous to SgcX of ECOLI

Structure

MW 38733 Da
356 aa
Gcp Glycoprotease (gcp/b3064)

Peptidase family M22 InterPro

Function

Structure

MW 36024 Da
356 aa
Hydrogenase 1 maturation protease (hyaD)

Peptidase family M52 InterPro

Function Involved in maturation (C-terminal processing) of HyaB, the subunit of hydrogenase 1

Structure

MW 21546 Da
195 aa
Hydrogenase 2 maturation protease (hybD)

Peptidase family M52 InterPro

Function Involved in maturation (C-terminal processing) of HybB, the subunit of hydrogenase 2

Structure PDB

MW 17751 Da
164 aa
Hydrogenase 3 maturation protease (hycI)

Peptidase family M52 InterPro

Function Involved in maturation of the large subunit of hydrogenlyase HycE

Structure

MW 16925 Da
155 aa
Isoaspartyl dipeptidase IadA (iadA)

Peptidase family M38

Function Hydrolyses l-isoaspartyl (l-beta-aspartyl) dipeptides, to degrade proteins damaged by l-isoaspartyl residue formation

Structure PDB

MW 41084 Da
390 aa
Oligopeptidase A (prlC)

Peptidase family M3 InterPro

Function

Structure

MW 77167 Da
680 aa
Aminoacyl-histidine dipeptidase/Peptidase D (pepD)

Peptidase family M25 InterPro

Function Xaa-His dipeptidase, has specificity for the unusual dipeptide beta-alanyl-l-histidine

Structure

MW 52784 Da
484 aa
X-Pro dipeptidase/Peptidase Q (pepQ)

Peptidase family M24B InterPro

Function Hydrolysis of Xaa-|-Pro dipeptides, but not on Pro-|-Pro

Structure

MW 50176 Da
443 aa
Aminotripeptidase/Peptidase T (pepT)

Peptidase family M20A InterPro

Function Hydrolyzes a tripeptides containing n-terminal Met, Leu, or Phe

Structure PDB

MW 44923 Da
408 aa
Probable zinc protease PqqL (pqqL/b1494)

Peptidase family M16 InterPro

Function

Structure

MW 104656 Da
931 aa
Putative sgc operon protein SgcX (sgcX)

Peptidase family M42/Glutamyl aminopeptidase (Lactococcus

Function Unclear, homolog of FrvX of E. coli

Structure

MW 41729 Da
383 aa (1-25 signal pept.)
SprT Protein (sprT)

Peptidase family Zn MTpeptdse InterPro

Function

Structure

MW 19348 Da
165 aa
Putative metalloprotease YcaL (ycaL)

Peptidase family M48 InterPro

Function Homolog of YggG of E. coli

Structure

MW 26740 Da
254 aa
Hypothetical protease YeaZ (yeaZ)

Peptidase family M22 InterPro

Function

Structure

MW 25181 Da
231 aa
Hypothetical protein YgeY (ygeY)

Peptidase family M20A InterPro

Function

Structure

MW 44804 Da
403 aa
Putative metalloprotease YggG (yggG)

Peptidase family M48 InterPro

Function Homolog of YcaL of E. coli

Structure

MW 26842 Da
252 aa
Hypothetical protein YibP (yibG)

Peptidase family M37 InterPro

Function

Structure

MW 46594 Da
419 aa

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Cytoplasmic membrane

FtsH (ftsH/hflB)

Peptidase family	M41/AAA Protease InterPro
Function	essential ATP-dependent zinc metalloprotease, cleaves soluble and integral membrane proteins
Structure	2 TM, cytoplasmic N-and C-termini
MW	70708 Da 644 aa

Heat shock protein HtpX (htpX)

Peptidase family M48 InterPro

Function

Structure 4 TM, cytoplasmic N-and C-termini

MW 31923 Da
293 aa
rseP (YaeL)

Peptidase family M50B

Function RIP protease, degrades the antisigma factor RseA

Structure 4 TM, PDZ domain

MW 49071 Da
450 aa
YfbL (yfbL)

Peptidase family M28A

Function

Structure 1TM

MW 35931 Da
323 aa

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Periplasm

Alkaline phosphatase isozyme conversion protein IAP (iap or b2753)

Peptidase family M28C

Function

Structure

MW 37920 Da
345 aa (1-24 signal pept.)
Protease III (ptrA)

Peptidase family M16

Function Endopeptidase, may have preference for small peptides

Structure

MW 107708 Da
962 aa (1-23 signal pept.)
Hypothetical protein YebA (yebA)

Peptidase family M37

Function

Structure

MW 49057 Da
440 aa (1-34 signal pept.)
Protein YhjJ (yhjJ)

Peptidase family M16

Function

Structure

MW 55527 Da
498 aa (1-24 signal pept.)

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Outer membrane

Lipoprotein NlpD (nlpD)

Peptidase family M37

Function

Structure

MW 40149 Da
379 aa (1-25 signal pept.)

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Peptidase family	M40 InterPro
Function
Structure
MW	46588 Da 436 aa

Peptidase family	M17 InterPro
Function
Structure
MW	54879 Da 503 aa

Peptidase family	M24A InterPro
Function	Removes the N-terminal methionine from nascent proteins
Structure	PDB
MW	29331 Da 264 aa

Peptidase family	M24B InterPro
Function	Releases any N-terminal amino acid preceding proline, even from short peptides
Structure	PDB
MW	49684 Da 440 aa

Peptidase family	M45 InterPro
Function	Hydrolyses Ala-Ala
Structure
MW	21213 Da 4002 aa

Peptidase family	M42/Glutamyl aminopeptidase (Lactococcus)
Function	Unclear, homologous to SgcX of ECOLI
Structure
MW	38733 Da 356 aa

Peptidase family	M22 InterPro
Function
Structure
MW	36024 Da 356 aa

Peptidase family	M52 InterPro
Function	Involved in maturation (C-terminal processing) of HyaB, the subunit of hydrogenase 1
Structure
MW	21546 Da 195 aa

Peptidase family	M38
Function	Hydrolyses l-isoaspartyl (l-beta-aspartyl) dipeptides, to degrade proteins damaged by l-isoaspartyl residue formation
Structure	PDB
MW	41084 Da 390 aa

Peptidase family	M25 InterPro
Function	Xaa-His dipeptidase, has specificity for the unusual dipeptide beta-alanyl-l-histidine
Structure
MW	52784 Da 484 aa

Peptidase family	M20A InterPro
Function	Hydrolyzes a tripeptides containing n-terminal Met, Leu, or Phe
Structure	PDB
MW	44923 Da 408 aa

Peptidase family	M42/Glutamyl aminopeptidase (Lactococcus
Function	Unclear, homolog of FrvX of E. coli
Structure
MW	41729 Da 383 aa (1-25 signal pept.)

Peptidase family	M50B
Function	RIP protease, degrades the antisigma factor RseA
Structure	4 TM, PDZ domain
MW	49071 Da 450 aa

Peptidase family	M28A
Function
Structure	1TM
MW	35931 Da 323 aa

Peptidase family	M16 InterPro
Function
Structure
MW	104656 Da 931 aa

Peptidase family	Zn MTpeptdse InterPro
Function
Structure
MW	19348 Da 165 aa

Peptidase family	M48 InterPro
Function	Homolog of YggG of E. coli
Structure
MW	26740 Da 254 aa

Peptidase family	M37 InterPro
Function
Structure
MW	46594 Da 419 aa

Peptidase family	M28C
Function
Structure
MW	37920 Da 345 aa (1-24 signal pept.)

Peptidase family	M16
Function	Endopeptidase, may have preference for small peptides
Structure
MW	107708 Da 962 aa (1-23 signal pept.)