BIOME - Core: Molecular Mechanisms of Cell State Transitions

CRC 1430 "Molecular Mechanisms of Cell State Transitions" & iRTG on "Molecular and Chemical Cell Biology"

The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states. These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell state.

Within our integrated Research Training Group on Molecular and Chemical Cell Biology  we provide an elaborated concept for the thorough training and qualification of doctoral researchers, that focuses both on (a) the theoretical knowledge and experimental skills necessary to work at the interface between biology, chemistry and medicine and (b) generic skills related training. The scientific research related qualification includes a profound training on the theoretical foundation of mechanistic cell biology, chemical biology, and the molecular and cellular basis of disease, but also on state-of-the-art methodologies. Regular lectures, annual retreats, invitation of guests and participation at international conferences will promote scientific discussions and support communication, collaboration and exchange of scientific ideas among doctoral researchers, sub-projects and (inter-)national experts by avoiding detours through various hierarchical levels. Hence, education within the iRTG will not only promote the excellence of science and contribute to the success of the CRC but will also prepare the participating doctoral researchers for their future careers.

CRC 1430 Web Site

PLEASE NOTE: CRC1430 is looking for talents. For further information and updates please visit the CRC´s website. Any enquiries or applications concerning this programme should be addressed directly to its project leaders or its coordinator ( and not to the Graduate School of Biomedical Science.

Speakers of the CRC:

Prof. Dr. Hemmo Meyer Molecular Biology I
Prof. Dr. Michael Ehrmann Microbiology

Speakers of the iRTG:

Prof. Dr. Stefan Westermann Molecular Genetics
Prof. Dr. Perihan Nalbant Molecular Cell Biology
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