Publikationen
Publikationen Strukturelle und Medizinische Biochemie
Es wurden 89 Publikationen gefunden
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The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain AllosteryIn: Proteins: Structure, Function and Genetics 2025 , in pressDOI (Open Access)
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Ultrasmall Gold Nanoparticles (2 nm) Decorated with a High Density of Photochemically Switchable LigandsIn: Chemistry - A European Journal 2025DOI (Open Access)
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Molecular Tweezers Block the Functional Pore of a Protein MachineIn: Journal of the American Chemical Society: JACS , Jg. 147 2025, Nr. 20, S. 16836 – 16849DOI (Open Access)
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Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1In: Chemistry - A European Journal , Jg. 30 2024, Nr. 56, e202401542DOI (Open Access)
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Increased Cytotoxicity of Bimetallic Ultrasmall Silver–Platinum Nanoparticles (2 nm) on Cells and Bacteria in Comparison to Silver Nanoparticles of the Same SizeIn: Materials , Jg. 17 2024, Nr. 15, 3702DOI (Open Access)
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The Molecular Footprint of Peptides on the Surface of Ultrasmall Gold Nanoparticles (2 nm) Is Governed by Steric DemandIn: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry , Jg. 128 2024, Nr. 17, S. 4266 – 4281
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Multivalent Molecular Tweezers Disrupt the Essential NDC80 Interaction with MicrotubulesIn: Journal of the American Chemical Society: JACS , Jg. 145 2023, Nr. 28, S. 15251 – 15264
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Potentiating Tweezer Affinity to a Protein Interface with Sequence-Defined Macromolecules on NanoparticlesIn: Biomacromolecules , Jg. 24 2023, Nr. 8, S. 3666 – 3679
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Ultrastructure and Surface Composition of Glutathione-Terminated Ultrasmall Silver, Gold, Platinum, and Alloyed Silver-Platinum Nanoparticles (2 nm)In: Inorganic Chemistry , Jg. 62 2023, Nr. 42, S. 17470 – 17485
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications , Jg. 14 2023, Nr. 1, 3258DOI, Online Volltext (Open Access)
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Binding Methylarginines and Methyllysines as Free Amino Acids : A Comparative Study of Multiple Host ClassesIn: ChemBioChem , Jg. 23 2022, Nr. 2, e202100502DOI (Open Access)
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Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligandIn: RSC Advances , Jg. 12 2022, Nr. 53, S. 34176 – 34184DOI (Open Access)
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Recognition of a Flexible Protein Loop in Taspase 1 by Multivalent Supramolecular TweezersIn: Biomacromolecules , Jg. 23 2022, Nr. 11, S. 4504 – 4518
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Water-Based Synthesis of Ultrasmall Nanoparticles of Platinum Group Metal Oxides (1.8 nm)In: Inorganic Chemistry , Jg. 61 2022, Nr. 12, S. 5133 – 5147
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New tools to probe the protein surface : Ultrasmall gold nanoparticles carry amino acid bindersIn: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry , Jg. 125 2021, Nr. 1, S. 115 – 127DOI (Open Access)
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Targeting the Surface of the Protein 14-3-3 by Ultrasmall (1.5 nm) Gold Nanoparticles Carrying the Specific Peptide CRafIn: ChemBioChem , Jg. 22 2021, Nr. 8, S. 1456 – 1463DOI (Open Access)
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Peptide-Conjugated Ultrasmall Gold Nanoparticles (2 nm) for Selective Protein TargetingIn: ACS Applied Bio Materials , Jg. 4 2021, Nr. 1, S. 945 – 965DOI (Open Access)
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Metal-Ligand Interface and Internal Structure of Ultrasmall Silver Nanoparticles (2 nm)In: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry , Jg. 125 2021, Nr. 21, S. 5645 – 5659
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Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezersIn: Nature Communications , Jg. 12 2021, Nr. 1, S. 1505DOI, Online Volltext (Open Access)
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Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerizationIn: Biological Chemistry , Jg. 401 2020, Nr. 8, S. 955 – 968DOI (Open Access)
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Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeastIn: The EMBO Journal , Jg. 39 2020, Nr. 14, S. e102938DOI, Online Volltext (Open Access)
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NMR Spectroscopy of supramolecular chemistry on protein surfacesIn: Beilstein Journal of Organic Chemistry , Jg. 16 2020, S. 2505 – 2522DOI (Open Access)
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Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole LigandIn: Angewandte Chemie International Edition , Jg. 59 2020, Nr. 14, S. 5567 – 5571DOI (Open Access)
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The other side of the corona : Nanoparticles inhibit the protease taspase1 in a size-dependent mannerIn: Nanoscale , Jg. 12 2020, Nr. 37, S. 19093 – 19103
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Solution NMR Spectroscopy with Isotope-Labeled Cysteine (¹³C and ¹⁵N) Reveals the Surface Structure of l -Cysteine-Coated Ultrasmall Gold Nanoparticles (1.8 nm)In: Langmuir , Jg. 35 2019, Nr. 3, S. 767 – 778
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Click chemistry on the surface of ultrasmall gold nanoparticles (2 nm) for covalent ligand attachment followed by nmr spectroscopyIn: Langmuir , Jg. 35 2019, Nr. 22, S. 7191 – 7204
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Multivalent Ligands with Tailor-Made Anion Binding Motif as Stabilizers of Protein–Protein InteractionsIn: ChemBioChem , Jg. 20 2019, Nr. 23, S. 2921 – 2926
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Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allosteryIn: Biomolecular NMR Assignments , Jg. 13 2019, Nr. 1, S. 85 – 89DOI (Open Access)
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Structural Analysis of the 42 kDa Parvulin of Trypanosoma bruceiIn: Biomolecules , Jg. 9 2019, Nr. 3, 93DOI, Online Volltext (Open Access)
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Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPaseIn: Biomolecules , Jg. 9 2019, Nr. 12, 876DOI, Online Volltext (Open Access)
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Rationally designed DNA-origami hosts for protein guest
Nantech2019, Nucleic Acid Nanotechnology: from algorithmic design to biochemical applications, Aalto University, Espoo, Finland May 27-29, 2019,2019 -
Structure and function of the human parvulins Pin1 and Par14/17In: Biological Chemistry , Jg. 399 2018, Nr. 2, S. 101 – 125DOI (Open Access)
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Cell entry of a host-targeting protein of oomycetes requires gp96In: Nature Communications , Jg. 9 2018, Nr. 1, S. 2347DOI (Open Access)
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The RxLR motif of the host targeting effector AVR3a of phytophthora infestans is cleaved before secretionIn: The Plant Cell , Jg. 29 2017, Nr. 6, S. 1184 – 1195DOI (Open Access)
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NmPin from the marine thaumarchaeote Nitrosopumilus maritimus is an active membrane associated prolyl isomeraseIn: BMC Biology (incorporating Journal of Biology) , Jg. 14 2016, Nr. 1, S. 53DOI (Open Access)
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Determinants of tyrosylprotein sulfation coding and substrate specificity of tyrosylprotein sulfotransferases in metazoansIn: Chemico-Biological Interactions , Jg. 259 2016, Nr. Part A, S. 17 – 22
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Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1In: PLoS ONE , Jg. 11 2016, Nr. 3, S. e0151431DOI (Open Access)
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Molecular tweezers target a protein-protein interface and thereby modulate complex formationIn: Chemical Communications: ChemComm , Jg. 52 2016, Nr. 98, S. 14141 – 14144DOI (Open Access)
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The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97In: The Journal of Biological Chemistry (JBC) , Jg. 290 2015, Nr. 49, S. 29414 – 29427DOI (Open Access)
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Heterodimers of Tyrosylprotein Sulfotransferases Suggest Existence of a Higher Organization Level of Transferases in the Membrane of the trans-Golgi ApparatusIn: Journal of Molecular Biology (JMB) , Jg. 427 2015, Nr. Issue 6, Part B, S. 1404 – 1412
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Structural model of the bilitranslocase transmembrane domain supported by NMR and FRET dataIn: PLoS ONE , Jg. 10 2015, Nr. 8, S. e0135455DOI (Open Access)
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Human DNA-binding peptidyl-prolyl cis/trans isomerase Par14 is cell cycle dependently expressed and associates with chromatin in vivoIn: BMC Biochemistry , Jg. 16 2015, Nr. 1DOI (Open Access)
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HumanbiologieStuttgart: Ulmer 2014
(UTB ; 4130) -
Peptidyl succinimidyl peptides as taspase 1 inhibitorsIn: ChemBioChem , Jg. 15 2014, Nr. 15, S. 2233 – 2237
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Transient domain interactions enhance the affinity of the mitotic regulator pin1 toward phosphorylated peptide ligandsIn: Structure , Jg. 21 2013, Nr. 10, S. 1769 – 1777DOI (Open Access)
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Design of a Modular Protein-Based MRI Contrast Agent for Targeted ApplicationIn: PLoS ONE , Jg. 8 2013, Nr. 6, S. e65346DOI, Online Volltext (Open Access)
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Identification and characterization of peptides that bind the PPIase domain of Parvulin17In: Journal of Peptide Science , Jg. 19 2013, Nr. 6, S. 362 – 369
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Document Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasmIn: PLoS ONE , Jg. 7 2012, Nr. 1, S. e29559DOI, Online Volltext (Open Access)
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Structure of the corrinoid : coenzyme M methyltransferase MtaA from Methanosarcina mazeiIn: Acta Crystallographica Section D: Biological Crystallography , Jg. 68 2012, Nr. 11, S. 1549 – 1557
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Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent mannerIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 109 2012, Nr. 6, S. 2096 – 2101
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A potential transcriptional regulator is out-of-frame translated from the metallothionein 2A messenger RNAIn: Analytical Biochemistry , Jg. 409 2011, Nr. 1, S. 159 – 161
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Single-Domain Parvulins Constitute a Specific Marker for Recently Proposed Deep-Branching Archaeal SubgroupsIn: Evolutionary Bioinformatics , Jg. 7 2011, S. 135 – 148DOI, Online Volltext (Open Access)
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Structure and Dynamics of the First Archaeal Parvulin Reveal a New Functionally Important Loop in Parvulin-type Prolyl IsomerasesIn: The Journal of Biological Chemistry (JBC) , Jg. 286 2011, S. 6554 – 6565DOI (Open Access)
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Crystallographic Proof for an Extended Hydrogen Bonding Network in Small Prolyl IsomerasesIn: Journal of the American Chemical Society: JACS , Jg. 133 2011, Nr. 50, S. 20096 – 20099
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The solution structure of pGolemi, a high affinity Mena EVH1 binding miniature protein, suggests explanations for paralog-specific binding to Ena/VASP homology (EVH) 1 domainsIn: Biological Chemistry , Jg. 390 2009, Nr. 5-6, S. 417 – 426
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Wie Proteine sich erkennen ... : ... und man ihnen dabei zusehen kann!In: Unikate: Berichte aus Forschung und Lehre 2009, Nr. 36: Naturwissenschaften/Medizin : Kernmagnetische Resonanz, S. 28 – 35DOI, Online Volltext (Open Access)
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Small family with key contacts : par14 and par17 parvulin proteins, relatives of pin1, now emerge in biomedical researchIn: Perspectives in Medicinal Chemistry , Jg. 2 2008, S. 11 – 20DOI (Open Access)
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15N magnetic relaxation study of backbone dynamics of the ribosomeassociated cold shock response protein Yfia of Escherichia coliIn: Acta Biochimica Polonica , Jg. 54 2007, Nr. 4, S. 769 – 775(Open Access)
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The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in HominidaeIn: BMC Biology (incorporating Journal of Biology) , Jg. 5 2007, 37
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Human TPST1 Transmembrane Domain Triggers Enzyme Dimerisation and Localisation to the Golgi CompartmentIn: Journal of Molecular Biology (JMB) , Jg. 361 2006, Nr. 3, S. 436 – 449
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GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1.In: Structure , Jg. 14 2006, S. 881 – 888DOI (Open Access)
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Isotopic labelling of recombinant proteins expressed in the protozoan host Leishmania tarentolae.In: Protein Expression & Purification , Jg. 48 2006, S. 167 – 172
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Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiationIn: BMC Molecular Biology , Jg. 7 2006, 9
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Specification of SUMO1- and SUMO2-interacting motifsIn: The Journal of Biological Chemistry (JBC) , Jg. 281 2006, Nr. 23, S. 16117 – 16127DOI (Open Access)
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The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate bindingIn: Journal of Molecular Biology (JMB) , Jg. 347 2005, Nr. 3, S. 623 – 635
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Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell lineIn: Chemical Communications: ChemComm , Jg. 4 2005, S. 516 – 518
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Book Review: Protein Structure: Determination, Analysis, and Applications for Drug Discovery. Edited by Daniel I. ChasmanIn: ChemBioChem , Jg. 5 2004, Nr. 4, S. 547 – 548
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Expression, purification and crystallization of human 3′- phosphoadenosine-5′-phosphosulfate synthetase 1In: Acta Crystallographica Section D: Structural Biology , Jg. 60 2004, Nr. 2, S. 350 – 352
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Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescensIn: Proceedings of the National Academy of Sciences of the United States of America , Jg. 101 2004, Nr. 47, S. 16431 – 16436DOI (Open Access)
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Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14In: Journal of Molecular Biology (JMB) , Jg. 330 2003, Nr. 5, S. 955 – 966
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Die Vorliebe für Physik und die StrukturbiologieIn: Nachrichten aus der Chemie , Jg. 51 2003, Nr. 9, S. 917 – 917
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Structural analysis of the mitotic regulator hPin1 in solution : insights into domain architecture and substrate bindingIn: The Journal of Biological Chemistry (JBC) , Jg. 278 2003, Nr. 28, S. 26183 – 26193DOI (Open Access)
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The N-terminal basic domain of human parvulin h Par14 is responsible for the entry to the nucleus and high-affinity DNA-bindingIn: Journal of Molecular Biology (JMB) , Jg. 321 2002, Nr. 2, S. 235 – 247
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Solution structure of the ribosome-associated cold shock response protein Yfia of Escherichia coliIn: Biochemical and Biophysical Research Communications (BBRC) , Jg. 299 2002, Nr. 5, S. 710 – 714
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Structural attributes in the conjugation of Ubiquitin, RUB and SUMO to protein substrates.In: Frontiers in Bioscience , Jg. 7 2002, S. 148 – 162
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Induction of tyrosylprotein sulfotransferase isoform shift in human endothelial cellsIn: Circulation , Jg. 106 2002, Nr. Suppl. 2, S. 287
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Letter to the Editor: ¹H, ¹³C and ¹⁵N resonance assignments of the ribosome-associated cold shock response protein Yfia of Escherichia coliIn: Journal of Biomolecular NMR , Jg. 23 2002, Nr. 4, S. 335 – 336
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Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cellsIn: Biochemical and Biophysical Research Communications (BBRC) , Jg. 294 2002, Nr. 3, S. 541 – 546
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Increased backbone flexibility in threonineIn: Biochemistry , Jg. 40 2001, Nr. 27, S. 7957 – 7963