Molecular Mechanisms of Cell State Transitions

Speaker: Prof. Dr. Hemmo Meyer

The DFG-funded CRC 1430 ‘Molecular Mechanisms of Cell State Transitions’ investigates fundamental molecular mechanisms underlying the regulation of cell proliferation. Cell proliferation must be tightly controlled in order to ensure the development of the organism and tissue regeneration while preventing neoplastic disorders. An essential feature of this control is the establishment of different, biochemically or epigenetically defined cell states and the regulated transitions between these states.

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Multilevel response to stressor increase and release in stream ecosystems (RESIST) 

Speaker:  Prof. Dr. Bernd Sures

The Collaborative ResearchCentre RESIST is investigating how  flowing waters recover after environmental stress. In Phase I, the "Asymmetric Response Concept" (ARC) was developed, which shows that recovery processes occur differently than the original degradation. Important findings are that ecological functions recover faster than species compositions and that biotic interactions and environmental factors influence regeneration differently. In Phase II, the focus will be expanded to include recovery processes after moderate and severe stress, including drought. The research combines laboratory experiments, field studies and modeling to gain transferable knowledge for river restoration.

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Horizon-2020 Project MERLiN

Project coordination: Prof. Dr. Daniel Hering

Europe's environment is in an alarming state, with climate change expected to further aggravate the situation. This poses severe threats to economic prosperity, human wellbeing and social peace – our society needs systemic transformative change.

Ecosystem restoration is key to this change, and freshwaters play an important role: the restoration of streams, rivers, peatlands and wetlands has a long tradition and offers an extensive knowledge base – freshwaters are ideal demonstrators of the necessary change.

The MERLIN project commits to transformative ecosystem restoration, mainstreaming Nature-based Solutions for the urgent systemic change of our society.

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eDNA-based approach for the EU Mission Ocean strategy

Prof. Dr. Florian Leese

Funded by the EU Horizon Europe programme, eDNAqua-Plan is a €1.9 million, 3-year project that will focus on the development of a digital ecosystem for eDNA reference libraries for aquatic ecosystems (marine and freshwater).

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New strategies to combat AMD

Prof. Dr. Michael Ehrmann

Prof. Dr. Markus Kaiser

The aim of the project is to optimize HTRA1 inhibitors as a strategy for the treatment of age-related macular degeneration (AMD). AMD is an incurable disease and the most common cause of blindness in people over the age of 60. In the ClearView project, the HTRA1 inhibitors developed by us will be optimized in terms of medicinal chemistry and their efficacy will be validated in various models (in vitro / ex vivo / in vivo) (proof of concept). The ClearView project is carried out in collaboration with the partners Lead Discovery Center GmbH, University of Duisburg-Essen and University Hospital Tübingen.

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