May 15, 2018
Title to be announced
Prof. Dr. Thomas Clavel
Institute of Medical Microbiology
Functional Microbiome Research Group
University Hospital RWTH Aachen
Paper of the Month (DGHM)
The German Society for Hygiene and Microbiology (DGHM) elected the following publication as "Paper of the Month":
Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer
Pastille E, Frede A, McSorley HJ, Gräb J, Adamczyk A, Kollenda S, Hansen W, Epple M, Buer J, Maizels RM, Klopfleisch R, Westendorf AM.
Evidence-based epidemiological studies indicate an inverse correlation between the incidence of inflammatory bowel diseases (IBD) and exposure to parasitic worms of the gastrointestinal tract (helminths). Consequently, helminths were tested in the therapy of IBD patients, resulting in clinical amelioration of the disease due to the induction of an immunosuppressive microenvironment. However, some infection-related cancers can be attributed to helminth infection, probably due to the generation of a microenvironment that might be conductive to the initiation and development of cancer. In the present study, we aimed to unravel the apparently controversial function of helminths in a mouse model of colitis-associated colon cancer. We show that helminth infection in the onset of colitis and colitis-associated colon cancer does not ameliorate colonic inflammation but activates intestinal immune cells that further facilitate tumor development. Therefore, a better understanding of mechanisms by which helminths modulate host immune responses in the gut should be defined precisely before application of helminths in the therapy of autoimmune diseases such as IBD.
F.l.t.r: First author, Dr. Eva Pastille, and last author, Prof. Dr. Astrid Westendorf.
Symposium Infection & Immunology 2017
15 - 16 May 2017, Kamp-Lintfort
Scientific Excellence Award
In the course of the Infection & Immunology Symposium of the Research Training Group 1949, which took place from 15 to 16 May 2017 in Kamp-Lintfort, four PhD students were awarded with the Scientific Excellence Award. The award honoured their excellent PhD studies.
The following PhD students received the award: Alexandra Adamczyk, M.Sc., Institute of Medical Microbiology, and Piyush Sharma, M.Sc., Institute of Immunology, both Medical Faculty of the University of Duisburg-Essen, as well as Dennis Lapuente, PhD, Department of Molecular and Medical Virology, Ruhr University Bochum, and Tina Senff, M.Sc., Institute of Virology, University Hospital Düsseldorf.
f.l.t.r.: Tina Senff, Dennis Lapuente, Alexandra Adamczyk, Piyush Sharma
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