Immune Response in Infectious Diseases –

Regulation between Innate and Adaptive Immunity

Annual Retreat 2018

​​​​​June 18 - 20, 2018, Kamp-Lintfort

​​​​​Gruppenfoto 2018 Web

Cover picture

Graduate student designs journal cover

The publication „Imaging of cytotoxic antiviral immunity while considering the 3R principle of animal research” in the Journal of Molecular Medicine by our graduate student Lucas Otto was chosen for the cover picture in the April issue 2018. Shown is a look into the tibial bone marrow of a living Friend retrovirus infected mouse during an ongoing adaptive immune response. Virus-specific CD8+ T cells (red) and their migration tracks (yellow lines) are depicted together with the bone surface (white) and the blood vessels (cyan). Besides the imaging aspect, the paper also offers a valuable cell transfer method that reduces the number of donor animals substantially.

Our field of research

Rtg 1949 Titel Graphik

Infectious diseases are worldwide among the ten leading causes of mortality. Despite intensive research efforts, effective therapies or prophylactic vaccines are available only for a limited number of pathogens. A detailed understanding of the pathomechanisms of infectious diseases is most important for the development of future therapeutic interventions. Traditionally, the host response to pathogens is divided into the innate and the adaptive immune response.

To date, research with a specific focus on the interaction between innate and adaptive immunity is still underrepresented. The scientific goal of the proposed Research Training Group (RTG) is to fill this gap by bringing together highly qualified researchers working on different aspects of the immune response in various infectious diseases or in vaccine development against pathogens. The mutual scientific question is: How is the adaptive immune response against pathogens modulated by the innate immune response, and how does the adaptive immune response influence innate immunity? The training program will ensure long-term progress in this important research field in the Rhine-Ruhr Area and provide the PhD students with fundamental education in the science of infection and immunity.