Publications
Selected Publications
2020

Efficient induction of cytotoxic T cells
by viral vector vaccination requires
STING-dependent DC functions
Barnowski C, Ciupka G, Tao R, Jin L, Busch DH, Tao S, and Drexler I. Efficient Induction of Cytotoxic T Cells by Viral Vector Vaccination Requires STING-Dependent DC Functions. Front. Immunol. 16 July 2020. doi.org/10.3389/fimmu.2020.01458.

CEACAM1 regulates CD8 + T Cell immunity and protects from severe pathology during Citrobacter rodentium induced colitis

Mouse Cytomegalovirus M34 encodes
a non-essential, nuclear, early-late
expressed protein required for efficient
viral replication

Immunotherapeutic blockade of CD47
inhibitory signaling enhances innate & adaptive immune responses to viral infection

Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology

Dead cells induce innate anergy via Mertk after acute viral infection

The human cytomegalovirus pUL145
isoforms act as viral DDB1-cullin-associated
factors to instruct host protein degradation
to impede innate immunity

Map3k14 as a regulator of innate and
adaptive immune response during acute
viral infection
2019

Depletion of Foxp3+ regulatory T cells is
accompanied by an increase in the relative
abundance of Firmicutes in the murine
gut microbiome

Diverse immunomodulatory effects of
individual IFNα subtypes on virus-specific CD8+ T cell responses

Toll-like receptor 7 activation enhances
CD8+ T cell effector functions by promoting
cellular glycolysis

Tamoxifen protects from
vesicular stomatitis virus infection

Intestinal acid sphingomyelinase protects
from severe pathogen-driven colitis

The IL-33/ST2 pathway shapes the
regulatory T cell phenotype to promote
intestinal cancer

T cell-specific overexpression of
acid sphingomyelinase results in elevated
T cell activation and reduced parasitemia during Plasmodium yoelii infection

Expansion of stem-cell-like CD4+ memory
T cells during acute HIV-1 infection is linked
to rapid disease progression

A tumor-peptide based nanoparticle vaccine elicits efficient tumor growth control in
anti-tumor immunotherapy

Glycosylation of HIV Env impacts IgG
subtype responses to vaccination
2018

A mass spectrometry-based profiling of
interactomes of viral DDB1- and cullin
ubiquitin ligase-binding proteins reveals
NF-κB inhibitory activity of the HIV-2-encoded Vpx

A systematic electron microscopic
study on the uptake of barium sulphate
nano-, submicro-, microparticles by
bone marrow-derived phagocytosing cells

CEACAM1 promotes CD8+ T cell
responses and improves control
of a chronic viral infection

Pre-activation of toll-like receptor 2
enhances CD8+ T-cell responses and
accelerates Hepatitis B virus clearance
in the mouse models

STAT2-dependent immune responses ensure host survival despite the presence of a
potent viral antagonist

Impact of the TAP-like transporter in antigen presentation and phagosome maturation

Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components

Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol

Cancer, drugs, and bugs -
Bacteriotherapy on the rise?

Imaging of cytotoxic antiviral immunity
while considering the 3R principle of
animal research

IL-1β as mucosal vaccine adjuvant:
the specific induction of tissue-resident
memory T cells improves the heterosubtypic immunity against influenza A viruses
2017

Sphingosine 1-phosphate- and C-C
chemokine receptor 2-dependent activation
of CD4+ plasmacytoid dendritic cells
in the bone marrow contributes to signs
of sepsis-induced immunosuppression

Conventional CD11chigh dendritic cells are important for T cell priming during the initial phase of Plasmodium yoelii infection,
but are dispensable at later time points

Broad recruitment of mGBP family members to Chlamydia trachomatis inclusions

Intestinal helminth infection drives
carcinogenesis in colitis-associated
colon cancer

Deciphering of the human interferon-regulated proteome by mass spectrometry-based quantitative analysis reveals extent and dynamics of protein induction
and repression

Local delivery of siRNA-loaded calcium
phosphate nanoparticles abates
pulmonary inflammation

SGLT1 deficiency turns Listeria infection into a lethal disease in mice

Acquired IFNg resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

Interference of retroviral envelope with vaccine-induced CD8+ T cell responses is
relieved by co-administration of
cytokine-encoding vectors

Differential expression of GPR15 on T cells during ulcerative colitis

Hypoxia enhances immunosuppression by inhibiting CD4+ effector T cell function
and promoting Treg activity

Different antiviral effects of IFNα and IFNβ in an HBV mouse model

DC-derived IL-10 modulates pro-inflammatory cytokine production
and promotes induction of CD4+IL-10+
regulatory T cells during Plasmodium yoelii infection
2016

Antigen-dependent cross-competition shapes the local repertoire of resident
memory CD8+ T cells in the skin

Opposing development of cytotoxic
and follicular helper CD4 T cells
controlled by the TCF-1-Bcl6 nexus

Targeted antibody-mediated depletion of CD19 CAR-T cells permanently reverses
B cell aplasia

Mucosal expression of DEC-205 targeted
allergen alleviates an asthmatic phenotype in mice

Brain-resident memory T cells represent
an autonomous cytotoxic barrier
to viral infection

Bile acids act as soluble host restriction
factors limiting Cytomegalovirus replication
in hepatocytes

Interferon alpha subtype-specific
suppression of HIV-1 infection in vivo

Combination of nanoparticle-based
therapeutic vaccination and transient
ablation of regulatory T cells enhances
anti-viral immunity during chronic
retroviral infection

Broad and potent antiviral activity
of the NAE inhibitor MLN4924
2015

The transcription and translation landscapes
during human cytomegalovirus infection
reveal novel host-pathogen interactions

Human TLR8 senses UR/URR motifs
in bacterial and mitochondrial RNA

Virus-induced type I Interferon deteriorates control of systemic Pseudomonas Aeruginosa infection

IL10-deficiency in CD4+ T cells exacerbates the IFNγ and IL17 response during bacteria induced Colitis

Modified vaccinia virus Ankara-infected
dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways
