Publications
Selected Publications
2021
Nedd8-Activating Enzyme Is a Druggable Host Dependency Factor of Human and Mouse Cytomegalovirus
Neuropilin-1 Is Expressed on Highly Activated CD4 + Effector T Cells and Dysfunctional CD4 + Conventional T Cells from Naive Mice
IL-33 Drives Expansion of Type 2 Innate Lymphoid Cells and Regulatory T Cells and Protects Mice From Severe, Acute Colitis
Inhibition of TLR4 Signaling Impedes Tumor Growth in Colitis-Associated Colon Cancer
Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity
A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells
2020
Interplay between Cellular Autophagy and Hepatitis B Virus Replication: A Systematic Review
A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope
Efficient induction of cytotoxic T cells
by viral vector vaccination requires
STING-dependent DC functions
An Inverse Relationship Between c-Kit/CD117 and mTOR Confers NK Cell Dysregulation Late After Severe Injury
CEACAM1 regulates CD8 + T Cell immunity and protects from severe pathology during Citrobacter rodentium induced colitis
Mouse Cytomegalovirus M34 encodes
a non-essential, nuclear, early-late
expressed protein required for efficient
viral replication
O-GlcNAc transferase promotes influenza A virus–induced cytokine storm by targeting interferon regulatory factor–5
Immunotherapeutic blockade of CD47
inhibitory signaling enhances innate & adaptive immune responses to viral infection
Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology
Targeting Autophagy in Innate Immune Cells: Angel or Demon During Infection and Vaccination?
Dead cells induce innate anergy via Mertk after acute viral infection
Effective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccine Delivery System
The human cytomegalovirus pUL145
isoforms act as viral DDB1-cullin-associated
factors to instruct host protein degradation
to impede innate immunity
Map3k14 as a regulator of innate and
adaptive immune response during acute
viral infection
2019
Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity
Depletion of Foxp3+ regulatory T cells is
accompanied by an increase in the relative
abundance of Firmicutes in the murine
gut microbiome
Diverse immunomodulatory effects of
individual IFNα subtypes on virus-specific CD8+ T cell responses
Toll-like receptor 7 activation enhances
CD8+ T cell effector functions by promoting
cellular glycolysis
Tamoxifen protects from
vesicular stomatitis virus infection
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling
Intestinal acid sphingomyelinase protects
from severe pathogen-driven colitis
The IL-33/ST2 pathway shapes the
regulatory T cell phenotype to promote
intestinal cancer
T cell-specific overexpression of
acid sphingomyelinase results in elevated
T cell activation and reduced parasitemia during Plasmodium yoelii infection
Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
Expansion of stem-cell-like CD4+ memory
T cells during acute HIV-1 infection is linked
to rapid disease progression
A tumor-peptide based nanoparticle vaccine elicits efficient tumor growth control in
anti-tumor immunotherapy
Glycosylation of HIV Env impacts IgG
subtype responses to vaccination
2018
A mass spectrometry-based profiling of
interactomes of viral DDB1- and cullin
ubiquitin ligase-binding proteins reveals
NF-κB inhibitory activity of the HIV-2-encoded Vpx
A systematic electron microscopic
study on the uptake of barium sulphate
nano-, submicro-, microparticles by
bone marrow-derived phagocytosing cells
CEACAM1 promotes CD8+ T cell
responses and improves control
of a chronic viral infection
Pre-activation of toll-like receptor 2
enhances CD8+ T-cell responses and
accelerates Hepatitis B virus clearance
in the mouse models
STAT2-dependent immune responses ensure host survival despite the presence of a
potent viral antagonist
Impact of the TAP-like transporter in antigen presentation and phagosome maturation
Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components
Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol
Cancer, drugs, and bugs -
Bacteriotherapy on the rise?
Imaging of cytotoxic antiviral immunity
while considering the 3R principle of
animal research
IL-1β as mucosal vaccine adjuvant:
the specific induction of tissue-resident
memory T cells improves the heterosubtypic immunity against influenza A viruses
2017
Sphingosine 1-phosphate- and C-C
chemokine receptor 2-dependent activation
of CD4+ plasmacytoid dendritic cells
in the bone marrow contributes to signs
of sepsis-induced immunosuppression
Conventional CD11chigh dendritic cells are important for T cell priming during the initial phase of Plasmodium yoelii infection,
but are dispensable at later time points
Broad recruitment of mGBP family members to Chlamydia trachomatis inclusions
Intestinal helminth infection drives
carcinogenesis in colitis-associated
colon cancer
Deciphering of the human interferon-regulated proteome by mass spectrometry-based quantitative analysis reveals extent and dynamics of protein induction
and repression
Local delivery of siRNA-loaded calcium
phosphate nanoparticles abates
pulmonary inflammation
SGLT1 deficiency turns Listeria infection into a lethal disease in mice
Acquired IFNg resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
Interference of retroviral envelope with vaccine-induced CD8+ T cell responses is
relieved by co-administration of
cytokine-encoding vectors
Differential expression of GPR15 on T cells during ulcerative colitis
Hypoxia enhances immunosuppression by inhibiting CD4+ effector T cell function
and promoting Treg activity
Different antiviral effects of IFNα and IFNβ in an HBV mouse model
DC-derived IL-10 modulates pro-inflammatory cytokine production
and promotes induction of CD4+IL-10+
regulatory T cells during Plasmodium yoelii infection
2016
Antigen-dependent cross-competition shapes the local repertoire of resident
memory CD8+ T cells in the skin
Opposing development of cytotoxic
and follicular helper CD4 T cells
controlled by the TCF-1-Bcl6 nexus
Targeted antibody-mediated depletion of CD19 CAR-T cells permanently reverses
B cell aplasia
Mucosal expression of DEC-205 targeted
allergen alleviates an asthmatic phenotype in mice
Brain-resident memory T cells represent
an autonomous cytotoxic barrier
to viral infection
Bile acids act as soluble host restriction
factors limiting Cytomegalovirus replication
in hepatocytes
Interferon alpha subtype-specific
suppression of HIV-1 infection in vivo
Combination of nanoparticle-based
therapeutic vaccination and transient
ablation of regulatory T cells enhances
anti-viral immunity during chronic
retroviral infection
Broad and potent antiviral activity
of the NAE inhibitor MLN4924
2015
The transcription and translation landscapes
during human cytomegalovirus infection
reveal novel host-pathogen interactions
Human TLR8 senses UR/URR motifs
in bacterial and mitochondrial RNA
Virus-induced type I Interferon deteriorates control of systemic Pseudomonas Aeruginosa infection
IL10-deficiency in CD4+ T cells exacerbates the IFNγ and IL17 response during bacteria induced Colitis
Modified vaccinia virus Ankara-infected
dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways
CEACAM1 induces B-cell survival and is
essential for protective antiviral antibody production
Contact
Research Training Group 1949
Immune Response in
Infectious Diseases -
Regulation between Innate
and Adaptive Immunity
Spokesperson:
Prof. Dr. Astrid Westendorf
Deputy: Prof. Dr. Jörg Timm
Deputy: Prof. Dr. Mirko Trilling
Coordination: Dr. Eva van Well
Phone: +49 201 723 35 88
E-Mail: eva.van-well@uni-due.de
