Molekularbiologie
Molekularbiologie
 
Publications AG Gulbins (last 5 years)

 

 

  1. Johnson BL, 3rd, Rice TC, Xia BT, Boone KI, Green EA, Gulbins E et al. Amitriptyline Usage Exacerbates the Immune Suppression Following Burn Injury. Shock (Augusta, Ga) 2016. 46: 541-548.
  2. Becker KA, Beckmann N, Adams C, Hessler G, Kramer M, Gulbins E et al. Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets. Clinical & experimental metastasis 2016.
  3. Wang L, Chen Y, Li X, Zhang Y, Gulbins E, Zhang Y. Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation. Oncotarget 2016.
  4. Hollmann C, Werner S, Avota E, Reuter D, Japtok L, Kleuser B et al. Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells. Journal of immunology (Baltimore, Md : 1950) 2016. 197: 3130-3141.
  5. Makdessi SA, Sweidan H, Schmid E, Weimar U, Gulbins E, Lang F. Quantitative Determination of Ceramide Molecular Species in Dendritic Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 39: 1608-1617.
  6. Hoehn RS, Seitz AP, Jernigan PL, Gulbins E, Edwards MJ. Ischemia/Reperfusion Injury Alters Sphingolipid Metabolism in the Gut. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 39: 1262-1270.
  7. Zoicas I, Reichel M, Gulbins E, Kornhuber J. Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory. PloS one 2016. 11: e0162498.
  8. Nojima H, Konishi T, Freeman CM, Schuster RM, Japtok L, Kleuser B et al. Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. PloS one 2016. 11: e0161443.
  9. Zhou Y, Salker MS, Walker B, Münzer P, Borst O, Gawaz M et al. Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 39: 985-995.
  10. Gulbins A, Grassmé H, Hoehn R, Kohnen M, Edwards MJ, Kornhuber J et al. Role of Janus-Kinases in Major Depressive Disorder. Neuro-Signals 2016. 24: 71-80.
  11. Gulbins A, Grassmé H, Hoehn R, Wilker B, Soddemann M, Kohnen M et al. Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 39: 790-801.
  12. Rice TC, Seitz AP, Edwards MJ, Gulbins E, Caldwell CC. Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection. Journal of leukocyte biology 2016.
  13. Hoehn R, Monse M, Pohl E, Wranik S, Wilker B, Keitsch S et al. Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System. Neuro-Signals 2016. 24: 48-58.
  14. Adams C, Icheva V, Deppisch C, Lauer J, Herrmann G, Graepler-Mainka U et al. Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 39: 565-572.
  15. Hoehn RS, Jernigan PL, Chang AL, Edwards MJ, Caldwell CC, Gulbins E et al. Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 39: 331-340.
  16. Schneider M, Levant B, Reichel M, Gulbins E, Kornhuber J, Müller CP. Lipids in psychiatric disorders and preventive medicine. Neuroscience and biobehavioral reviews 2016.
  17. Tavakoli Tabazavareh S, Seitz A, Jernigan P, Sehl C, Keitsch S, Lang S et al. Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 38: 2094-2102.
  18. Folkesson M, Vorkapic E, Gulbins E, Japtok L, Kleuser B, Welander M et al. Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms. Journal of vascular surgery 2016.
  19. Hoehn RS, Jernigan PL, Japtok L, Chang AL, Midura EF, Caldwell CC et al. Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation. Annals of surgery 2016.
  20. Huston JP, Kornhuber J, Muhle C, Japtok L, Komorowski M, Mattern C et al. A sphingolipid mechanism for behavioral extinction. Journal of neurochemistry 2016. 137: 589-603.
  21. Carpinteiro A, Beckmann N, Seitz A, Hessler G, Wilker B, Soddemann M et al. Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 38: 1-14.
  22. Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC et al. Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation. PloS one 2015. 10: e0146210.
  23. Li C, Peng H, Japtok L, Seitz A, Riehle A, Wilker B et al. Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis. Frontiers in bioscience (Elite edition) 2016. 8: 311-325.
  24. Jernigan PL, Hoehn RS, Grassmé H, Edwards MJ, Müller CP, Kornhuber J et al. Sphingolipids in Major Depression. Neuro-Signals 2015. 23: 49-58.
  25. Grassmé H, Jernigan PL, Hoehn RS, Wilker B, Soddemann M, Edwards MJ et al. Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression. Neuro-Signals 2015. 23: 84-92.
  26. Leanza L, Managó A, Zoratti M, Gulbins E, Szabo I. Pharmacological targeting of ion channels for cancer therapy: In vivo evidences. Biochimica et biophysica acta 2016. 1863: 1385-1397.
  27. Managó A, Leanza L, Carraretto L, Sassi N, Grancara S, Quintana-Cabrera R et al. Early effects of the antineoplastic agent salinomycin on mitochondrial function. Cell death & disease 2015. 6: e1930.
  28. Schumacher F, Chakraborty S, Kleuser B, Gulbins E, Schwerdtle T, Aschner M et al. Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization-tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans. Talanta 2015. 144: 71-79.
  29. Reichel M, Honig S, Liebisch G, Lüth A, Kleuser B, Gulbins E et al. Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. Biochimica et biophysica acta 2015. 1851: 1501-1510.
  30. Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V et al. Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015. 36: 2379-2392.
  31. Nojima H, Freeman CM, Schuster RM, Japtok L, Kleuser B, Edwards MJ et al. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. Journal of hepatology 2016. 64: 60-68.
  32. Gulbins E, Walter S, Becker KA, Halmer R, Liu Y, Reichel M et al. A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression. Journal of neurochemistry 2015. 134: 183-192.
  33. Gulbins E. Highlight: molecular medicine of sphingolipids. Biological chemistry 2015. 396: 569-571.
  34. Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Požgajovà M et al. Regulation of hematogenous tumor metastasis by acid sphingomyelinase. EMBO molecular medicine 2015. 7: 714-734.
  35. Nojima H, Freeman CM, Gulbins E, Lentsch AB. Sphingolipids in liver injury, repair and regeneration. Biological chemistry 2015. 396: 633-643.
  36. Seitz AP, Grassmé H, Edwards MJ, Pewzner-Jung Y, Gulbins E. Ceramide and sphingosine in pulmonary infections. Biological chemistry 2015. 396: 611-620.
  37. Managó A, Becker KA, Carpinteiro A, Wilker B, Soddemann M, Seitz AP et al. Pseudomonas aeruginosa pyocyanin induces neutrophil death via mitochondrial reactive oxygen species and mitochondrial acid sphingomyelinase. Antioxidants & redox signaling 2015. 22: 1097-1110.
  38. Lang E, Bissinger R, Gulbins E, Lang F. Ceramide in the regulation of eryptosis, the suicidal erythrocyte death. Apoptosis : an international journal on programmed cell death 2015. 20: 758-767.
  39. Peng H, Li C, Kadow S, Henry BD, Steinmann J, Becker KA et al. Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis. Journal of molecular medicine (Berlin, Germany) 2015. 93: 675-689.
  40. Müller CP, Reichel M, Muhle C, Rhein C, Gulbins E, Kornhuber J. Brain membrane lipids in major depression and anxiety disorders. Biochimica et biophysica acta 2015. 1851: 1052-1065.
  41. Chen Y, Li X, Boini KM, Pitzer AL, Gulbins E, Zhang Y et al. Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis. Biochimica et biophysica acta 2015. 1853: 396-408.
  42. Leanza L, Venturini E, Kadow S, Carpinteiro A, Gulbins E, Becker KA. Targeting a mitochondrial potassium channel to fight cancer. Cell calcium 2015. 58: 131-138.
  43. Henry BD, Neill DR, Becker KA, Gore S, Bricio-Moreno L, Ziobro R et al. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nature biotechnology 2015. 33: 81-88.
  44. Beckmann N, Sharma D, Gulbins E, Becker KA, Edelmann B. Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons. Frontiers in physiology 2014. 5: 331.
  45. Hilker R, Munder A, Klockgether J, Losada PM, Chouvarine P, Cramer N et al. Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment. Environmental microbiology 2015. 17: 29-46.
  46. Neuber C, Schumacher F, Gulbins E, Kleuser B. Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. Analytical chemistry 2014. 86: 9065-9073.
  47. Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J et al. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO molecular medicine 2014. 6: 1205-1214.
  48. Lang E, Gatidis S, Freise NF, Bock H, Kubitz R, Lauermann C et al. Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology (Baltimore, Md) 2015. 61: 275-284.
  49. Brown MB, Hunt WR, Noe JE, Rush NI, Schweitzer KS, Leece TC et al. Loss of cystic fibrosis transmembrane conductance regulator impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smoke. Pulmonary circulation 2014. 4: 260-268.
  50. Reichel M, Richter-Schmidinger T, Muhle C, Rhein C, Alexopoulos P, Schwab SG et al. The common acid sphingomyelinase polymorphism p.G508R is associated with self-reported allergy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014. 34: 82-91.
  51. Muhle C, Amova V, Biermann T, Bayerlein K, Richter-Schmidinger T, Kraus T et al. Sex-dependent decrease of sphingomyelinase activity during alcohol withdrawal treatment. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014. 34: 71-81.
  52. Siegmann N, Worbs D, Effinger F, Bormann T, Gebhardt M, Ulrich M et al. Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in cystic fibrosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014. 34: 56-70.
  53. Grassmé H, Carpinteiro A, Edwards MJ, Gulbins E, Becker KA. Regulation of the inflammasome by ceramide in cystic fibrosis lungs. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014. 34: 45-55.
  54. Simonis A, Hebling S, Gulbins E, Schneider-Schaulies S, Schubert-Unkmeir A. Differential activation of acid sphingomyelinase and ceramide release determines invasiveness of Neisseria meningitidis into brain endothelial cells. PLoS pathogens 2014. 10: e1004160.
  55. Quillin RC, 3rd, Wilson GC, Nojima H, Freeman CM, Wang J, Schuster RM et al. Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice. Hepatology research : the official journal of the Japan Society of Hepatology 2015. 45: 305-314.
  56. Kornhuber J, Müller CP, Becker KA, Reichel M, Gulbins E. The ceramide system as a novel antidepressant target. Trends in pharmacological sciences 2014. 35: 293-304.
  57. Vidigal PG, Musken M, Becker KA, Haussler S, Wingender J, Steinmann E et al. Effects of green tea compound epigallocatechin-3-gallate against Stenotrophomonas maltophilia infection and biofilm. PloS one 2014. 9: e92876.
  58. Li X, Zhang Y, Xia M, Gulbins E, Boini KM, Li PL. Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. PloS one 2014. 9: e87552.
  59. Leanza L, Zoratti M, Gulbins E, Szabo I. Mitochondrial ion channels as oncological targets. Oncogene 2014. 33: 5569-5581.
  60. Zhang Y, Xu M, Xia M, Li X, Boini KM, Wang M et al. Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovascular research 2014. 102: 68-78.
  61. Münzer P, Borst O, Walker B, Schmid E, Feijge MA, Cosemans JM et al. Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation. Arteriosclerosis, thrombosis, and vascular biology 2014. 34: 61-71.
  62. Yang W, Schmid E, Nurbaeva MK, Szteyn K, Leibrock C, Yan J et al. Role of acid sphingomyelinase in the regulation of mast cell function. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2014. 44: 79-90.
  63. Xu M, Li XX, Xiong J, Xia M, Gulbins E, Zhang Y et al. Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. Biochimica et biophysica acta 2013. 1833: 3228-3236.
  64. Gulbins E, Kolesnick RN. It takes a CAD to kill a tumor cell with a LMP. Cancer cell 2013. 24: 279-281.
  65. Leanza L, Biasutto L, Managó A, Gulbins E, Zoratti M, Szabo I. Intracellular ion channels and cancer. Frontiers in physiology 2013. 4: 227.
  66. Gulbins E, Palmada M, Reichel M, Lüth A, Bohmer C, Amato D et al. Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nature medicine 2013. 19: 934-938.
  67. Gramatzki D, Herrmann C, Happold C, Becker KA, Gulbins E, Weller M et al. Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway. PloS one 2013. 8: e63527.
  68. Muhle C, Huttner HB, Walter S, Reichel M, Canneva F, Lewczuk P et al. Characterization of acid sphingomyelinase activity in human cerebrospinal fluid. PloS one 2013. 8: e62912.
  69. Kornhuber J, Tripal P, Gulbins E, Muehlbacher M. Functional inhibitors of acid sphingomyelinase (FIASMAs). Handbook of experimental pharmacology 2013. 169-186.
  70. Henry B, Ziobro R, Becker KA, Kolesnick R, Gulbins E. Acid sphingomyelinase. Handbook of experimental pharmacology 2013. 77-88.
  71. Nahrlich L, Mainz JG, Adams C, Engel C, Herrmann G, Icheva V et al. Therapy of CF-patients with amitriptyline and placebo--a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-study. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2013. 31: 505-512.
  72. Muhle C, Reichel M, Gulbins E, Kornhuber J. Sphingolipids in psychiatric disorders and pain syndromes. Handbook of experimental pharmacology 2013. 431-456.
  73. Grassmé H, Riethmüller J, Gulbins E. Ceramide in cystic fibrosis. Handbook of experimental pharmacology 2013. 265-274.
  74. Abed M, Towhid ST, Pakladok T, Alesutan I, Götz F, Gulbins E et al. Effect of bacterial peptidoglycan on erythrocyte death and adhesion to endothelial cells. International journal of medical microbiology : IJMM 2013. 303: 182-189.
  75. Ziobro R, Henry B, Edwards MJ, Lentsch AB, Gulbins E. Ceramide mediates lung fibrosis in cystic fibrosis. Biochemical and biophysical research communications 2013. 434: 705-709.
  76. Leanza L, Trentin L, Becker KA, Frezzato F, Zoratti M, Semenzato G et al. Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia. Leukemia 2013. 27: 1782-1785.
  77. Johnson KT, Wiesweg B, Schott M, Ehlers M, Müller M, Minich WB et al. Examination of orbital tissues in murine models of Graves' disease reveals expression of UCP-1 and the TSHR in retrobulbar adipose tissues. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2013. 45: 401-407.
  78. Li X, Gulbins E, Zhang Y. Role of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injury. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012. 30: 905-914.
  79. Abed M, Towhid ST, Mia S, Pakladok T, Alesutan I, Borst O et al. Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cells. American journal of physiology Cell physiology 2012. 303: C991-999.
  80. Li X, Gulbins E, Zhang Y. Oxidative stress triggers Ca-dependent lysosome trafficking and activation of acid sphingomyelinase. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012. 30: 815-826.
  81. Leanza L, Zoratti M, Gulbins E, Szabo I. Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels. Current medicinal chemistry 2012. 19: 5394-5404.
  82. Rhein C, Tripal P, Seebahn A, Konrad A, Kramer M, Nagel C et al. Functional implications of novel human acid sphingomyelinase splice variants. PloS one 2012. 7: e35467.
  83. Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E et al. Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO molecular medicine 2012. 4: 577-593.
  84. Becker KA, Henry B, Ziobro R, Tümmler B, Gulbins E, Grassmé H. Role of CD95 in pulmonary inflammation and infection in cystic fibrosis. Journal of molecular medicine (Berlin, Germany) 2012. 90: 1011-1023.
  85. Szabo I, Leanza L, Gulbins E, Zoratti M. Physiology of potassium channels in the inner membrane of mitochondria. Pflugers Archiv : European journal of physiology 2012. 463: 231-246.
  86. Henry B, Möller C, Dimanche-Boitrel MT, Gulbins E, Becker KA. Targeting the ceramide system in cancer. Cancer letters 2013. 332: 286-294.
  87. Munder A, Wolbeling F, Kerber-Momot T, Wedekind D, Baumann U, Gulbins E et al. Acute intratracheal Pseudomonas aeruginosa infection in cystic fibrosis mice is age-independent. Respiratory research 2011. 12: 148.
  88. Meyer zu Horste M, Stroher E, Berchner-Pfannschmidt U, Schmitz-Spanke S, Pink M, Gothert JR et al. A novel mechanism involved in the pathogenesis of Graves ophthalmopathy (GO): clathrin is a possible targeting molecule for inhibiting local immune response in the orbit. The Journal of clinical endocrinology and metabolism 2011. 96: E1727-1736.
  89. Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M et al. Identification of novel functional inhibitors of acid sphingomyelinase. PloS one 2011. 6: e23852.
  90. Becker KA, Henry B, Ziobro R, Riethmüller J, Gulbins E. Lipids in cystic fibrosis. Expert review of respiratory medicine 2011. 5: 527-535.
  91. Dimanche-Boitrel MT, Rebillard A, Gulbins E. Ceramide in chemotherapy of tumors. Recent patents on anti-cancer drug discovery 2011. 6: 284-293.
  92. Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC et al. Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PloS one 2011. 6: e19783.
  93. Lang F, Ullrich S, Gulbins E. Ceramide formation as a target in beta-cell survival and function. Expert opinion on therapeutic targets 2011. 15: 1061-1071.
  94. Reichel M, Beck J, Mühle C, Rotter A, Bleich S, Gulbins E et al. Activity of secretory sphingomyelinase is increased in plasma of alcohol-dependent patients. Alcoholism, clinical and experimental research 2011. 35: 1852-1859.
  95. Cheng Y, Gulbins E, Siemen D. Activation of the permeability transition pore by Bax via inhibition of the mitochondrial BK channel. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011. 27: 191-200.
  96. Avota E, Gulbins E, Schneider-Schaulies S. DC-SIGN mediated sphingomyelinase-activation and ceramide generation is essential for enhancement of viral uptake in dendritic cells. PLoS pathogens 2011. 7: e1001290.
  97. Zhang Y, Li X, Carpinteiro A, Goettel JA, Soddemann M, Gulbins E. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nature medicine 2011. 17: 341-346.