Molekularbiologie
Molekularbiologie
 
Publications AG Becker-Flegler (last 5 years)

 

 

  1. Becker KA, Beckmann N, Adams C, Hessler G, Kramer M, Gulbins E et al. Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets. Clinical & experimental metastasis 2016.
  2. Hollmann C, Werner S, Avota E, Reuter D, Japtok L, Kleuser B et al. Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells. Journal of immunology 2016.
  3. Tavakoli Tabazavareh S, Seitz A, Jernigan P, Sehl C, Keitsch S, Lang S et al. Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 38: 2094-2102.
  4. Carpinteiro A, Beckmann N, Seitz A, Hessler G, Wilker B, Soddemann M et al. Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016. 38: 1-14.
  5. Gulbins E, Walter S, Becker KA, Halmer R, Liu Y, Reichel M et al. A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression. Journal of neurochemistry 2015. 134: 183-192.
  6. Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Pozgajova M, Schmid KW, Adams C, Muller S, Kleuser B, Edwards MJ, Grassme H, Helfrich I, Gulbins E. Regulation of hematogenous tumor metastasis by acid sphingomyelinase. EMBO Mol Med 2015.
  7. Manago A, Becker KA, Carpinteiro A, Wilker B, Soddemann M, Seitz AP, Edwards MJ, Grassme H, Szabo I, Gulbins E. Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase. Antioxid Redox Signal 2015 22: 1097-1110.
  8. Hajj C, Becker A, Haimovitz-Friedman A. Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathways. Biological chemistry 2015.
  9. Peng H, Li C, Kadow S, Henry BD, Steinmann J, Becker KA, Riehle A, Beckmann N, Wilker B, Li PL, Pritts T, Edwards MJ, Zhang Y, Gulbins E, Grassme H. Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis. J Mol Med (Berl) 2015.
  10. Henry BD, Neill DR, Becker KA, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Muhlemann K, Steinmann J, Kleuser B, Japtok L, Luginbuhl M, Wolfmeier H, Scherag A, Gulbins E, Kadioglu A, Draeger A, Babiychuk EB. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nat Biotechnol 2015 33: 81-88.
  11. Vidigal PG, Musken M, Becker KA, Haussler S, Wingender J, Steinmann E, Kehrmann J, Gulbins E, Buer J, Rath PM, Steinmann J. Effects of green tea compound epigallocatechin-3-gallate against Stenotrophomonas maltophilia infection and biofilm. PLoS One 2014 9: e92876.
  12. Siegmann N, Worbs D, Effinger F, Bormann T, Gebhardt M, Ulrich M, Wermeling F, Muller-Hermelink E, Biedermann T, Tighe M, Edwards MJ, Caldwell C, Leadbetter E, Karlsson MC, Becker KA, Gulbins E, Doring G. Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in cystic fibrosis. Cell Physiol Biochem 2014 34: 56-70.
  13. Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassme H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO Mol Med 2014 6: 1205-1214.
  14. Leanza L, Venturini E, Kadow S, Carpinteiro A, Gulbins E, Becker KA. Targeting a mitochondrial potassium channel to fight cancer. Cell Calcium 2014.
  15. Kornhuber J, Muller CP, Becker KA, Reichel M, Gulbins E. The ceramide system as a novel antidepressant target. Trends Pharmacol Sci 2014 35: 293-304.
  16. Grassme H, Carpinteiro A, Edwards MJ, Gulbins E, Becker KA. Regulation of the inflammasome by ceramide in cystic fibrosis lungs. Cell Physiol Biochem 2014 34: 45-55.
  17. Beckmann N, Sharma D, Gulbins E, Becker KA, Edelmann B. Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons. Front Physiol 2014 5: 331.
  18. Leanza L, Trentin L, Becker KA, Frezzato F, Zoratti M, Semenzato G, Gulbins E, Szabo I. Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia. Leukemia 2013 27: 1782-1785.
  19. Henry B, Ziobro R, Becker KA, Kolesnick R, Gulbins E. Acid sphingomyelinase. Handb Exp Pharmacol 2013: 77-88.
  20. Henry B, Moller C, Dimanche-Boitrel MT, Gulbins E, Becker KA. Targeting the ceramide system in cancer. Cancer Lett 2013 332: 286-294.
  21. Gulbins E, Palmada M, Reichel M, Luth A, Bohmer C, Amato D, Muller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal P, Staedtler S, Ackermann TF, van Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassme H, Kornhuber J. Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nat Med 2013 19: 934-938.
  22. Grassme H, Becker KA. Bacterial infections and ceramide. Handb Exp Pharmacol 2013: 305-320.
  23. Gramatzki D, Herrmann C, Happold C, Becker KA, Gulbins E, Weller M, Tabatabai G. Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway. PLoS One 2013 8: e63527.
  24. Becker KA, Henry B, Ziobro R, Tummler B, Gulbins E, Grassme H. Role of CD95 in pulmonary inflammation and infection in cystic fibrosis. J Mol Med (Berl) 2012 90: 1011-1023.
  25. Becker KA, Henry B, Ziobro R, Riethmuller J, Gulbins E. Lipids in cystic fibrosis. Expert Rev Respir Med 2011 5: 527-535.