AG Grassme: Publikationen/Publications

Publikationen/Publications

Selected publications

2020-2026

  1. Paasch D, Schevel H, Riehle A, Costa B, Toufaili H, Gehnen T, Dahlmann J, Pavlou A, Neehus AL, Nguyen AHH, Schiering E, Buchegger T, Bustamante J, Hansen G, Kalinke U, Gulbins E, Grassmé H*, Lachmann N*. Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models. Clin Transl Immunology. 2026 Jan 13;15(1): e70071. doi: 10.1002/cti2.70071. PMID: 41541231; PMCID: PMC12800570 (*shared senior authorship). https://doi.org/10.1002/cti2.70071
  2. Wu Y, Schnitker F, Liu Y, Keitsch S, Caicci F, Schumacher F, Riehle A, Pollmeier B, Kehrmann J, Kleuser B, Kamler M, Szabo I, Grassmé H, Gulbins E. Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections. J Mol Med (Berl). 2025 May;103(5):547-558. doi: 10.1007/s00109-025-02534-z. Epub 2025 Mar 28. PMID: 40153002; PMCID: PMC12078450. https://doi.org/10.1007/s00109-025-02534-z
  3. Grassmé H, Wilson GC, Wu Y, Hasenberg M, Keitsch S, Caicci F, Edwards MJ, Szabo I, Gulbins E. Sphingosine-mediated death of Pseudomonas aeruginosa involves degradation of cardiolipin by the maintenance of outer lipid asymmetry system. Infect Immun. 2025 Apr 8;93(4): e0059124. doi: 10.1128/iai.00591-24. Epub 2025 Mar 10. PMID: 40062881; PMCID: PMC11977310. https://doi.org/10.1128/iai.00591-24
  4. May H, Liu Y, Kadow S, Edwards MJ, Keitsch S, Wilker B, Kamler M, Grassmé H, Wu Y, Gulbins E. Sphingosine kills intracellular Pseudomonas aeruginosa and Staphylococcus aureus. Pathog Dis. 2024 Feb 7;82: ftae016. doi: 10.1093/femspd/ftae016. PMID: 39030066; PMCID: PMC11285155. https://doi.org/10.1093/femspd/ftae016
  5. Wu Y, Riehle A, Pollmeier B, Kadow S, Schumacher F, Drab M, Kleuser B, Gulbins E, Grassmé H. Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and mice. Tuberculosis (Edinb). 2024 Jul; 147:102493. doi: 10.1016/j.tube.2024.102493. Epub 2024 Feb 12. PMID: 38547568. https://doi.org/10.1016/j.tube.2024.102493
  6. Schnitker F, Liu Y, Keitsch S, Soddemann M, Verhasselt HL, Kehrmann J, Grassmé H, Kamler M, Gulbins E, Wu Y. Reduced Sphingosine in Cystic Fibrosis Increases Susceptibility to Mycobacterium abscessus Infections. Int J Mol Sci. 2023 Sep 12;24(18):14004. doi: 10.3390/ijms241814004. PMID: 37762308; PMCID: PMC10530875. https://doi.org/10.3390/ijms241814004
  7. Wu, Y.; Liu, Y.; Gulbins, E.; Grassmé, H. The Anti-Infectious Role of Sphingosine in Microbial Diseases. Cells 2021, 10, 1105. https://doi.org/10.3390/cells10051105
  8. Wu Y, Li C, Peng H, Swaidan A, Riehle A, Pollmeier B, Zhang Y, Gulbins E, Grassmé H. Acid sphingomyelinase contributes to the control of mycobacterial infection via a signaling cascade leading from reactive oxygen species to cathepsin D. Cells 2020;9(11):2406. https://doi.org/10.3390/cells9112406

2015-2019

  1. Li C, Wang A, Wu Y, Gulbins E, Grassmé H, Zhao Z. Acid Sphingomyelinase-Ceramide System in Bacterial Infections. Cell Physiol Biochem. 2019;52(2):280-301. doi: 10.33594/000000021. Epub 2019 Feb 28. Review. PubMed PMID: 30816675. https://doi.org/10.33594/000000021
  2. Wu Y, Li C, Riehle A, Pollmeier B, Gulbins E, Grassmé H. Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin. Cell Physiol Biochem. 2018;51(4):1815-1829. doi: 10.1159/000495683. Epub 2018 Nov 30. PubMed PMID: 30504725. https://doi.org/10.1159/000495683
  3. Wu Y, Gulbins E, Grassmé H. The function of sphingomyelinases in mycobacterial infections. Biol Chem. 2018 Sep 25;399(10):1125-1133. doi: 10.1515/hsz-2018-0179. Review. PubMed PMID: 29924725. https://doi.org/10.1515/hsz-2018-0179
  4. Becker KA, Riethmüller J, Seitz AP, Gardner A, Boudreau R, Kamler M, Kleuser B, Schuchman E, Caldwell CC, Edwards MJ, Grassmé H, Brodlie M, Gulbins E. Sphingolipids as targets for inhalation treatment of cystic fibrosis. Adv Drug Deliv Rev. 2018 Aug;133: 66-75. doi: 10.1016/j.addr.2018.04.015. Epub 2018 Apr 24. Review. PubMed PMID: 29698625. https://doi.org/10.1016/j.addr.2018.04.015
  5. Becker KA, Fahsel B, Kemper H, Mayeres J, Li C, Wilker B, Keitsch S, Soddemann M, Sehl C, Kohnen M, Edwards MJ, Grassmé H, Caldwell CC, Seitz A, Fraunholz M, Gulbins E. Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide. Infect Immun. 2017 Dec 19;86(1). pii: e00606-17. doi: 10.1128/IAI.00606-17. Print 2018 Jan. PubMed PMID: 29084896; PubMed Central PMCID: PMC5736828. https://doi.org/10.1128/iai.00606-17
  6. Li C, Wu Y, Riehle A, Orian-Rousseau V, Zhang Y, Gulbins E, Grassmé H. Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase. Antioxid Redox Signal. 2017 Aug 29. doi: 10.1089/ars.2017.6994. [Epub ahead of print] PubMed PMID: 28747072. https://doi.org/10.1089/ars.2017.6994
  7. Grassmé H, Henry B, Ziobro R, Becker KA, Riethmüller J, Gardner A, Seitz AP, Steinmann J, Lang S, Ward C, Schuchman EH, Caldwell CC, Kamler M, Edwards MJ, Brodlie M, Gulbins E. β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections. Cell Host Microbe. 2017 Jun 14;21(6):707-718.e8. doi: 10.1016/j.chom.2017.05.001. Epub 2017 May 25. PubMed PMID: 28552668; PubMed Central PMCID: PMC5475347. https://doi.org/10.1016/j.chom.2017.05.001
  8. Li C, Wu Y, Riehle A, Ma J, Kamler M, Gulbins E, Grassmé H. Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic Pneumonia. Infect Immun. 2017 Apr 21;85(5). pii: e00883-16. doi: 10.1128/IAI.00883-16. Print 2017 May. PubMed PMID: 28289144; PubMed Central PMCID: PMC5400852. https://doi.org/10.1128/iai.00883-16
  9. Wu Y, Gulbins E, Grassmé H. Crosstalk Between Sphingomyelinases and Reactive Oxygen Species in Mycobacterial Infection. Antioxid Redox Signal. 2017 Apr 6. doi: 10.1089/ars.2017.7050. [Epub ahead of print] PubMed PMID: 28276697. https://doi.org/10.1089/ars.2017.7050
  10. Tavakoli Tabazavareh S, Seitz A, Jernigan P, Sehl C, Keitsch S, Lang S, Kahl BC, Edwards M, Grassmé H, Gulbins E, Becker KA. Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis. Cell Physiol Biochem. 2016;38(6):2094-102. doi: 10.1159/000445567. Epub 2016 May 17. PubMed PMID: 27184795. https://doi.org/10.1159/000445567
  11. Li C, Peng H, Japtok L, Seitz A, Riehle A, Wilker B, Soddemann M, Kleuser B, Edwards M, Lammas D, Zhang Y, Gulbins E, Grassme H. Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis. Front Biosci (Elite Ed). 2016 Jan 1;8: 311-25. PubMed PMID: 26709664. https://doi.org/10.2741/e769
  12. Seitz AP, Grassmé H, Edwards MJ, Pewzner-Jung Y, Gulbins E. Ceramide and sphingosine in pulmonary infections. Biol Chem. 2015 Jun;396(6-7):611-20. doi: 10.1515/hsz-2014-0285. PubMed PMID: 25720061. https://doi.org/10.1515/hsz-2014-0285
  13. Peng H, Li C, Kadow S, Henry BD, Steinmann J, Becker KA, Riehle A, Beckmann N, Wilker B, Li PL, Pritts T, Edwards MJ, Zhang Y, Gulbins E, Grassmé H. Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis. J Mol Med (Berl). 2015 Jun;93(6):675-89. doi: 10.1007/s00109-014-1246-y. Epub 2015 Jan 25. PubMed PMID: 25616357; PubMed Central PMCID: PMC4432103. https://doi.org/10.1007/s00109-014-1246-y

Earlier

  1. *Grassmé H, *Gulbins E, Brenner B, Ferlinz K, Sandhoff K, Harzer K, Lang F, Meyer TF. Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells. Cell 1997; 91:605-15. (*shared first authorship). https://doi.org/10.1016/s0092-8674(00)80448-1
  2. Grassmé H, Kirschnek S, Riethmueller J, Riehle A, von Kürthy G, Lang F, Weller M, Gulbins E. CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science 2000; 290:527-30. https://doi.org/10.1126/science.290.5491.527
  3. Grassmé H, Jendrossek V, Riehle A, von Kürthy G, Berger J, Schwarz H, Weller M, Kolesnick R, Gulbins E. Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat Med 2003; 9:322-30. 
    https://doi.org/10.1038/nm823
  4. Teichgräber V, Ulrich M, Endlich N, Riethmüller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kürthy G, Schmid KW, Weller M, Tümmler B, Lang F, Grassmé H, Döring G, Gulbins E. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med 2008;14: 382-91.  https://doi.org/10.1038/nm1748
  5. Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO Mol Med 2014; 6:1205-14. https://doi.org/10.15252/emmm.201404075

Members

Members

Heike Grassmé (Dr. rer. nat.)
Tel.: +49(0)201-723-2133
Heike.Gulbins@uk-essen.de

Andrea Riehle (Dipl.-Ing. Chem.'in)
Tel.: +49(0)201-723-2133
Andrea.Riehle@uk-essen.de

Yun Long (M.Sc.)
Tel.: +49(0)201-723-3186
Yun.Long@uk-essen.de
 

Former members

Dr. Yuqing Wu
Dr. Cao Li,
Dr. Huiming Peng
Fabian Schnitker
Barbara Pollmeier