Z02

© UDE/Bettina Engel-Albustin

Project Area Z - Central Services

Dr. Nina Schulze

Imaging Center Campus Essen (ICCE)

University of Duisburg-Essen

Phone: +49 201 183 2622
Email

Detection and modulation of cell state transitions using advanced light microscopy

To investigate and fully understand the molecular triggers and cell signaling events underlying dynamic cell state transitions, many projects within the CRC1430 will utilize imaging-based acute perturbation and detection as key methodological strategies. Project Z02 will serve as a central platform for imaging-based detection via advanced light microscopy, supporting all members of the CRC in developing and optimizing customized protocols for their specific applications and with image analysis. Utilizing a variety of different imaging techniques in combination with a diverse set of sample materials ranging from cell populations to individual molecules will allow us to study dynamic switches over different scales in time and space.
Z02 is organized by the Imaging Center Campus Essen (ICCE) at the Center of Medical Biotechnology (ZMB), which, in addition to its high-level expertise in these topics, provides access to a variety of state-of-the-art microscope systems.

Project Members

Dr. Johannes Koch

johannes.koch@uni-due.de

Dr. Kristina Mrug

kristina.mrug@uni-due.de

Publications

    Journal articles

  • Reinders, Maike; Kravic, Bojana; Gahlot, Pinki; Koska, Sandra; van den Boom, Johannes; Schulze, Nina; Levantovsky, Sophie; Kleine, Stefan; Kaiser, Markus; Kulathu, Yogesh; Behrends, Christian; Meyer, Hemmo
    ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains
    In: The EMBO Journal, Vol. 44, 2025, Nr. 18, pp. 5086 – 5111
    DOI (Open Access)
  • Wagner, Jessica; Feller, Konstantina; Schrenke, Nicole; Schulze, Nina; Paschen, Annette; Dehmelt, Leif; Nalbant, Perihan
    Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion
    In: Molecular Biology of the Cell, Vol. 36, 2025, Nr. 11
    DOI (Open Access)
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell, 2024, pp. 1556 – 1569.e10
    DOI, Online Full Text (Open Access)
  • Nanda, Suchet; Calderon, Abram; Sachan, Arya; Duong, Thanh-Thuy; Koch, Johannes; Xin, Xiaoyi; Solouk-Stahlberg, Djamschid; Wu, Yao-Wen; Nalbant, Perihan; Dehmelt, Leif
    Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cycles
    In: Nature Communications, Vol. 14, 2023, Nr. 1, 8356
    DOI (Open Access)
  • Thier, Beatrice; Zhao, Fang; Stupia, Simone; Brüggemann, Alicia; Koch, Johannes; Schulze, Nina; Horn, Susanne; Coch, Christoph; Hartmann, Gunther; Sucker, Antje; Schadendorf, Dirk; Paschen, Annette
    Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
    In: Journal for ImmunoTherapy of Cancer, Vol. 10, 2022, Nr. 6, e003863
    DOI (Open Access)

    • Preprints

  • Klink, Nikolas; Urban, Sebastian; Seier, Johanna A.; Adhikari, Bikash; Schwalm, Martin P.; Müller, Juliane; Dorsch, Madeleine; Kaschani, Farnusch; Koch, Johannes; Führer, Siska; Kaiser, Markus; Schulze, Nina; Knapp, Stefan; Wolf, Elmar; Paschen, Annette; Grüner, Barbara M.; Gersch, Malte
    Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion
    2025
    DOI, Online Full Text (Open Access)
  • Blümke, Anika; Hagemeier, Birte; Ripkens, Kamilla; Schulze, Nina; Strzala, Michal; Koci, Michelle; Kaschani, Farnusch; Kaiser, Markus; Erkelenz, Michael; Schlücker, Sebastian; Merdanovic, Melisa; Poepsel, Simon; Hellerschmied-Jelinek, Doris; Burston, Steve; Ehrmann, Michael
    A non-autonomous protein quality control mechanism targeting tau aggregate propagation
    2024
    DOI (Open Access)

    • Posters / Proceedings posters

  • Lama, Soni; Koch, Johannes; Schulze, Nina; Rehwald, Stephanie
    Sharing, storing and analysing cell image data in a Collaborative Research Centre using OMERO
    Data Steward goes Germany 2023, 25.-26.09.2023, Dresden,
    2023
    DOI (Open Access)

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