Dr. Farnusch Kaschani

Analytics Core Facility Essen (ACE)

Center of Medical Biotechnology (ZMB)
University of Duisburg-Essen

Phone: +49 201 183 4924
Email

Mass spectrometry (MS)-based proteomics has evolved into a robust and powerful technology for timely mechanistic molecular biology research and is thus ideally suited to support the investigation of cell state transitions. The Analytics Core Facility Essen (ACE) will provide state-of-the-art high-resolution, label-based or label-free quantitative ‘bottom up’ mass spectrometry-based proteomics as well as the required expertise for sample preparation workflows and data evaluation to all CRC members. This will for example allow to reveal molecular mechanisms regulating cell state transitions by identifying and dissecting protein-protein interactions (using label-free quantification strategies, proximity labelling or crosslinking MS) and characterizing dynamic changes in expression levels or post-translational modification (PTM) patterns in isolates or whole proteomes.