Publikationen/Publications

Relevant publications

1. Patel SH, Bachmann M, Kadow S, et al. Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo. J Mol Med (Berl). 2023;101:295–310. doi:10.1007/s00109-023-02290-y https://pubmed.ncbi.nlm.nih.gov/36790532/
2. Kadow S, Schumacher F, Kramer M, et al. Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma. Cancers (Basel). 2022;14:1955. doi:10.3390/cancers14081955 https://pubmed.ncbi.nlm.nih.gov/35454865/
3. Schumacher F, Carpinteiro A, Edwards MJ, et al. Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma. J Mol Med (Berl). 2022;100:1493–1508. doi:10.1007/s00109-022-02250-y https://pubmed.ncbi.nlm.nih.gov/36045177/
4. Schumacher F, Edwards MJ, Mühle C, et al. Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice. J Biol Chem. 2022;298:102185. doi:10.1016/j.jbc.2022.102185 https://pubmed.ncbi.nlm.nih.gov/35753355/
5. Naser E, Kadow S, Schumacher F, et al. Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro. J Lipid Res. 2020;61:896–910. doi:10.1194/jlr.RA120000682 https://pubmed.ncbi.nlm.nih.gov/32156719/
6. Beckmann N, Becker KA, Kadow S, et al. Acid Sphingomyelinase Deficiency Ameliorates Farber Disease. Int J Mol Sci. 2019;20:6253. doi:10.3390/ijms20246253 https://pubmed.ncbi.nlm.nih.gov/31835809/
7. Beckmann N, Kadow S, Schumacher F, et al. Pathological manifestations of Farber disease in a new mouse model. Biol Chem. 2018;399:1183–1202. doi:10.1515/hsz-2018-0170
8. Leanza L, Romio M, Becker KA, et al. Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo. Cancer Cell. 2017;31:516–531.e10. doi:10.1016/j.ccell.2017.03.003 https://pubmed.ncbi.nlm.nih.gov/29908121/
9. Biljes D, Hammerschmidt-Kamper C, Kadow S, et al. Impaired glucose and lipid metabolism in ageing aryl hydrocarbon receptor deficient mice. EXCLI J. 2015;14:1153–1163. doi:10.17179/excli2015-638 https://pubmed.ncbi.nlm.nih.gov/26664351/
10. Gulbins E, Palmada M, Reichel M, et al. Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nat Med. 2013;19:934–938. doi:10.1038/nm.3214 https://pubmed.ncbi.nlm.nih.gov/23770692/

Note: “Relevant publications” includes selected key publications that provide the scientific basis for the current research areas; it is not intended as a complete publication list of the group.

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