IMB: AG Kadow
Group Kadow Research Interests
Origin, transport and systemic relevance of sphingolipids in depression
Changes in sphingolipid metabolism are associated with depression, but their origin and systemic relevance remain incompletely understood. We are interested in how ceramides and related sphingolipids are transported throughout the organism and how this influences their biological effects.
Sex- and depot-specific sphingolipid metabolism in adipose tissue
We are interested in why sphingolipid metabolism differs between white and brown adipose tissue, between individual fat depots and between males and females. A particular focus is how these differences relate to mitochondrial function, adipose tissue phenotype and systemic metabolism.
Sphingolipid-dependent membrane remodeling in cancer
Changes in sphingolipid metabolism can alter the organization and properties of cellular membranes. We investigate how this remodeling influences fundamental properties and interactions of tumor cells.