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2018

Schotten, L;  Darwiche, K; Taube, C; Aigner, C; ,Welter, S.; Eisenmann, S;Schlegel, A; ,Koenig, T;Hager, T; Freitag, L; ,He, K; Oezkan, F; DNA-Methylierungsmarker PTGER4 und SHOX2 erleichtern die Diagnosestellung von Lungenkrebs bei Patienten mit auffälligem CT-Thorax Befund (DGP 2018)

2019

Stockhammer, P., Ploenes, T., Theegarten, D., Schuler, M., Maier, S., Aigner, C., & Hegedus, B. (2020). Detection of TGF-β in pleural effusions for diagnosis and prognostic stratification of malignant pleural mesothelioma. Lung cancer (Amsterdam, Netherlands), 139, 124–132. https://doi.org/10.1016/j.lungcan.2019.11.013

 

Toffalori C, Zito L, Gambacorta V, et al. Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation. Nat Med. 2019;25(4):603-611. doi:10.1038/s41591-019-0400-z

 

Masuda T, Sankowski R, Staszewski O, et al. Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature. 2019;566(7744):388-392. doi:10.1038/s41586-019-0924-x

 

2020

Beyer, L., Günther, R., Koch, J. C., Klebe, S., Hagenacker, T., Lingor, P., Biesalski, A. S., Hermann, A., Nabers, A., Gold, R., Tönges, L., & Gerwert, K. (2021). TDP-43 as structure-based biomarker in amyotrophic lateral sclerosis. Annals of clinical and translational neurology, 8(1), 271–277. https://doi.org/10.1002/acn3.51256

 

Hegedűs L, Rittler D, Garay T, Stockhammer P, Kovács I, Döme B, Theurer S, Hager T, Herold T, Kalbourtzis S, Bankfalvi A, Schmid KW, Führer D, Aigner C, Hegedűs B. HDAC Inhibition Induces PD-L1 Expression in a Novel Anaplastic Thyroid Cancer Cell Line. Pathol Oncol Res. 2020 Oct;26(4):2523-2535. doi: 10.1007/s12253-020-00834-y. Epub 2020 Jun 26. PMID: 32591993; PMCID: PMC7471186.

 

Metzenmacher M, Váraljai R, Hegedüs B, Cima I, Forster J, Schramm A, Scheffler B, Horn PA, Klein CA, Szarvas T, Reis H, Bielefeld N, Roesch A, Aigner C, Kunzmann V, Wiesweg M, Siveke JT, Schuler M, Lueong SS. Plasma Next Generation Sequencing and Droplet Digital-qPCR-Based Quantification of Circulating Cell-Free RNA for Noninvasive Early Detection of Cancer. Cancers (Basel). 2020 Feb 4;12(2):353. doi: 10.3390/cancers12020353.

 

Stockhammer P, Ho CSL, Hegedus L, et al. HDAC inhibition synergizes with ALK inhibitors to overcome resistance in a novel ALK mutated lung adenocarcinoma model. Lung Cancer. 2020;144:20-29. doi:10.1016/j.lungcan.2020.04.002

 

Hack T, Bertram S, Blair H, et al. Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model. Mol Cancer Res. 2020;18(10):1603-1612. doi:10.1158/1541-7786.MCR-20-0091

 

Herrera-Rios D, Mughal SS, Teuber-Hanselmann S, et al. Macrophages/Microglia Represent the Major Source of Indolamine 2,3-Dioxygenase Expression in Melanoma Metastases of the Brain. Front Immunol. 2020;11:120. Published 2020 Feb 5. doi:10.3389/fimmu.2020.00120

 

Ickler J, Francois S, Widera M, Santiago ML, Dittmer U, Sutter K. HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells. PLoS One. 2020;15(1):e0218905. Published 2020 Jan 14. doi:10.1371/journal.pone.0218905

 

Steens J, Klar L, Hansel C, et al. The vascular nature of lung-resident mesenchymal stem cells. Stem Cells Transl Med. 2021;10(1):128-143. doi:10.1002/sctm.20-0191

 

Zhang Z, Trippler M, Real CI, et al. Hepatitis B Virus Particles Activate Toll-Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes. Hepatology. 2020;72(3):829-844. doi:10.1002/hep.31112

 

2021

Lu IN, Dobersalske C, Rauschenbach L, et al. Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression. Nat Commun. 2021;12(1):3895. Published 2021 Jun 23. doi:10.1038/s41467-021-23995-z

Hegedüs L, Okumus Ö, Livingstone E, et al. Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation. Cancers (Basel). 2021;13(4):829. Published 2021 Feb 16. doi:10.3390/cancers13040829

 

Ho CSL, Tüns AI, Schildhaus HU, et al. HER2 mediates clinical resistance to the KRASG12C inhibitor sotorasib, which is overcome by co-targeting SHP2. Eur J Cancer. 2021;159:16-23. doi:10.1016/j.ejca.2021.10.003

 

Luo X, Zhang R, Lu M, et al. Hippo Pathway Counter-Regulates Innate Immunity in Hepatitis B Virus Infection. Front Immunol. 2021;12:684424. Published 2021 May 25. doi:10.3389/fimmu.2021.684424

 

Metzenmacher M, Hegedüs B, Forster J, et al. Combined multimodal ctDNA analysis and radiological imaging for tumor surveillance in Non-small cell lung cancer. Transl Oncol. 2022;15(1):101279. doi:10.1016/j.tranon.2021.101279

 

Schuhenn J, Meister TL, Todt D, et al. Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2022;119(8):e2111600119. doi:10.1073/pnas.2111600119

 

Stefani D, Hegedues B, Collaud S, et al. Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage. PLoS One. 2021;16(6):e0252304. Published 2021 Jun 2. doi:10.1371/journal.pone.0252304

 

Stockhammer P, Okumus Ö, Hegedus L, et al. HDAC Inhibition Induces Cell Cycle Arrest and Mesenchymal-Epithelial Transition in a Novel Pleural-Effusion Derived Uterine Carcinosarcoma Cell Line. Pathol Oncol Res. 2021;27:636088. Published 2021 Mar 26. doi:10.3389/pore.2021.636088

 

Yang Z, Liang SQ, Saliakoura M, et al. Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS-mutant cancer. EMBO Mol Med. 2021;13(9):e13193. doi:10.15252/emmm.202013193

 

2022

Hegedüs L, Szücs KD, Kudla M, et al. Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells. Front Cell Dev Biol. 2022;10:852812. Published 2022 Mar 22. doi:10.3389/fcell.2022.852812

 

Kadow S, Schumacher F, Kramer M, et al. Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma. Cancers (Basel). 2022;14(8):1955. Published 2022 Apr 13. doi:10.3390/cancers14081955

 

Lipp JJ, Wang L, Yang H, et al. Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients. Oncoimmunology. 2022;11(1):2019466. Published 2022 Feb 9. doi:10.1080/2162402X.2021.2019466

 

Stockhammer, P., Ploenes, T., Theegarten, D., Schuler, M., Maier, S., Aigner, C., & Hegedus, B. (2020). Detection of TGF-β in pleural effusions for diagnosis and prognostic stratification of malignant pleural mesothelioma. Lung cancer (Amsterdam, Netherlands), 139, 124–132. https://doi.org/10.1016/j.lungcan.2019.11.013

 

Metzenmacher M, Hegedüs B, Forster J, et al. The clinical utility of cfRNA for disease detection and surveillance: A proof of concept study in non-small cell lung cancer. Thorac Cancer. 2022;13(15):2180-2191. doi:10.1111/1759-7714.14540

 

Yang Z, Liang SQ, Zhao L, et al. Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer. J Exp Clin Cancer Res. 2022;41(1):25. Published 2022 Jan 17. doi:10.1186/s13046-022-02240-5

 

Falkenhorst J, Grunewald S, Krzeciesa D, et al. Plasma Sequencing for Patients with GIST-Limitations and Opportunities in an Academic Setting. Cancers (Basel). 2022;14(22):5496. Published 2022 Nov 9. doi:10.3390/cancers14225496

 

Vogtmann R, Burk LV, Serdar M, Kimmig R, Bendix I, Gellhaus A. Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth-Restricted Foetuses upon Experimental Preeclampsia. Oxid Med Cell Longev. 2022;2022:3024032. Published 2022 Jun 2. doi:10.1155/2022/3024032

 

Thielmann CM, Matull J, Roth S, et al. Genetic and Clinical Characteristics of ARID1A Mutated Melanoma Reveal High Tumor Mutational Load without Implications on Patient Survival. Cancers (Basel). 2022;14(9):2090. Published 2022 Apr 22. doi:10.3390/cancers14092090

 

Luengen AE, Cheremkhina M, Gonzalez-Rubio J, et al. Bone Marrow Derived Mesenchymal Stromal Cells Promote Vascularization and Ciliation in Airway Mucosa Tri-Culture Models in Vitro. Front Bioeng Biotechnol. 2022;10:872275. Published 2022 Jun 17. doi:10.3389/fbioe.2022.872275

 

Karakoese Z, Schwerdtfeger M, Karsten CB, Esser S, Dittmer U, Sutter K. Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals. Front Immunol. 2022;13:936918. Published 2022 Jul 13. doi:10.3389/fimmu.2022.936918

 

2023

Gonzalez-Rubio J, Le-Trilling VTK, Baumann L, et al. SARS-CoV-2 particles promote airway epithelial differentiation and ciliation. Front Bioeng Biotechnol. 2023;11:1268782. Published 2023 Nov 2. doi:10.3389/fbioe.2023.1268782

Elsner C, Appeltrath GA, Konik M, et al. False-Positive Screening and Confirmatory HIV Diagnostic Test in a Patient with Cured SARS-CoV-2 Infection Is Not Mediated by Env/Spike Cross-Reactive Antibodies. Viruses. 2023;15(5):1161. Published 2023 May 13. doi:10.3390/v15051161

Kinast V, Andreica I, Ahrenstorf G, et al. Janus kinase-inhibition modulates hepatitis E virus infection. Antiviral Res. 2023;217:105690. doi:10.1016/j.antiviral.2023.105690

Langer MM, Bauschen A, Guckenbiehl S, et al. Evolution of non-thyroidal illness syndrome in acute decompensation of liver cirrhosis and acute-on-chronic liver failure. Front Endocrinol (Lausanne). 2023;14:1104388. Published 2023 Jan 23. doi:10.3389/fendo.2023.1104388

Stockhammer P, Baumeister H, Ploenes T, et al. Krebs von den Lungen 6 (KL-6) is a novel diagnostic and prognostic biomarker in pleural mesothelioma. Lung Cancer. 2023;185:107360. doi:10.1016/j.lungcan.2023.107360

Váraljai R, Zimmer L, Al-Matary Y, et al. Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma. Nat Cancer. 2023;4(9):1292-1308. doi:10.1038/s43018-023-00610-2

Westhölter D, Pipping J, Raspe J, et al. Plasma levels of chemokines decrease during elexacaftor/tezacaftor/ivacaftor therapy in adults with cystic fibrosis. Heliyon. 2023;10(1):e23428. Published 2023 Dec 12. doi:10.1016/j.heliyon.2023.e23428

Westhölter D, Raspe J, Uebner H, et al. Regulatory T cell enhancement in adults with cystic fibrosis receiving Elexacaftor/Tezacaftor/Ivacaftor therapy. Front Immunol. 2023;14:1107437. Published 2023 Feb 16. doi:10.3389/fimmu.2023.1107437

2024

Baranyi M, Molnár E, Hegedűs L, et al. Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors. Br J Cancer. 2024;130(6):1059-1072. doi:10.1038/s41416-024-02586-x

Barbet K, Schmitz MS, Westhölter D, et al. Bronchoscopic biopsies - a novel source for primary airway epithelial cells in respiratory research. Respir Res. 2024;25(1):439. Published 2024 Dec 24. doi:10.1186/s12931-024-03060-1

Dobersalske C, Rauschenbach L, Hua Y, et al. Cranioencephalic functional lymphoid units in glioblastoma. Nat Med. 2024;30(10):2947-2956. doi:10.1038/s41591-024-03152-x

Vogtmann R, Riedel A, Sassmannshausen I, et al. Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice. Int J Mol Sci. 2024;25(4):2040. Published 2024 Feb 7. doi:10.3390/ijms25042040

Storey CM, Cheng M, Altai M, et al. Key Regulatory Elements of the TGFβ-LRRC15 Axis Predict Disease Progression and Immunotherapy Resistance Across Cancer Types. Preprint. bioRxiv. 2024;2024.11.22.624939. Published 2024 Nov 25. doi:10.1101/2024.11.22.624939

Smiths, Lueong & Metzenmacher, Martin & Zaun, Gregor & Mayer, Gina & Hemmer, Erik & Lückerath, Katharina & Pomykala, Kelsey & Hegedus, Balazs & Trajkovic-Arsic, Marija & Szarvas, Tibor & Váraljai, Renáta & Keup, Corinna & Tinhofer-Keilholtz, Ingeborg & George, Stephen & Kasimir-Bauer, Sabine & Peña-Llopis, Samuel & Kürten, Cornelius & Boosfeld, Lukas & Rösch, Alexander. (2023). Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers. 10.21203/rs.3.rs-3576016/v1.

Phan J, Chen B, Zhao Z, et al. Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis. Science. 2024;386(6722):eado6836. doi:10.1126/science.ado6836

Zacher C, Schönfelder K, Rohn H, Siffert W, Möhlendick B. The single nucleotide polymorphism rs4986790 (c.896A>G) in the gene TLR4 as a protective factor in corona virus disease 2019 (COVID-19). Front Immunol. 2024;15:1355193. Published 2024 Feb 16. doi:10.3389/fimmu.2024.1355193

Kolb A, Kulis-Mandic AM, Klein M, et al. Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance. Nat Commun. 2025;16(1):5387. Published 2025 Jun 25. doi:10.1038/s41467-025-60929-5

Matull J, Placke JM, Lodde G, et al. Clinical and genetic characteristics of BAP1-mutated non-uveal and uveal melanoma. Front Immunol. 2024;15:1383125. Published 2024 Jun 5. doi:10.3389/fimmu.2024.1383125

Jürgens M, Claus M, Wingert S, et al. Chronic stimulation desensitizes β2-adrenergic receptor responses in natural killer cells. Eur J Immunol. 2024;54(12):e2451299. doi:10.1002/eji.202451299

Ullrich V, Ertmer S, Baginska A, et al. KDM5B predicts temozolomide-resistant subclones in glioblastoma. iScience. 2023;27(1):108596. Published 2023 Dec 3. doi:10.1016/j.isci.2023.108596

Schuler M, Cuppens K, Plönes T, et al. Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial. Nat Med. 2024;30(6):1602-1611. doi:10.1038/s41591-024-02965-0

 

Schuler M, Hense J, Darwiche K, et al. Early Metabolic Response by PET Predicts Sensitivity to Next-Line Targeted Therapy in EGFR-Mutated Lung Cancer with Unknown Mechanism of Acquired Resistance. J Nucl Med. 2024;65(6):851-855. Published 2024 Jun 3. doi:10.2967/jnumed.123.266979

 

Surguta SE, Baranyi M, Svajda L, et al. Differential effects of hypoxia on motility using various in vitro models of lung adenocarcinoma. Sci Rep. 2024;14(1):20482. Published 2024 Sep 3. doi:10.1038/s41598-024-70769-w

2025

Ghadimi M, Pelzer U, Besselink MG, et al. Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemotherapy alone: a randomized controlled trial. BMC Cancer. 2025;25(1):208. Published 2025 Feb 6. doi:10.1186/s12885-025-13573-7

 

Kerkhoff M, Schaefer C, Dirks WG, et al. New cell lines expanding the diversity of Ewing sarcoma models. Int J Cancer. 2026;158(3):642-655. doi:10.1002/ijc.70172

 

Kolb A, Kulis-Mandic AM, Klein M, et al. Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance. Nat Commun. 2025;16(1):5387. Published 2025 Jun 25. doi:10.1038/s41467-025-60929-5

 

Langer MM, Guckenbiehl S, Bauschen A, et al. Extracellular vesicles of patients with acute-on-chronic liver failure induce mitochondrial dysfunction in T cells. Front Immunol. 2025;16:1656692. Published 2025 Sep 22. doi:10.3389/fimmu.2025.1656692

 

Metzenmacher M, Zaun G, Trajkovic-Arsic M, et al. Minimally invasive determination of pancreatic ductal adenocarcinoma (PDAC) subtype by means of circulating cell-free RNA. Mol Oncol. 2025;19(2):357-376. doi:10.1002/1878-0261.13747

 

Neuhoff S, Schmitt LI, Liebig KC, et al. Neuronal Pentraxin 2 as a Potential Biomarker for Nusinersen Therapy Response in Adults with Spinal Muscular Atrophy: A Pilot Study. Biomedicines. 2025;13(8):1821. Published 2025 Jul 25. doi:10.3390/biomedicines13081821

 

Oster C, Matyar A, Schmidt T, et al. Decoding glioblastoma survival: unraveling the prognostic potential of olfactory function in a prospective observational study. Neurol Res Pract. 2025;7(1):51. Published 2025 Jul 24. doi:10.1186/s42466-025-00410-2

 

Rauschenbach L, Gerach FM, Berliner C, et al. [68Ga]‑DOTA‑conjugated somatostatin receptor‑targeting peptide PET for the differentiation between meningioma and glioblastoma: A case report and review of the literature. Oncol Lett. 2025;29(4):199. Published 2025 Feb 24. doi:10.3892/ol.2025.14945

 

Schwab H, Kerkhoff M, Plaumann P, et al. Characterization of a novel sarcoma cell line with an EWSR1::POU2AF3 fusion. Pathol Oncol Res. 2025;31:1611986. Published 2025 Mar 11. doi:10.3389/pore.2025.1611986

 

Thielmann CM, Seier JA, Schielke L, et al. Extracorporeal photopheresis as a therapeutic approach for treatment resistant immune-related adverse events in anti-PD-1-treated melanoma patients. Front Immunol. 2025;16:1727312. Published 2025 Dec 16. doi:10.3389/fimmu.2025.1727312

 

Vega-Rubin-de-Celis S, Kristani A, Kudla M, et al. Autophagy suppression via SRC induction represents a therapeutic vulnerability for BAP1-mutant cancers. Autophagy. 2025;21(12):3324-3343. doi:10.1080/15548627.2025.2535265

 

Zhao B, Fang R, Schürmann H, et al. PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma. Cell Rep. 2025;44(4):115541. doi:10.1016/j.celrep.2025.115541

2026

 

Sasula MJ, Held ATJ, Schefczyk S, et al. High copper levels induce oxidative stress and inflammatory processes in a cell culture model of Wilson's disease. Mol Cell Biochem. Published online January 22, 2026. doi:10.1007/s11010-026-05481-6