Publikationen / publications


Doege A, Steens R, Dünker N, Busch MA. (2022) Retinoblastoma Cell Growth In Vitro and Tumor Formation In Ovo-Influence of Different Culture Conditions. Methods Protoc. 5(2):21. .

Busch, MA, Haase, A, Miroschnikov, N, Doege, A, Biewald, E, Bechrakis, N.E., Beier, M, Kanber, D, Lohmann, D, Metz, K, Dünker, N (2022) TFF1 in aqueous humor – a potential new biomarker for retinoblastoma. Cancers Volume 14 (3), 677

Guder WK, Hartmann W, Buhles C, Burdack M, Busch M, Dünker N, Hardes J, Dirksen U, Bauer S, Streitbürger A. (2022) 5-ALA-mediated fluorescence of musculoskeletal tumors in a chick chorio-allantoic membrane model: preclinical in vivo qualification analysis as a fluorescence-guided surgery agent in Orthopedic Oncology. J Orthop Surg Res.17(1):34.

Dräger O, Metz K, Busch M, Dünker N. (2022) Role of L1CAM in retinoblastoma tumorigenesis: identification of novel therapeutic targets. Mol Oncol. 16(4):957-981

Busch M, Miroschnikov N, Dankert JT, Wiesehöfer M, Metz K, Stephan H, Dünker N. (2021) Impact of RARα and miR-138 on retinoblastoma etoposide resistance. Tumour Biol. 2021;43(1):11-26.

Apaolaza PS, Busch M, Asin-Prieto E, Peynshaert K, Rathod R, Remaut K, Dünker N, Göpferich A. (2020) Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: Evaluation of the surface properties and effect on their distribution. Exp Eye Res. 2020 Jul 25;198:10815

Dünker N, Jendrossek V. (2019) Implementation of the Chick Chorioallantoic Membrane (CAM) Model in Radiation Biology and Experimental Radiation Oncology Research. Cancers 11(10). pii: E1499. doi: 10.3390/cancers11101499

Busch M, Klein S, Große-Kreul J, Scheiner O, Metz K, Stephan H, Dünker N (2019) p53, miR-34a and EMP1 - newly identified targets of TFF3 signaling in Y79 retinoblastoma cells. Int. J. Mol. Sci. 2019, 20(17), 4129

Busch M, Papior D, Stephan H, Dünker N (2018) Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines. Oncol Rep. 39(1):160-172.


Busch M, Große-Kreul J, Wirtz JJ, Beier M, Stephan H, Royer-Pokora B, Metz K, Dünker N (2017) Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulation. Int J Cancer. 2017 Aug 1;141(3):549-560.

Große-Kreul J, Busch M, Winter C, Pikos S, Stephan H, Dünker N (2016) Forced Trefoil Factor Family Peptide 3 (TFF3) Expression Reduces Growth, Viability, and Tumorigenicity of Human Retinoblastoma Cell Lines. PLoS One. 2016 Sep 14;11(9):e0163025.

Busch, M, Dünker, N (2015) Trefoil factor family peptides - friends or foes? Biomol Concepts 2015 Dec 6(5-6):343-59.

Müller P, Doliva R, Busch M, Philippeit C, Stephan H, Dünker N (2015) Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines. Plos One Jul 14;10(7):e0131467.

Busch M, Philippeit C, Weise A, Dünker N (2014) Re-characterization of established human retinoblastoma cell lines. Histochem Cell Biol 143(3): 325-338.

Philippeit C, Busch M, Dünker N (2014) Epigenetic Control of Trefoil Factor Family (TFF) Peptide Expression in Human Retinoblastoma Cell Lines. Cell Physiol Biochem 34(3):1001-14.

Weise, A, Dünker N (2013) High trefoil factor 1 (TFF1) expression in human retinoblastoma cells correlates with low growth kinetics, increased cyclin-dependent kinase (CDK) inhibitor levels and a selective down-regulation of CDK6. Histochem Cell Biol 139(2):323-38

Paunel-Görgülü A, Franke A, Paulsen F, Dünker N (2011) TFF (trefoil factor family) peptide 2 acts pro-proliferative and pro-apoptotic in the murine retina. Histochem Cell Biol 135, 5: 461- 473

Sebastian Gustmann, Ludger Klein-Hitpass, Harald Stephan, Susanne Weber, Norbert Bornfeld, Marc Kaulisch, Dietmar R. Lohmann, Dünker N (2011) Loss at chromosome arm 16q in retinoblastoma: Confirmation of the association with diffuse vitreous seeding and refinement of the recurrently deleted region. Genes, Chromosomes and Cancer 50(5): 327-337

Maike Haubold, Andreas Weise, Harald Stephan, Dünker N (2010) Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells. Int J Biol Sci 6: 700-715

Scheerer N, Dünker N, Imagawa S, Yamamoto M, Suzuki N, Fandrey J (2010) The anemia of the newborn induces erythropoietin expression in the developing mouse retina. Am J Physiol Regul Integr Comp Physiol. Jul; 299(1):R111-8

Gustmann S, Dünker N (2010). In vivo-like organotypic murine retinal wholemount culture. JoVE.; doi: 10.3791/1634

Dohle DS, Pasa SD, Gustmann S, Laub M, Wissler JH, Jennissen HP, Dünker N (2009) Chick ex ovo culture and ex ovo CAM assay: How it really works. JoVE. 33.

Pyziak E, Dünker N (2009) Correlation of neurotrophin expression and survival promoting capacities with different programmed cell death periods in the developing murine retina. Neuroanatomy Research at the Leading Edge: Neuroanatomy Research Advances. Eds: Flynn CE, Callaghan BR;  NOVA Publishers

Pryce BA, Spencer S Watson SS, Murchison ND, Julia A, Staverosky JA, Dünker N and Schweitzer R (2009) Recruitment and maintenance of tendon progenitors by TGF signaling are essential for tendon formation. Development 136, 1351-1361

Roussa E, Wiehle M, Dünker N, Becker-Katins S, Oehlke O, Krieglstein K. (2006) Transforming growth factor beta is required for differentiation of mouse mesencephalic progenitors into dopaminergic neurons in vitro and in vivo: ectopic induction in dorsal mesencephalon. Stem Cells 24(9):2120-9

Beier M, Franke A, Paunel-Görgülü A N, Scheerer N, Dünker N (2006) Transforming growth factor beta mediates apoptosis during all postnatal programmend cell death periods of the developing murine retina. Neuroscience Research 56, 193-203

Franke AG, Gubbe C, Beier M, Dünker N (2006) Transforming growth factor-beta and bone morphogenetic proteins: Cooperative players in chick and murine prorammend retinal cell death. J Comp Neurol 495(3):263-278

Dünker N (2005)Transforming growth factor beta (TGF-ß) and programmed cell death in the vertebrate retina. Int Rev Cytology: Survey Cell Biol 245, 17-43

Dünker N, Valenciano AI, Franke A, Hernandez-Sanchez C, Dressel R, Behrendt M, de Pablo F, Krieglstein K, de la Rosa EJ (2005) Balance of pro-apoptotic transforming growth factor-beta and anti-apoptotic insulin effects in the control of cell death in the postnatal mouse retina. Eur J Neurosci 22, 28-38

Rahal B, Dünker N, Combs S, Krieglstein K (2004) Isoform-specific role of Transfroming growth factor- ß 2 in the regulation and differentiation of murine adrenal chromaffin cells in vivo. J Neurosci Research 78,493-498

Dünker N, Krieglstein K (2003) Reduced programmed cell death in the retina and defects in lens and cornea of Tgfß2-/-Tgfß3 -/- double deficient mice. Cell Tiss Res 313, 1-10

Dünker N (2003) Transforming growth factor beta mediated programmed cell death in tissue regeneration of the murine intestinal mucosa. Annals Anat. 185, 299-300

Farkas LM, Dünker N, Roussa E, Unsicker K, Krieglstein K (2003) TGF-ßs are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. J Neurosci 23, 5178-5186

Schuster N, Bender H, Rössler OG, Philippi A, Dünker N, Thiel G, Krieglstein K (2003) TGF-ß and TNF-a cooperate to induce apoptosis in the oligodendroglial cell line OLI-neu. J Neurosci Res 73,324-333

Sculean A, Junker R, Donos N, Windisch P, Brecx M, Dünker N (2003) Immunohistochemical evaluation of matrix molecules associated with wound healing following treatment with an enamel matrix protein derivative in humans. Clin Oral Investig 7,167-74.

Dünker N, Schmitt K, Schuster N., Krieglstein K (2002) The role of Transforming growth factor beta 2 and 3 in mediating apoptosis in the murine intestinal mucosa. Gastroenterol 122, 1364-1375.

Dünker N, Schmitt K, Krieglstein K (2002) TGF-ß is required for programmed cell death in interdigital webs of the developing mouse limb. Mech Dev 113, 111-120.

Schuster S, Dünker N, Krieglstein K (2002) Transforming Growth Factor-ß induced cell death in the developing chick retina is mediated via JNK activation and Bcl-XL downregulation. Neurosci Lett 330, 239

Dünker N, Krieglstein K (2002) Tgfß2-/-Tgfß3-/- double knockout mice display severe midline fusion defects and early embryonic lethality. Anat Embryol 206, 73-83

Dünker N, Schmitt K, Schuster N., Krieglstein K. (2002) The role of Transforming growth factor beta 2 and 3 in mediating apoptosis in the murine intestinal mucosa. Gastroenterol 122, 1364-1375.

Dünker N, Aumüller G (2002) Transforming growth factor-beta 2 heterozygous mutant mice exhibit cowper`s gland hyperplasia and cystic dilations of the gland ducts (Cowper`s Syringoceles). J Anat 201, 173-183

Dünker N, Schmitt K, Krieglstein K (2002) TGF-ß is required for programmed cell death in interdigital webs of the developing mouse limb. Mech Dev 113, 111-120.

Sculean A, Junker R, Donos N, Berakdar M, Dünker N (2002) Immunohistochemical evaluation of matrix molecules associated with wound healing following regenerative periodontal treatment in monkeys. Clin Oral Inv 6, 175-182

Dünker N, Schuster N, Krieglstein K (2001) TGF-ß modulates programmed cell death in the retina of the developing chick embryo. Development 128, 1933-1942

Krieglstein K, Richter S, Farkas L, Schuster N, Dünker N, Oppenheim RW, Unsicker K. (2000) Reduction of endogenous transforming growth factors beta prevents ontogenetic neuron death. Nat Neurosci 3, 1085-90.

Dünker N, Krieglstein K (2000) Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis. Eur. J. Biochem. 267, 6982-8.

Dünker N, Wake MH, Olson WM. (2000) Embryonic and larval development in the caecilian Ichthyophis kohtaoensis (amphibia, Gymnophiona): a staging table. J Morphol 243, 3-34.

Dünker N (1999) Serotonergic neurons and processes in the adult and developing retina of Ichthyophis kohtaoensis (amphibia; Gymnophiona). Anat Embryol 199, 35-44.

Dünker N (1999) A double-label analysis demonstrating the partial coexistence of tyrosine hydroxylase and GABA in retinal neurons of Ichthyophis kohtaoensis (amphibia; gymnophiona). Cell Tissue Res 294, 387-90.

Dünker N (1998) Colocalization of serotonin and GABA in retinal neurons of Ichthyophis kohtaoensis (amphibia; Gymnophiona). Anat Embryol 197, 69-75.

Dünker N (1997) Development and organization of the retinal dopaminergic system of Ichthyophis kohtaoensis (amphibia; Gymnophiona). Cell Tissue Res 289, 265-74.




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