Publikationen / publications

Publications

 

Dräger O, Metz K, Busch M, Dünker N. (2021) Role of L1CAM in retinoblastoma tumorigenesis: identification of novel therapeutic targets. Mol Oncol.  doi: 10.1002/1878-0261.13054. Epub ahead of print. PMID: 34228897 https://doi.org/10.1002/1878-0261.13054

Busch M, Miroschnikov N, Dankert JT, Wiesehöfer M, Metz K, Stephan H, Dünker N. (2021) Impact of RARα and miR-138 on retinoblastoma etoposide resistance. Tumour Biol. 2021;43(1):11-26. doi: 10.3233/TUB-200072 .

Apaolaza PS, Busch M, Asin-Prieto E, Peynshaert K, Rathod R, Remaut K, Dünker N, Göpferich A. (2020) Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: Evaluation of the surface properties and effect on their distribution. Exp Eye Res. 2020 Jul 25;198:10815 https://pubmed.ncbi.nlm.nih.gov/32721426/

Dünker N, Jendrossek V. (2019) Implementation of the Chick Chorioallantoic Membrane (CAM) Model in Radiation Biology and Experimental Radiation Oncology Research. Cancers 11(10). pii: E1499. doi: 10.3390/cancers11101499

Busch M, Klein S, Große-Kreul J, Scheiner O, Metz K, Stephan H, Dünker N (2019) p53, miR-34a and EMP1 - newly identified targets of TFF3 signaling in Y79 retinoblastoma cells. Int. J. Mol. Sci. 2019, 20(17), 4129 https://doi.org/10.3390/ijms20174129

Busch M, Papior D, Stephan H, Dünker N (2018) Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines. Oncol Rep. 39(1):160-172. doi: 10.3892/or.2017.6100

Busch M, Metz K, Beier M, Biewald E, Dünker N (2018) TREFOIL FACTOR FAMILY 1 EXPRESSION CORRELATES WITH CLINICAL OUTCOME IN PATIENTS WITH RETINOBLASTOMA. Retina Dec 38(12):2422-2428 doi: 10.1097/IAE.0000000000001881 . https://www.ncbi.nlm.nih.gov/pubmed/29016460

Busch M, Große-Kreul J, Wirtz JJ, Beier M, Stephan H, Royer-Pokora B, Metz K, Dünker N (2017) Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulation. Int J Cancer. 2017 Aug 1;141(3):549-560. doi: 10.1002/ijc.30768 . Epub 2017 May 19 https://www.ncbi.nlm.nih.gov/pubmed/28481041

Große-Kreul J, Busch M, Winter C, Pikos S, Stephan H, Dünker N (2016) Forced Trefoil Factor Family Peptide 3 (TFF3) Expression Reduces Growth, Viability, and Tumorigenicity of Human Retinoblastoma Cell Lines. PLoS One. 2016 Sep 14;11(9):e0163025. doi: 10.1371/journal.pone.0163025 eCollection 2016. https://www.ncbi.nlm.nih.gov/pubmed/27626280

Busch, M, Dünker, N (2015) Trefoil factor family peptides - friends or foes? Biomol Concepts 2015 Dec 6(5-6):343-59. doi: 10.1515/bmc-2015-0020 http://www.ncbi.nlm.nih.gov/pubmed/26479350

Müller P, Doliva R, Busch M, Philippeit C, Stephan H, Dünker N (2015) Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines. Plos One Jul 14;10(7):e0131467. doi: 10.1371/journal.pone.0131467 . http://www.ncbi.nlm.nih.gov/pubmed/26173116

Busch M, Philippeit C, Weise A, Dünker N (2014) Re-characterization of established human retinoblastoma cell lines. Histochem Cell Biol 143(3): 325-338. http://www.ncbi.nlm.nih.gov/pubmed/25326674

Philippeit C, Busch M, Dünker N (2014) Epigenetic Control of Trefoil Factor Family (TFF) Peptide Expression in Human Retinoblastoma Cell Lines. Cell Physiol Biochem 34(3):1001-14.  http://www.ncbi.nlm.nih.gov/pubmed/25199519

Weise, A, Dünker N (2013) High trefoil factor 1 (TFF1) expression in human retinoblastoma cells correlates with low growth kinetics, increased cyclin-dependent kinase (CDK) inhibitor levels and a selective down-regulation of CDK6. Histochem Cell Biol 139(2):323-38 http://www.ncbi.nlm.nih.gov/pubmed/22983508

Paunel-Görgülü A, Franke A, Paulsen F, Dünker N (2011) TFF (trefoil factor family) peptide 2 acts pro-proliferative and pro-apoptotic in the murine retina. Histochem Cell Biol 135, 5: 461- 473 http://www.ncbi.nlm.nih.gov/pubmed/21512811

Sebastian Gustmann, Ludger Klein-Hitpass, Harald Stephan, Susanne Weber, Norbert Bornfeld, Marc Kaulisch, Dietmar R. Lohmann, Dünker N (2011) Loss at chromosome arm 16q in retinoblastoma: Confirmation of the association with diffuse vitreous seeding and refinement of the recurrently deleted region. Genes, Chromosomes and Cancer 50(5): 327-337 http://www.ncbi.nlm.nih.gov/pubmed/21305643

Maike Haubold, Andreas Weise, Harald Stephan, Dünker N (2010) Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells. Int J Biol Sci 6: 700-715 http://www.ncbi.nlm.nih.gov/pubmed/21152263

Scheerer N, Dünker N, Imagawa S, Yamamoto M, Suzuki N, Fandrey J (2010) The anemia of the newborn induces erythropoietin expression in the developing mouse retina. Am J Physiol Regul Integr Comp Physiol. Jul; 299(1):R111-8 http://www.ncbi.nlm.nih.gov/pubmed/20463184

Gustmann S, Dünker N (2010). In vivo-like organotypic murine retinal wholemount culture. JoVE. https://www.jove.com/index/details.stp?id=1634; doi: 10.3791/1634

Dohle DS, Pasa SD, Gustmann S, Laub M, Wissler JH, Jennissen HP, Dünker N (2009) Chick ex ovo culture and ex ovo CAM assay: How it really works. JoVE. 33. http://www.jove.com/index/details.stp?id=1620

Pyziak E, Dünker N (2009) Correlation of neurotrophin expression and survival promoting capacities with different programmed cell death periods in the developing murine retina. Neuroanatomy Research at the Leading Edge: Neuroanatomy Research Advances. Eds: Flynn CE, Callaghan BR;  NOVA Publishers https://www.novapublishers.com/catalog/product_info.php?products_id=10062

Pryce BA, Spencer S Watson SS, Murchison ND, Julia A, Staverosky JA, Dünker N and Schweitzer R (2009) Recruitment and maintenance of tendon progenitors by TGF signaling are essential for tendon formation. Development 136, 1351-1361 http://www.ncbi.nlm.nih.gov/pubmed/19304887

Roussa E, Wiehle M, Dünker N, Becker-Katins S, Oehlke O, Krieglstein K. (2006) Transforming growth factor beta is required for differentiation of mouse mesencephalic progenitors into dopaminergic neurons in vitro and in vivo: ectopic induction in dorsal mesencephalon. Stem Cells 24(9):2120-9 http://www.ncbi.nlm.nih.gov/pubmed/16741229

Beier M, Franke A, Paunel-Görgülü A N, Scheerer N, Dünker N (2006) Transforming growth factor beta mediates apoptosis during all postnatal programmend cell death periods of the developing murine retina. Neuroscience Research 56, 193-203 http://www.ncbi.nlm.nih.gov/pubmed/16945440

Franke AG, Gubbe C, Beier M, Dünker N (2006) Transforming growth factor-beta and bone morphogenetic proteins: Cooperative players in chick and murine prorammend retinal cell death. J Comp Neurol 495(3):263-278  http://www.ncbi.nlm.nih.gov/pubmed/16440295

Dünker N (2005)Transforming growth factor beta (TGF-ß) and programmed cell death in the vertebrate retina. Int Rev Cytology: Survey Cell Biol 245, 17-43 http://www.ncbi.nlm.nih.gov/pubmed/16125544

Dünker N, Valenciano AI, Franke A, Hernandez-Sanchez C, Dressel R, Behrendt M, de Pablo F, Krieglstein K, de la Rosa EJ (2005) Balance of pro-apoptotic transforming growth factor-beta and anti-apoptotic insulin effects in the control of cell death in the postnatal mouse retina. Eur J Neurosci 22, 28-38 http://www.ncbi.nlm.nih.gov/pubmed/16029193

Rahal B, Dünker N, Combs S, Krieglstein K (2004) Isoform-specific role of Transfroming growth factor- ß 2 in the regulation and differentiation of murine adrenal chromaffin cells in vivo. J Neurosci Research 78,493-498

Dünker N, Krieglstein K (2003) Reduced programmed cell death in the retina and defects in lens and cornea of Tgfß2-/-Tgfß3 -/- double deficient mice. Cell Tiss Res 313, 1-10

Dünker N (2003) Transforming growth factor beta mediated programmed cell death in tissue regeneration of the murine intestinal mucosa. Annals Anat. 185, 299-300

Farkas LM, Dünker N, Roussa E, Unsicker K, Krieglstein K (2003) TGF-ßs are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. J Neurosci 23, 5178-5186

Schuster N, Bender H, Rössler OG, Philippi A, Dünker N, Thiel G, Krieglstein K (2003) TGF-ß and TNF-a cooperate to induce apoptosis in the oligodendroglial cell line OLI-neu. J Neurosci Res 73,324-333

Sculean A, Junker R, Donos N, Windisch P, Brecx M, Dünker N (2003) Immunohistochemical evaluation of matrix molecules associated with wound healing following treatment with an enamel matrix protein derivative in humans. Clin Oral Investig 7,167-74.

Dünker N, Schmitt K, Schuster N., Krieglstein K (2002) The role of Transforming growth factor beta 2 and 3 in mediating apoptosis in the murine intestinal mucosa. Gastroenterol 122, 1364-1375.

Dünker N, Schmitt K, Krieglstein K (2002) TGF-ß is required for programmed cell death in interdigital webs of the developing mouse limb. Mech Dev 113, 111-120.

Schuster S, Dünker N, Krieglstein K (2002) Transforming Growth Factor-ß induced cell death in the developing chick retina is mediated via JNK activation and Bcl-XL downregulation. Neurosci Lett 330, 239

Dünker N, Krieglstein K (2002) Tgfß2-/-Tgfß3-/- double knockout mice display severe midline fusion defects and early embryonic lethality. Anat Embryol 206, 73-83

Dünker N, Schmitt K, Schuster N., Krieglstein K. (2002) The role of Transforming growth factor beta 2 and 3 in mediating apoptosis in the murine intestinal mucosa. Gastroenterol 122, 1364-1375.

Dünker N, Aumüller G (2002) Transforming growth factor-beta 2 heterozygous mutant mice exhibit cowper`s gland hyperplasia and cystic dilations of the gland ducts (Cowper`s Syringoceles). J Anat 201, 173-183

Dünker N, Schmitt K, Krieglstein K (2002) TGF-ß is required for programmed cell death in interdigital webs of the developing mouse limb. Mech Dev 113, 111-120.

Sculean A, Junker R, Donos N, Berakdar M, Dünker N (2002) Immunohistochemical evaluation of matrix molecules associated with wound healing following regenerative periodontal treatment in monkeys. Clin Oral Inv 6, 175-182

Dünker N, Schuster N, Krieglstein K (2001) TGF-ß modulates programmed cell death in the retina of the developing chick embryo. Development 128, 1933-1942

Krieglstein K, Richter S, Farkas L, Schuster N, Dünker N, Oppenheim RW, Unsicker K. (2000) Reduction of endogenous transforming growth factors beta prevents ontogenetic neuron death. Nat Neurosci 3, 1085-90.

Dünker N, Krieglstein K (2000) Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis. Eur. J. Biochem. 267, 6982-8.

Dünker N, Wake MH, Olson WM. (2000) Embryonic and larval development in the caecilian Ichthyophis kohtaoensis (amphibia, Gymnophiona): a staging table. J Morphol 243, 3-34.

Dünker N (1999) Serotonergic neurons and processes in the adult and developing retina of Ichthyophis kohtaoensis (amphibia; Gymnophiona). Anat Embryol 199, 35-44.

Dünker N (1999) A double-label analysis demonstrating the partial coexistence of tyrosine hydroxylase and GABA in retinal neurons of Ichthyophis kohtaoensis (amphibia; gymnophiona). Cell Tissue Res 294, 387-90.

Dünker N (1998) Colocalization of serotonin and GABA in retinal neurons of Ichthyophis kohtaoensis (amphibia; Gymnophiona). Anat Embryol 197, 69-75.

Dünker N (1997) Development and organization of the retinal dopaminergic system of Ichthyophis kohtaoensis (amphibia; Gymnophiona). Cell Tissue Res 289, 265-74.

 

 

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