A09

© UKE/Reinhardt

Project Area A - Biology and Molecular Oncology

Prof. Dr. Christian Reinhardt

Clinic for Hematology and Stem Cell Transplantation

University Hospital Essen

Phone: +49 201 723 3136
Email

Targeting oncogene-induced DNA repair pathway switches

Reinhardt has identified a cell state transition in KRAS-driven non-small cell lung cancer cells that features a critical change in DNA damage repair competence accompanied with increased mutational burden and altered cancer drug sensitivities. He will unravel the molecular role of proteins of the ubiquilin family that mediate this transition, identify the gene regulatory elements that trigger ubiquilin overexpression and dissect the mechanism and additional targets of the ubiquilins using proteomics. In addition to these mechanistic studies, he will determine thera-peutic vulnerabilities in vitro and in mouse models.

Project Members

Dr. Svenja Höfmann

svenja.hoefmann@uk-essen.de

Publications

    Journal articles

  • Stahl, David; Gödel, Philipp; Balke-Want, Hyatt; Gholamipoorfard, Rahil; Segbers, Paul; Tetenborg, Luis; Koker, Mirjam; Dörr, Janina; Gregor, Lisa; Bachurski, Daniel; Rose, France; Simon, Adrian G.; Good, Zinaida; Jakob, Josefine; Häupl, Björn; Nill, Marieke; Flümann, Ruth; Riet, Tobias; Lange, Dinah; Blakemore, Stuart J.; Baurmann, Herrad; Voltin, Conrad-Amadeus; Potter, Nicole; Schlözer, Lilli; Freihammer, Max; Wagener-Ryczek, Svenja; Iuga, Andra-Iza; Heger, Jan-Michel; Ludwig, Hanna; Schleifenbaum, Julia K.; Propp, Jessica; Bröckelmann, Paul J.; Jachimowicz, Ron D.; Knittel, Gero; Borchmann, Sven; Merkelbach-Bruse, Sabine; Pallasch, Christian; Peifer, Martin; Rybniker, Jan; Quaas, Alexander; Nitz, Mark; Brägelmann, Johannes; Müller, Werner; Persigehl, Thorsten; Bozek, Katarzyna; Theobald, Sebastian J.; Büttner, Reinhard; Oellerich, Thomas; Hallek, Michael; Kobold, Sebastian; Chmielewski, Markus; Reinhardt, Christian; Mackall, Crystal; Abedpour, Nima; Borchmann, Peter; Ullrich, Roland T.
    CSF1R⁺ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma
    In: Cancer Cell, Vol. 43, 2025, Nr. 8, pp. 1476 – 1494.e10
    DOI (Open Access)
  • Hesterberg, Rebecca S.; Davis, Joshua T.; Handoo, Komal J.; Elmarsafawi, Aya G.; Augello, Anthony C.; Cheng, Chia-Ho; Atkins, Reginald; Lee, Dae Hyun; Yang, Chunying; Yao, Jiqiang; Patel, Krishna R.; Mediavilla-Varela, Melanie; Pinilla-Ibarz, Javier; Soto-Palma, Carolina; Locke, Frederick L.; Song, Xiaofei; Wang, Xuefeng; Berglund, Anders E.; Rodriguez, Paulo C.; Knittel, Gero; Flümann, Ruth; Reinhardt, Hans Christian; Shaw, Timothy I.; Yu, Xiaoqing; Niedernhofer, Laura J.; Cleveland, John L.
    Lymphoma accelerates T cell and tissue aging
    In: Cancer Cell, Vol. 43, 2025, Nr. 10, pp. 1917 – 1936.e8
    DOI (Open Access)
  • Ibruli, Olta; Rose, France; Beleggia, Filippo; Schmitt, Anna; Cartolano, Maria; Fernandez, Lucia Torres; Saggau, Julia; Bonasera, Debora; Kiljan, Martha; Gozum, Gokcen; Lichius, Luca; Cai, Jiali; Niu, Li-Na; Caiaffa, Manoela Iannicelli; Herter, Jan M.; Walczak, Henning; Liccardi, Gianmaria; Grüll, Holger; Büttner, Reinhard; Bosco, Graziella; George, Julie; Thomas, Roman K.; Bozek, Kasia; Reinhardt, Hans Christian; Herter-Sprie, Grit S.
    A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade
    In: Journal of Cancer Research and Clinical Oncology, Vol. 150, 2024, Nr. 11, 496
    DOI (Open Access)
  • Flümann, Ruth; Hansen, Julia; Meinel, Jörn; Pfeiffer, Pauline; Wittkopf, Hannah Goldfarb; Lütz, Anna; Wirtz, Jessica; Möllmann, Michael; Zhou, Tanja; Tabatabai, Areya; Lohmann, Tim; Jauch, Maximilian; Beleggia, Filippo; Pelzer, Benedikt; Ullrich, Fabian; Höfmann, Svenja; Arora, Aastha; Persigehl, Thorsten; Büttner, Reinhard; von Tresckow, Bastian; Klein, Sebastian; Jachimowicz, Ron D.; Reinhardt, Hans Christian; Knittel, Gero
    An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma
    In: Blood Advances, Vol. 8, 2024, Nr. 5, pp. 1063 – 1074
    DOI (Open Access)
  • Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Darkwah Oppong, Marvin; Werner, Rudolf A.; Gull, Hanah; Schröder, Thomas; Linsenmann, Thomas; Buck, Andreas K.; Gunzer, Matthias; Stuschke, Martin; Keyvani, Kathy; Forsting, Michael; Glas, Martin; Kipnis, Jonathan; Steindler, Dennis A.; Reinhardt, Hans Christian; Green, Edward W.; Platten, Michael; Tasdogan, Alpaslan; Herrmann, Ken; Rambow, Florian; Cima, Igor; Sure, Ulrich; Scheffler, Björn
    Cranioencephalic functional lymphoid units in glioblastoma
    In: Nature Medicine, Vol. 30, 2024, Nr. 10, pp. 2947 – 2956
    DOI (Open Access)
  • Heger, Jan-Michel; d'Hargues, Yannick; Kleinert, Fanni; Mattlener, Julia; Weiss, Jonathan; Franzen, Fabian; Becker, Christian; Becker, Kerstin; Gödel, Philipp; Schmiel, Marcel; Meinel, Jörn; Flümann, Ruth; Simon, Florian; Reinhardt, H. Christian; Borchmann, Peter; Borchmann, Sven; Balke-Want, Hyatt; Knittel, Gero; von Tresckow, Bastian
    Noninvasive minimal residual disease assessment in relapsed/refractory large B-cell lymphoma using digital droplet PCR
    In: European Journal of Haematology, Vol. 112, 2024, Nr. 6, pp. 957 – 963
    DOI (Open Access)
  • Flümann, Ruth; Hansen, Julia; Pelzer, Benedikt W.; Nieper, Pascal; Lohmann, Tim; Kisis, Ilmars; Riet, Tobias; Kohlhas, Viktoria; Nguyen, Phuong-Hien; Peifer, Martin; Abedpour, Nima; Bosco, Graziella; Thomas, Roman K.; Kochanek, Moritz; Knüfer, Jacqueline; Jonigkeit, Lorenz; Beleggia, Filippo; Holzem, Alessandra; Büttner, Reinhard; Lohneis, Philipp; Meinel, Jörn; Ortmann, Monika; Persigehl, Thorsten; Hallek, Michael; Calado, Dinis Pedro; Chmielewski, Markus; Klein, Sebastian; Göthert, Joachim R.; Chapuy, Bjoern; Zevnik, Branko; Wunderlich, F. Thomas; von Tresckow, Bastian; Jachimowicz, Ron D.; Melnick, Ari M.; Reinhardt, Hans Christian; Knittel, Gero
    Distinct genetically-determined origins of Myd88/Bcl2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategies
    In: Blood Cancer Discovery, Vol. 4, 2023, Nr. 1, pp. 78 – 97
    DOI (Open Access)
  • Váraljai, Renáta; Zimmer, Lisa; Al-Matary, Yahya; Kaptein, Paulien; Albrecht, Lea J.; Shannan, Batool; Brase, Jan C.; Gusenleitner, Daniel; Amaral, Teresa; Wyss, Nina; Utikal, Jochen; Flatz, Lukas; Rambow, Florian; Reinhardt, Hans Christian; Dick, Jenny; Engel, Daniel R.; Horn, Susanne; Ugurel, Selma; Sondermann, Wiebke; Livingstone, Elisabeth; Sucker, Antje; Paschen, Annette; Zhao, Fang; Placke, Jan-Malte; Klose, Jasmin M.; Fendler, Wolfgang; Thommen, Daniela S.; Helfrich, Iris; Schadendorf, Dirk; Rösch, Alexander
    Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
    In: Nature Cancer, Vol. 4, 2023, Nr. 9, pp. 1292 – 1308
    DOI (Open Access)

    • Prefaces/Postfaces

  • Venturutti, Leandro; Rivas, Martin A.; Pelzer, Benedikt W.; Flümann, Ruth; Hansen, Julia; Karagiannidis, Ioannis; Xia, Min; McNally, Dylan R.; Isshiki, Yusuke; Lytle, Andrew; Teater, Matt; Chin, Christopher R.; Meydan, Cem; Knittel, Gero; Ricker, Edd; Mason, Christopher E.; Ye, Xiaofei; Pan-Hammarström, Qiang; Steidl, Christian; Scott, David W.; Reinhardt, Hans Christian; Pernis, Alessandra B.; Béguelin, Wendy; Melnick, Ari M.
    An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas
    In: Cancer Discovery. Philadelphia: American Association for Cancer Research (AACR), Vol. 13, 2023, Nr. 1, pp. 216 – 243
    DOI, Online Full Text (Open Access)

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