A09

© UKE/Reinhardt

Project Area A - Biology and Molecular Oncology

Prof. Dr. Christian Reinhardt

Clinic for Hematology and Stem Cell Transplantation

University Hospital Essen

Phone: +49 201 723 3136
Email

Targeting oncogene-induced DNA repair pathway switches

Reinhardt has identified a cell state transition in KRAS-driven non-small cell lung cancer cells that features a critical change in DNA damage repair competence accompanied with increased mutational burden and altered cancer drug sensitivities. He will unravel the molecular role of proteins of the ubiquilin family that mediate this transition, identify the gene regulatory elements that trigger ubiquilin overexpression and dissect the mechanism and additional targets of the ubiquilins using proteomics. In addition to these mechanistic studies, he will determine thera-peutic vulnerabilities in vitro and in mouse models.

Project Members

Dr. Sebastian Klein

sebastian.klein@uk-essen.de

Publications

    Journal articles

  • Heger, Jan-Michel; d'Hargues, Yannick; Kleinert, Fanni; Mattlener, Julia; Weiss, Jonathan; Franzen, Fabian; Becker, Christian; Becker, Kerstin; Gödel, Philipp; Schmiel, Marcel; Meinel, Jörn; Flümann, Ruth; Simon, Florian; Reinhardt, Christian; Borchmann, Peter; Borchmann, Sven; Balke-Want, Hyatt; Knittel, Gero; von Tresckow, Bastian
    Noninvasive minimal residual disease assessment in relapsed/refractory large B-cell lymphoma using digital droplet PCR
    In: European Journal of Haematology (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Flümann, Ruth; Hansen, Julia; Pelzer, Benedikt W.; Nieper, Pascal; Lohmann, Tim; Kisis, Ilmars; Riet, Tobias; Kohlhas, Viktoria; Nguyen, Phuong-Hien; Peifer, Martin; Abedpour, Nima; Bosco, Graziella; Thomas, Roman K.; Kochanek, Moritz; Knüfer, Jacqueline; Jonigkeit, Lorenz; Beleggia, Filippo; Holzem, Alessandra; Büttner, Reinhard; Lohneis, Philipp; Meinel, Jörn; Ortmann, Monika; Persigehl, Thorsten; Hallek, Michael; Calado, Dinis Pedro; Chmielewski, Markus; Klein, Sebastian; Göthert, Joachim R.; Chapuy, Bjoern; Zevnik, Branko; Wunderlich, F. Thomas; von Tresckow, Bastian; Jachimowicz, Ron D.; Melnick, Ari M.; Reinhardt, Christian; Knittel, Gero
    Distinct genetically-determined origins of Myd88/Bcl2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategies
    In: Blood Cancer Discovery Vol. 4 (2023) Nr. 1, pp. 78 - 97
    Online Full Text: dx.doi.org/ (Open Access)
  • Váraljai, Renáta; Zimmer, Lisa; Al-Matary, Yahya; Kaptein, Paulien; Albrecht, Lea J.; Shannan, Batool; Brase, Jan C.; Gusenleitner, Daniel; Amaral, Teresa; Wyss, Nina; Utikal, Jochen; Flatz, Lukas; Rambow, Florian; Reinhardt, Hans Christian; Dick, Jenny; Engel, Daniel; Horn, Susanne; Ugurel, Selma; Sondermann, Wiebke; Livingstone, Elisabeth; Sucker, Antje; Paschen, Annette; Zhao, Fang; Placke, Jan-Malte; Klose, Jasmin M.; Fendler, Wolfgang; Thommen, Daniela S.; Helfrich, Iris; Schadendorf, Dirk; Rösch, Alexander
    Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
    In: Nature Cancer Vol. 4 (2023) Nr. 9, pp. 1292 - 1308
    Online Full Text: dx.doi.org/ (Open Access)