Prof. Dr. Markus Kaiser

Chemical Biology

University of Duisburg-Essen

Phone: +49 201 183 4980
Email

This project deals with the development of chemical tools for deciphering molecular mechanisms of cell state transitions. In subproject 1, we will investigate chemical strategies to achieve targeted protein degradation, e.g. by the design and synthesis of chemically novel PROTACs. These studies will include the development of new E3 ubiquitin ligase recruiting units. In subproject 2, we will generate small molecule tools for acute perturbation of the metastatic switch. To this end, we will explore structure-activity relationships as well as the biological scope and selectivity of established inhibitors of metastasis. In the long term, these studies should result in the development of novel anticancer agents with complementary bioactivities to current chemotherapeutics.