ICCE - Publications

Selected Publications


Laksono, S., ElSherbiny, IMA., Huber, SA., Panglisch, S. (2020). Fouling scenarios in hollow fiber membranes during mini-plant filtration and correlation to microalgae-loaded feed characteristics. Chem Eng  J 127723.

Kamps, D., Koch, J., Juma, VO., Campillo-Funollet, E., Graessl, M., Banerjee, S., Mazel, T., Chen, X., Wu, YW., Portet, S., Madzvamuse, A., Nalbant, P., Dehmelt, L. (2020). Optogenetic tuning reveals Rho amplification-dependent dynamics of a cell contraction signal network. Cell Rep 33(9).

Kornakov, N., Mollers, B., and Westermann, S. (2020). The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientation. J Cell Biol 219.

Dubbert, J., Hoing, A., Riek, N., Knauer, S.K., and Voskuhl, J. (2020). Supramolecular subphthalocyanine complexes-cellular uptake and phototoxicity. Chem Commun (Camb) 56, 7653-7656.

Goehring, A., Michin, I., Gerdes, T., Schulze, N., Blueggel, M., Rehic, E., Kaschani, F., Kaiser, M., and Bayer, P. (2020). Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerization. Biol Chem 401, 955-968.

Killinger, K., Bohm, M., Steinbach, P., Hagemann, G., Bluggel, M., Janen, K., Hohoff, S., Bayer, P., Herzog, F., and Westermann, S. (2020). Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast. EMBO J 39, e102938.

Kollenda, S., Kopp, M., Wens, J., Koch, J., Schulze, N., Papadopoulos, C., Pohler, R., Meyer, H., and Epple, M. (2020). A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cells. Acta Biomater 111, 406-417.

Riebe, S., Zimmermann, A., Koch, J., Vallet, C., Knauer, S.K., Sowa, A., Wölper, C., and Voskuhl, J. (2020). Lipofection with estrone-based luminophores featuring aggregation-induced emission properties. RSC Advances 10, 19643-19647.

Vallet, C., Aschmann, D., Beuck, C., Killa, M., Meiners, A., Mertel, M., Ehlers, M., Bayer, P., Schmuck, C., Giese, M., and Knauer, S.K. (2020). Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand. Angew Chem Int Ed Engl 59, 5567-5571.

van den Boom, J., Hensel, A., Trusch, F., Matena, A., Siemer, S., Guel, D., Docter, D., Hoing, A., Bayer, P., Stauber, R.H., and Knauer, S.K. (2020). The other side of the corona: nanoparticles inhibit the protease taspase1 in a size-dependent manner. Nanoscale.


Arhzaouy, K., Papadopoulos, C., Schulze, N., Pittman, S.K., Meyer, H., and Weihl, C.C. (2019). VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle. Autophagy 15, 1082-1099.

Jiang, H., Hu, X.Y., Mosel, S., Knauer, S.K., Hirschhauser, C., and Schmuck, C. (2019). A Branched Tripeptide with an Anion-Binding Motif as a New Delivery Carrier for Efficient Gene Transfection. Chembiochem 20, 1410-1416.

Koerver, L., Papadopoulos, C., Liu, B., Kravic, B., Rota, G., Brecht, L., Veenendaal, T., Polajnar, M., Bluemke, A., Ehrmann, M., Klumperman, J., Jaattela, M., Behrends, C., and Meyer, H. (2019). The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage. EMBO Rep 20, e48014.

Kohler, K., Sanchez-Pulido, L., Hofer, V., Marko, A., Ponting, C.P., Snijders, A.P., Feederle, R., Schepers, A., and Boos, D. (2019). The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7. PLoS Biol 17, e2006767.

Sokolova, V., Rojas-Sanchez, L., Bialas, N., Schulze, N., and Epple, M. (2019). Calcium phosphate nanoparticle-mediated transfection in 2D and 3D mono- and co-culture cell models. Acta Biomater 84, 391-401.


Hu, X.Y., Ehlers, M., Wang, T., Zellermann, E., Mosel, S., Jiang, H., Ostwaldt, J.E., Knauer, S.K., Wang, L., and Schmuck, C. (2018). Formation of Twisted beta-Sheet Tapes from a Self-Complementary Peptide Based on Novel Pillararene-GCP Host-Guest Interaction with Gene Transfection Properties. Chemistry 24, 9754-9759.

Hulsmann, J., Kravic, B., Weith, M., Gstaiger, M., Aebersold, R., Collins, B.C., and Meyer, H. (2018). AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation. Mol Cell Proteomics 17, 1295-1307.

Li, M., Mosel, S., Knauer, S.K., and Schmuck, C. (2018). A dipeptide with enhanced anion binding affinity enables cell uptake and protein delivery. Org Biomol Chem 16, 2312-2317.

Mueller, J.W., Idkowiak, J., Gesteira, T.F., Vallet, C., Hardman, R., van den Boom, J., Dhir, V., Knauer, S.K., Rosta, E., and Arlt, W. (2018). Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1. J Biol Chem 293, 9724-9735.

Schrenk, C., Fetz, V., Vallet, C., Heiselmayer, C., Schroder, E., Hensel, A., Hahlbrock, A., Wunsch, D., Goesswein, D., Bier, C., Habtemichael, N., Schneider, G., Stauber, R.H., and Knauer, S.K. (2018). TFIIA transcriptional activity is controlled by a 'cleave-and-run' Exportin-1/Taspase 1-switch. J Mol Cell Biol 10, 33-47.

Sokolova, V., Loza, K., Knuschke, T., Heinen-Weiler, J., Jastrow, H., Hasenberg, M., Buer, J., Westendorf, A.M., Gunzer, M., and Epple, M. (2018). A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells. Acta Biomater 80, 352-363.


Graessl, M., Koch, J., Calderon, A., Kamps, D., Banerjee, S., Mazel, T., Schulze, N., Jungkurth, J.K., Patwardhan, R., Solouk, D., Hampe, N., Hoffmann, B., Dehmelt, L., and Nalbant, P. (2017). An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns. J Cell Biol 216, 4271-4285.

Jiang, H., Hu, X.Y., Schlesiger, S., Li, M., Zellermann, E., Knauer, S.K., and Schmuck, C. (2017). Morphology-Dependent Cell Imaging by Using a Self-Assembled Diacetylene Peptide Amphiphile. Angew Chem Int Ed Engl 56, 14526-14530.

Junghanel, S., Karczewski, S., Backer, S., Knauer, S.K., and Schmuck, C. (2017). A Systematic Structure-Activity Study of a New Type of Small Peptidic Transfection Vector Reveals the Importance of a Special Oxo-Anion-Binding Motif for Gene Delivery. Chembiochem 18, 2268-2279.

Kopp, M., Rotan, O., Papadopoulos, C., Schulze, N., Meyer, H., and Epple, M. (2017). Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3): Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cells. PLoS One 12, e0178260.

Papadopoulos, C., Kirchner, P., Bug, M., Grum, D., Koerver, L., Schulze, N., Poehler, R., Dressler, A., Fengler, S., Arhzaouy, K., Lux, V., Ehrmann, M., Weihl, C.C., and Meyer, H. (2017). VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J 36, 135-150.

Rotan, O., Severin, K.N., Popsel, S., Peetsch, A., Merdanovic, M., Ehrmann, M., and Epple, M. (2017). Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles. Beilstein J Nanotechnol 8, 381-393.

Schmitzberger, F., Richter, M.M., Gordiyenko, Y., Robinson, C.V., Dadlez, M., and Westermann, S. (2017). Molecular basis for inner kinetochore configuration through RWD domain-peptide interactions. EMBO J 36, 3458-3482.

van der Meer, S.B., Knuschke, T., Frede, A., Schulze, N., Westendorf, A.M., and Epple, M. (2017). Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo. Acta Biomater 57, 414-425.


Li, M., Ehlers, M., Schlesiger, S., Zellermann, E., Knauer, S.K., and Schmuck, C. (2016). Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection. Angew Chem Int Ed Engl 55, 598-601.

Schmidt, N., Irle, I., Ripkens, K., Lux, V., Nelles, J., Johannes, C., Parry, L., Greenow, K., Amir, S., Campioni, M., et al. (2016). Epigenetic silencing of serine protease HTRA1 drives polyploidy. BMC Cancer 16, 399.

van den Boom, J., Wolf, M., Weimann, L., Schulze, N., Li, F., Kaschani, F., Riemer, A., Zierhut, C., Kaiser, M., Iliakis, G., Funabiki, H., and Meyer, H. (2016). VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Mol Cell 64, 189-198.


Beaufort, N., Scharrer, E., Lux, V., Ehrmann, M., Haffner, C., and Dichgans, M. (2015). Reply to Liu et al.: Loss of TGF-beta signaling in CARASIL pathogenesis. Proc Natl Acad Sci U S A 112, E1694.

Hartmann-Fatu, C., Trusch, F., Moll, C.N., Michin, I., Hassinen, A., Kellokumpu, S., and Bayer, P. (2015). Heterodimers of tyrosylprotein sulfotransferases suggest existence of a higher organization level of transferases in the membrane of the trans-Golgi apparatus. J Mol Biol 427, 1404-1412.

Jeruschke, S., Jeruschke, K., DiStasio, A., Karaterzi, S., Buscher, A.K., Nalbant, P., Klein-Hitpass, L., Hoyer, P.F., Weiss, J., Stottmann, R.W., and Weber, S. (2015). Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression. PLoS One 10, e0137043.

Li, M., Schlesiger, S., Knauer, S.K., and Schmuck, C. (2015). A tailor-made specific anion-binding motif in the side chain transforms a tetrapeptide into an efficient vector for gene delivery. Angew Chem Int Ed Engl 54, 2941-2944.

Poepsel, S., Sprengel, A., Sacca, B., Kaschani, F., Kaiser, M., Gatsogiannis, C., Raunser, S., Clausen, T., and Ehrmann, M. (2015). Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat Chem Biol 11, 862-869.

Wunsch, D., Hahlbrock, A., Heiselmayer, C., Backer, S., Schrenk, C., Benne, F., Schilling, O., and Knauer, S.K. (2015). Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition. Biol Chem 396, 367-376.


Beaufort, N., Scharrer, E., Kremmer, E., Lux, V., Ehrmann, M., Huber, R., Houlden, H., Werring, D., Haffner, C., and Dichgans, M. (2014). Cerebral small vessel disease-related protease HtrA1 processes latent TGF-beta binding protein 1 and facilitates TGF-beta signaling. Proc Natl Acad Sci U S A 111, 16496-16501.

Eiteneuer, A., Seiler, J., Weith, M., Beullens, M., Lesage, B., Krenn, V., Musacchio, A., Bollen, M., and Meyer, H. (2014). Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1. EMBO J 33, 2704-2720.

Riemer, A., Dobrynin, G., Dressler, A., Bremer, S., Soni, A., Iliakis, G., and Meyer, H. (2014). The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. Cell Cycle 13, 919-927.

Schulze, N., Graessl, M., Blancke Soares, A., Geyer, M., Dehmelt, L., and Nalbant, P. (2014). FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers. J Cell Sci 127, 1379-1393.


Dr. Nina Schulze

Phone: +49201 183 2622

Room: S05 V05 F48

Campus Essen
Universitätsstraße 2
45141 Essen


Dr. Johannes Koch

Phone: +49201 183 2622

Room: S05 V05 F48

Campus Essen
Universitätsstraße 2
45141 Essen