ICCE - Publications

Selected Publications

Koerver, L., Papadopoulos, C., Liu, B., Kravic, B., Rota, G., Brecht, L., Veenendaal, T., Polajnar, M., Bluemke, A., Ehrmann, M., Klumperman, J., Jäättelä. M., Behrends, C., Meyer, H. (2019). The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysomoal damage. EMBO Rep.

Jiang, H., Hu, XY., Mosel, S., Knauer, SK., Hirschhäuser, C., Schmuck, C. (2019). A branched tripeptide with an anion-binding motif as a new delivery carrier for efficient gene transfection. Chembiochem 20, 1410-1416.

Köhler, K., Sanchez-Pulido, L., Höfer, V., Marko, A., Ponting, CP., Snijders, AP., Feederle, R., Schepers, A.,  Boos, D. (2019). The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7. PLoS Biol. 17(1).

Arhzaouy, K., Papadopoulos, C., Schulze, N., Pittman, SK., Meyer, H., Weihl, CC. (2019). VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle. Autophagy 1-18.

Sokolova, V., Rojas-Sánchez, L., Bialas, N., Schulze, N., Epple, M. (2019). Calcium phosphate nanoparticle-mediated tranfection in 2D and 3D mono- and co-culture cell models. Acta Biomater 84, 391-401.

Siemer, S., Westmeier, D., Vallet, C., Becker, S., Voskuhl, J, Ding, GB., Thines, E., Stauber, RH., Knauer, SK. (2019). Resistance to nano-based antifungals is mediated by biomolecule coronas. ACS Appl Mater Interfaces, 11, 104-114.

Rojas-Sánchez, L., Sokolova, V., Riebe, S., Voskuhl, J., Epple, M. (2018). Covalent surface functionalization of calcium phosphate nanoparticles with fluorescent dyes by copper-catalysed and by strain-promoted azide-alkyne click chemistry. Chem Nano Mat, 4, 1-12.

Hu, XY., Ehlers, M., Wang, T., Zellermann, E., Mosel, S., Jiang, H., Ostwaldt, JE., Knauer, SK., Wang, L., Schmuck, C. (2018). Formation of twisted ß-sheet tapes from a self-complementary peptide based on novel Pillaarene-GCP host-guest interaction with gene transfection properties. Chemistry, 24, 9754-9759.

Sokolova, V., Loza, K., Knuschke, T., Heinen-Weiler, J., Jastrow, H., Hasenberg, M., Buer, J., Westendorf, AM., Gunzer, M, Epple, M. (2018). A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells. Acta Biomater, 80, 352-363.

Hülsmann, J., Kravic, B., Weith, M., Gstaiger, M., Aebersold, R., Collins, BC., Meyer, H. (2018). AP-SWATH reveals direct involvement of VCP/p97 in integrated stress response signaling through facilitating CReP/PPP1R15B degradation. Mol Cell Proteomics 17, 1295-1307.

Mueller, JW., Idkowiak, J., Gesteira, TF., Vallet, C., Hardman, R., van den Boom, J., Dhir, V., Knauer, SK., Rosta, E., Arlt, W. (2018).Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1. J Biol Chem., 293, 9724-9735.

Li, M., Mosel, S., Knauer SK, and Schmuck, C. (2018). A dipeptide with enhanced anion binding affinity enables cell uptake and protein delivery. Org Biomol Chem., 16, 2312-2317.

Schrenk, C., Fetz, V., Vallet, C., Heiselmayer, C., Schroder, E., Hensel, A., Hahlbrock, A., Wunsch, D., Goesswein, D., Bier, C., Habtemichael, N., Schneider, G., Stauber, R.H., and Knauer, S.K. (2018). TFIIA transcriptional activity is controlled by a 'cleave-and-run' Exportin-1/Taspase 1-switch. J Mol Cell Biol, 1-15.

Stelzer, J., Vallet, C., Sowa, A., Gonzalez-Abradelo, D., Riebe, S., Daniliuc, C., Ehlers, M., Strassert, CA., Knauer SK., Voskuhl, J. (2018). On the influence of substitution patterns in thioether-based luminophores with aggregation-induced emission properties. Chem. Select3, 985-991.

Jiang, H., Hu, XY., Schlesiger, S.,Li, M., Zellermann, E., Knauer SK, and Schmuck, C. (2017). Morphology-dependent cell imaging by using a self-assembled diacetylene peptide amphiphile. Angew Chem Int Ed Engl.13, 14526-14530.

Junghänel, S., Karczewski, S., Bäcker, S., Knauer SK, and Schmuck, C. (2017). A systemativ structure-activity study of a new type of small peptidic transfection vector reveals the importance of a special oxo-anion-binding motif for gene delivery. Chembiochem18, 2268-2279.

Graessl, M., Koch, J., Calderon, A., Kamps, D., Banerjee, S., Mazel, T., Schulze, N., Jungkurth, J.K., Patwardhan, R., Solouk, D., Hampe, N., Hoffmann, B., Dehmelt, L., and Nalbant, P. (2017). An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns. J Cell Biol 216, 4271-4285.

Schmitzberger F, Richter MM, Gordiyenko Y, Robinson CV, Dadlez M, and Westermann S. (2017). Molecular basis for inner kinetochore configuration through RWD domain–peptide interactions. EMBO J 36, 3458-3482.

Kopp, M., Rotan, O., Papadopoulos, C., Schulze, N., Meyer, H., and Epple, M. (2017). Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3): Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cells. PLoS One 12, e0178260.

van der Meer, S.B., Knuschke, T., Frede, A., Schulze, N., Westendorf, A.M., and Epple, M. (2017). Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo. Acta Biomater. 57, 414-425.

Rotan O, Severin KN, Poepsel S, Peetsch A, Merdanovic M, Ehrmann M, and Epple M (2017). Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles. Beilstein J Nanotechnol 8, 381-393.

Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, Poehler R, Dressler A, Fengler S, Arhzaouy K, et al. (2017). VCP/p97 cooperates with YOD1 UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J 36, 135-150.

van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, Riemer A, Zierhut C, Kaiser M, Iliakis G, et al. (2016). VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Mol Cell 64, 189-198.

Li M, Ehlers M, Schlesiger S, Zellermann E, Knauer SK, and Schmuck C (2016). Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection. Angew Chem Int Ed Engl 55, 598-601.

Schmidt N, Irle I, Ripkens K, Lux V, Nelles J, Johannes C, Parry L, Greenow K, Amir S, Campioni M, et al. (2016). Epigenetic silencing of serine protease HTRA1 drives polyploidy. BMC Cancer 16, 399.

Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, and Ehrmann M (2015). Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat Chem Biol 11, 862-869.

Wünsch D, Hahlbrock A, Heiselmayer C, Backer S, Schrenk C, Benne F, Schilling O, and Knauer SK (2015). Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition. Biol Chem 396, 367-376.

Beaufort N, Scharrer E, Lux V, Ehrmann M, Haffner C, and Dichgans M (2015). Reply to Liu et al,: Loss of TGF-beta signaling in CARASIL pathogenesis. Proc Natl Acad Sci USA 112, E1694.

Li M, Schlesiger S, Knauer SK, and Schmuck C (2015). A tailor-made specific anion-binding motif in the side chain transforms a tetrapeptide into an efficient vector for gene delivery. Angew Chem Int Ed Engl 54, 2941-2944.

Hartmann-Fatu C, Trusch F, Moll CN, Michin I, Hassinen A, Kellokumpu S, and Bayer P (2015). Heterodimers of tyrosylprotein sulfotransferases suggest existence of a higher organization level of transferases in the membrane of the trans-Golgi apparatus. J Mol Biol 427, 1404-1412.

Jeruschke S, Jeruschke K, DiStasio A, Karaterzi S, Buscher AK, Nalbant P, Klein-Hitpass L, Hoyer PF, Weiss J, Stottmann R,W, et al. (2015). Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression. PLoS One 10, e0137043.

Eiteneuer A, Seiler J, Weith M, Beullens M, Lesage B, Krenn V, Musacchio A, Bollen M, and Meyer H (2014). Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1. EMBO J 33, 2704-2720.

Beaufort N, Scharrer E, Kremmer E, Lux V, Ehrmann M, Huber R, Houlden H, Werring D, Haffner C, and Dichgans M (2014). Cerebral small vessel disease-related protease HtrA1 processes latent TGF-beta binding protein 1 and facilitates TGF-beta signaling. Proc Natl Acad Sci USA 111, 16496-16501.

Riemer A, Dobrynin G, Dressler A, Bremer S, Soni A, Iliakis G, and Meyer H (2014). The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. Cell Cycle 13, 919-927.

Schulze N, Graessl M, Blancke Soares A, Geyer M, Dehmelt L, and Nalbant P (2014). FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers. J Cell Sci 127, 1379-1393.

Kirchner P, Bug M, and Meyer H (2013). Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase. J Biol Chem 288, 7363-7372.


Dr. Nina Schulze

Phone: +49201 183 2622

Room: S05 V05 F48

Campus Essen
Universitätsstraße 2
45141 Essen


Dr. Johannes Koch

Phone: +49201 183 2622

Room: S05 V05 F48

Campus Essen
Universitätsstraße 2
45141 Essen