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Fusco, S. and B. Siebers (2024). Extreme biocatalysts: from basic research to biotechnological applications. Int. J. Mol. Sci., 25, 6492.

Ninck, S., T. Klaus, T. V. Kochetkova, S. P. Esser, L. Sewald, F. Kaschani, C. Bräsen, A. J. Probst, I. Kublanov, B. Siebers and M. Kaiser (2024). Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities. Environ Microbiome 19(1):36. doi: 10.1186/s40793-024-00577-2 PubMed

Cowan, D. A., S.-V. Albers, G. Antranikian, H. Atomi, B. Averhoff, M. Basen, A. J. M. Driessen, M. Jebbar, Z. Kelman, M. Kerou, J. Littlechild, V. Müller, P. Schönheit, B. Siebers and K. Vorgias (2024). Extremophiles in a changing world. Extremophiles 28:2, 26. doi: 10.1007/s00792-024-01341-7 PubMed

Kuschmierz, L., A. Wagner, T. Busche, J. Kalinowski, C. Bräsen and B. Siebers (2024). 5′-untranslated region sequences enhance plasmid-based protein production in Sulfolobus acidocaldarius. bioRxiv 2024.03.01.582787;

Schmerling, C., C. Schroeder, X. Zhou, T. Busche, J. Kalinowski, L. Montero, O. Schmitz, F. Kaschani, S. Ninck, M. Kaiser, J. Bost, A. Recalde, S.-V. Albers, B. Siebers and C. Bräsen (2024). Glycerol degradation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius involves an unusual glycerol-3-phosphate dehydrogenase. bioRxiv 2024.02.29.582781;

Maklad, H. R., S. P. dit Ruys, I. Bervoets, D. Vertommen, G. J. Gutierrez, W. F. Vranken, B. Siebers and E. Peeters (2024). Protein kinase Sut1 from the Crenarchaeon Sulfolobus acidocaldarius displays tyrosine phosphorylation activity. bioRxiv 2024.01.14.552423;


Bost, J., A. Recalde, B. Waßmer, A. Wagner, B. Siebers and S.-V. Albers (2023). Application of the endogenous CRISPR-Cas type I-D system for genetic engineering in the thermoacidophilic archaeon Sulfolobus acidocaldarius. Front. Microbiol. 14:1254891. doi: 10.3389/fmicb.2023.1254891 PubMed

De Rose, S. A., M. N. Isupov, H. L. Worthy, C. Stracke, N. J. Harmer, B. Siebers, J. A. Littlechild and The HotSolute consortium (2023). Structural characterization of a novel cyclic 2,3-diphosphoglycerate synthetase involved in extremolyte production in the archaeon Methanothermus fervidus. Front. Microbiol. 14: 1267570. doi: 10.3389/fmicb.2023.1267570 PubMed


Ninck, S., T. Klaus, T. V. Kochetkova, S. P. Esser, L. Sewald, F. Kaschani, C. Bräsen, A. J. Probst, I. V. Kublanov, B. Siebers and M. Kaiser (2022). Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities. bioRxiv 2022.11.11.516116;

Schmerling, C., L. Sewald, G. Heilmann, F. Witfeld, D. Begerow, K. Jensen, C. Bräsen, F. Kaschani, H. S. Overkleeft, B. Siebers and M. Kaiser (2022). Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling. Commun. Biol. 5:1254. doi: 10.1038/s42003-022-04141-x PubMed

Kuschmierz L., M. Meyer, C. Bräsen, J. Wingender, O. J. Schmitz and B. Siebers (2022). Exopolysaccharide composition and size in Sulfolobus acidocaldarius biofilms. Front. Microbiol. 13:982745. doi: 10.3389/fmicb.2022.982745 PubMed

Alharbi F., T. Knura, B. Siebers and K. Ma (2022). Thermostable and O2-insensitive pyruvate decarboxylases from thermoacidophilic Archaea catalyzing the production of acetaldehyde. Biology 2022, 11, 1247. doi: 10.3390/biology11081247 PubMed

Höfmann S., P. A. Dziwornu, T. Klaus, T. Knura, R. Wohlgemuth, C. Bräsen and B. Siebers (2022). Simplified enzymatic synthesis of 2-keto-3-deoxy-D-gluconate from D-gluconate using the gluconate dehydratase from Thermoproteus tenax. Methods Mol. Biol. 2022; 2522:351-362. doi: 10.1007/978-1-0716-2445-6_23 PubMed

Schmerling, C., T. Kouril, J. Snoep, C. Bräsen and B. Siebers (2022). Enhanced underground metabolism challenges life at high temperature–metabolic thermoadaptation in hyperthermophilic Archaea. Curr. Opin. Syst. Biol. 30:100423. doi: 10.1016/j.coisb.2022.100423 PubMed

Klaus T., S. Ninck, A. Albersmeier, T. Busche, D. Wibberg, J. Jiang, A. G. Elcheninov, K. S. Zayulina, F. Kaschani, C. Bräsen, H. S. Overkleeft, J. Kalinowski, I. V. Kublanov, M. Kaiser and B. Siebers (2022). Activity-based protein profiling for the identification of novel CAZymes involved in xylan degradation in the hyperthermophilic Euryarchaeon Thermococcus sp. strain 2319x1E. Front. Microbiol. 12:734039. doi: 10.3389/fmicb.2021.734039 PubMed


Kuschmierz L., L. Shen, C. Bräsen, J. Snoep and B. Siebers (2021). Workflows for optimization of enzyme cascades and whole cell catalysis based on enzyme kinetic characterization and pathway modelling. Curr Opin Biotechnol. 74:55-60. doi: 10.1016/j.copbio.2021.10.020. Epub ahead of print. PMID: 34794111. PubMed

Benninghoff J. C., L. Kuschmierz, X. Zhou, A. Albersmeier, T. K. Pham, T. Busche, P. C. Wright, J. Kalinowski, K. S. Makarova, C. Bräsen, H.-C. Flemming, J. Wingender and B. Siebers (2021). Exposure to 1-Butanol Exemplifies the Response of the Thermoacidophilic Archaeon Sulfolobus acidocaldarius to Solvent Stress. Appl Environ Microbiol. 2021 Mar 19:AEM.02988-20. doi: 10.1128/AEM.02988-20. Online ahead of print. PMID: 33741627. PubMed

Lewis A. M., A. Recalde, C. Bräsen, J. A. Counts, P. Nussbaum, J. Bost, L. Schocke, L. Shen, D. J. Willard, T. E. F. Quax, E. Peeters, B. Siebers, S.-V. Albers and R. M. Kelly (2021). The biology of thermoacidophilic archaea from the order Sulfolobales. FEMS Microbiol Rev. 21:fuaa063. doi: 10.1093/femsre/fuaa063. Epub ahead of print. PMID: 33476388. PubMed

Wolf J., J. Koblitz, A. Albersmeier, J. Kalinowski, B. Siebers, D. Schomburg and M. Neumann-Schaal (2021). Utilization of phenol as carbon source by the thermoacidophilic archaeon Saccharolobus solfataricus P2 is limited by oxygen supply and the cellular stress response. Frontiers in Microbiology (Biology of Archaea) 11, 587032. doi: 10.3389/fmicb.2020.587032. PubMed


Stracke C., B. H. Meyer, A. Hagemann, E. Jo, A. Lee, S.-V. Albers, J. Cha, C. Bräsen and B. Siebers (2020). Salt stress response of Sulfolobus acidocaldarius involves complex trehalose metabolism utilizing a novel trehalose-6-phosphate synthase (TPS)/trehalose-6-phosphate phosphatase (TPP) pathway. Appl Environ Microbiol. 86(24):e01565-20. doi: 10.1128/AEM.01565-20. PMID: 33008820; PMCID: PMC7688234. PubMed

Sutiono S., B. Siebers and V. Sieber (2020). Characterization of highly active 2-keto-3-deoxy-L-arabinonate and 2-keto-3-deoxy-D-xylonate dehydratases in terms of the biotransformation of hemicellulose sugars to chemicals. Applied Microbiology and Biotechnology, doi: 10.1007/s00253-020-10742-5. Online ahead of print. PMID: 32566996. PubMed

Maklad H. R., G. J. Gutierrez, D. Esser, B. Siebers and E. Peeters (2020). Phosphorylation of the acyl-CoA binding pocket of the FadR transcription regulator in Sulfolobus acidocaldarius. Biochimie. 2020; S0300-9084(20)30115-2. doi:10.1016/j.biochi.2020.05.007. PubMed

Van der Kolk N., A. Wagner, M. Wagner, B. Waßmer, B. Siebers and S.-V. Albers (2020). Identification of XylR, the activator of arabinose/xylose inducible regulon in Sulfolobus acidocaldarius and its application for homologous protein expression. Front. Microbiol. 11, 1066. doi: 10.3389/fmicb.2020.01066. PubMed

Tjaden B., K. Baum, V. Marquardt, M. Simon, M. Trajkovic-Arsic, T. Kouril, B. Siebers, J. Lisec, J. T. Siveke, J. H. Schulte, U. Benary, M. Remke, J. Wolf and A. Schramm (2020). N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma. Scientific Reports 10, 7157. doi: 10.1038/s41598-020-64040-1. PubMed

Krevet S., L. Shen, T. Bohnen, B. Schoenenberger, R. Meier, M. Obkircher, K. Bangert, R. Koehling, E. Allenspach, B. Siebers and C. Bräsen (2020). Enzymatic synthesis of 2-keto-3-deoxy-6-phosphogluconate by the 6-phosphogluconate-dehydratase from Caulobacter crescentus. Frontiers in Bioengineering and Biotechnology 8. doi:10.3389/fbioe.2020.00185. PubMed

Shen L., M. Kohlhaas, J. Enoki, R. Meier, B. Schönenberger, R. Wohlgemuth, R. Kourist, F. Niemeyer, D. van Niekerk, C. Bräsen, J. Niemeyer, J. Snoep and B. Siebers (2020). A combined experimental and modelling approach for the Weimberg pathway optimisation. Nat Commun. 11(1), 1098. doi: 10.1038/s41467-020-14830-y. PubMed


Haferkamp P., B. Tjaden, L. Shen, C. Bräsen, T. Kouril and B. Siebers (2019). The Carbon switch at the level of pyruvate and phosphoenolpyruvate in Sulfolobus solfataricus P2. Front Microbiol. 10, 757. doi: 10.3389/fmicb.2019.00757. PubMed

Wang K., D. Sybers, H. Ramadan Maklad, L. Lemmens, C. Lewyllie, X. Zhou, F. Schult, C. Bräsen, B. Siebers, K. Valegård, A.-C. Lindås and E. Peeters (2019). A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius. Nature Communications 10(1), 1542. (doi: 10.1038/s41467-019-09479-1.) PubMed

Schocke L., C. Bräsen and B. Siebers (2019). Thermoacidophilic Sulfolobus species as source for extremozymes and as novel archaeal platform organisms. Current Opinion in Biotechnology 59, 71-77. doi: 10.1016/j.copbio.2019.02.012. PubMed

Bischof L. F., M. F. Haurat, L. Hoffmann, A. Albersmeier, J. Wolf, A. Neu, T. K. Pham, S. P. Albaum, T. Jakobi, S. Schouten, M. Neumann-Schaal, P. C. Wright, J. Kalinowski, B. Siebers and S.-V. Albers (2019). Early response of Sulfolobus acidocaldarius to nutrient limitation. Front Microbiol. 9, 3201. doi: 10.3389/fmicb.2018.03201. PubMed


Wohlgemuth R., J. Littlechild, D. Monti, K. Schnorr, T. van Rossum, B. Siebers, P. Menzel, I. V. Kublanov, A. G. Rike, G. Skretas, Z. Szabo, X. Peng and M. J. Young (2018). Discovering novel hydrolases from hot environments. Biotechnology Advances 36, 2077–2100. doi: 10.1016/j.biotechadv.2018.09.004. PubMed

Schult F., T. N. Le, A. Albersmeier, B. Rauch, P. Blumenkamp, C. van der Does, A. Goesmann, J. Kalinowski, S.-V. Albers and B. Siebers (2018). Effect of UV irradiation on Sulfolobus acidocaldarius and involvement of the general transcription factor TFB3 in the early UV response. Nucleic Acids Research. doi: 10.1093/nar/gky527. PubMed


Knüppel R., R. H. Christensen, F. C. Gray, D. Esser, D. Strauß, J. Medenbach, B. Siebers, S. A. MacNeill, N. LaRonde and S. Ferreira-Cerca (2017). Insights into the evolutionary conserved regulation of Rio ATPase activity. Nucleic Acids Research doi: 10.1093/nar/gkx1236. [Epub ahead of print]. PubMed

Quehenberger J., L. Shen, S.-V. Albers, B. Siebers and O. Spadiut (2017). Sulfolobus – A potential key organism in future biotechnology. Front. Microbiol. 8, 2474. doi: 10.3389/fmicb.2017.02474. PubMed

Wagner M., L. Shen, A. Albersmeier, N. van der Kolk, S. Kim, J. Cha, C. Bräsen, J. Kalinowski, B. Siebers and S.-V. Albers (2017). Sulfolobus acidocaldarius uptakes pentoses via a cut2-type ABC transporter and metabolizes them through the aldolase-independent Weimberg pathway. Appl Environ Microbiol. 2017 Nov 17. pii: AEM.01273-17. doi: 10.1128/AEM.01273-17. PubMed

Kourist R., J. González-Sabín, B. Siebers and M. Julsing (2017). Editorial: Applied Microbiology for Chemical Syntheses. Front Microbiol. 8, 1931. PubMed

Kouril T., J. J. Eicher, B. Siebers and J. L. Snoep (2017). Phosphoglycerate kinase acts as a futile cycle at high temperature. Microbiology 163, 1604–1612, doi: 10.1099/mic.0.000542. PubMed

Figueiredo A. S., T. Kouril, D. Esser, P. Haferkamp, P. Wieloch, D. Schomburg, P. Ruoff, B. Siebers and J. Schaber (2017). Systems Biology of the modified branched Entner-Doudoroff pathway in Sulfolobus solfataricus. PLoS One 12(7):e0180331. doi: 10.1371/journal.pone.0180331. PubMed

Stark H., J. Wolf, A. Albersmeier, T. K. Pham, J. D. Hofmann, B. Siebers, J. Kalinowski, P. C. Wright, M. Neumann-Schaal and D. Schomburg (2017). Oxidative Stickland reactions in an obligate aerobic organism - amino acid catabolism in the Crenarchaeon Sulfolobus solfataricus. FEBS J., doi: 10.1111/febs.14105. PubMed

Zhang Y., T. Kouril, J. L. Snoep, B. Siebers, M. Barberis and H. V. Westerhoff (2017). The peculiar glycolytic pathway in hyperthermophylic Archaea: understanding its whims by experimentation in silico. Int J Mol Sci.;18(4), 876. doi: 10.3390/ijms18040876. PubMed

Zweerink S., V. Kallnik, S. Ninck, S. Nickel, J. Verheyen, M. Blum, A. Wagner, I. Feldmann, A. Sickmann, S.-V. Albers, C. Bräsen, F. Kaschani, B. Siebers and M. Kaiser (2017). Activity based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea. Nature Communications 8, 15352. doi: 10.1038/ncomms15352. PubMed


Benninghoff J., J. Wingender, H.-C. Flemming and B. Siebers (2016). Biofilms X-treme: Composition of extracellular polymeric substances and exopolysaccharide synthesis in Archaea. In: The Perfect Slime: Microbial Extracellular Polymeric Substances. (2106) Heidelberg, New York, Springer International: 301-317.

Wolf J., H. Stark, K. Fafenrot, A. Albersmeier, T. K. Pham, K. B. Müller, B. Meyer, L. Hoffmann, L. Shen, S. P. Albaum, T. Kouril, K. Schmidt-Hohagen, M. Neumann-Schaal, C. Bräsen, J. Kalinowski, P. C. Wright, S.-V. Albers, D. Schomburg and B. Siebers (2016). A systems biology approach reveals major metabolic changes in the thermoacidophilic archaeon Sulfolobus solfataricus in response to the carbon source L-fucose versus D-glucose. Mol Microbiol. 102(5), 882-908, doi: 10.1111/mmi.13498. PubMed

Esser D., L. Hoffmann, T. K. Pham, C. Bräsen, W. Qiu, P. C. Wright, S.-V. Albers and B. Siebers (2016). Protein phosphorylation and its role in archaeal signal transduction. FEMS Microbiol Rev. 40(5), 625-47. doi: 10.1093/femsre/fuw020. PubMed

Gavrilov S. N., C. Stracke, K. Jensen, P. Menzel, V. Kallnik, A. Slesarev, T. Sokolova, K. Zayulina, C. Bräsen, E. A. Bonch-Osmolovskaya, X. Peng, I. V. Kublanov and B. Siebers (2016). Isolation and Characterization of the First Xylanolytic Hyperthermophilic Euryarchaeon Thermococcus sp. Strain 2319x1 and Its Unusual Multidomain Glycosidase. Front Microbiol. 7, 552. doi: 10.3389/fmicb.2016.00552. PubMed

Siebers B. (2016). Archaeen-Stoffwechsel: Kohlenhydratstoffwechsel in Archaea – Besonderheiten und Herausforderung. BioSpektrum (05/2016).

Reinberger S. und B. Siebers (2016). Kleine Überlebenskünstler für die Biotechnologie. Systembiologie Broschüre des BMBF (April, 2016).


Jachlewski S., W. D. Jachlewski, U. Linne, C. Bräsen, J. Wingender and B. Siebers (2015). Isolation of extracellular polymeric substances from biofilms of the thermoacidophilic archaeon Sulfolobus acidocaldarius. Front. Bioeng. Biotechnol. 3, 123, PubMed

Range S., D. Hagmeyer, O. Rotan, V. Sokolova, J. Verheyen, B. Siebers and M. Epple (2015). A continuous method to prepare poorly crystalline silver-doped calcium phosphate ceramics with antibacterial properties. RSC Adv., 5, 43172, DOI: 10.1039/c5ra00401b.


Nelson-Sathi S., F. L. Sousa, M. Röttger, N. Lozada-Chávez, T. Thiergart, A. Janssen, D. Bryant, G. Landan, P. Schönheit, B. Siebers, J. O. McInerney and W. F. Martin (2014). Origins of major archaeal clades correspond to gene acquisitions from bacteria. Nature, 517(7532), 77-80, doi: 10.1038/nature13805, PMID: 25317564. PubMed

Matsubara K., R. Köhling, B. Schönenberger, T. Kouril, D. Esser, C. Bräsen, B. Siebers and R. Wohlgemuth (2014). One-step synthesis of 2-keto-3-deoxy-D-gluconate by biocatalytic dehydration of D-gluconate. Journal of Biotechnology, 191, 69-77, doi: 10.1016/j.jbiotec.2014.06.005. PubMed

Kallnik V., A. Bunescu, C. Sayer, C. Bräsen, R. Wohlgemuth, J. Littlechild and B. Siebers (2014). Characterization of a phosphotriesterase-like lactonase from the hyperthermoacidophilic crenarchaeon Vulcanisaeta moutnovskia. Journal of Biotechnology 190, 11-7, doi: 10.1016/j.jbiotec.2014.04.026, PMID: 24858677. PubMed

Bräsen C. und B. Siebers (2014). Systembiologie X-trem - Von der Grundlagenforschung zur Anwendung in hyperthermophilen Archaea. GIT Labor-Fachzeitschrift 12/2014, S. 20–23.

Albers S.-V. and B. Siebers (2014). The family Sulfolobaceae. In The Prokaryotes, 5th Edition, Springer: Other Major Lineages of Bacteria and The Archaea. Editor-in-chief: Rosenberg, Eugene DeLong, E.F., Lory, S., Stackebrandt, E., Thompson, F. (Eds.); 2014:323-346. vol 9783642389542.

Bräsen C., Esser D., Rauch B. and Siebers B. (2014). Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation. Microbiol Mol Biol Rev. 2014 Mar;78(1):89-175. doi: 10.1128/MMBR.00041-13. PMID:24600042. PubMed


Wagner M., A. Wagner, X. Ma, J. Kort, A. Ghosh, B. Rauch, B. Siebers and S.-V. Albers (2013). Investigation of the malE promoter and MalR, a positive regulator of the maltose regulon, for an improved expression system in Sulfolobus acidocaldarius. Appl. Env. Microbiol. 80(3), 1072-81, doi: 10.1128/AEM.03050-13. PubMed

Reimann J., D. Esser, A. Orell, F. Amman, T. K. Pham, J. Noirel, A. C. Lindas, R. Bernander, P. C. Wright, B. Siebers and S.-V. Albers (2013). Archaeal signal transduction: Impact of protein phosphatase deletions on cell size, motility and energy metabolism in Sulfolobus acidocaldarius. Mol Cell Proteomics 12, 3908-23, doi: 10.1074/mcp.M113.027375. PubMed

Kouril T., D. Esser, J. Kort, H. V. Westerhoff, B. Siebers and J. L. Snoep (2013). Intermediate instability at high temperature leads to low pathway efficiency for in vitro reconstituted gluconeogenesis of Sulfolobus solfataricus. FEBS Journal 280, 4666–4680 doi:10.1111/febs.12438. PubMed

Kort J. C., D. Esser, K. T. Pham, J. Noirel, P. C. Wright and B. Siebers (2013). A Cool Tool for Hot and Sour Archaea: Proteomics of Sulfolobus solfataricus. Proteomics 13 (18-19):2831-50. doi: 10.1002/pmic.201300088. PMID: 23894103. PubMed

Orell A., E. Peeters, V. Vassen, S. Jachlewski, S. Schalles, B. Siebers and S.-V. Albers (2013). Lrs14 transcriptional regulators influence biofilm formation and cell motility of Crenarchaea. The ISME Journal, 7(10):1886-98,  doi: 10.1038/ismej.2013.68, PMID: 23657363. PubMed

Zaparty M., A. Hagemann, C. Bräsen, R. Hensel, A. N. Lupas, H. Brinkmann and B. Siebers (2013). The first prokaryotic trehalose synthase complex identified in the hyperthermophilic Crenarchaeon Thermoproteus tenax. PLoS ONE 8(4): e61354. doi:10.1371/journal.pone.0061354. PubMed

Kouril T., P. Wieloch, J. Reimann, M. Wagner, M. Zaparty, S.-V. Albers, D. Schomburg, P. Ruoff and B. Siebers (2013). Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2. FEBS Journal, 280(4), 1126-38, doi: 10.1111/febs.12106, PMID:23279921. PubMed

Esser D and B. Siebers (2013). Atypical protein kinases of the RIO family in Archaea. Biochem Soc Trans. 41, 399-404, doi: 10.1042/BST20120317. PubMed

Esser D., T. Kouril, F. Talfournier, J. Polkowska, T. Schrader, C. Bräsen and B. Siebers (2013). Unraveling the function of paralogs of the aldehyde dehydrogenase super family from Sulfolobus solfataricus. Extremophiles, 17(2), 205-16, doi: 10.1007/s00792-012-0507-3, PMID:23296511. PubMed

Peetsch A., C. Greulich, D. Braun, C. Stroetges, H. Rehage, B. Siebers, M. Köller and M. Epple (2013). Silver-doped calcium phosphate nanoparticles: Synthesis, characterization, and toxic effects towards mammalian and prokaryotic cells. Colloids and Surfaces B: Biointerfaces, 10.1016/j.colsurfb.2012.09.040. PubMed


Ulas T., S. A. Riemer, M. Zaparty, B. Siebers and D. Schomburg (2012). Genome-scale reconstruction and analysis of the metabolic network in the hyperthermophilic Archaeon Sulfolobus solfataricus. PLoS ONE 7(8), e43401, doi:10.1371/journal.pone.0043401, PMID: 22952675. PubMed

Greulich C., D. Braun, A. Peetsch, J. Diendorf, B. Siebers, M. Epple and M. Köller (2012). The toxic effect of silver ions and silver nanoparticles towards bacteria and human cells occurs in the same concentration range. RSC Adv., 2012, DOI: 10.1039/C2RA20684F.

Esser D., K. T. Pham, J. Reimann, S.-V. Albers, B. Siebers and P. C. Wright (2012). Change of carbon source causes dramatic effects in the phospho-proteome of the archaeon Sulfolobus solfataricus. J Proteome Res. 11, 4823-22, doi: 10.1021/pr300190k, PMID: 22639831. PubMed

Siebers B. (2012). The third domain of life - Interview with B. Siebers. International Innovation Magazine, Issue Environment, pp. 30-32.

Kouril T., A. Kolodkin, M. Zaparty, R. Steuer, P. Ruoff, H. V. Westerhoff, J. L. Snoep, B. Siebers and SulfoSYS consortium (2012). Sulfolobus Systems Biology: Cool hot design for metabolic pathways. In Systems Biology of Microorganisms, Edited by Wren B & Robertson B, Horizon Scientific Press and Caister Academic Press, Norwich, UK.

Koerdt A., S. Jachlewski, A. Ghosh, J. Wingender, B. Siebers and S.-V. Albers (2012). Complementation of Sulfolobus solfataricus PBL2025 with an α-mannosidase: effects on surface attachment and biofilm formation. Extremophiles 16, 115-25. PubMed


Siebers B., M. Zaparty, G. Raddatz, B. Tjaden, S.-V. Albers, S. D. Bell, F. Blombach, A. Kletzin, N. Kyrpides, C. Lanz, A. Plagens, M. Rampp, A. Rosinus, M. von Jan, K. S. Makarova, H.-P. Klenk, S. C. Schuster and R. Hensel (2011). The complete genome sequence of Thermoproteus tenax: A physiologically versatile member of the Crenarchaeota. PLoS ONE 6, e24222. PubMed

Esser D., T. Kouril, M. Zaparty, P. Sierocinski, P. P. Chan, T. Lowe, J. Van der Oost, S.-V. Albers, D. Schomburg, K. S. Makarova and B. Siebers (2011). Functional curation of the Sulfolobus solfataricus P2 and S. acidocaldarius 98-3 complete genome sequences. Extremophiles. 2011 Nov;15(6):711-2. doi: 10.1007/s00792-011-0392-1. Epub 2011 Sep 13. PMID: 21912952. PubMed

Marrero Coto J., A. E. Ehrenhofer-Murray, T. Pons and B. Siebers (2011). Functional analysis of archaeal MBF1 by complementation studies in yeast. Biol Direct. 6, 18. PubMed

Haferkamp P., S. Kutschki, J. Treichel, H. Hemeda, K. Sewczyk, D. Hoffmann, M. Zaparty and B. Siebers (2011). An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of sugar degradation? Biochem Soc Trans. 39, 77-81. PubMed

Zaparty, M. and B. Siebers (2011). Physiology, Metabolism and Enzymology of Thermoacidophiles. In Extremophiles Handbook K. Horikoshi, G. Antranikian, A.T. Bull, F.T. Robb, and K.O. Stetter, eds. (Tokyo, Springer).


Zaparty M., D. Esser, S. Gertig, P. Haferkamp, T. Kouril, A. Manica, T. K. Pham, J. Reimann, K. Schreiber, P. Sierocinski, D. Teichmann, M. van Wolferen, M. von Jan, P. Wieloch, S.-V. Albers, A. J. Driessen, H.-P. Klenk, C. Schleper, D. Schomburg, J. van der Oost, P. C. Wright and B. Siebers (2010). “Hot standards” for the thermoacidophilic archaeon Sulfolobus solfataricus. Extremophiles, 14, 119-42, DOI: 10.1007/s00792-009-0280-0. PubMed


Blombach, F., K. S. Makarova, J. Marrero, B. Siebers, E. V. Koonin and J. Van der Oost (2009). Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea. Biol. Direct, 4, 39, doi: 10. 1186/1745-6150-4-39. PubMed

Albers S.-V., N.-K. Birkeland, A. J. Driessen, S. Gertig, P. Haferkamp, H.-P. Klenk, T. Kouril, A. Manica, T. K. Pham, P. Ruoff, C. Schleper, D. Schomburg, K. J. Sharkey, B. Siebers, P. Sierocinski, R. Steuer, J. van der Oost, H. V. Westerhoff, P. Wieloch, P. C. Wright and M. Zaparty (2009). SulfoSYS - Sulfolobus Systems Biology: towards a Silicon Cell Model for the central carbohydrate metabolism of the Archaeon Sulfolobus solfataricus under temperature variation. Biochem. Soc. Trans., 37, 58-64. PubMed


Zaparty M., B. Tjaden, R. Hensel and B. Siebers (2008). The central carbohydrate metabolism of the hyperthermophilic crenarchaeote Thermoproteus tenax: pathways and insights into their regulation. Arch. Microbiol. 190, 231-245 (DOI: 10.1007/s00203-008-0375-5). PubMed

Kouril T., M. Zaparty, J. Marrero, H. Brinkmann and B. Siebers (2008). A novel trehalose synthesizing pathway in the hyperthermophilic Crenarchaeon Thermoproteus tenax: the unidirectional TreT pathway. Arch. Microbiol. 190 (3), 355-69 (DOI: 10.1007/s00203-008-0377-3). PubMed

Zaparty M., A. Zaigler, C. Stamme, J. Soppa, R. Hensel and B. Siebers (2008). DNA Microarray Analysis of the Central Carbohydrate Metabolism: Glycolytic/Gluconeogenic Carbon Switch in the Hyperthermophilic Crenarchaeum Thermoproteus tenax. J. Bacteriol. 190 (6), 2231-2238 (doi:10.1128/JB.01524-07). PubMed

Pauluhn A., H. Ahmed, E. Lorentzen, S. Buchinger, D. Schomburg, B. Siebers and E. Pohl (2008). Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax. Proteins. 2008 Jan. 10, [Epub ahead of print]. PubMed

Ettema T. J. G., H. Ahmed, J. Van der Oost and B. Siebers (2008). The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) of Sulfolobus solfataricus: a key enzyme of the semi-phosporylative Entner-Doudoroff branch. Extremophiles 12 (1), 75-88 (DOI:10.1007/s00792-007-0082-1). PubMed


Kehrer D., H. Ahmed, H. Brinkmann and B. Siebers (2007). Glycerate kinase of the hyperthermophilic Archaeon Thermoproteus tenax: New insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase families. BMC Genomics 8, 301 (doi:10.1186/1471-2164-8-301). PubMed

Luo X., U. Schwarz-Linek, C. H. Botting, R. Hensel, B. Siebers and M. F. White (2007). CC1, a novel crenarchaeal DNA binding protein. J. Bacteriol. 189 (2), 403-409 (doi:10.1128/JB.01246-06). PubMed

Van der Oost J. and B. Siebers (2007). The glycolytic pathways of Archaea – Evolution by Tinkering. In: Archaea: Evolution, Physiology and Molecular Biology. 1st edition. Edited by: Roger A. Garrett and Hans-Peter Klenk. Blackwell Publishing, 247-260.


Tjaden B., A. Plagens, C. Dörr, B. Siebers and R. Hensel (2006). Phosphoenolpyruvate synthetase and pyruvate, phosphate dikinase of Thermoproteus tenax: Key pieces of the puzzle of archaeal carbohydrate metabolism. Mol. Microbiol. 60, 287-98. PubMed

Siebers B. and P. Schönheit (2005). Unusual pathways and enzymes of central carbohydrate metabolism in Archaea. Curr. Opin. Microbiol. 8, 695-705. PubMed

Ahmed H., T. J. G. Ettema, B. Tjaden, A. C. M. Geerling, J. Van der Oost and B. Siebers (2005). The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic Archaea - a re-evaluation. Biochem. J. 390, 529-540. PubMed

Lorentzen E., B. Siebers, R. Hensel and E. Pohl (2005)*. The mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase; Structural analysis of reaction intermediates. Biochemistry 44 (11), 4222-4229.

*chosen "Hidden jewels" March 2005, by Faculty of 1000 Biology Member Karen Allen (Boston University School of Medicine, USA). PubMed

Brouns S. J. J., T. J. G. Ettema, K. M. Stedman, J. Walther, H. Smidt, A. P. L. Snijders, M. Young, R. Bernander, P. C. Wright, B. Siebers and J. Van der Oost (2005). The hyperthermophilic archaeon Sulfolobus - from exploration and exploitation. In: Geothermal Biology and Geochemistry in Yellowstone National Park: proceeding of the Thermal Biology Institute workshop (Eds. B. Inskeep and T. R. McDermott), 261-276.


Siebers B., B. Tjaden, K. Michalke, C. Dörr, H. Ahmed, M. Zaparty, P. Gordon, C. W. Sensen, A. Zibat, H.-P. Klenk, S. C. Schuster and R. Hensel (2004). Reconstruction of the central carbohydrate metabolism of Thermoproteus tenax by use of genomic and biochemical data. J. Bacteriol. 186 (7), 2179-2194. PubMed

Lorentzen E., B. Siebers, R. Hensel and E. Pohl (2004). Structure, function and evolution of the archaeal class I fructose-1,6-bisphosphate aldolase. Biochem. Soc. Trans. 32, 259-263. PubMed

Ahmed H., B. Tjaden, R. Hensel and B. Siebers (2004). Embden-Meyerhof-Parnas and Entner-Doudoroff pathway in Thermoproteus tenax: Metabolic parallelism or specific adaptation? Biochem. Soc. Trans. 32, 303-304. PubMed


Lorentzen E., E. Pohl, P. Zwart, A. Stark, R. B. Russell, T. Knura, R. Hensel and B. Siebers (2003). Crystal structure of an archaeal Class I aldolase and the evolution of (βα)8 barrel proteins. J. Biol. Chem. 278, 47253-47260. PubMed

Dörr C., M. Zaparty, B. Tjaden, H. Brinkmann and B. Siebers (2003). The hexokinase of the hyperthermophile Thermoproteus tenax. ATP-dependent hexokinases and ADP-dependent glucokinases, two alternatives for glucose phosphorylation in Archaea. J. Biol. Chem. 278, 18744-18753. PubMed


Siebers B., H. Brinkmann, C. Dörr , B. Tjaden, H. Lilie, J. Van der Oost and C. H. Verhees (2001). Archaeal fructose-1,6-bisphosphate aldolases constitute a new family of archaeal type Class I aldolase. J. Biol. Chem. 276, 28710-28718. PubMed

Walden H., G. S. Bell, R. J. M. Russell, B. Siebers, R. Hensel and G. L. Taylor (2001). Tiny TIM: a small, tetrameric, hyperthermostable triosephosphate isomerase. J. Mol. Biol. 306, 745-757. PubMed

Brunner N. A., B. Siebers and R. Hensel (2001). Role of two different glyceraldehyde-3-phosphate dehydrogenases in controlling the reversible Embden-Meyerhof-Parnas pathway in Thermoproteus tenax: regulation on protein and transcript level. Extremophiles 5, 101-109. PubMed

Siebers B. and R. Hensel (2001). Pyrophosphate-dependent 6-phosphofructokinase from Thermoproteus tenax. Methods Enzymol. 331, 54-62. PubMed


Schramm A., B. Siebers, B. Tjaden, H. Brinkmann and R. Hensel (2000). Pyruvate kinase of the hyperthermophilic Crenarchaeote Thermoproteus tenax: physiological role and phylogenetic aspects. J. Bacteriol. 182, 2001-2009. PubMed

Siebers B., H.-P. Klenk and R. Hensel (1998). PPi-dependent phosphofructokinase from Thermoproteus tenax, an archaeal descendant of an ancient line in the phosphofructokinase evolution. J. Bacteriol. 180, 2137-2143. PubMed

Brunner N. A., H. Brinkmann, B. Siebers and R. Hensel (1998). NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax: the first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties. J. Biol. Chem. 273, 6149-6156. PubMed

Hensel R., K. Matussek, K. Michalke, L. Tacke, B. J. Tindall, M. Kohlhoff, B. Siebers and J. Dielenschneider (1997). Sulfophobococcus zilligii gen. nov., spec. nov. a novel hyperthermophilic archaeum isolated from hot alkaline springs of Iceland. Syst. Appl. Microbiol. 20, 102-110.

Siebers B., V. F. Wendisch and R. Hensel (1997). Carbohydrate metabolism inThermoproteus tenax: in vivo utilization of the non-phosphorylative Entner-Doudoroff pathway and characterization of its first enzyme, glucose dehydrogenase. Arch. Microbiol. 168, 120-127. PubMed

Hensel R., S. Fabry, J. Biro, C. Bogedain, I. Jakob and B. Siebers (1994). Glyceraldehyde-3-phosphate dehydrogenases from archaea: objects for studying protein thermoadaptation. Biocatalysis 11, 151-164.

Siebers B. and R. Hensel (1993). Glucose catabolism of the hyperthermophilic archaeum Thermoproteus tenax. FEMS Microbiol. Letts. 111, 1-8.

Siebers B., P. Gräf and E. W. Weiler (1990). Calcium fluxes across the plasma membranes of Commelina communis L. assayed in a cell-free system. Plant Physiol. 93, 940-947. PubMed