ZMB Member Matthias Epple

ZMB Member
Matthias Epple

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Matthias Epple portrait
M. Epple

Prof. Dr. Matthias Epple

Faculty of Chemistry
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

  • Synthesis and functionalization of inorganic nanoparticles, e.g. for gene and drug delivery and immunization
  • Synthesis and characterization of metallic and bimetallic nanoparticles
  • Development and application of biomaterials: polymers, ceramics, metals, composites; in close collaboration with physicians
  • Study of biominerals with high-end solid-state chemical methods
  • Biomimetic crystallization of inorganic materials, pathological crystallization phenomena
  • Reactivity of solids

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Selected Publications

    Journal articles

  • Du, Yanqin; Yang, Xiaoli; Li, Jia; Sokolova, Viktoriya; Zou, Shi; Han, Meihong; Yan, Hu; Wey, Karolin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Epple, Matthias; Wu, Jun
    Delivery of toll-like receptor 3 ligand poly(I:C) to the liver by calcium phosphate nanoparticles conjugated with an F4/80 antibody exerts an anti-hepatitis B virus effect in a mouse model
    In: Acta Biomaterialia (2021)
    ISSN: 1878-7568; 1742-7061
  • Xiang, Chen; Tenkumo, Taichi; Ogawa, Toru; Kanda, Yoshiaki; Nakamura, Keisuke; Shirato, Midori; Sokolova, Viktoriya; Epple, Matthias; Kamano, Yuya; Egusa, Hiroshi; Sasaki, Keiichi
    Gene transfection achieved by utilizing antibacterial calcium phosphate nanoparticles for enhanced regenerative therapy
    In: Acta Biomaterialia Vol. 119 (2021) pp. 375 - 389
    ISSN: 1878-7568; 1742-7061
  • Ruks, Tatjana; Loza, Kateryna; Heggen, Marc; Prymak, Oleg; Sehnem, Andre Luiz; Oliveira, Cristiano L. P.; Bayer, Peter; Beuck, Christine; Epple, Matthias
    Peptide-Conjugated Ultrasmall Gold Nanoparticles (2 nm) for Selective Protein Targeting
    In: ACS Applied Bio Materials Vol. 4 (2021) Nr. 1, pp. 945 - 965
    ISSN: 2576-6422
  • Kollenda, Sebastian; Kopp, Mathis; Wens, Jasmin; Koch, Johannes; Schulze, Nina; Papadopoulos, Chrisovalantis; Pöhler, Robert; Meyer, Hemmo; Epple, Matthias
    A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cells
    In: Acta Biomaterialia Vol. 111 (2020) pp. 406 - 417
    ISSN: 1878-7568; 1742-7061
  • Kollenda, Sebastian; Klose, Jasmin; Knuschke, Torben; Sokolova, Viktoriya; Schmitz, Jochen; Staniszewska, Magdalena; Costa, Pedro Fragoso; Herrmann, Ken; Westendorf, Astrid; Fendler, Wolfgang P.; Epple, Matthias
    In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CT
    In: Acta Biomaterialia Vol. 109 (2020) pp. 244 - 253
    ISSN: 1878-7568; 1742-7061
  • Tenkumo, Taichi; Rojas-Sánchez, Leonardo; Vanegas Sáenz, Juan Ramón; Ogawa, Toru; Miyashita, Makiko; Yoda, Nobuhiro; Prymak, Oleg; Sokolova, Viktoriya; Sasaki, Keiichi; Epple, Matthias
    Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste
    In: Acta Biomaterialia Vol. 105 (2020) pp. 263 - 279
    ISSN: 1878-7568; 1742-7061
  • Sokolova, Viktoriya; Nzou, Goodwell; van der Meer, Selina; Ruks, Tatjana; Heggen, Marc; Loza, Kateryna; Hagemann, Nina; Murke, Florian; Giebel, Bernd; Hermann, Dirk M.; Atala, Anthony J.; Epple, Matthias
    Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model
    In: Acta Biomaterialia Vol. 111 (2020) pp. 349 - 362
    ISSN: 1878-7568; 1742-7061
  • Sokolova, Viktoriya; Rojas-Sánchez, Leonardo; Białas, Nataniel; Schulze, Nina; Epple, Matthias
    Calcium phosphate nanoparticle-mediated transfection in 2D and 3D mono- and co-culture cell models
    In: Acta Biomaterialia Vol. 84 (2019) pp. 391 - 401
    ISSN: 1878-7568; 1742-7061
  • Chernozem, Roman V.; Surmeneva, M.A.; Shkarina, Svetlana N.; Loza, Kateryna; Epple, Matthias; Ulbricht, Mathias; Cecilia, Angelica; Krause, Bärbel; Baumbach, T.; Abalymov, Anatoly A.; Parakhonskiy, Bogdan V.; Skirtach, André G.; Surmenev, R.A.
    Piezoelectric 3-D Fibrous Poly(3-hydroxybutyrate)-Based Scaffolds Ultrasound-Mineralized with Calcium Carbonate for Bone Tissue Engineering : Inorganic Phase Formation, Osteoblast Cell Adhesion, and Proliferation
    In: ACS Applied Materials & Interfaces Vol. 11 (2019) Nr. 21, pp. 19522 - 19533
    ISSN: 1944-8252; 1944-8244
  • Sokolova, Viktoriya; Loza, Kateryna; Knuschke, Torben; Heinen-Weiler, J.; Jastrow, Holger; Hasenberg, Mike; Buer, Jan; Westendorf, Astrid; Gunzer, Matthias; Epple, Matthias
    A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells
    In: Acta Biomaterialia Vol. 80 (2018) pp. 352 - 363
    ISSN: 1878-7568; 1742-7061
  • Epple, Matthias
    Review of potential health risks associated with nanoscopic calcium phosphate
    In: Acta Biomaterialia Vol. 77 (2018) pp. 1 - 14
    ISSN: 1878-7568; 1742-7061
  • van der Meer, Selina; Knuschke, Torben; Frede, Annika; Schulze, Nina; Westendorf, Astrid; Epple, Matthias
    Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo
    In: Acta Biomaterialia Vol. 57 (2017) pp. 414 - 425
    ISSN: 1878-7568; 1742-7061
  • Sokolova, Viktoriya; Shi, Zou; Huang, Shunmei; Du, Yanqin; Kopp, Mathis; Frede, Annika; Knuschke, Torben; Buer, Jan; Yang, Dongliang; Wu, Jun; Westendorf, Astrid; Epple, Matthias
    Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulation
    In: Acta Biomaterialia Vol. 64 (2017) pp. 401 - 410
    ISSN: 1878-7568; 1742-7061
  • Haedicke, Katja; Kozlova, Diana; Gräfe, Susanna; Teichgräber, Ulf; Epple, Matthias; Hilger, Ingrid
    Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapy
    In: Acta Biomaterialia Vol. 14 (2015) pp. 197 - 207
    ISSN: 1878-7568; 1742-7061
  • Althoff, Kristina; Lindner, Sven; Odersky, Andrea; Mestdagh, Pieter; Beckers, Anneleen; Karczewski (ehem.Tillmann), Sarah; Molenaar, Jan J; Bohrer, Anna; Knauer, Shirley; Speleman, Frank; Epple, Matthias; Kozlova, Diana; Yoon, Sena; Baek, Kwanghee; Vandesompele, Jo; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin
    In: International Journal of Cancer Vol. 136 (2015) Nr. 6, pp. 1308 - 1320
    ISSN: 0020-7136; 1097-0215
  • Kordelas, L; Rebmann, Vera; Ludwig, A-K; Radtke, Stefan; Ruesing, J; Döppner, Thorsten R.; Epple, Matthias; Horn, Peter; Beelen, Dietrich; Giebel, Bernd
    MSC-derived exosomes : a novel tool to treat therapy-refractory graft-versus-host disease
    In: Leukemia Vol. 28 (2014) Nr. 4, pp. 970 - 973
    ISSN: 0887-6924; 1476-5551
  • Temchura, Vladimir V.; Kozlova, Diana; Sokolova, Viktoriya; Überla, Klaus; Epple, Matthias
    Targeting and activation of antigen-specific B-cells by calcium phosphate nanoparticles, loaded with protein antigen
    In: Biomaterials Vol. 35 (2014) Nr. 23, pp. 6098 - 6105
    ISSN: 0142-9612; 1878-5905
  • Arcos, D.; Boccaccini, A.R.; Bohner, M.; Díez-Pérez, A.; Epple, Matthias; Gómez-Barrena, E.; Herrera, A.; Planell, J. A.; Rodríguez-Mañas, L.; Maria Vallet-Regi, M.
    The relevance of biomaterials to the prevention and treatment of osteoporosis
    In: Acta Biomaterialia Vol. 10 (2014) Nr. 5, pp. 1793 - 1805
    ISSN: 1878-7568; 1742-7061
  • Enax, Joachim; Janus, Anna M.; Raabe, Dierk; Epple, Matthias; Fabritius, Helge-Otto
    Ultrastructural organization and micromechanical properties of shark tooth enameloid
    In: Acta Biomaterialia Vol. 10 (2014) Nr. 9, pp. 3959 - 3968
    ISSN: 1878-7568; 1742-7061
  • Sokolova, Viktoriya; Kozlova, Diana; Knuschke, Torben; Buer, Jan; Westendorf, Astrid; Epple, Matthias
    Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cells
    In: Acta Biomaterialia Vol. 9 (2013) Nr. 7, pp. 7527 - 7535
    ISSN: 1878-7568; 1742-7061
  • Chernousova, Svitlana; Epple, Matthias
    Silver as Antibacterial Agent : Ion, Nanoparticle, and Metal
    In: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 6, pp. 1636 - 1653
    ISSN: 1433-7851; 1521-3773; 0570-0833
  • Hu, Jun; Kovtun, Anna; Tomaszewski, Anke; Singer, Bernhard B.; Seitz, Berthold; Epple, Matthias; Steuhl, Klaus-Peter; Ergün, Süleyman; Fuchsluger, Thomas
    A new tool for the transfection of corneal endothelial cells : calcium phosphate nanoparticles
    In: Acta Biomaterialia Vol. 8 (2012) Nr. 3, pp. 1156 - 1163
    ISSN: 1878-7568; 1742-7061
  • Greulich, Christina; Diendorf, Jörg; Geßmann, Jan; Simon, Tobias; Habijan, Tim; Eggeler, Gunther; Schildhauer, Thomas A.; Epple, Matthias; Köller, Manfred
    Cell type-specific responses of peripheral blood mononuclear cells to silver nanoparticles
    In: Acta Biomaterialia Vol. 7 (2011) Nr. 9, pp. 3505 - 3514
    ISSN: 1878-7568; 1742-7061
  • Sokolova, Viktoriya; Knuschke, Torben; Buer, Jan; Westendorf, Astrid; Epple, Matthias
    Quantitative determination of the composition of multi-shell calcium phosphate-oligonucleotide nanoparticles and their application for the activation of dendritic cells
    In: Acta Biomaterialia Vol. 7 (2011) Nr. 11, pp. 4029 - 4036
    ISSN: 1878-7568; 1742-7061
  • Greulich, Christina; Diendorf, Jörg; Simon, Tobias; Eggeler, Gunther; Epple, Matthias; Köller, Manfred
    Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cells
    In: Acta Biomaterialia Vol. 7 (2011) Nr. 1, pp. 347 - 354
    ISSN: 1878-7568; 1742-7061
  • Jayabalan, Muthu; Shalumon, K. T.; Mitha, M. K.; Ganesan, Kathirvel; Epple, Matthias
    Effect of hydroxyapatite on the biodegradation and the biomechanical stability of polyester nanocomposites for orthopaedic applications
    In: Acta Biomaterialia Vol. 6 (2010) Nr. 3, pp. 763 - 775
    ISSN: 1878-7568; 1742-7061
  • Zhang, Xin; Kovtun, Anna; Mendoza-Palomares, Carlos; Oulad-Abdelghani, Mustapha; Fioretti, Florence; Rinckenbach, Simon; Mainard, Didier; Epple, Matthias; Benkirane-Jessel, Nadia
    SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing
    In: Biomaterials Vol. 31 (2010) Nr. 23, pp. 6013 - 6018
    ISSN: 0142-9612; 1878-5905
  • Detsch, Rainer; Hagmeyer, Daniel; Neumann, Markus C; Schaefer, Susannne; Vortkamp, Andrea; Wülling, Manuela; Ziegler, Günter; Epple, Matthias
    The resorption of nanocrystalline calcium phosphates by osteoclast-like cells
    In: Acta Biomaterialia Vol. 6 (2010) Nr. 8, pp. 3223 - 3233
    ISSN: 1878-7568; 1742-7061
  • Sokolova, Victoriya; Knuschke, Torben; Kovtun, Anna; Buer, Jan; Epple, Matthias; Westendorf, Astrid
    The use of calcium phosphate nanoparticles encapsulating toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation
    In: Biomaterials Vol. 31 (2010) Nr. 21, pp. 5627 - 5633
    ISSN: 0142-9612; 1878-5905
  • Schwiertz, Janine; Wiehe, Arno; Gräfe, Susanna; Gitter, Burkhard; Epple, Matthias
    Calcium phosphate nanoparticles as efficient carriers for photodynamic therapy against cells and bacteria
    In: Biomaterials Vol. 30 (2009) Nr. 19, pp. 3324 - 3331
    ISSN: 0142-9612; 1878-5905
  • Neumann, Sebastian; Kovtun, Anna; Dietzel, Irmgard D.; Epple, Matthias; Heumann, Rolf
    The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfection
    In: Biomaterials Vol. 30 (2009) Nr. 35, pp. 6794 - 6802
    ISSN: 0142-9612; 1878-5905
  • Ewence, A. E.; Bootman, M.; Roderick, L.; Skepper, J. N.; McCarthy, G.; Epple, Matthias; Neumann, M.; Shanahan, C. M.; Proudfoot, D.
    Calcium phosphate crystals induce cell death in human vascular smooth muscle cells : A potential mechanism in atherosclerotic plaque destabilization
    In: Circulation Research Vol. 103 (2008) pp. e28 - e32
    ISSN: 1524-4571; 0009-7330
  • Epple, Matthias
    From metal complexes to nanominerals : the formation of inorganic nanoparticles on fibrils of transferrin
    In: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 27, pp. 4960 - 4961
    ISSN: 1521-3773
  • Sokolova, Viktoriya; Epple, Matthias
    Inorganic nanoparticles as carriers of nucleic acids into cells
    In: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 8, pp. 1382 - 1395
    ISSN: 1521-3773; 1433-7851; 0570-0833
  • Epple, Matthias
    Von Metallkomplexen zu Nanomineralien : die Bildung anorganischer Nanopartikel auf Fibrillen von Transferrin
    In: Angewandte Chemie International Edition Vol. 120 (2008) Nr. 27, pp. 5038 - 5039
    ISSN: 1521-3757
  • Neues, Frank; Epple, Matthias
    X-ray Microcomputer Tomography for the Study of Biomineralized Endo- and Exoskeletons of Animals
    In: Chemical Reviews Vol. 108 (2008) Nr. 11, pp. 4734 - 4741
    ISSN: 1520-6890; 0009-2665
  • Neues, Frank; Epple, Matthias
    X-ray micro computer tomography for the study of bio¬minera¬lized endo- and exoskeletons of animals
    In: Chemical Reviews Vol. 108 (2008) pp. 4734 - 4741
    ISSN: 1520-6890; 0009-2665
  • Eufinger, Harald; Rasche, Christian; Lehmbrock, Jutta; Wehmöller, Michael; Weihe, Stephan; Schmitz, Inge; Schiller, Carsten; Epple, Matthias
    Performance of functionally graded implants of polylactides and calcium phosphate/calcium carbonate in an ovine model for computer assisted craniectomy and cranioplasty
    In: Biomaterials Vol. 28 (2007) Nr. 3, pp. 475 - 485
    ISSN: 0142-9612; 1878-5905
  • Sokolova, Viktoriya; Radtke, Ina; Heumann, Rolf; Epple, Matthias
    Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles
    In: Biomaterials Vol. 27 (2006) Nr. 16, pp. 3147 - 3153
    ISSN: 0142-9612; 1878-5905
  • Prymak, Oleg; Bogdanski, Denise; Köller, Manfred; Esenwein, Stefan A.; Muhr, Gert; Beckmann, Felix; Donath, Tilmann; Assad, Michel; Epple, Matthias
    Morphological characterization and in vitro biocompatibility of a porous nickel-titanium alloy
    In: Biomaterials Vol. 26 (2005) Nr. 29, pp. 5801 - 5807
    ISSN: 0142-9612; 1878-5905
  • Tadic, Drazen; Beckmann, Felix; Schwarz, Karsten; Epple, Matthias
    A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sintering
    In: Biomaterials Vol. 25 (2004) Nr. 16, pp. 3335 - 3340
    ISSN: 0142-9612; 1878-5905
  • Tadic, Drazen; Epple, Matthias
    A thorough physicochemical characterisation of 14 calcium phosphate-based bone substitution materials in comparison to natural bone
    In: Biomaterials Vol. 25 (2004) Nr. 6, pp. 987 - 994
    ISSN: 0142-9612; 1878-5905
  • Schiller, Carsten; Rasche, Christian; Wehmöller, Michaela; Beckmann, Felix; Eufinger, Harald; Epple, Matthias; Weihe, Stephan
    Geometrically structured implants for cranial reconstruction made of biodegradable polyesters and calcium phosphate/calcium carbonate
    In: Biomaterials Vol. 25 (2004) Nr. 7-8, pp. 1239 - 1247
    ISSN: 0142-9612; 1878-5905
  • Bogdanski, Denise; Esenwein, Stefan A.; Prymak, Oleg; Epple, Matthias; Muhr, Gert; Köller, Manfred
    Inhibition of PMN apoptosis after adherence to dip-coated calcium phosphate surfaces on a NiTi shape memory alloy
    In: Biomaterials Vol. 25 (2004) Nr. 19, pp. 4627 - 4632
    ISSN: 0142-9612; 1878-5905
  • Choi, Jongsik; Bogdanski, Denise; Köller, Manfred; Esenwein, Stefan A.; Müller, Dietmar; Muhr, Gert; Epple, Matthias
    Calcium phosphate coating of nickel-titanium shape-memory alloys : Coating procedure and adherence of leukocytes and platelets
    In: Biomaterials Vol. 24 (2003) Nr. 21, pp. 3689 - 3696
    ISSN: 0142-9612; 1878-5905
  • Schiller, Carsten; Epple, Matthias
    Carbonated calcium phosphates are suitable pH-stabilising fillers for biodegradable polyesters
    In: Biomaterials Vol. 24 (2003) Nr. 12, pp. 2037 - 2043
    ISSN: 0142-9612; 1878-5905
  • Tadic, Drazen; Epple, Matthias
    Mechanically stable implants of synthetic bone mineral by cold isostatic pressing
    In: Biomaterials Vol. 24 (2003) Nr. 25, pp. 4565 - 4571
    ISSN: 0142-9612; 1878-5905
  • Dorozhkin, Sergey V.; Epple, Matthias
    Biological and Medical Significance of Calcium Phosphates
    In: Angewandte Chemie International Edition Vol. 41 (2002) Nr. 17, pp. 3130 - 3146
    ISSN: 1521-3773; 0570-0833; 1433-7851
  • Tadic, Drazen; Peters, Fabian; Epple, Matthias
    Continuous synthesis of amorphous carbonated apatites
    In: Biomaterials Vol. 23 (2002) Nr. 12, pp. 2553 - 2559
    ISSN: 0142-9612
  • Bogdanski, Denise; Koller, Manfred; Muller, Dietmar; Muhr, Gert; Bram, Martin; Buchkremer, Hans Peter; Stover, Detlev; Choi, Jongsik; Epple, Matthias
    Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material
    In: Biomaterials Vol. 23 (2002) Nr. 23, pp. 4549 - 4555
    ISSN: 0142-9612
  • Cammenga, Heiko Karl; Epple, Matthias
    Basic Principles of Thermoanalytical Techniques and Their Applications in Preparative Chemistry
    In: Angewandte Chemie International Edition Vol. 34 (1995) Nr. 11, pp. 1171 - 1187
    ISSN: 1521-3773; 0570-0833; 1433-7851