ZMB Member Matthias Epple
ZMB Member
Matthias Epple
Next ZMB-Member
Prof. Dr. Matthias Epple
Group
Inorganic ChemistryFaculty of Chemistry
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 2402
- Website
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
- Synthesis and functionalization of inorganic nanoparticles, e.g. for gene and drug delivery and immunization
- Synthesis and characterization of metallic and bimetallic nanoparticles
- Development and application of biomaterials: polymers, ceramics, metals, composites; in close collaboration with physicians
- Study of biominerals with high-end solid-state chemical methods
- Biomimetic crystallization of inorganic materials, pathological crystallization phenomena
- Reactivity of solids
Selected Publications
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Delivery of toll-like receptor 3 ligand poly(I:C) to the liver by calcium phosphate nanoparticles conjugated with an F4/80 antibody exerts an anti-hepatitis B virus effect in a mouse modelIn: Acta Biomaterialia (2021)
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Gene transfection achieved by utilizing antibacterial calcium phosphate nanoparticles for enhanced regenerative therapyIn: Acta Biomaterialia Vol. 119 (2021) pp. 375 - 389
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Peptide-Conjugated Ultrasmall Gold Nanoparticles (2 nm) for Selective Protein TargetingIn: ACS Applied Bio Materials (2021) in press
ISSN: 2576-6422Online Full Text: dx.doi.org/ -
A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cellsIn: Acta Biomaterialia Vol. 111 (2020) pp. 406 - 417
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CTIn: Acta Biomaterialia Vol. 109 (2020) pp. 244 - 253
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate pasteIn: Acta Biomaterialia Vol. 105 (2020) pp. 263 - 279
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid modelIn: Acta Biomaterialia Vol. 111 (2020) pp. 349 - 362
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Calcium phosphate nanoparticle-mediated transfection in 2D and 3D mono- and co-culture cell modelsIn: Acta Biomaterialia Vol. 84 (2019) pp. 391 - 401
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Piezoelectric 3-D Fibrous Poly(3-hydroxybutyrate)-Based Scaffolds Ultrasound-Mineralized with Calcium Carbonate for Bone Tissue Engineering : Inorganic Phase Formation, Osteoblast Cell Adhesion, and ProliferationIn: ACS Applied Materials & Interfaces Vol. 11 (2019) Nr. 21, pp. 19522 - 19533
ISSN: 1944-8252; 1944-8244Online Full Text: dx.doi.org/ -
A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cellsIn: Acta Biomaterialia Vol. 80 (2018) pp. 352 - 363
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Review of potential health risks associated with nanoscopic calcium phosphateIn: Acta Biomaterialia Vol. 77 (2018) pp. 1 - 14
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivoIn: Acta Biomaterialia Vol. 57 (2017) pp. 414 - 425
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulationIn: Acta Biomaterialia Vol. 64 (2017) pp. 401 - 410
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapyIn: Acta Biomaterialia Vol. 14 (2015) pp. 197 - 207
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating SurvivinIn: International Journal of Cancer Vol. 136 (2015) Nr. 6, pp. 1308 - 1320
ISSN: 0020-7136; 1097-0215Online Full Text: dx.doi.org/ (Open Access) -
MSC-derived exosomes : a novel tool to treat therapy-refractory graft-versus-host diseaseIn: Leukemia Vol. 28 (2014) Nr. 4, pp. 970 - 973
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
Targeting and activation of antigen-specific B-cells by calcium phosphate nanoparticles, loaded with protein antigenIn: Biomaterials Vol. 35 (2014) Nr. 23, pp. 6098 - 6105
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
The relevance of biomaterials to the prevention and treatment of osteoporosisIn: Acta Biomaterialia Vol. 10 (2014) Nr. 5, pp. 1793 - 1805
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Ultrastructural organization and micromechanical properties of shark tooth enameloidIn: Acta Biomaterialia Vol. 10 (2014) Nr. 9, pp. 3959 - 3968
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cellsIn: Acta Biomaterialia Vol. 9 (2013) Nr. 7, pp. 7527 - 7535
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Silver as Antibacterial Agent : Ion, Nanoparticle, and MetalIn: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 6, pp. 1636 - 1653
ISSN: 1433-7851; 1521-3773Online Full Text: dx.doi.org/ -
A new tool for the transfection of corneal endothelial cells : calcium phosphate nanoparticlesIn: Acta Biomaterialia Vol. 8 (2012) Nr. 3, pp. 1156 - 1163
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Cell type-specific responses of peripheral blood mononuclear cells to silver nanoparticlesIn: Acta Biomaterialia Vol. 7 (2011) Nr. 9, pp. 3505 - 3514
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Quantitative determination of the composition of multi-shell calcium phosphate-oligonucleotide nanoparticles and their application for the activation of dendritic cellsIn: Acta Biomaterialia Vol. 7 (2011) Nr. 11, pp. 4029 - 4036
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cellsIn: Acta Biomaterialia Vol. 7 (2011) Nr. 1, pp. 347 - 354
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Effect of hydroxyapatite on the biodegradation and the biomechanical stability of polyester nanocomposites for orthopaedic applicationsIn: Acta Biomaterialia Vol. 6 (2010) Nr. 3, pp. 763 - 775
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencingIn: Biomaterials Vol. 31 (2010) Nr. 23, pp. 6013 - 6018
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
The resorption of nanocrystalline calcium phosphates by osteoclast-like cellsIn: Acta Biomaterialia Vol. 6 (2010) Nr. 8, pp. 3223 - 3233
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
The use of calcium phosphate nanoparticles encapsulating toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activationIn: Biomaterials Vol. 31 (2010) Nr. 21, pp. 5627 - 5633
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Calcium phosphate nanoparticles as efficient carriers for photodynamic therapy against cells and bacteriaIn: Biomaterials Vol. 30 (2009) Nr. 19, pp. 3324 - 3331
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfectionIn: Biomaterials Vol. 30 (2009) Nr. 35, pp. 6794 - 6802
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Calcium phosphate crystals induce cell death in human vascular smooth muscle cells : A potential mechanism in atherosclerotic plaque destabilizationIn: Circulation Research Vol. 103 (2008) pp. e28 - e32
ISSN: 1524-4571; 0009-7330Online Full Text: dx.doi.org/ -
From metal complexes to nanominerals : the formation of inorganic nanoparticles on fibrils of transferrinIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 27, pp. 4960 - 4961
ISSN: 1521-3773Online Full Text: dx.doi.org/ -
Inorganic nanoparticles as carriers of nucleic acids into cellsIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 8, pp. 1382 - 1395
ISSN: 1521-3773Online Full Text: dx.doi.org/ -
Von Metallkomplexen zu Nanomineralien : die Bildung anorganischer Nanopartikel auf Fibrillen von TransferrinIn: Angewandte Chemie International Edition Vol. 120 (2008) Nr. 27, pp. 5038 - 5039
ISSN: 1521-3757Online Full Text: dx.doi.org/ -
X-ray Microcomputer Tomography for the Study of Biomineralized Endo- and Exoskeletons of AnimalsIn: Chemical Reviews Vol. 108 (2008) Nr. 11, pp. 4734 - 4741
ISSN: 1520-6890; 0009-2665Online Full Text: dx.doi.org/ -
X-ray micro computer tomography for the study of bio¬minera¬lized endo- and exoskeletons of animalsIn: Chemical Reviews Vol. 108 (2008) pp. 4734 - 4741
ISSN: 1520-6890; 0009-2665 -
Performance of functionally graded implants of polylactides and calcium phosphate/calcium carbonate in an ovine model for computer assisted craniectomy and cranioplastyIn: Biomaterials Vol. 28 (2007) Nr. 3, pp. 475 - 485
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticlesIn: Biomaterials Vol. 27 (2006) Nr. 16, pp. 3147 - 3153
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Morphological characterization and in vitro biocompati-bility of a porous nickel-titanium alloyIn: Biomaterials Vol. 26 (2005) pp. 5801 - 5807
ISSN: 0142-9612; 1878-5905 -
Morphological characterization and in vitro biocompatibility of a porous nickel-titanium alloyIn: Biomaterials Vol. 26 (2005) Nr. 29, pp. 5801 - 5807
ISSN: 0142-9612Online Full Text: dx.doi.org/ -
A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sinteringIn: Biomaterials Vol. 25 (2004) Nr. 16, pp. 3335 - 3340
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
A thorough physicochemical characterisation of 14 calcium phosphate-based bone substitution materials in comparison to natural boneIn: Biomaterials Vol. 25 (2004) Nr. 6, pp. 987 - 994
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Geometrically structured implants for cranial reconstruction made of biodegradable polyesters and calcium phosphate/calcium carbonateIn: Biomaterials Vol. 25 (2004) Nr. 7-8, pp. 1239 - 1247
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Inhibition of PMN apoptosis after adherence to dip-coated calcium phosphate surfaces on a NiTi shape memory alloyIn: Biomaterials Vol. 25 (2004) Nr. 19, pp. 4627 - 4632
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Calcium phosphate coating of nickel-titanium shape-memory alloys : Coating procedure and adherence of leukocytes and plateletsIn: Biomaterials Vol. 24 (2003) Nr. 21, pp. 3689 - 3696
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Carbonated calcium phosphates are suitable pH-stabilising fillers for biodegradable polyestersIn: Biomaterials Vol. 24 (2003) Nr. 12, pp. 2037 - 2043
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Mechanically stable implants of synthetic bone mineral by cold isostatic pressingIn: Biomaterials Vol. 24 (2003) Nr. 25, pp. 4565 - 4571
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Biological and Medical Significance of Calcium PhosphatesIn: Angewandte Chemie International Edition Vol. 41 (2002) Nr. 17, pp. 3130 - 3146
ISSN: 1433-7851; 1521-3773Online Full Text: dx.doi.org/ -
Continuous synthesis of amorphous carbonated apatitesIn: Biomaterials Vol. 23 (2002) Nr. 12, pp. 2553 - 2559
ISSN: 0142-9612Online Full Text: dx.doi.org/ -
Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti materialIn: Biomaterials Vol. 23 (2002) Nr. 23, pp. 4549 - 4555
ISSN: 0142-9612Online Full Text: dx.doi.org/ -
Basic Principles of Thermoanalytical Techniques and Their Applications in Preparative ChemistryIn: Angewandte Chemie International Edition Vol. 34 (1995) Nr. 11, pp. 1171 - 1187
ISSN: 1521-3773; 0570-0833Online Full Text: dx.doi.org/