ZMB Member Matthias Epple

ZMB Member
Matthias Epple

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Matthias Epple portrait
M. Epple

Prof. Dr. Matthias Epple

Group

Inorganic Chemistry

Faculty of Chemistry
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

  • Synthesis and functionalization of inorganic nanoparticles, e.g. for gene and drug delivery and immunization
  • Synthesis and characterization of metallic and bimetallic nanoparticles
  • Development and application of biomaterials: polymers, ceramics, metals, composites; in close collaboration with physicians
  • Study of biominerals with high-end solid-state chemical methods
  • Biomimetic crystallization of inorganic materials, pathological crystallization phenomena
  • Reactivity of solids

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Selected Publications

    Journal articles

  • Sokolova, V.; Loza, Kateryna; Ebel, J.F.; Buer, Jan; Westendorf, Astrid; Epple, Matthias
    Barium sulphate microparticles are taken up by three different cell types: HeLa, THP-1, and hMSC
    In: Acta Biomaterialia, Vol. 164, 2023, pp. 577 – 587
    DOI
  • Machla, F.; Sokolova, V.; Platania, V.; Prymak, O.; Kostka, K.; Kruse, B.; Agrymakis, M.; Pasadaki, S.; Kritis, A.; Alpantaki, K.; Vidaki, M.; Chatzinikolaidou, M.; Epple, Matthias; Bakopoulou, A.
    Tissue engineering at the dentin-pulp interface using human treated dentin scaffolds conditioned with DMP1 or BMP2 plasmid DNA-carrying calcium phosphate nanoparticles
    In: Acta Biomaterialia, Vol. 159, 2023, pp. 156 – 172
    DOI
  • Damm, D.; Kostka, Kathrin; Weingärtner, C.; Wagner, J.T.; Rojas-Sánchez, L.; Gensberger-Reigl, S.; Sokolova, Viktoriya; Überla, K.; Epple, Matthias; Temchura, V.
    Covalent coupling of HIV-1 glycoprotein trimers to biodegradable calcium phosphate nanoparticles via genetically encoded aldehyde-tags
    In: Acta Biomaterialia, Vol. 140, 2022, pp. 586 – 600
    DOI (Open Access)
  • Wey, Karolin; Schirrmann, Ronja; Diesing, Detlef; Lang, Stephan; Brandau, Sven; Hansen, Stefan; Epple, Matthias
    Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteins
    In: Biomaterials, Vol. 276, 2021
    DOI
  • Du, Yanqin; Yang, Xiaoli; Li, Jia; Sokolova, Viktoriya; Zou, Shi; Han, Meihong; Yan, Hu; Wey, Karolin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Epple, Matthias; Wu, Jun
    Delivery of toll-like receptor 3 ligand poly(I:C) to the liver by calcium phosphate nanoparticles conjugated with an F4/80 antibody exerts an anti-hepatitis B virus effect in a mouse model
    In: Acta Biomaterialia, Vol. 133, 2021, pp. 297 – 307
    DOI
  • Xiang, Chen; Tenkumo, Taichi; Ogawa, Toru; Kanda, Yoshiaki; Nakamura, Keisuke; Shirato, Midori; Sokolova, Viktoriya; Epple, Matthias; Kamano, Yuya; Egusa, Hiroshi; Sasaki, Keiichi
    Gene transfection achieved by utilizing antibacterial calcium phosphate nanoparticles for enhanced regenerative therapy
    In: Acta Biomaterialia, Vol. 119, 2021, pp. 375 – 389
    DOI
  • Bialas, Nataniel; Müller, Elena K.; Epple, Matthias; Hilger, Ingrid
    Silica-coated calcium phosphate nanoparticles for gene silencing of NF-κB p65 by siRNA and their impact on cellular players of inflammation
    In: Biomaterials, Vol. 276, 2021, pp. 121013
    DOI
  • Kollenda, Sebastian; Kopp, Mathis; Wens, Jasmin; Koch, Johannes; Schulze, Nina; Papadopoulos, Chrisovalantis; Pöhler, Robert; Meyer, Hemmo; Epple, Matthias
    A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cells
    In: Acta Biomaterialia, Vol. 111, 2020, pp. 406 – 417
    DOI
  • Rojas-Sánchez, Leonardo; Zhang, Ejuan; Sokolova, Viktoriya; Zhong, Maohua; Yan, Hu; Lu, Mengji; Li, Qian; Yan, Huimin; Epple, Matthias
    Genetic immunization against hepatitis B virus with calcium phosphate nanoparticles in vitro and in vivo
    In: Acta Biomaterialia, Vol. 110, 2020, pp. 254 – 265
    DOI
  • Kollenda, Sebastian; Klose, Jasmin; Knuschke, Torben; Sokolova, Viktoriya; Schmitz, Jochen; Staniszewska, Magdalena; Costa, Pedro Fragoso; Herrmann, Ken; Westendorf, Astrid; Fendler, Wolfgang; Epple, Matthias
    In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CT
    In: Acta Biomaterialia, Vol. 109, 2020, pp. 244 – 253
    DOI
  • Tenkumo, Taichi; Rojas-Sánchez, Leonardo; Vanegas Sáenz, Juan Ramón; Ogawa, Toru; Miyashita, Makiko; Yoda, Nobuhiro; Prymak, Oleg; Sokolova, Viktoriya; Sasaki, Keiichi; Epple, Matthias
    Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste
    In: Acta Biomaterialia, Vol. 105, 2020, pp. 263 – 279
    DOI
  • Sokolova, Viktoriya; Nzou, Goodwell; van der Meer, Selina; Ruks, Tatjana; Heggen, Marc; Loza, Kateryna; Hagemann, Nina; Murke, Florian; Giebel, Bernd; Hermann, Dirk M.; Atala, Anthony J.; Epple, Matthias
    Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model
    In: Acta Biomaterialia, Vol. 111, 2020, pp. 349 – 362
    DOI
  • Sokolova, Viktoriya; Rojas-Sánchez, Leonardo; Bialas, Nataniel; Schulze, Nina; Epple, Matthias
    Calcium phosphate nanoparticle-mediated transfection in 2D and 3D mono- and co-culture cell models
    In: Acta Biomaterialia, Vol. 84, 2019, pp. 391 – 401
    DOI
  • Sokolova, Viktoriya; Loza, Kateryna; Knuschke, Torben; Heinen-Weiler, J.; Jastrow, Holger; Hasenberg, Mike; Buer, Jan; Westendorf, Astrid; Gunzer, Matthias; Epple, Matthias
    A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells
    In: Acta Biomaterialia, Vol. 80, 2018, pp. 352 – 363
    DOI
  • Epple, Matthias
    Review of potential health risks associated with nanoscopic calcium phosphate
    In: Acta Biomaterialia, Vol. 77, 2018, pp. 1 – 14
    DOI
  • van der Meer, Selina; Knuschke, Torben; Frede, Annika; Schulze, Nina; Westendorf, Astrid; Epple, Matthias
    Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo
    In: Acta Biomaterialia, Vol. 57, 2017, pp. 414 – 425
    DOI
  • Sokolova, Viktoriya; Shi, Zou; Huang, Shunmei; Du, Yanqin; Kopp, Mathis; Frede, Annika; Knuschke, Torben; Buer, Jan; Yang, Dongliang; Wu, Jun; Westendorf, Astrid; Epple, Matthias
    Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulation
    In: Acta Biomaterialia, Vol. 64, 2017, pp. 401 – 410
    DOI
  • Haedicke, Katja; Kozlova, Diana; Gräfe, Susanna; Teichgräber, Ulf; Epple, Matthias; Hilger, Ingrid
    Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapy
    In: Acta Biomaterialia, Vol. 14, 2015, pp. 197 – 207
    DOI
  • Althoff, Kristina; Lindner, Sven; Odersky, Andrea; Mestdagh, Pieter; Beckers, Anneleen; Karczewski, Sarah; Molenaar, Jan J; Bohrer, Anna; Knauer, Shirley; Speleman, Frank; Epple, Matthias; Kozlova, Diana; Yoon, Sena; Baek, Kwanghee; Vandesompele, Jo; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin
    In: International Journal of Cancer, Vol. 136, 2015, Nr. 6, pp. 1308 – 1320
    DOI (Open Access)
  • Kordelas, L; Rebmann, Vera; Ludwig, A-K; Radtke, Stefan; Ruesing, J; Döppner, Thorsten R.; Epple, Matthias; Horn, Peter; Beelen, Dietrich; Giebel, Bernd
    MSC-derived exosomes : a novel tool to treat therapy-refractory graft-versus-host disease
    In: Leukemia, Vol. 28, 2014, Nr. 4, pp. 970 – 973
    DOI
  • Temchura, Vladimir V.; Kozlova, Diana; Sokolova, Viktoriya; Überla, Klaus; Epple, Matthias
    Targeting and activation of antigen-specific B-cells by calcium phosphate nanoparticles, loaded with protein antigen
    In: Biomaterials, Vol. 35, 2014, Nr. 23, pp. 6098 – 6105
    DOI
  • Arcos, D.; Boccaccini, A.R.; Bohner, M.; Díez-Pérez, A.; Epple, Matthias; Gómez-Barrena, E.; Herrera, A.; Planell, J. A.; Rodríguez-Mañas, L.; Maria Vallet-Regi, M.
    The relevance of biomaterials to the prevention and treatment of osteoporosis
    In: Acta Biomaterialia, Vol. 10, 2014, Nr. 5, pp. 1793 – 1805
    DOI
  • Enax, Joachim; Janus, Anna M.; Raabe, Dierk; Epple, Matthias; Fabritius, Helge-Otto
    Ultrastructural organization and micromechanical properties of shark tooth enameloid
    In: Acta Biomaterialia, Vol. 10, 2014, Nr. 9, pp. 3959 – 3968
    DOI
  • Sokolova, Viktoriya; Kozlova, Diana; Knuschke, Torben; Buer, Jan; Westendorf, Astrid; Epple, Matthias
    Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cells
    In: Acta Biomaterialia, Vol. 9, 2013, Nr. 7, pp. 7527 – 7535
    DOI
  • Chernousova, Svitlana; Epple, Matthias
    Silver as Antibacterial Agent : Ion, Nanoparticle, and Metal
    In: Angewandte Chemie International Edition, Vol. 52, 2013, Nr. 6, pp. 1636 – 1653
    DOI
  • Hu, Jun; Kovtun, Anna; Tomaszewski, Anke; Singer, Bernhard B.; Seitz, Berthold; Epple, Matthias; Steuhl, Klaus-Peter; Ergün, Süleyman; Fuchsluger, Thomas
    A new tool for the transfection of corneal endothelial cells : calcium phosphate nanoparticles
    In: Acta Biomaterialia, Vol. 8, 2012, Nr. 3, pp. 1156 – 1163
    DOI
  • Greulich, Christina; Diendorf, Jörg; Geßmann, Jan; Simon, Tobias; Habijan, Tim; Eggeler, Gunther; Schildhauer, Thomas A.; Epple, Matthias; Köller, Manfred
    Cell type-specific responses of peripheral blood mononuclear cells to silver nanoparticles
    In: Acta Biomaterialia, Vol. 7, 2011, Nr. 9, pp. 3505 – 3514
    DOI
  • Sokolova, Viktoriya; Knuschke, Torben; Buer, Jan; Westendorf, Astrid; Epple, Matthias
    Quantitative determination of the composition of multi-shell calcium phosphate-oligonucleotide nanoparticles and their application for the activation of dendritic cells
    In: Acta Biomaterialia, Vol. 7, 2011, Nr. 11, pp. 4029 – 4036
    DOI
  • Greulich, Christina; Diendorf, Jörg; Simon, Tobias; Eggeler, Gunther; Epple, Matthias; Köller, Manfred
    Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cells
    In: Acta Biomaterialia, Vol. 7, 2011, Nr. 1, pp. 347 – 354
    DOI
  • Jayabalan, Muthu; Shalumon, K. T.; Mitha, M. K.; Ganesan, Kathirvel; Epple, Matthias
    Effect of hydroxyapatite on the biodegradation and the biomechanical stability of polyester nanocomposites for orthopaedic applications
    In: Acta Biomaterialia, Vol. 6, 2010, Nr. 3, pp. 763 – 775
    DOI
  • Zhang, Xin; Kovtun, Anna; Mendoza-Palomares, Carlos; Oulad-Abdelghani, Mustapha; Fioretti, Florence; Rinckenbach, Simon; Mainard, Didier; Epple, Matthias; Benkirane-Jessel, Nadia
    SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing
    In: Biomaterials, Vol. 31, 2010, Nr. 23, pp. 6013 – 6018
    DOI
  • Detsch, Rainer; Hagmeyer, Daniel; Neumann, Markus C; Schaefer, Susannne; Vortkamp, Andrea; Wülling, Manuela; Ziegler, Günter; Epple, Matthias
    The resorption of nanocrystalline calcium phosphates by osteoclast-like cells
    In: Acta Biomaterialia, Vol. 6, 2010, Nr. 8, pp. 3223 – 3233
    DOI
  • Sokolova, Victoriya; Knuschke, Torben; Kovtun, Anna; Buer, Jan; Epple, Matthias; Westendorf, Astrid
    The use of calcium phosphate nanoparticles encapsulating toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation
    In: Biomaterials, Vol. 31, 2010, Nr. 21, pp. 5627 – 5633
    DOI
  • Schwiertz, Janine; Wiehe, Arno; Gräfe, Susanna; Gitter, Burkhard; Epple, Matthias
    Calcium phosphate nanoparticles as efficient carriers for photodynamic therapy against cells and bacteria
    In: Biomaterials, Vol. 30, 2009, Nr. 19, pp. 3324 – 3331
    DOI
  • Neumann, Sebastian; Kovtun, Anna; Dietzel, Irmgard D.; Epple, Matthias; Heumann, Rolf
    The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfection
    In: Biomaterials, Vol. 30, 2009, Nr. 35, pp. 6794 – 6802
    DOI
  • Ewence, A. E.; Bootman, M.; Roderick, L.; Skepper, J. N.; McCarthy, G.; Epple, Matthias; Neumann, M.; Shanahan, C. M.; Proudfoot, D.
    Calcium phosphate crystals induce cell death in human vascular smooth muscle cells : A potential mechanism in atherosclerotic plaque destabilization
    In: Circulation Research, Vol. 103, 2008, pp. e28 – e32
    DOI
  • Epple, Matthias
    From metal complexes to nanominerals : the formation of inorganic nanoparticles on fibrils of transferrin
    In: Angewandte Chemie International Edition, Vol. 47, 2008, Nr. 27, pp. 4960 – 4961
    DOI
  • Sokolova, Viktoriya; Epple, Matthias
    Inorganic nanoparticles as carriers of nucleic acids into cells
    In: Angewandte Chemie International Edition, Vol. 47, 2008, Nr. 8, pp. 1382 – 1395
    DOI
  • Neues, Frank; Epple, Matthias
    X-ray Microcomputer Tomography for the Study of Biomineralized Endo- and Exoskeletons of Animals
    In: Chemical Reviews, Vol. 108, 2008, Nr. 11, pp. 4734 – 4741
    DOI
  • Neues, Frank; Epple, Matthias
    X-ray micro computer tomography for the study of bio¬minera¬lized endo- and exoskeletons of animals
    In: Chemical Reviews, Vol. 108, 2008, pp. 4734 – 4741
  • Eufinger, Harald; Rasche, Christian; Lehmbrock, Jutta; Wehmöller, Michael; Weihe, Stephan; Schmitz, Inge; Schiller, Carsten; Epple, Matthias
    Performance of functionally graded implants of polylactides and calcium phosphate/calcium carbonate in an ovine model for computer assisted craniectomy and cranioplasty
    In: Biomaterials, Vol. 28, 2007, Nr. 3, pp. 475 – 485
    DOI
  • Sokolova, Viktoriya; Radtke, Ina; Heumann, Rolf; Epple, Matthias
    Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles
    In: Biomaterials, Vol. 27, 2006, Nr. 16, pp. 3147 – 3153
    DOI
  • Prymak, Oleg; Bogdanski, Denise; Köller, Manfred; Esenwein, Stefan A.; Muhr, Gert; Beckmann, Felix; Donath, Tilmann; Assad, Michel; Epple, Matthias
    Morphological characterization and in vitro biocompatibility of a porous nickel-titanium alloy
    In: Biomaterials, Vol. 26, 2005, Nr. 29, pp. 5801 – 5807
    DOI
  • Tadic, Drazen; Beckmann, Felix; Schwarz, Karsten; Epple, Matthias
    A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sintering
    In: Biomaterials, Vol. 25, 2004, Nr. 16, pp. 3335 – 3340
    DOI
  • Tadic, Drazen; Epple, Matthias
    A thorough physicochemical characterisation of 14 calcium phosphate-based bone substitution materials in comparison to natural bone
    In: Biomaterials, Vol. 25, 2004, Nr. 6, pp. 987 – 994
    DOI
  • Schiller, Carsten; Rasche, Christian; Wehmöller, Michaela; Beckmann, Felix; Eufinger, Harald; Epple, Matthias; Weihe, Stephan
    Geometrically structured implants for cranial reconstruction made of biodegradable polyesters and calcium phosphate/calcium carbonate
    In: Biomaterials, Vol. 25, 2004, Nr. 7-8, pp. 1239 – 1247
    DOI
  • Bogdanski, Denise; Esenwein, Stefan A.; Prymak, Oleg; Epple, Matthias; Muhr, Gert; Köller, Manfred
    Inhibition of PMN apoptosis after adherence to dip-coated calcium phosphate surfaces on a NiTi shape memory alloy
    In: Biomaterials, Vol. 25, 2004, Nr. 19, pp. 4627 – 4632
    DOI
  • Choi, Jongsik; Bogdanski, Denise; Köller, Manfred; Esenwein, Stefan A.; Müller, Dietmar; Muhr, Gert; Epple, Matthias
    Calcium phosphate coating of nickel-titanium shape-memory alloys : Coating procedure and adherence of leukocytes and platelets
    In: Biomaterials, Vol. 24, 2003, Nr. 21, pp. 3689 – 3696
    DOI
  • Schiller, Carsten; Epple, Matthias
    Carbonated calcium phosphates are suitable pH-stabilising fillers for biodegradable polyesters
    In: Biomaterials, Vol. 24, 2003, Nr. 12, pp. 2037 – 2043
    DOI
  • Tadic, Drazen; Epple, Matthias
    Mechanically stable implants of synthetic bone mineral by cold isostatic pressing
    In: Biomaterials, Vol. 24, 2003, Nr. 25, pp. 4565 – 4571
    DOI
  • Dorozhkin, Sergey V.; Epple, Matthias
    Biological and Medical Significance of Calcium Phosphates
    In: Angewandte Chemie International Edition, Vol. 41, 2002, Nr. 17, pp. 3130 – 3146
    DOI
  • Tadic, Drazen; Peters, Fabian; Epple, Matthias
    Continuous synthesis of amorphous carbonated apatites
    In: Biomaterials, Vol. 23, 2002, Nr. 12, pp. 2553 – 2559
    DOI
  • Bogdanski, Denise; Koller, Manfred; Muller, Dietmar; Muhr, Gert; Bram, Martin; Buchkremer, Hans Peter; Stover, Detlev; Choi, Jongsik; Epple, Matthias
    Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material
    In: Biomaterials, Vol. 23, 2002, Nr. 23, pp. 4549 – 4555
    DOI
  • Cammenga, Heiko Karl; Epple, Matthias
    Basic Principles of Thermoanalytical Techniques and Their Applications in Preparative Chemistry
    In: Angewandte Chemie International Edition, Vol. 34, 1995, Nr. 11, pp. 1171 – 1187
    DOI
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