ZMB Member Dana Branzei

ZMB Member
Dana Branzei

Next ZMB-Member
Dana Branzei portrait
© UDE/Bettina Engel-Albustin

Prof. Dr. Dana Branzei

Group

Biological and Genomic Treatment Approaches

Research Center One Health Ruhr
University Alliance Ruhr
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

Dana Branzei, investigates how cells are able to repair and tolerate DNA damage and how the various DNA repair mechanisms are coupled with each other and with other cellular processes. With her studies on the inner workings of error-free DNA damage tolerance, she achieved a breakthrough: she was able to demonstrate that DNA repair mechanisms are integrated into the recognition of DNA damage and into the reactions of chromatin assembly.
These processes take place within the replisome, the biochemical machinery responsible for the duplication of the genome. Dana Branzei has focused on the complex question of how simultaneous processes occur in cells that link genome duplication with DNA repair and chromosome assembly. Her research findings make a fundamental contribution to the understanding of genes that mediate a predisposition to the development of cancer. In addition, their findings support research into the causes of genome changes that are often triggered by chemotherapy.

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Selected Publications

    Journal articles

  • Boavida, Ana; Napolitano, Luisa MR; Santos, Diana; Cortone, Giuseppe; Jegadesan, Nanda K; Onesti, Silvia; Branzei, Dana; Pisani, Francesca M
    FANCJ DNA helicase is recruited to the replisome by AND-1 to ensure genome stability
    In: EMBO Reports, Vol. 25, 2024, Nr. 2, pp. 876 – 901
    DOI (Open Access)
  • Kannan, Annapoorna; Leela, Shyni Gangadharan; Branzei, Dana; Gangwani, Laxman
    Role of senataxin in R-loop-mediated neurodegeneration
    In: Brain Communications, Vol. 6, 2024, Nr. 4, fcae239
    DOI (Open Access)
  • Branzei, Dana; Bene, Szabolcs; Gangwani, Laxman; Szakal, Barnabas
    The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity
    In: DNA Repair, Vol. 142, 2024, 103742
    DOI (Open Access)
  • Szakal, Barnabas; Branzei, Dana
    Hot on RAD51C : Structure and functions of RAD51C-XRCC3
    In: Molecular Oncology, Vol. 17, 2023, Nr. 10, pp. 1950 – 1952
    DOI (Open Access)
  • Psakhye, Ivan; Kawasumi, Ryotaro; Abe, Takuya; Hirota, Kouji; Branzei, Dana
    PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion
    In: Nature Structural & Molecular Biology, Vol. 30, 2023, Nr. 9, pp. 1286 – 1294
    DOI (Open Access)
  • Kannan, Annapoorna; Cuartas, Juliana; Gangwani, Pratik; Branzei, Dana; Gangwani, Laxman
    Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4
    In: Brain: A Journal of Neurology, Vol. 145, 2022, Nr. 9, pp. 3072 – 3094
    DOI (Open Access)
  • Dolce, Valeria; Dusi, Sabrina; Giannattasio, Michele; Joseph, Chinnu Rose; Fumasoni, Marco; Branzei, Dana
    Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance
    In: Genes and Development, Vol. 36, 2022, Nr. 3-4, pp. 167 – 179
    DOI (Open Access)
  • Joseph, Chinnu Rose; Dusi, Sabrina; Giannattasio, Michele; Branzei, Dana
    Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase
    In: Nature Communications, Vol. 13, 2022, Nr. 1, 2480
    DOI (Open Access)
  • Humphreys, Ian; Pei, Jimin; Baek, Minkyung; Krishnakumar, Aditya; Anishchenko, Ivan; Ovchinnikov, Sergey; Zhang, Jing; Ness, Travis J.; Banjade, Sudeep; Bagde, Saket R.; Stancheva, Viktoriya G.; Li, Xiao-Han; Liu, Kaixian; Zheng, Zhi; Barrero, Daniel J.; Roy, Upasana; Kuper, Jochen; Fernández, Israel S.; Szakal, Barnabas; Branzei, Dana; Rizo, Josep; Kisker, Caroline; Greene, Eric C.; Biggins, Sue; Keeney, Scott; Miller, Elizabeth A.; Fromme, J. Christopher; Hendrickson, Tamara L.; Cong, Qian; Baker, David
    Computed structures of core eukaryotic protein complexes
    In: Science, Vol. 374, 2021, Nr. 6573, eabm4805
    DOI, Online Full Text (Open Access)
  • Jegadesan, Nanda Kumar; Branzei, Dana
    DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 118, 2021, Nr. 17, e2024258118
    DOI (Open Access)
  • Branzei, Dana; Szakal, Barnabas
    DNA helicases in homologous recombination repair
    In: Current Opinion in Genetics and Development, Vol. 71, 2021, pp. 27 – 33
    DOI
  • Psakhye, Ivan; Branzei, Dana
    SMC complexes are guarded by the SUMO protease Ulp2 against SUMO-chain-mediated turnover
    In: Cell Reports, Vol. 36, 2021, Nr. 5, 109485
    DOI (Open Access)
  • Agashe, Sumedha; Joseph, Chinnu Rose; Reyes, Teresa Anne Clarisse; Menolfi, Demis; Giannattasio, Michele; Waizenegger, Anja; Szakal, Barnabas; Branzei, Dana
    Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
    In: Nature Communications, Vol. 12, 2021, Nr. 1, 2111
    DOI (Open Access)
  • Kawasumi, Ryotaro; Abe, Takuya; Psakhye, Ivan; Miyata, Keiji; Hirota, Kouji; Branzei, Dana
    Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release
    In: Genes and Development, Vol. 35, 2021, Nr. 19-20, pp. 1368 – 1382
    DOI (Open Access)
  • Waizenegger, Anja; Urulangodi, Madhusoodanan; Lehmann, Carl P.; Reyes, Teresa Anne Clarisse; Saugar, Irene; Tercero, José Antonio; Szakal, Barnabas; Branzei, Dana
    Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
    In: Nature Communications, Vol. 11, 2020, Nr. 1, 5746
    DOI (Open Access)
  • Lehmann, Carl P.; Jiménez-Martín, Alberto; Branzei, Dana; Tercero, José Antonio
    Prevention of unwanted recombination at damaged replication forks
    In: Current genetics, Vol. 66, 2020, Nr. 6, pp. 1045 – 1051
    DOI (Open Access)
  • Rossi, Francesco; Helbling-Leclerc, Anne; Kawasumi, Ryotaro; Jegadesan, Nanda Kumar; Xu, Xinlin; Devulder, Pierre; Abe, Takuya; Takata, Minoru; Xu, Dongyi; Rosselli, Filippo; Branzei, Dana
    SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability
    In: EMBO Reports, Vol. 21, 2020, Nr. 2, e48222
    DOI (Open Access)
  • Jiménez-Martín, Alberto; Saugar, Irene; Joseph, Chinnu Rose; Mayer, Alexandra; Lehmann, Carl P.; Szakal, Barnabas; Branzei, Dana; Tercero, José Antonio
    The Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks
    In: Science Advances, Vol. 6, 2020, Nr. 15, eaaz3327
    DOI (Open Access)
  • Lerner, Leticia K; Holzer, Sandro; Kilkenny, Mairi L; Šviković, Saša; Murat, Pierre; Schiavone, Davide; Eldridge, Cara B; Bittleston, Alice; Maman, Joseph D; Branzei, Dana; Stott, Katherine; Pellegrini, Luca; Sale, Julian E
    Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication
    In: The EMBO Journal, Vol. 39, 2020, Nr. 18, e104185
    DOI (Open Access)
  • Giannattasio, Michele; Branzei, Dana
    DNA replication through strand displacement during lagging strand DNA synthesis in Saccharomyces cerevisiae
    In: Genes, Vol. 10, 2019, Nr. 2, 167
    DOI (Open Access)
  • Gallo, David; Kim, TaeHyung; Szakal, Barnabas; Saayman, Xanita; Narula, Ashrut; Park, Yoona; Branzei, Dana; Zhang, Zhaolei; Brown, Grant W.
    Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates
    In: Molecular Cell, Vol. 73, 2019, Nr. 5, pp. 900 – 914.e9
    DOI (Open Access)
  • Psakhye, Ivan; Castellucci, Federica; Branzei, Dana
    SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation
    In: Molecular Cell, Vol. 76, 2019, Nr. 4, pp. 632 – 645.e6
    DOI (Open Access)
  • Bharti, Sanjay Kumar; Sommers, Joshua A.; Awate, Sanket; Bellani, Marina A.; Khan, Irfan; Bradley, Lynda; King, Graeme A.; Seol, Yeonee; Vidhyasagar, Venkatasubramanian; Wu, Yuliang; Abe, Takuye; Kobayashi, Koji; Shin-Ya, Kazuo; Kitao, Hiroyuki; Wold, Marc S.; Branzei, Dana; Neuman, Keir C.; Brosh, Robert M.
    A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair
    In: Nucleic Acids Research, Vol. 46, 2018, Nr. 12, pp. 6238 – 6256
    DOI (Open Access)
  • Abe, Takuya; Kawasumi, Ryotaro; Giannattasio, Michele; Dusi, Sabrina; Yoshimoto, Yui; Miyata, Keiji; Umemura, Koyuki; Hirota, Kouji; Branzei, Dana
    AND-1 fork protection function prevents fork resection and is essential for proliferation
    In: Nature Communications, Vol. 9, 2018, Nr. 1, 3091
    DOI (Open Access)
  • Kannan, Annapoorna; Bhatia, Kanchan; Branzei, Dana; Gangwani, Laxman
    Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy
    In: Nucleic Acids Research, Vol. 46, 2018, Nr. 16, pp. 8326 – 8346
    DOI (Open Access)
  • Abe, Takuya; Branzei, Dana; Hirota, Kouji
    DNA damage tolerance mechanisms revealed from the analysis of immunoglobulin v gene diversification in avian DT40 cells
    In: Genes, Vol. 9, 2018, Nr. 12, 614
    DOI (Open Access)
  • Litwin, Ireneusz; Bakowski, Tomasz; Szakal, Barnabas; Pilarczyk, Ewa; Maciaszczyk-Dziubinska, Ewa; Branzei, Dana; Wysocki, Robert
    Error‐free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin
    In: The EMBO Journal, Vol. 37, 2018, Nr. 18, e98732
    DOI (Open Access)
  • Iacovella, Maria G.; Bremang, Michael; Basha, Omer; Giacò, Luciano; Carotenuto, Walter; Golfieri, Cristina; Szakal, Barnabas; Maschio, Marianna Dal; Infantino, Valentina; Beznoussenko, Galina V.; Joseph, Chinnu R.; Visintin, Clara; Mironov, Alexander A.; Visintin, Rosella; Branzei, Dana; Ferreira-Cerca, Sébastien; Yeger-Lotem, Esti; De Wulf, Peter
    Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae
    In: Nucleic Acids Research, Vol. 46, 2018, Nr. 15, pp. 7586 – 7611
    DOI (Open Access)
  • Branzei, Dana; Giannattasio, Michele
    SIRFing the replication fork : Assessing protein interactions with nascent DNA
    In: The Journal of Cell Biology (JCB), Vol. 217, 2018, Nr. 4, pp. 1177 – 1179
    DOI (Open Access)
  • Nakazato, Arisa; Kajita, Kinumi; Ooka, Masato; Akagawa, Remi; Abe, Takuya; Takeda, Shunichi; Branzei, Dana; Hirota, Kouji
    SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells
    In: DNA Repair, Vol. 68, 2018, pp. 50 – 57
    DOI
  • Srivatsan, Anjana; Li, Bin-Zhong; Szakal, Barnabas; Branzei, Dana; Putnam, Christopher D.; Kolodner, Richard D.
    The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects
    In: Nature Communications, Vol. 9, 2018, Nr. 1, 3680
    DOI (Open Access)
  • Abe, Takuya; Ooka, Masato; Kawasumi, Ryotaro; Miyata, Keiji; Takata, Minoru; Hirota, Kouji; Branzei, Dana
    Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 115, 2018, Nr. 33, pp. 8412 – 8417
    DOI (Open Access)
  • Branzei, Dana; Szakal, Barnabas
    Building up and breaking down : mechanisms controlling recombination during replication
    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 52, 2017, Nr. 4, pp. 381 – 394
    DOI (Open Access)
  • Kawasumi, Ryotaro; Abe, Takuya; Arakawa, Hiroshi; Garre, Massimiliano; Hirota, Kouji; Branzei, Dana
    ESCO1/2’s roles in chromosome structure and interphase chromatin organization
    In: Genes and Development, Vol. 31, 2017, Nr. 21, pp. 2136 – 2150
    DOI (Open Access)
  • Petrakis, Theodoros G.; Komseli, Eirini-Stavroula; Papaioannou, Marilena; Vougas, Kostas; Polyzos, Alexandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Trougakos, Ioannis P.; Thanos, Dimitris; Branzei, Dana; Townsend, Paul; Gorgoulis, Vassilis G.
    Erratum to ‘Exploring and exploiting the systemic effects of deregulated replication licensing’ [Seminars in Cancer Biology 37–38C, (2016) 3–15]
    In: Seminars in Cancer Biology, Vol. 43, 2017, pp. 180
    DOI (Open Access)
  • Sebesta, Marek; Urulangodi, Madhusoodanan; Stefanovie, Barbora; Szakal, Barnabas; Pacesa, Martin; Lisby, Michael; Branzei, Dana; Krejci, Lumir
    Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains
    In: Nucleic Acids Research, Vol. 45, 2017, Nr. 1, pp. 215 – 230
    DOI (Open Access)
  • Branzei, Dana; Ciliberto, Andrea
    Not all roads lead to Cdk1
    In: Cell Cycle, Vol. 16, 2017, Nr. 5, pp. 395 – 396
    DOI
  • Giannattasio, Michele; Branzei, Dana
    S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion
    In: Cellular and Molecular Life Sciences - CMLS, Vol. 74, 2017, Nr. 13, pp. 2361 – 2380
    DOI (Open Access)
  • Abe, Takuya; Kawasumi, Ryotaro; Arakawa, Hiroshi; Hori, Tetsuya; Shirahige, Katsuhiko; Losada, Ana; Fukagawa, Tatsuo; Branzei, Dana
    Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion
    In: OncoTarget, Vol. 7, 2016, Nr. 42, pp. 67934 – 67947
    DOI (Open Access)
  • Branzei, Dana; Psakhye, Ivan
    DNA damage tolerance
    In: Current Opinion in Cell Biology, Vol. 40, 2016, pp. 137 – 144
    DOI
  • Branzei, Dana
    DNA damage tolerance branches out toward sister chromatid cohesion
    In: Molecular and Cellular Oncology, Vol. 3, 2016, Nr. 1, e1035478
    DOI (Open Access)
  • Branzei, Dana; Szakal, Barnabas
    DNA damage tolerance by recombination : Molecular pathways and DNA structures
    In: DNA Repair, Vol. 44, 2016, pp. 68 – 75
    DOI (Open Access)
  • Petrakis, Theodoros G.; Komseli, Eirini-Stavroula; Papaioannou, Marilena; Vougas, Kostas; Polyzos, Alexandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Trougakos, Ioannis P.; Thanos, Dimitris; Branzei, Dana; Townsend, Paul; Gorgoulis, Vassilis G.
    Exploring and exploiting the systemic effects of deregulated replication licensing
    In: Seminars in Cancer Biology, Vol. 37-38, 2016, pp. 3 – 15
    DOI
  • Branzei, Dana; Menolfi, Demis
    G2/M chromosome transactions essentially relying on Smc5/6
    In: Cell Cycle, Vol. 15, 2016, Nr. 5, pp. 611 – 612
    DOI
  • Branzei, Dana; Szakal, Barnabas
    Priming for tolerance and cohesion at replication forks
    In: Nucleus, Vol. 7, 2016, Nr. 1, pp. 8 – 12
    DOI (Open Access)
  • Urulangodi, Madhusoodanan; Szakal, Barnabas; Branzei, Dana
    SUMO-mediated global and local control of recombination
    In: Cell Cycle, Vol. 15, 2016, Nr. 2, pp. 160 – 161
    DOI
  • Bonner, Jacob N.; Choi, Koyi; Xue, Xiaoyu; Torres, Nikko P.; Szakal, Barnabas; Wei, Lei; Wan, Bingbing; Arter, Meret; Matos, Joao; Sung, Patrick; Brown, Grant W.; Branzei, Dana; Zhao, Xiaolan
    Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates
    In: Cell Reports, Vol. 16, 2016, Nr. 2, pp. 368 – 378
    DOI (Open Access)
  • Hoppe, Thorsten; Branzei, Dana
    Stefan Jentsch (1955–2016)—Maestro of the ubiquitin family
    In: The EMBO Journal, Vol. 36, 2016, Nr. 1, pp. 1 – 2
    DOI
  • Böhm, Stefanie; Szakal, Barnabas; Herken, Benjamin W.; Sullivan, Meghan R.; Mihalevic, Michael J.; Kabbinavar, Faiz F.; Branzei, Dana; Clark, Nathan L.; Bernstein, Kara A.
    The budding yeast ubiquitin protease Ubp7 is a novel component involved in s phase progression
    In: The Journal of Biological Chemistry (JBC), Vol. 291, 2016, Nr. 9, pp. 4442 – 4452
    DOI (Open Access)
  • Choi, Koyi; Batke, Sabrina; Szakal, Barnabas; Lowther, Jonathan; Hao, Fanfan; Sarangi, Prabha; Branzei, Dana; Ulrich, Helle D.; Zhao, Xiaolan
    Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance
    In: Nucleic Acids Research, Vol. 43, 2015, Nr. 5, pp. 2666 – 2677
    DOI (Open Access)
  • Fumasoni, Marco; Zwicky, Katharina; Vanoli, Fabio; Lopes, Massimo; Branzei, Dana
    Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex
    In: Molecular Cell, Vol. 57, 2015, Nr. 5, pp. 812 – 823
    DOI (Open Access)
  • Menolfi, Demis; Delamarre, Axel; Lengronne, Armelle; Pasero, Philippe; Branzei, Dana
    Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance
    In: Molecular Cell, Vol. 60, 2015, Nr. 6, pp. 835 – 846
    DOI (Open Access)
  • Urulangodi, Madhusoodanan; Sebesta, Marek; Menolfi, Demis; Szakal, Barnabas; Sollier, Julie; Sisakova, Alexandra; Krejci, Lumir; Branzei, Dana
    Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication
    In: Genes and Development, Vol. 29, 2015, Nr. 19, pp. 2067 – 2080
    DOI (Open Access)
  • Hang, Lisa E.; Peng, Jie; Tan, Wei; Szakal, Barnabas; Menolfi, Demis; Sheng, Ziwei; Lobachev, Kirill; Branzei, Dana; Feng, Wenyi; Zhao, Xiaolan
    Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases
    In: Molecular Cell, Vol. 60, 2015, Nr. 2, pp. 268 – 279
    DOI (Open Access)
  • Xue, Xiaoyu; Choi, Koyi; Bonner, Jacob N.; Szakal, Barnabas; Chen, Yu-Hung; Papusha, Alma; Saro, Dorina; Niu, Hengyao; Ira, Grzegorz; Branzei, Dana; Sung, Patrick; Zhao, Xiaolan
    Selective modulation of the functions of a conserved DNA motor by a histone fold complex
    In: Genes and Development, Vol. 29, 2015, Nr. 10, pp. 1000 – 1005
    DOI (Open Access)
  • Gritenaite, Dalia; Princz, Lissa N.; Szakal, Barnabas; Bantele, Susanne C. S.; Wendeler, Lina; Schilbach, Sandra; Habermann, Bianca H.; Matos, Joao; Lisby, Michael; Branzei, Dana; Pfander, Boris
    A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication
    In: Genes and Development, Vol. 28, 2014, Nr. 14, pp. 1604 – 1619
    DOI (Open Access)
  • Gonzalez-Huici, Victor; Szakal, Barnabas; Urulangodi, Madhusoodanan; Psakhye, Ivan; Castellucci, Federica; Menolfi, Demis; Rajakumara, Eerappa; Fumasoni, Marco; Bermejo, Rodrigo; Jentsch, Stefan; Branzei, Dana
    DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity
    In: The EMBO Journal, Vol. 33, 2014, Nr. 4, pp. 327 – 340
    DOI (Open Access)
  • Abe, Takuya; Branzei, Dana
    High levels of BRC4 induced by a Tet-On 3G system suppress DNA repair and impair cell proliferation in vertebrate cells
    In: DNA Repair, Vol. 22, 2014, pp. 153 – 164
    DOI (Open Access)
  • Kramarz, Karol; Litwin, Ireneusz; Cal-Bąkowska, Magdalena; Szakal, Barnabas; Branzei, Dana; Wysocki, Robert; Dziadkowiec, Dorota
    Swi2/Snf2-like protein Uls1 functions in the Sgs1-dependent pathway of maintenance of rDNA stability and alleviation of replication stress
    In: DNA Repair, Vol. 21, 2014, pp. 24 – 35
    DOI
  • Giannattasio, Michele; Zwicky, Katharina; Follonier, Cindy; Foiani, Marco; Lopes, Massimo; Branzei, Dana
    Visualization of recombination-mediated damage bypass by template switching
    In: Nature Structural & Molecular Biology, Vol. 21, 2014, Nr. 10, pp. 884 – 892
    DOI
  • Chen, Yu-Hung; Szakal, Barnabas; Castellucci, Federica; Branzei, Dana; Zhao, Xiaolan
    DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of smc6 mutants
    In: Molecular Biology of the Cell, Vol. 24, 2013, Nr. 15, pp. 2431 – 2441
    DOI (Open Access)
  • Karras, Georgios Ioannis; Fumasoni, Marco; Sienski, Grzegorz; Vanoli, Fabio; Branzei, Dana; Jentsch, Stefan
    Noncanonical Role of the 9-1-1 Clamp in the Error-Free DNA Damage Tolerance Pathway
    In: Molecular Cell, Vol. 49, 2013, Nr. 3, pp. 536 – 546
    DOI (Open Access)
  • Szakal, Barnabas; Branzei, Dana
    Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover
    In: The EMBO Journal, Vol. 32, 2013, Nr. 8, pp. 1155 – 1167
    DOI (Open Access)
  • Bustard, Denise E.; Menolfi, Demis; Jeppsson, Kristian; Ball, Lindsay G.; Dewey, Sidney Carter; Shirahige, Katsuhiko; Sjögren, Camilla; Branzei, Dana; Cobb, Jennifer A.
    During Replication Stress, Non-Smc Element 5 (Nse5) Is Required for Smc5/6 Protein Complex Functionality at Stalled Forks
    In: The Journal of Biological Chemistry (JBC), Vol. 287, 2012, Nr. 14, pp. 11374 – 11383
    DOI (Open Access)
  • Daee, Danielle L.; Ferrari, Elisa; Longerich, Simonne; Zheng, Xiao-feng; Xue, Xiaoyu; Branzei, Dana; Sung, Patrick; Myung, Kyungjae
    Rad5-dependent DNA Repair Functions of the Saccharomyces cerevisiae FANCM Protein Homolog Mph1
    In: The Journal of Biological Chemistry (JBC), Vol. 287, 2012, Nr. 32, pp. 26563 – 26575
    DOI (Open Access)
  • Era, Saho; Abe, Takuya; Arakawa, Hiroshi; Kobayashi, Shunsuke; Szakal, Barnabas; Yoshikawa, Yusuke; Motegi, Akira; Takeda, Shunichi; Branzei, Dana
    The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment
    In: Biochemical and Biophysical Research Communications (BBRC), Vol. 426, 2012, Nr. 3, pp. 310 – 316
    DOI
  • Yong-Gonzales, Vladimir; Hang, Lisa E.; Castellucci, Federica; Branzei, Dana; Zhao, Xiaolan
    The Smc5-Smc6 Complex Regulates Recombination at Centromeric Regions and Affects Kinetochore Protein Sumoylation during Normal Growth
    In: PLoS ONE, Vol. 7, 2012, Nr. 12, e51540
    DOI (Open Access)
  • Branzei, Dana
    The three SMC sisters
    In: Nature Reviews Molecular Cell Biology, Vol. 12, 2011, Nr. 6, pp. 343 – 343
    DOI
  • Branzei, Dana
    Ubiquitin family modifications and template switching
    In: FEBS Letters, Vol. 585, 2011, Nr. 18, pp. 2810 – 2817
    DOI (Open Access)
  • Branzei, Dana; Foiani, Marco
    Leaping forks at inverted repeats
    In: Genes and Development, Vol. 24, 2010, Nr. 1, pp. 5 – 9
    DOI (Open Access)
  • Branzei, Dana; Foiani, Marco
    Maintaining genome stability at the replication fork
    In: Nature Reviews Molecular Cell Biology, Vol. 11, 2010, Nr. 3, pp. 208 – 219
    DOI
  • Vanoli, Fabio; Fumasoni, Marco; Szakal, Barnabas; Maloisel, Laurent; Branzei, Dana
    Replication and Recombination Factors Contributing to Recombination-Dependent Bypass of DNA Lesions by Template Switch
    In: PLoS Genetics, Vol. 6, 2010, Nr. 11, e1001205
    DOI (Open Access)
  • Choi, Koyi; Szakal, Barnabas; Chen, Yu-Hung; Branzei, Dana; Zhao, Xiaolan
    The Smc5/6 Complex and Esc2 Influence Multiple Replication-associated Recombination Processes in Saccharomyces cerevisiae
    In: Molecular Biology of the Cell, Vol. 21, 2010, Nr. 13, pp. 2306 – 2314
    DOI (Open Access)
  • Chen, Yu-Hung; Choi, Koyi; Szakal, Barnabas; Arenz, Jacqueline; Duan, Xinyuan; Ye, Hong; Branzei, Dana; Zhao, Xiaolan
    Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 106, 2009, Nr. 50, pp. 21252 – 21257
    DOI (Open Access)
  • Bernstein, Kara A; Shor, Erika; Sunjevaric, Ivana; Fumasoni, Marco; Burgess, Rebecca C; Foiani, Marco; Branzei, Dana; Rothstein, Rodney
    Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair
    In: The EMBO Journal, Vol. 28, 2009, Nr. 7, pp. 915 – 925
    DOI (Open Access)
  • Sollier, Julie; Driscoll, Robert; Castellucci, Federica; Foiani, Marco; Jackson, Stephen P.; Branzei, Dana
    The Saccharomyces cerevisiae Esc2 and Smc5-6 Proteins Promote Sister Chromatid Junction-mediated Intra-S Repair
    In: Molecular Biology of the Cell, Vol. 20, 2009, Nr. 6, pp. 1671 – 1682
    DOI (Open Access)
  • Branzei, Dana; Foiani, Marco
    The checkpoint response to replication stress
    In: DNA Repair, Vol. 8, 2009, Nr. 9, pp. 1038 – 1046
    DOI
  • Bermejo, Rodrigo; Branzei, Dana; Foiani, Marco
    Cohesion by topology: : sister chromatids interlocked by DNA
    In: Genes and Development, Vol. 22, 2008, Nr. 17, pp. 2297 – 2301
    DOI (Open Access)
  • Ohuchi, Takashi; Seki, Masayuki; Branzei, Dana; Maeda, Daisuke; Ui, Ayako; Ogiwara, Hideaki; Tada, Shusuke; Enomoto, Takemi
    Rad52 sumoylation and its involvement in the efficient induction of homologous recombination
    In: DNA Repair, Vol. 7, 2008, Nr. 6, pp. 879 – 889
    DOI
  • Branzei, Dana; Foiani, Marco
    Regulation of DNA repair throughout the cell cycle
    In: Nature Reviews Molecular Cell Biology, Vol. 9, 2008, Nr. 4, pp. 297 – 308
    DOI
  • Branzei, Dana; Vanoli, Fabio; Foiani, Marco
    SUMOylation regulates Rad18-mediated template switch
    In: Nature, Vol. 456, 2008, Nr. 7224, pp. 915 – 920
    DOI
  • Branzei, Dana; Foiani, Marco
    Interplay of replication checkpoints and repair proteins at stalled replication forks
    In: DNA Repair, Vol. 6, 2007, Nr. 7, pp. 994 – 1003
    DOI
  • Branzei, Dana; Foiani, Marco
    RecQ helicases queuing with Srs2 to disrupt Rad51 filaments and suppress recombination
    In: Genes and Development, Vol. 21, 2007, Nr. 23, pp. 3019 – 3026
    DOI (Open Access)
  • Branzei, Dana; Foiani, Marco
    Template Switching : From Replication Fork Repair to Genome Rearrangements
    In: Cell, Vol. 131, 2007, Nr. 7, pp. 1228 – 1230
    DOI (Open Access)
  • Vijeh Motlagh, Niloofar Davoodi; Seki, Masayuki; Branzei, Dana; Enomoto, Takemi
    Mgs1 and Rad18/Rad5/Mms2 are required for survival of Saccharomyces cerevisiae mutants with novel temperature/cold sensitive alleles of the DNA polymerase δ subunit, Pol31
    In: DNA Repair, Vol. 5, 2006, Nr. 12, pp. 1459 – 1474
    DOI
  • Branzei, Dana; Foiani, Marco
    The Rad53 signal transduction pathway : Replication fork stabilization, DNA repair, and adaptation
    In: Experimental Cell Research, Vol. 312, 2006, Nr. 14, pp. 2654 – 2659
    DOI
  • Branzei, Dana; Sollier, Julie; Liberi, Giordano; Zhao, Xiaolan; Maeda, Daisuke; Seki, Masayuki; Enomoto, Takemi; Ohta, Kunihiro; Foiani, Marco
    Ubc9- and Mms21-Mediated Sumoylation Counteracts Recombinogenic Events at Damaged Replication Forks
    In: Cell, Vol. 127, 2006, Nr. 3, pp. 509 – 522
    DOI (Open Access)
  • Branzei, Dana; Foiani, Marco
    The DNA damage response during DNA replication
    In: Current Opinion in Cell Biology, Vol. 17, 2005, Nr. 6, pp. 568 – 575
    DOI
  • Branzei, Dana; Seki, Masayuki; Enomoto, Takemi
    Rad18/Rad5/Mms2‐mediated polyubiquitination of PCNA is implicated in replication completion during replication stress
    In: Genes to Cells, Vol. 9, 2004, Nr. 11, pp. 1031 – 1042
    DOI (Open Access)
  • Maeda, Daisuke; Seki, Masayuki; Onoda, Fumitoshi; Branzei, Dana; Kawabe, Yoh-Ichi; Enomoto, Takemi
    Ubc9 is required for damage-tolerance and damage-induced interchromosomal homologous recombination in S. cerevisiae
    In: DNA Repair, Vol. 3, 2004, Nr. 3, pp. 335 – 341
    DOI
  • Branzei, Dana; Seki, Masayuki; Onoda, Fumitoshi; Yagi, Hideki; Kawabe, Yoh-ichi; Enomoto, Takemi
    Characterization of the slow-growth phenotype of S. cerevisiae whip/mgs1 sgs1 double deletion mutants
    In: DNA Repair, Vol. 1, 2002, Nr. 8, pp. 671 – 682
    DOI
  • Branzei, Dana; Seki, M.; Onoda, F.; Enomoto, T.
    The product of Saccharomyces cerevisiae WHIP/MGS1, a gene related to replication factor C genes, interacts functionally with DNA polymerase δ
    In: Molecular Genetics and Genomics, Vol. 268, 2002, Nr. 3, pp. 371 – 386
    DOI
  • Kawabe, Yoh-ichi; Branzei, Dana; Hayashi, Tomoko; Suzuki, Hirobumi; Masuko, Takashi; Onoda, Fumitoshi; Heo, Seok-Jin; Ikeda, Hideo; Shimamoto, Akira; Furuichi, Yasuhiro; Seki, Masayuki; Enomoto, Takemi
    A Novel Protein Interacts with the Werner's Syndrome Gene Product Physically and Functionally
    In: The Journal of Biological Chemistry (JBC), Vol. 276, 2001, Nr. 23, pp. 20364 – 20369
    DOI (Open Access)
  • Branzei, Dana; Onoda, Fumitoshi; Kawabe, Yohichi; Seki, Masayuki; Enomoto, Takemi
    Functional analysis of WHIP, a novel protein that interacts with the Werner's syndrome gene product
    In: Folia Pharmacologica Japonica, Vol. 118, 2001, Nr. SUPPL. 1, pp. 104P – 105P