ZMB Member Lisa Becker

ZMB Member
Lisa Becker

Next ZMB-Member
Lisa Becker portrait
© UDE/Alexandra Roth

Jun.-Prof. Dr. Lisa Becker

Tumor Microenvironment and Vascular Metabolism

Institute for Tumor Metabolism
Clinic for Dermatology
University Hospital Essen
Hufelandstraße 55
45122 Essen

Research Overview

  • Investigating endothelial–immune cell interactions within the tumor microenvironment
  • Defining the role of endothelial cell metabolism in melanoma metastasis
  • Identifying vascular metabolic vulnerabilities to overcome resistance to immunotherapy
  • Integrating transgenic animal models with advanced 3D platforms to study tumor vasculature and immune responses

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Publications

    Journal articles

  • Alnaqbi, Halima; Becker, Lisa M.; Mousa, Mira; Alshamsi, Fatima; Azzam, Sarah K.; Emini Veseli, Besa; Hymel, Lauren A.; Alhosani, Khalood; Alhusain, Marwa; Mazzone, Massimiliano; Alsafar, Habiba; Carmeliet, Peter
    Immunomodulation by endothelial cells: prospects for cancer therapy
    In: Trends in Cancer, Vol. 10, 2024, Nr. 11, pp. 1072 – 1091
    DOI
  • Zhou, Xunian; LeBleu, Valerie S.; Fletcher-Sananikone, Eliot; Kim, Jiha; Dai, Jianli; Li, Bingrui; Wu, Chia-Chin; Sugimoto, Hikaru; Miyake, Toru; Becker, Lisa M.; Volpert, Olga V.; Lawson, Erica; Espinosa Da Silva, Cristina; Patel, Sarah I.; Kizu, Akane; Ehsanipour, Ehsan A.; Sha, Di; Karam, Jose Antonio; McAndrews, Kathleen M.; Kalluri, Raghu
    Vascular heterogeneity of tight junction Claudins guides organotropic metastasis
    In: Nature Cancer, Vol. 5, 2024, Nr. 9, pp. 1371 – 1389
    DOI, Online Full Text (Open Access)
  • Becker, Lisa M.; Chen, Shiau-Haln; Rodor, Julie; de Rooij, Laura P.M.H.; Baker, Andrew H.; Carmeliet, Peter
    Deciphering endothelial heterogeneity in health and disease at single-cell resolution : progress and perspectives
    In: Cardiovascular Research, Vol. 119, 2023, Nr. 1, pp. 6 – 27
    DOI (Open Access)
  • Truong, Anh-Co K.; Becker, Lisa M.; Dekoning, Nora; Bouché, Ann; Veys, Koen; Hosseinkhani, Baharak; Dewerchin, Mieke; Eelen, Guy; Carmeliet, Peter
    Detailed protocol for a corneal thermal cauterization-based (lymph-)angiogenesis assay in mice
    In: MethodsX, Vol. 11, 2023, pp. 102446
    DOI (Open Access)
  • De Rooij, Laura P.M.H.; Becker, Lisa M.; Teuwen, Laure-Anne; Boeckx, Bram; Jansen, Sander; Feys, Simon; Verleden, Stijn; Liesenborghs, Laurens; Stalder, Anna K.; Libbrecht, Sasha; Van Buyten, Tina; Philips, Gino; Subramanian, Abhishek; Dumas, Sébastien J.; Meta, Elda; Borri, Mila; Sokol, Liliana; Dendooven, Amélie; Truong, Anh-Co K.; Gunst, Jan; Van Mol, Pierre; Haslbauer, Jasmin D.; Rohlenova, Katerina; Menter, Thomas; Boudewijns, Robbert; Geldhof, Vincent; Vinckier, Stefan; Amersfoort, Jacob; Wuyts, Wim; Van Raemdonck, Dirk; Jacobs, Werner; Ceulemans, Laurens J.; Weynand, Birgit; Thienpont, Bernard; Lammens, Martin; Kuehnel, Mark; Eelen, Guy; Dewerchin, Mieke; Schoonjans, Luc; Jonigk, Danny; Van Dorpe, Jo; Tzankov, Alexandar; Wauters, Els; Mazzone, Massimiliano; Neyts, Johan; Wauters, Joost; Lambrechts, Diether; Carmeliet, Peter
    The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution
    In: Cardiovascular Research, Vol. 119, 2023, Nr. 2, pp. 520 – 535
    DOI (Open Access)
  • De Rooij, Laura P.M.H.; Becker, Lisa M.; Carmeliet, Peter
    A Role for the Vascular Endothelium in Post-Acute COVID-19?
    In: Circulation, Vol. 145, 2022, Nr. 20, pp. 1503 – 1505
    DOI, Online Full Text (Open Access)
  • McAndrews, Kathleen M; Miyake, Toru; Ehsanipour, Ehsan A; Kelly, Patience J; Becker, Lisa M.; McGrail, Daniel J; Sugimoto, Hikaru; LeBleu, Valerie S; Ge, Yejing; Kalluri, Raghu
    Dermal αSMA⁺ myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production
    In: The EMBO Journal, Vol. 41, 2022, Nr. 7, e109470
    DOI (Open Access)
  • Cuypers, Anne; Truong, Anh-Co Khanh; Becker, Lisa M.; Saavedra-García, Paula; Carmeliet, Peter
    Tumor vessel co-option : The past & the future
    In: Frontiers in Oncology, Vol. 12, 2022, 965277
    DOI (Open Access)
  • Pasut, Alessandra; Becker, Lisa M.; Cuypers, Anne; Carmeliet, Peter
    Endothelial cell plasticity at the single-cell level
    In: Angiogenesis, Vol. 24, 2021, Nr. 2, pp. 311 – 326
    DOI (Open Access)
  • Subramanian, Abhishek; Becker, Lisa M.; Carmeliet, Peter
    Endothelial metabolism going single
    In: Nature Metabolism, Vol. 3, 2021, Nr. 5, pp. 593 – 594
    DOI
  • Teuwen, Laure-Anne; De Rooij, Laura P.M.H.; Cuypers, Anne; Rohlenova, Katerina; Dumas, Sébastien J.; García-Caballero, Melissa; Meta, Elda; Amersfoort, Jacob; Taverna, Federico; Becker, Lisa M.; Veiga, Nuphar; Cantelmo, Anna Rita; Geldhof, Vincent; Conchinha, Nadine V.; Kalucka, Joanna; Treps, Lucas; Conradi, Lena-Christin; Khan, Shawez; Karakach, Tobias K.; Soenen, Stefaan; Vinckier, Stefan; Schoonjans, Luc; Eelen, Guy; Van Laere, Steven; Dewerchin, Mieke; Dirix, Luc; Mazzone, Massimiliano; Luo, Yonglun; Vermeulen, Peter; Carmeliet, Peter
    Tumor vessel co-option probed by single-cell analysis
    In: Cell Reports, Vol. 35, 2021, Nr. 11, 109253
    DOI (Open Access)
  • Becker, Lisa M.; O'Connell, Joyce T.; Vo, Annie P.; Cain, Margo P.; Tampe, Desiree; Bizarro, Lauren; Sugimoto, Hikaru; McGow, Anna K.; Asara, John M.; Lovisa, Sara; McAndrews, Kathleen M.; Zielinski, Rafal; Lorenzi, Philip L.; Zeisberg, Michael; Raza, Sughra; LeBleu, Valerie S.; Kalluri, Raghu
    Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer
    In: Cell Reports, Vol. 31, 2020, Nr. 9, 107701
    DOI (Open Access)
  • McAndrews, Kathleen M.; Dowlatshahi, Dara P.; Dai, Jianli; Becker, Lisa M.; Hensel, Janine; Snowden, Laura M.; Leveille, Jennifer M.; Brunner, Michael R.; Holden, Kylie W.; Hopkins, Nikolas S.; Harris, Alexandria M.; Kumpati, Jerusha; Whitt, Michael A.; Jack Lee, J.; Ostrosky-Zeichner, Luis L.; Papanna, Ramesha; LeBleu, Valerie S.; Allison, James P.; Kalluri, Raghu
    Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity
    In: JCI Insight, Vol. 5, 2020, Nr. 18, e142386
    DOI (Open Access)
  • Eikesdal, Hans Petter; Becker, Lisa M.; Teng, Yingqi; Kizu, Akane; Carstens, Julienne L.; Kanasaki, Keizo; Sugimoto, Hikaru; LeBleu, Valerie S.; Kalluri, Raghu
    BMP7 Signaling in TGFBR2 -Deficient Stromal Cells Provokes Epithelial Carcinogenesis
    In: Molecular Cancer Research, Vol. 16, 2018, Nr. 10, pp. 1568 – 1578
    DOI, Online Full Text (Open Access)
  • Becker, Lisa M.; LeBleu, Valerie S.
    Endoglin targeting in colorectal tumor microenvironment
    In: Clinical Cancer Research, Vol. 24, 2018, Nr. 24, pp. 6110 – 6111
    DOI
  • Havranek, Ondrej; Xu, Jingda; Köhrer, Stefan; Wang, Zhiqiang; Becker, Lisa; Comer, Justin M.; Henderson, Jared; Ma, Wencai; Ma, John Man Chun; Westin, Jason R.; Ghosh, Dipanjan; Shinners, Nicholas; Sun, Luhong; Yi, Allen F.; Karri, Anusha R.; Burger, Jan A.; Zal, Tomasz; Davis, R. Eric
    Tonic B-cell receptor signaling in diffuse large B-cell lymphoma
    In: Blood, Vol. 130, 2017, Nr. 8, pp. 995 – 1006
    DOI, Online Full Text (Open Access)