ZMB Member Mike Blüggel

ZMB Member
Mike Blüggel

Next ZMB-Member
Mike Blüggel portrait
© UDE

Dr. Mike Blüggel

Junior Group

Functional Biochemistry

Center of Medical Biotechnology
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

The Blüggel lab of Functional Biochemistry for protein modulation was established within the Faculty of Biology in 2025. We focus on understanding how each protein interacts in several dynamic complexes and how we can manipulate the function in time and space. For this, we use specifically designed nanobodies (VHH) in different organisms: cancer cell lines, parasites, and patient material.
Read more

Publications

    Journal articles

  • Hommel, Katrin; Theisen, Sebastian; Blueggel, Mike; Niemeyer, Felix C.; Beuck, Christine; Bayer, Peter; Zadmard, Reza; Schrader, Thomas; Knauer, Shirley K.
    Highly Preorganized Calixarene Tweezers for Protein Recognition.
    In: Biomacromolecules, Vol. 26, 2025, Nr. 8, pp. 5310 – 5319
    DOI
  • Kirupakaran, Abbna; van den Boom, Johannes; Blueggel, Mike; Beuck, Christine; Niemeyer, Felix; Hayduk, Matthias; Balszuweit, Jan; Bayer, Peter; Voskuhl, Jens; Meyer, Hemmo; Schrader, Thomas
    Molecular Tweezers Block the Functional Pore of a Protein Machine
    In: Journal of the American Chemical Society: JACS, Vol. 147, 2025, Nr. 20, pp. 16836 – 16849
    DOI (Open Access)
  • Bietti, Antonio; Kauth, Alisa-Maite; Hommel, Katrin; Blüggel, Mike; Mohr, Laurenz; Niemeyer, Felix; Beuck, Christine; Bayer, Peter; Knauer, Shirley; Ravoo, Bart Jan; Schrader, Thomas
    Molecular Tweezers with Built-in Photoswitches Modulate Protein Activity
    In: RSC Chemical Biology, Vol. 6, 2025, Nr. 12, pp. 1837 – 1847
    DOI (Open Access)
  • Blüggel, Mike
    Nanobody-gestützte Toolbox für die Proteinkontrolle der nächsten Generation
    In: Biospektrum, Vol. 31, 2025, Nr. 7, pp. 768 – 769
    DOI (Open Access)
  • Bietti, Antonio L. Figueroa; Kauth, Alisa-Maite A.; Hommel, Katrin; Blueggel, Mike; Mohr, Laurenz; Niemeyer, Felix C.; Beuck, Christine; Bayer, Peter; Knauer, Shirley K.; Jan Ravoo, Bart; Schrader, Thomas
    Photoresponsive molecular tweezers modulate Taspase 1 activity
    In: RSC Chemical Biology, Vol. 6, 2025, Nr. 12, pp. 1837 – 1847
    DOI (Open Access)
  • Blüggel, Mike; Gül, Désirée; Stauber, Roland H.; Knauer, Shirley
    Small but mighty : The versatility of nanobodies in modern medicine
    In: Nanoscale Horizons, Vol. 10, 2025, Nr. 10, pp. 2158 – 2171
    DOI (Open Access)
  • Sternberg, Anna; Borger, Jennifer Lynne; Thies, Mathilda; Matena, Anja; Blüggel, Mike; Kamba, Bianca; Beuck, Christine; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter
    The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery
    In: Proteins: Structure, Function and Genetics, Vol. 93, 2025, Nr. 9, pp. 1481 – 1497
    DOI (Open Access)
  • Knauer, Shirley; Blüggel, Mike
    Nanobodies : Effektive Immunwaffen gegen Krebs
    In: Biospektrum, Vol. 30, 2024, Nr. 7, pp. 760 – 762
    DOI (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications, Vol. 14, 2023, Nr. 1, 3258
    DOI, Online Full Text (Open Access)
  • Killinger, Kerstin; Böhm, Miriam; Steinbach, Philine; Hagemann, Götz; Blüggel, Mike; Jänen, Karolin; Hohoff, Simone; Bayer, Peter; Herzog, Franz; Westermann, Stefan
    Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast
    In: The EMBO Journal, Vol. 39, 2020, Nr. 14, pp. e102938
    DOI, Online Full Text (Open Access)
  • Göhring, Anna; Michin, Irina; Gerdes, Tina; Schulze, Nina; Blüggel, Mike; Rehic, Edisa; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter
    Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerization
    In: Biological Chemistry, Vol. 401, 2020, Nr. 8, pp. 955 – 968
    DOI (Open Access)
  • Blüggel, Mike; van den Boom, Johannes; Meyer, Hemmo; Bayer, Peter; Beuck, Christine
    Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPase
    In: Biomolecules, Vol. 9, 2019, Nr. 12, 876
    DOI, Online Full Text (Open Access)
Read more