ZMB Member Sven Heiles

ZMB Member
Sven Heiles

Next ZMB-Member
portrait photo of ZMB member Sven Heiles
© ISAS

Jun.-Prof. Dr. Sven Heiles

Group

Lipidomics

Leibniz-Institut für Analytische Wissenschaften
ISAS – e.V.
Abteilung Bioanalytik
Otto-Hahn-Straße 6b
44227 Dortmund

Faculty of Chemistry
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

portrait photo of ZMB member Sven Heiles
© ISAS

Research Overview

The research of my group is focused on the development and application of mass spectrometric methods to interrogate lipid metabolism during disease progression. To this end the group develops mass spectrometry imaging, liquid-chromatography mass spectrometry, derivatization, and sample preparation strategies to chart lipidomic changes and associated multi-omic adaptions within tissues, cells, or body fluids. These new insights are used to unveil underlying metabolic processes during disease progression and identify putative biomolecules for diagnostic use. The developed assays are applied to study infectious diseases (parasite infection) or co-morbidities leading to heart failure.
Read more

Selected Publications

    Journal articles

  • Yu, Jing; Alshaar, Belal; Heiles, Sven
    Comprehensive lipid structure annotation via photochemical epoxidation and mass spectrometry
    In: Analytical and Bioanalytical Chemistry, Vol. 417, 2025, Nr. 20, pp. 4513 – 4524
    DOI (Open Access)
  • Tuz, Ali A.; Ghosh, Susmita; Karsch, Laura; Antler, Medina; Lakovic, Vivian; Lohmann, Sabrina; Lehmann, Amber Hope; Beer, Alexander; Nagel, Dennis; Jung, Marcel; Hörenbaum, Nils; Kaygusuz, Viola; Qefalia, Altea; Alshaar, Belal; Amookazemi, Niloufar; Bolsega, Silvia; Basic, Marijana; Siveke, Jens T.; Heiles, Sven; Grüneboom, Anika; Lueong, Smiths; Herz, Josephine; Sickmann, Albert; Hagemann, Nina; Hasenberg, Anja; Hermann, Dirk M.; Gunzer, Matthias; Singh, Vikramjeet
    Gut microbiota deficiency reduces neutrophil activation and is protective after ischemic stroke
    In: Journal of Neuroinflammation, Vol. 22, 2025, Nr. 1, 137
    DOI (Open Access)
  • Müller, Marion; Schubert, Torben; Welke, Cornelius; Maske, Tibor; Patschkowski, Thomas; Donhauser, Elfi; Heinen-Weiler, Jacqueline; Hormann, Felix-Levin; Heiles, Sven; Schulz, Tina Johanna; Lengenfelder, Luisa Andrea; Landwehrjohann, Lucia; Vogt, Elisa Theres; Stratmann, Bernd; Hense, Jurek; Lüdtke, Simon; Düfer, Martina; Tolstik, Elena; Dierks, Johann; Lorenz, Kristina; Huxohl, Tamino; Reil, Jan-Christian; Sequeira, Vasco; Schopfer, Francisco Jose; Freeman, Bruce A.; Rudolph, Volker; Schlomann, Uwe; Klinke, Anna
    Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 3933
    DOI (Open Access)
  • Yu, Jing; Heiles, Sven
    Structure selective fragment ions of epoxidized sphingolipids
    In: International Journal of Mass Spectrometry and Ion Physics, Vol. 515, 2025, 117483
    DOI (Open Access)
  • Luh, David; Ghezellou, Parviz; Heiles, Sven; Gramberg, Svenja; Haeberlein, Simone; Spengler, Bernhard
    Glycolipidomics of Liver Flukes and Host Tissues during Fascioliasis : Insights from Mass Spectrometry Imaging
    In: ACS Infectious Diseases, Vol. 10, 2024, Nr. 12, pp. 4233 – 4245
    DOI (Open Access)
  • Luh, David; Heiles, Sven; Roderfeld, Martin; Grevelding, Christoph G.; Roeb, Elke; Spengler, Bernhard
    Hepatic Topology of Glycosphingolipids in Schistosoma mansoni-Infected Hamsters
    In: Analytical Chemistry, Vol. 96, 2024, Nr. 16, pp. 6311 – 6320
    DOI (Open Access)
  • Weintraut, Timo; Heiles, Sven; Gerbig, Dennis; Henss, Anja; Junck, Johannes; Düring, Rolf-Alexander; Rohnke, Marcus
    Lipid-related ion suppression on the herbicide atrazine in earthworm samples in ToF-SIMS and matrix-assisted laser desorption ionization mass spectrometry imaging and the role of gas-phase basicity
    In: Biointerphases, Vol. 19, 2024, Nr. 2, 021003
    DOI (Open Access)
  • Rezaei, Azar; Heiles, Sven; Spengler, Bernhard; Schindler, Siegfried
    Mass spectrometric analysis of transition metal complexes formed through contact of artificial sweat with circulating Euro coins
    In: Zeitschrift für Anorganische und Allgemeine Chemie (ZAAC), Vol. 650, 2024, Nr. 4, e202300213
    DOI (Open Access)
  • Schäfer, Sascha; Heiles, Sven; Schäfer, Rolf
    On the dipole moment distribution of rigid symmetric rotors
    In: The Journal of Chemical Physics (JCP), Vol. 161, 2024, Nr. 4, 044312
    DOI
  • Kanter, Jean-Philippe; Honold, Philipp Jakob; Luh, David; Heiles, Sven; Spengler, Bernhard; Fraatz, Marco Alexander; Zorn, Holger; Hammer, Andreas Klaus
    Biocatalytic Production of Odor-Active Fatty Aldehydes from Fungal Lipids
    In: Journal of Agricultural and Food Chemistry, Vol. 71, 2023, Nr. 21, pp. 8112 – 8120
    DOI
  • Hormann, Felix-Levin; Sommer, Simon; Heiles, Sven
    Formation and Tandem Mass Spectrometry of Doubly Charged Lipid-Metal Ion Complexes
    In: Journal of the American Society for Mass Spectrometry (JASMS), Vol. 34, 2023, Nr. 7, pp. 1436 – 1446
    DOI
  • Müller, Max A.; Zweig, Norman; Spengler, Bernhard; Weinert, Maria; Heiles, Sven
    Lipid Signatures and Inter-Cellular Heterogeneity of Naı̈ve and Lipopolysaccharide-Stimulated Human Microglia-like Cells
    In: Analytical Chemistry, Vol. 95, 2023, Nr. 31, pp. 11672 – 11679
    DOI, Online Full Text (Open Access)
  • Schneemann, Julian; Schäfer, Karl-Christian; Spengler, Bernhard; Heiles, Sven
    IR-MALDI Mass Spectrometry Imaging with Plasma Post-Ionization of Nonpolar Metabolites
    In: Analytical Chemistry, Vol. 94, 2022, Nr. 46, pp. 16086 – 16094
    DOI (Open Access)
  • Dreisbach, Domenic; Heiles, Sven; Bhandari, Dhaka R.; Petschenka, Georg; Spengler, Bernhard
    Molecular Networking and On-Tissue Chemical Derivatization for Enhanced Identification and Visualization of Steroid Glycosides by MALDI Mass Spectrometry Imaging
    In: Analytical Chemistry, Vol. 94, 2022, Nr. 46, pp. 15971 – 15979
    DOI
Read more