There were 1148 publications found

• Wu, Tong; Dhaka, Kapil; Luo, Mengjia; Wang, Bingqing; Wang, Meng; Xi, Shibo; Zhang, Mingsheng; Huang, Fuqiang; Exner, Kai S.; Lum, Yanwei

  CCooperative Active Sites on Ag2Pt3TiS6 for Enhanced Low-Temperature Ammonia Fuel Cell Electrocatalysis

  In: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 6, e202418691 , in press

  DOI (Open Access)
• Klein, Lukas; Tu, Mengyu; Krebs, Niklas; Urbach, Laura; Grimm, Daniela; Latif, Muhammad Umair; Penz, Frederike; Blandau, Anna; Wu, Xueyan; Samuel, Rebecca Diya; Küffer, Stefan; Wegwitz, Florian; Chan, Nathan; Aliar, Kazeera; Vyas, Foram; Kishore, Uday; Hessmann, Elisabeth; Trumpp, Andreas; Espinet, Elisa; Papantonis, Argyris; Khokha, Rama; Ellenrieder, Volker; Grünwald, Barbara; Singh, Shiv K.

  Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 335

  DOI (Open Access)
• Chestnykh, Daria; Mühle, Christiane; Schumacher, Fabian; Kalinichenko, Liubov S.; Löber, Stefan; Gmeiner, Peter; Alzheimer, Christian; von Hörsten, Stephan; Kleuser, Burkhard; Uebe, Steffen; Ekici, Arif B.; Gulbins, Erich; Kornhuber, Johannes; Jin, Hee Kyung; Bae, Jae-sung; Lourdusamy, Anbarasu; Müller, Christian P.

  Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia

  In: Molecular Psychiatry, Vol. 30, 2025, Nr. 7, pp. 2891 – 2906

  DOI (Open Access)
• Spangenberg, Philippa; Bessler, Sebastian; Widera, Lars; Bottek, Jenny; Richter, Mathis; Thiebes, Stephanie; Siemes, Devon; Krauß, Sascha D.; Migas, Lukasz G.; Kasarla, Siva Swapna; Phapale, Prasad; Kleesiek, Jens; Führer, Dagmar; Möller, Lars; Heuer, Heike; Van de Plas, Raf; Gunzer, Matthias; Soehnlein, Oliver; Soltwisch, Jens; Shevchuk, Olga; Dreisewerd, Klaus; Engel, Daniel R.

  msiFlow : automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysis

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 1065

  DOI (Open Access)
• Sewald, Leonard; Tabak, Werner W. A.; Fehr, Lorenz; Zolg, Samuel; Najdzion, Maja; Verhoef, Carlo J. A.; Podlesainski, David; Geiss-Friedlander, Ruth; Lammens, Alfred; Kaschani, Farnusch; Hellerschmied, Doris; Huber, Robert; Kaiser, Markus

  Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 3208

  DOI (Open Access)
• Wolchok, Jedd D.; Chiarion-Sileni, Vanna; Rutkowski, Piotr; Cowey, C. Lance; Schadendorf, Dirk; Wagstaff, John; Queirolo, Paola; Dummer, Reinhard; Butler, Marcus O.; Hill, Andrew G.; Postow, Michael A.; Gaudy-Marqueste, Caroline; Medina, Theresa; Lao, Christopher D.; Walker, John; Márquez-Rodas, Iván; Haanen, John B. A. G.; Guidoboni, Massimo; Maio, Michele; Schöffski, Patrick; Carlino, Matteo S.; Sandhu, Shahneen; Lebbé, Céleste; Ascierto, Paolo A.; Long, Georgina V.; Ritchings, Corey; Nassar, Ayman; Askelson, Margarita; Benito, Melanie Pe; Wang, Wenjia; Hodi, F. Stephen; Larkin, James; CheckMate 067 Investigators

  Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma

  In: The New England Journal of Medicine, Vol. 392, 2025, Nr. 1, pp. 11 – 22

  DOI, Online Full Text (Open Access)
• Müller, Marion; Schubert, Torben; Welke, Cornelius; Maske, Tibor; Patschkowski, Thomas; Donhauser, Elfi; Heinen-Weiler, Jacqueline; Hormann, Felix-Levin; Heiles, Sven; Schulz, Tina Johanna; Lengenfelder, Luisa Andrea; Landwehrjohann, Lucia; Vogt, Elisa Theres; Stratmann, Bernd; Hense, Jurek; Lüdtke, Simon; Düfer, Martina; Tolstik, Elena; Dierks, Johann; Lorenz, Kristina; Huxohl, Tamino; Reil, Jan-Christian; Sequeira, Vasco; Schopfer, Francisco Jose; Freeman, Bruce A.; Rudolph, Volker; Schlomann, Uwe; Klinke, Anna

  Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 3933

  DOI (Open Access)
• Doglioni, Ginevra; Fernández-García, Juan; Igelmann, Sebastian; Altea-Manzano, Patricia; Blomme, Arnaud; La Rovere, Rita; Liu, Xiao-Zheng; Liu, Yawen; Tricot, Tine; Nobis, Max; An, Ning; Leclercq, Marine; El Kharraz, Sarah; Karras, Panagiotis; Hsieh, Yu-Heng; Solari, Fiorella A.; Martins Nascentes Melo, Luiza; Allies, Gabrielle; Scopelliti, Annalisa; Rossi, Matteo; Vermeire, Ines; Broekaert, Dorien; Ferreira Campos, Ana Margarida; Neven, Patrick; Maetens, Marion; Van Baelen, Karen; Alkan, H. Furkan; Planque, Mélanie; Floris, Giuseppe; Sickmann, Albert; Tasdogan, Alpaslan; Marine, Jean-Christophe; Scheele, Colinda L. G. J.; Desmedt, Christine; Bultynck, Geert; Close, Pierre; Fendt, Sarah-Maria

  Aspartate signalling drives lung metastasis via alternative translation

  In: Nature, Vol. 638, 2025, Nr. 2, pp. 244 – 250

  DOI
• Ronnacker, Julian; Grau, Michael; Klasmeier, Maximilian; Klesse, Christian; Baldauf, Henning; Abert, Stefan; Berdel, Andrew F.; Füsser, Friederike T.; Sandmann, Sarah; Albring, Jörn; Reicherts, Christian; Call, Simon; Marx, Julia; Floeth, Matthias; Eßeling, Eva; Kolloch, Lina; Berning, Philipp; Scheller, Annika; Wethmar, Klaus; Schmidt, Hartmut; Schlüter, Bernhard; Berdel, Wolfgang E.; Ostendorf, Benjamin N.; Tavazoie, Sohail F.; Mikesch, Jan-Henrik; Lenz, Georg; Fleischhauer, Katharina; Schetelig, Johannes; Stelljes, Matthias; Schliemann, Christoph

  Common hereditary variants of the APOE gene and posttransplant outcome in acute myeloid leukemia

  In: Blood, Vol. 145, 2025, Nr. 17, pp. 1943 – 1956

  DOI
• Haggenmüller, Sarah; Wies, Christoph; Abels, Julia; Winterstein, Jana T.; Heinlein, Lukas; Nogueira Garcia, Carina; Utikal, Jochen S.; Wohlfeil, Sebastian A.; Meier, Friedegund; Hobelsberger, Sarah; Gellrich, Frank F.; Sergon, Mildred; Hauschild, Axel; French, Lars E.; Heinzerling, Lucie; Schlager, Justin G.; Ghoreschi, Kamran; Schlaak, Max; Hilke, Franz J.; Poch, Gabriela; Korsing, Sören; Sarfert, Cosimo; Berking, Carola; Heppt, Markus V.; Erdmann, Michael; Haferkamp, Sebastian; Drexler, Konstantin; Schadendorf, Dirk; Sondermann, Wiebke; Goebeler, Matthias; Schilling, Bastian; Kather, Jakob Nikolas; Fröhling, Stefan; Llamas-Velasco, Mar; Requena, Luis C.; Ferrara, Gerardo; Fernandez-Figueras, Maite; Fraitag, Sylvie; Müller, Cornelia S. L.; Starz, Hans; Kutzner, Heinz; Barnhill, Raymond; Carr, Richard; Resnik, Kenneth S.; Braun, Stephan Alexander; Holland-Letz, Tim; Brinker, Titus J.

  Discordance, accuracy and reproducibility study of pathologists’ diagnosis of melanoma and melanocytic tumors

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 789

  DOI (Open Access)
• Cai, Ling; Wu, Fangjiang; Zhou, Qinbo; Gao, Ying; Yao, Bo; DeBerardinis, Ralph J.; Acquaah-Mensah, George K.; Aidinis, Vassilis; Beane, Jennifer E.; Biswal, Shyam; Chen, Ting; Concepcion-Crisol, Carla P.; Grüner, Barbara M.; Jia, Deshui; Jones, Robert A.; Kurie, Jonathan M.; Lee, Min Gyu; Lindahl, Per; Lissanu, Yonathan; Lorz, Corina; MacPherson, David; Martinelli, Rosanna; Mazur, Pawel K.; Mazzilli, Sarah A.; Mii, Shinji; Moll, Herwig P.; Moorehead, Roger A.; Morrisey, Edward E.; Ng, Sheng Rong; Oser, Matthew G.; Pandiri, Arun R.; Powell, Charles A.; Ramadori, Giorgio; Santos, Mirentxu; Snyder, Eric L.; Sotillo, Rocio; Su, Kang-Yi; Taki, Tetsuro; Taparra, Kekoa; Tran, Phuoc T.; Xia, Yifeng; van Veen, J. Edward; Winslow, Monte M.; Xiao, Guanghua; Rudin, Charles M.; Oliver, Trudy G.; Xie, Yang; Minna, John D.

  The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models

  In: Cancer Research, Vol. 85, 2025, Nr. 10, pp. 1769 – 1783

  DOI
• Amaral, T.; Ottaviano, M.; Arance, A.; Blank, C.; Chiarion-Sileni, V.; Donia, M.; Dummer, R.; Garbe, C.; Gershenwald, J.E.; Gogas, H.; Guckenberger, M.; Haanen, J.; Hamid, O.; Hauschild, A.; Höller, C.; Lebbé, C.; Lee, R.J.; Long, G.V.; Lorigan, P.; Muñoz Couselo, E.; Nathan, P.; Robert, C.; Romano, E.; Schadendorf, Dirk; Sondak, V.; Suijkerbuijk, K.P.M.; van Akkooi, A.C.J.; Michelin, O.; Ascierto, P.A.; Michielin, O.

  Cutaneous melanoma : ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

  In: Annals of Oncology, Vol. 36, 2025, Nr. 1, pp. 10 – 30

  DOI
• Giuranna, Johanna; Zheng, Yiran; Brandt, Matthäus; Jall, Sigrid; Mukherjee, Amrita; Shankhwar, Soni; Renner, Simone; Kurapati, Nirup Kumar; May, Caroline; Peters, Triinu; Herpertz-Dahlmann, Beate; Seitz, Jochen; de Zwaan, Martina; Herzog, Wolfgang; Ehrlich, Stefan; Zipfel, Stephan; Giel, Katrin; Egberts, Karin; Burghardt, Roland; Föcker, Manuel; Marcus, Katrin; Keyvani, Kathy; Müller, Timo D.; Schmitz, Frank; Rajcsanyi, Luisa Sophie; Hinney, Anke

  Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation

  In: Molecular Psychiatry, Vol. 30, 2025, Nr. 5, pp. 1836 – 1846

  DOI (Open Access)
• Katz, Liora S.; Visser, Emira J.; Plitzko, Kathrin F.; Pennings, Marloes A. M.; Cossar, Peter J.; Tse, Isabelle L.; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian; Scott, Donald K.

  Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 2110

  DOI (Open Access)
• Pekayvaz, Kami; Kilani, Badr; Joppich, Markus; Eivers, Luke; Brambs, Sophia; Knottenberg, Viktoria; Akgöl, Sezer; Yue, Keyang; Li, Lukas; Martinez-Navarro, Alejandro; Kaiser, Rainer; Meißner, Nina; Schulz, Heiko; Belz, Larissa; Akhalkatsi, Anastassia; Stockhausen, Sven; Mueller, Tonina T.; Millonig, Simon; Hartelt, Lea; Gold, Christoph; Janjic, Aleksandar; Polewka, Vivien; Wendler, Franziska; Droste zu Senden, Augustin; Titova, Anna; Leunig, Alexander; Voelkl, Michael; Engelmann, Bernd; Hernandez Petzsche, Moritz R.; Boeckh-Behrens, Tobias; Liebig, Thomas; Winning, Sandra; Fandrey, Joachim; Dichgans, Martin; Enard, Wolfgang; Zimmer, Ralf; Tiedt, Steffen; Massberg, Steffen; Nicolai, Leo; Stark, Konstantin

  Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution

  In: Immunity, Vol. 58, 2025, Nr. 5, pp. 1343 – 1358.e13

  DOI (Open Access)
• Schmiedtchen, Marco; Maisuls, Iván; Siera, Hannah; Balszuweit, Jan; Wölper, Christoph; Giese, Michael R. A.; Haberhauer, Gebhard; Strassert, Cristian A.; Voskuhl, Jens

  In situ Cyclization of Aromatic Thioethers in Emissive Materials to Generate Phosphorescent Dibenzothiophenes

  In: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 2, e202414326

  DOI (Open Access)
• Schwarz, Tatjana; Ptok, Johannes; Damagnez, Maximilian; Menne, Christopher; Alizei, Elahe Salimi; Lang-Meli, Julia; Maas, Michelle; Habermann, Daniel; Hoffmann, Daniel; Schulze zur Wiesch, Julian; Lauer, Georg; Kefalakes, Helenie; Cornberg, Markus; Kraft, Anke RM.; Gliga, Smaranda; Bock, Hans H.; Horn, Peter A.; Maini, Mala K.; Thimme, Robert; Wedemeyer, Heiner; Nattermann, Jacob; Heinemann, Falko M.; Luedde, Tom; Neumann-Haefelin, Christoph; Walker, Andreas; Timm, Jörg

  HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication

  In: Journal of Hepatology, Vol. 82, 2025, Nr. 5, pp. 805 – 815

  DOI (Open Access)
• Lopez, Juanita; Powles, Thomas; Braiteh, Fadi; Siu, Lillian L.; LoRusso, Patricia; Friedman, Claire F.; Balmanoukian, Ani S.; Gordon, Michael; Yachnin, Jeffrey; Rottey, Sylvie; Karydis, Ioannis; Fisher, George A.; Schmidt, Marcus; Schuler, Martin; Sullivan, Ryan J.; Burris, Howard A.; Galvao, Vladimir; Henick, Brian S.; Dirix, Luc; Jaeger, Dirk; Ott, Patrick A.; Wong, Kit Man; Jerusalem, Guy; Schiza, Aglaia; Fong, Lawrence; Steeghs, Neeltje; Leidner, Rom S.; Rittmeyer, Achim; Laurie, Scott A.; Gort, Eelke; Aljumaily, Raid; Melero, Ignacio; Sabado, Rachel L.; Rhee, Ina; Mancuso, Michael R.; Muller, Lars; Fine, Gregg D.; Yadav, Mahesh; Kim, Leesun; Leveque, Vincent J. P.; Robert, Alberto; Darwish, Martine; Qi, Ting; Zhu, Jiawen; Zhang, Jingbin; Twomey, Patrick; Rao, Gautham K.; Low, Donald W.; Petry, Chris; Lo, Amy A.; Schartner, Jill M.; Delamarre, Lélia; Mellman, Ira; Löwer, Martin; Müller, Felicitas; Derhovanessian, Evelyna; Cortini, Andrea; Manning, Luisa; Maurus, Daniel; Brachtendorf, Sebastian; Lörks, Verena; Omokoko, Tana; Godehardt, Eva; Becker, Dirk; Hawner, Christine; Wallrapp, Christine; Albrecht, Christian; Kröner, Christoph; Tadmor, Arbel D.; Diekmann, Jan; Vormehr, Mathias; Jork, Anette; Paruzynski, Anna; Lang, Maren; Blake, Jonathon; Hennig, Oliver; Kuhn, Andreas N.; Sahin, Ugur; Türeci, Özlem; Camidge, D. Ross

  Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial

  In: Nature Medicine, Vol. 31, 2025, Nr. 1, pp. 152 – 164

  DOI (Open Access)
• Braun, Lukas M.; Giesler, Sophie; Andrieux, Geoffroy; Riemer, Roxane; Talvard-Balland, Nana; Duquesne, Sandra; Rückert, Tamina; Unger, Susanne; Kreutmair, Stefanie; Zwick, Melissa; Follo, Marie; Hartmann, Alina; Osswald, Natascha; Melchinger, Wolfgang; Chapman, Stefanie; Hutchinson, James A.; Haferkamp, Sebastian; Torster, Leopold; Kött, Julian; Gebhardt, Christoffer; Hellwig, Dirk; Karantzelis, Nikolaos; Wallrabenstein, Till; Lowinus, Theresa; Yücel, Mehtap; Brehm, Niklas; Rawluk, Justyna; Pfeifer, Dietmar; Bronsert, Peter; Rogg, Manuel; Mattern, Sven; Heikenwälder, Mathias; Fusco, Stefano; Malek, Nisar P.; Singer, Stephan; Schmitt-Graeff, Annette; Ceteci, Fatih; Greten, Florian R.; Blazar, Bruce R.; Boerries, Melanie; Köhler, Natalie; Duyster, Justus; Ihorst, Gabriele; Lassmann, Silke; Keye, Philip; Minguet, Susana; Schadendorf, Dirk; Ugurel, Selma; Rafei-Shamsabadi, David; Thimme, Robert; Hasselblatt, Peter; Bengsch, Bertram; Schell, Christoph; Pearce, Erika L.; Meiss, Frank; Becher, Burkhard; Funke-Lorenz, Carolin; Placke, Jan-Malte; Apostolova, Petya; Zeiser, Robert

  Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

  In: Cancer Cell, Vol. 43, 2025, Nr. 2, pp. 269 – 291.e19

  DOI (Open Access)
• Lu, Zhe; Stencel, Olivia; Liu, Wei; Vasileiou, Eleni; Xu, Haifeng C; Pandey, Piyush; Stachura, Paweł; Elwy, Abdelrahman; Tsombal, Anastassia; Mai, Ann-Sophie; Auer, Franziska; Morcos, Mina N F; Seidl, Maximilian; Koziel, Sarah; Bruch, Peter-Martin; Dietrich, Sascha; Elitzur, Sarah; Hartmann, Gunther; Lang, Karl S.; Janssen, Stefan; Fischer, Ute; Bhatia, Sanil; Lang, Philipp A; Borkhardt, Arndt; Hauer, Julia; Pandyra, Aleksandra A

  Immune training enhances anti-viral responses and improves outcomes in Pax5−/⁺ mice susceptible to chronic infection

  In: EMBO Molecular Medicine, Vol. 17, 2025, Nr. 4, pp. 696 – 721

  DOI (Open Access)
• Martinez-Rivas, Gemma; Ayala, Maria Victoria; Bender, Sebastien; Codo, Gilles Roussine; Swiderska, Weronika Karolina; Lampis, Alessio; Pedroza, Laura; Merdanovic, Melisa; Sicard, Pierre; Pinault, Emilie; Richard, Laurence; Lavatelli, Francesca; Giorgetti, Sofia; Canetti, Diana; Rinsant, Alexa; Kaaki, Sihem; Ory, Cécile; Oblet, Christelle; Pollet, Justine; Naser, Eyad; Carpinteiro, Alexander; Roussel, Muriel; Javaugue, Vincent; Jaccard, Arnaud; Bonaud, Amélie; Delpy, Laurent; Ehrmann, Michael; Bridoux, Frank; Sirac, Christophe

  A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 2992

  DOI (Open Access)
• Salguero-Linares, Jose; Armengot, Laia; Ayet, Joel; Ruiz-Solaní, Nerea; Saile, Svenja C; Salas-Gómez, Marta; Fernandez, Esperanza; Denolf, Lode; Navarrete, Fernando; Krumbach, Jenna; Kaiser, Markus; Stael, Simon; Van Breusegem, Frank; Gevaert, Kris; Kaschani, Farnusch; Petersen, Morten; El Kasmi, Farid; Valls, Marc; Coll, Núria S

  Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability

  In: EMBO Reports, Vol. 26, 2025, Nr. 9, pp. 2378 – 2412

  DOI (Open Access)
• Cai, Ling; Hammond, Nia G.; Tasdogan, Alpaslan; Alsamraae, Massar; Yang, Chendong; Cameron, Robert B.; Quan, Peiran; Solmonson, Ashley; Gu, Wen; Pachnis, Panayotis; Kaur, Mayher; Chang, Brianna K.; Zhou, Qin; Hensley, Christopher T.; Do, Quyen N.; Martins Nascentes Melo, Luiza; Ubellacker, Jessalyn M.; Kaushik, Akash; Clare, Maia G.; Alcazar, Isabel N.; Kurylowicz, Katarzyna; Marcuccilli, Joseph D.; Allies, Gabriele; Kutritz, Andrea; Klode, Joachim; Ramesh, Vijayashree; Rogers, Thomas J.; Rao, Aparna D.; Crentsil, Hannah E.; Li, Hong; Brister, Fang; McDaniel, Phyllis; Xu, Xiaohong; Evers, Bret M.; Zacharias, Lauren G.; Sudderth, Jessica; Xu, Jian; Mathews, Thomas P.; Oliver, Dwight; Minna, John D.; Waters, John; Morrison, Sean J.; Kernstine, Kemp H.; Faubert, Brandon; DeBerardinis, Ralph J.

  High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients

  In: Cancer Discovery, Vol. 15, 2025, Nr. 4, pp. 702 – 716

  DOI (Open Access)
• Kolb, Antonia; Kulis-Mandic, Ana-Marija; Klein, Matthias; Stastny, Anna; Haist, Maximilian; Votteler, Vanessa; Weidenthaler-Barth, Beate; Sinnberg, Tobias; Sucker, Antje; Allies, Gabriele; Albrecht, Jessica Lea; Tasdogan, Alpaslan; Tuettenberg, Andrea; Gaida, Matthias M.; Deppermann, Carsten; Stege, Henner; Schadendorf, Dirk; Grabbe, Stephan; Schulze-Osthoff, Klaus; Kramer, Daniela

  Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 5387

  DOI (Open Access)
• Usama, Muhammad; Razzaq, Samad; Hättig, Christof; Steinmann, Stephan N.; Exner, Kai S.

  Oxygen evolution reaction on IrO₂(110) is governed by Walden-type mechanisms

  In: Nature Communications, Vol. 16, 2025, Nr. 1, 6137

  DOI (Open Access)
• Lipson, Evan J.; Dolfi, Sonia; Tang, Hao; Tawbi, Hussein A.; Medina-Soto, Francisco; Castillo Gutiérrez, Erika; Rutkowski, Piotr; Gogas, Helen; Murillo, Emilio; Ascierto, Paolo A.; Desai, Keyur; Maio, Michele; Demers, Korey; Mazzei, Antonella; Keidel, Sarah; Miller-Moslin, Karen; Yu, Jia Xin; Hodi, F Stephen; Schadendorf, Dirk; Long, Georgina V.; Garnett-Benson, Charlie

  Unraveling Relatlimab-Specific Biology Using Biomarker Analyses in Patients with Advanced Melanoma in RELATIVITY-047

  In: Clinical Cancer Research, Vol. 31, 2025, Nr. 17, pp. 3702 – 3714

  DOI (Open Access)
• Majunke, Nicolas; Haertel, Franz; Binzenhöfer, Leonhard; Fischer, Natalie; Höpler, Julia; Scherzer, Marie; Hoffmann, Sabine; Scherer, Clemens; Lanz, Hugo; Hering, Daniel; Gade, Nils; Roden, Daniel; Huseynov, Aydin; Akin, Ibrahim; Graf, Tobias; Sinning, Jan-Malte; Jung, Christian; Pappalardo, Federico; Camane, Evija; Ērglis, Andrejs; Schwinger, Robert H G; Crusius, Lisa; Mangner, Norman; Sobrino, Teresa López; Sabate, Manel; Hoyer, Daniel; Tongers, Jörn; Verbelen, Tom; Goslar, Tomaz; Noc, Marko; Amr, Ebe; Billig, Hannah; De Roeck, Frederic; Sturkenboom, Nicole; Lüdike, Peter; Hullermann, Carsten; Schäfer, Andreas; Ferreira, Rita; Kriz, Marvin; Dettling, Angela; Beer, Benedikt; Schrage, Benedikt; Kirschbaum, Klara; Probst, Lukas; Leistner, David M; Meder, Benjamin; Hagl, Christian; Zeymer, Uwe; Massberg, Steffen; Dutzmann, Jochen; Möbius-Winkler, Sven; Rassaf, Tienush; Combes, Alain; Zimmer, Sebastian; Nickenig, Georg; Uribarri, Aitor; Thiele, Holger; Lüsebrink, Enzo

  Fulminant myocarditis : outcome predictors in an international cohort study

  In: European Heart Journal, 2025, in press

  DOI
• Cmentowski, Verena; Musacchio, Andrea

  The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona

  In: Science Advances, Vol. 11, 2025, Nr. 37, eady6890

  DOI (Open Access)
• Führer, Siska; Gallant, Kai; Kaschani, Farnusch; Kaiser, Markus; Janning, Petra; Waldmann, Herbert; Gersch, Malte

  Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome Analysis

  In: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 32, e202508916

  DOI (Open Access)
• Zeymer, Uwe; Freund, Anne; Noc, Marko; Akin, Ibrahim; Huber, Kurt; Pöss, Janine; Schneider, Steffen; Rassaf, Tienush; Jung, Christian; Tigges, Eike; Ouarrak, Taoufik; Desch, Steffen; Thiele, Holger

  Influence of Resuscitated Cardiac Arrest on Efficacy and Safety of Extracorporeal Life Support in Infarct-Related Cardiogenic Shock : A Substudy of the ECLS-SHOCK Trial

  In: Circulation, Vol. 151, 2025, Nr. 24, pp. 1752 – 1754

  DOI
• Sanguankiattichai, Nattapong; Chandrasekar, Balakumaran; Sheng, Yuewen; Hardenbrook, Nathan; Tabak, Werner W.A.; Drapal, Margit; Kaschani, Farnusch; Grünwald-Gruber, Clemens; Krahn, Daniel; Buscaill, Pierre; Yamamoto, Suzuka; Kato, Atsushi; Nash, Robert; Fleet, George; Strasser, Richard; Fraser, Paul D.; Kaiser, Markus; Zhang, Peijun; Preston, Gail M.; van der Hoorn, Renier A.L.

  Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology

  In: Science, Vol. 388, 2025, Nr. 6744, pp. 297 – 303

  DOI
• Gyan-Barimah, Caleb; Dhaka, Kapil; Lee, Ha-Young; Wei, Yi; Maulana, Muhammad Irfansyah; Yu, Jeong-Hoon; Yu, Bo; Exner, Kai; Yu, Jong-Sung

  Intermetallic Platinum-Calcium Alloy Breaks the Activity-Stability Trade-Off in Fuel Cell for Enhanced Performance

  In: Small, Vol. 21, 2025, Nr. 31, 2503692

  DOI (Open Access)
• Rodier, Clement; Estabrook, Ian D.; Chan, Eunice HoYee; Rice, Gavin; Loreau, Vincent; Raunser, Stefan; Görlich, Dirk; Friedrich, Benjamin M.; Schnorrer, Frank

  Muscle growth by sarcomere divisions

  In: Science Advances, Vol. 11, 2025, Nr. 28, eadw9445

  DOI (Open Access)
• Kim, Jinjong; Usama, Muhammad; Exner, Kai; Joo, Sang Hoon

  Renaissance of Chlorine Evolution Reaction : Emerging Theory and Catalytic Materials

  In: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 1, e202417293

  DOI (Open Access)
• Pabst, Kim M; Weber, Manuel; Laschinsky, Christina; Sandach, Patrick; Bartel, Timo; Küper, Alina T; Kessler, Lukas; Trajkovic-Arsic, Marija; Eckstein, Markus; Gilman, Elena; Nader, Michael; Barbato, Francesco; Podleska, Lars; Hadaschik, Boris; Hamacher, Rainer; Kersting, David; von Ostau (N.), Nicola; von Tresckow, Bastian; Kaelberlah, Hans-Peter; Kesch, Claudia; Kuemmel, Sherko; Reinacher-Schick, Anke; Schuler, Martin; Siveke, Jens; Grünwald, Viktor; Herrmann, Ken; Fendler, Wolfgang P.

  [⁶⁸Ga]Ga-FAPI-46 PET accuracy for cancer imaging with histopathology validation : A single-centre, single-arm, interventional, phase 2 trial

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  Comparison of pulsed field ablation versus cryoballon and radiofrequency ablation for pulmonary vein isolation in atrial fibrillation patients with heart failure

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  Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O) : disease-free survival results from a randomised, open-label, phase 2 trial

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  Circulating tumor DNA analysis of the phase III VOYAGER trial : KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenib

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  Health-related quality of life and pain outcomes with [¹⁷⁷Lu]Lu-PSMA-617 plus standard of care versus standard of care in patients with metastatic castration-resistant prostate cancer (VISION) : a multicentre, open-label, randomised, phase 3 trial

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  Impact of bimetallic interface design on heat generation in plasmonic Au/Pd nanostructures studied by single-particle thermometry

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  Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection

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  Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors

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  Extracorporeal Life Support in Infarct-Related Cardiogenic Shock

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  Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

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  Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG¹²C mutation : a randomised, open-label, phase 3 trial

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  Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

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  LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth

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  Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype

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  Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy

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  Differentiating between Acidic and Basic Surface Hydroxyls on Metal Oxides by Fluoride Substitution : A Case Study on Blue TiO₂ from Laser Defect Engineering

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  A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

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  Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease

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  Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers

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  Cell-intrinsic ceramides determine T cell function during melanoma progression

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  In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors

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  Stroke genetics informs drug discovery and risk prediction across ancestries

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  Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin

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  Structural basis of actin filament assembly and aging

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  Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin

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  CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor

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  A cryogenic, coincident fluorescence, electron, and ion beam microscope

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  Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemia

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  Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW) : a multi-cohort, open-label, registrational, phase 1/2 study

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  Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib

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  Cellular model system to dissect the isoform-selectivity of Akt inhibitors

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  Metabolic requirements of NK cells during the acute response against retroviral infection

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  Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteins

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  Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore

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  Nomograms to predict outcomes after ¹⁷⁷Lu-PSMA therapy in men with metastatic castration-resistant prostate cancer : An international, multicentre, retrospective study

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  MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

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  Diagnostic Accuracy of ⁶⁸Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node Dissection : A Multicenter Prospective Phase 3 Imaging Trial

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  Multiple Hepatic and Pulmonary Tumors Combined with Bilateral Adrenal Masses in a Young Woman with von Hippel–Lindau Disease

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  Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

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  PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice

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  Nuclear medicine theranostics comes of age

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  Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies

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  EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

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  Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

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  Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly

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  Bone sarcomas : ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

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  Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study

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  Enhanced detection of minimal residual disease by targeted sequencing of phased variants in circulating tumor DNA

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  Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanisms

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  NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

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  TRIP6 functions in brain ciliogenesis

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  Sugar-modified B-cell receptors in DLBCL

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  Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

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  Soft tissue and visceral sarcomas : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

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  An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

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  Nuclear receptor coactivator NCOA3 regulates UV radiation⇓induced DNA damage and melanoma susceptibility

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  Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas

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  Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial

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  BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis

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  Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

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  Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization

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  Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trial

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  Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains

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  Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

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  FAST : a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma

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  Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

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  Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid

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  Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability

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  Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM

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  UMI or not UMI, that is the question for scRNA-seq zero-inflation

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  Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domain

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  Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

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  Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors

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  Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling

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  Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections

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  Leadership challenges defused

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  SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

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  Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

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  Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation study

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  PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

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  Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

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  PI3KC2β inactivation stabilizes VE‐cadherin junctions and preserves vascular integrity

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  The West German heart and vascular center at university medicine Essen

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  Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial

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  Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial

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  Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment

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  Single-Particle Hyperspectral Imaging Reveals Kinetics of Silver Ion Leaching from Alloy Nanoparticles

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  Sotorasib for Lung Cancers with KRAS p.G12C Mutation

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  Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression

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  Assembly principles and stoichiometry of a complete human kinetochore module

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  Neutrophils self-limit swarming to contain bacterial growth in vivo

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  Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer

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  GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancer

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  The molecular basis for sarcomere organization in vertebrate skeletal muscle

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  Cryo-EM Resolves Molecular Recognition Of An Optojasp Photoswitch Bound To Actin Filaments In Both Switch States

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  Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM

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  TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

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  Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens

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  High-resolution structures of the actomyosin-v complex in three nucleotide states provide insights into the force generation mechanism

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  Dead Cells Induce Innate Anergy via Mertk after Acute Viral Infection

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  Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma

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  Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS) : a double-blind, randomised, placebo-controlled, phase 3 trial

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  Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

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  A clinical perspective on the 2019 ESC/EAS guidelines for the management of dyslipidaemias: PCSK-9 inhibitors for all?

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  Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome

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  Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical Trial

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  Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV⁶⁰⁰-mutant, stage III melanoma (COMBI-AD) : Exploratory biomarker analyses from a randomised, phase 3 trial

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  Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52

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  Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trial

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  Corrigendum to “Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics”

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  High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

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  A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

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  Cardiac fibroblast activation detected by positron emission tomography/computed tomography as a possible sign of cardiotoxicity

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  Predominance of Central Memory T Cells with High T-Cell Receptor Repertoire Diversity is Associated with Response to PD-1/PD-L1 Inhibition in Merkel Cell Carcinoma

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  Survival Outcomes Associated with 3 Years vs 1 Year of Adjuvant Imatinib for Patients with High-Risk Gastrointestinal Stromal Tumors : An Analysis of a Randomized Clinical Trial after 10-Year Follow-up

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  Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 Trial

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  Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4) : A randomised, phase 2/3 trial

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  A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus : the MONO study

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  Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

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  Five-year outcomes with dabrafenib plus trametinib in metastatic melanoma

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  Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

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  Value of Progression of Coronary Artery Calcification for Risk Prediction of Coronary and Cardiovascular Events : Result of the HNR Study (Heinz Nixdorf Recall)

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  Overall survival at 4 years of follow-up in a phase III trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067)

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  Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib + trametinib (D + T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

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  Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trial

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  Antidepressants regulate autophagy by targeting acid sphingomyelinase

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  A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases

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  Adjuvant pembrolizumab versus placebo in resected stage III melanoma

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  The landscape of genomic alterations across childhood cancers

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  Bortezomib before and after high-dose therapy in myeloma : Long-term results from the phase III HOVON-65/GMMG-HD4 trial

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  Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

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  Hierarchical Assembly of DNA Filaments with Designer Elastic Properties

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  Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals

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  Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

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  An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma

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  Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease

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  A critical view on transgenerational epigenetic inheritance in humans

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  Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

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  Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

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  Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.

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  BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

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  Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

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  A distinct oncogenerative multinucleated cancer cell serves as a source of stemness and tumor heterogeneity

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  Circulating cell-free miR-375 as surrogate marker of tumor burden in Merkel cell carcinoma

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  Integrated genomic classification of melanocytic tumors of the central nervous system using mutation analysis, copy number alterations, and DNA methylation profiling

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  Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targeting

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  PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma

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  Adjuvant melanoma therapy with new drugs : Should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?

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  Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2) : An open-label, multicentre, phase 2 trial

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  Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS) : A multicentre, open-label, randomised, phase 3 trial

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  Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

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  Sphingolipids as targets for inhalation treatment of cystic fibrosis

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  Ideal Dimers of Gold Nanospheres for Precision Plasmonics : Synthesis and Characterization at the Single-Particle Level for Identification of Higher Order Modes

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  Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

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  Mycophenolate plus methylprednisolone versus methylprednisolone alone in active, moderate-to-severe Graves' orbitopathy (MINGO) : a randomised, observer-masked, multicentre trial

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  Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trial

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  Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysis

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  CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection

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  Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs

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  Human CD30⁺ B cells represent a unique subset related to Hodgkin lymphoma cells

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  Quantitative Determination of Contribution by Enhanced Local Electric Field, Antenna-Amplified Light Scattering, and Surface Energy Transfer to the Performance of Plasmonic Organic Solar Cells

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  Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

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  Evolution of the Optical Gap in the Acene Series : Undecacene

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  Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia

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  Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype

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  Critical influences on the pathogenesis of follicular lymphoma

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  Cell entry of a host-targeting protein of oomycetes requires gp96

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  Small Meets Smaller : Effects of Nanomaterials on Microbial Biology, Pathology, and Ecology

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  Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trial

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  Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib plus trametinib (D plus T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

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  Extrahepatic Comorbidities Do Not Alter the Safety and Efficacy of Radioembolization of NAFLD-Associated HCC

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  Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

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  BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling

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  PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer

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  Two intermittent vismodegib dosing regimens in patients with multiple basal-cell carcinomas (MIKIE) : a randomised, regimen-controlled, double-blind, phase 2 trial

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  Vemurafenib in metastatic melanoma patients with brain metastases : An open-label, single-arm, phase 2, multicentre study

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  Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma : long-term survival and safety analysis of a phase 3 study

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  Docetaxel, oxaliplatin, and fluorouracil/leucovorin (FLOT) for resectable esophagogastric cancer : Updated results from multicenter, randomized phase 3 FLOT4-AIO trial (German Gastric Group at AIO)

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  Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma : a randomised, double-blind, multicentre, phase 3 trial

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  Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO) : a multicentre, open-label, randomised, phase 3 trial

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  The International Human Epigenome Consortium : A Blueprint for Scientific Collaboration and Discovery

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  Time to Give Up on Cardioprotection? : A Critical Appraisal of Clinical Studies on Ischemic Pre-, Post-, and Remote Conditioning

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  Melanoma Lesions Independently Acquire T-cell Resistance during Metastatic Latency

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  Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus

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  Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment : a pooled analysis of individual patient data from randomised trials

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  Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1) : updated results from the multicentre, open-label, phase 1 trial

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  IMAB362 : a novel immunotherapeutic antibody targeting the tight-junction protein component CLAUDIN18.2 in gastric cancer

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  Combination of encorafenib and cetuximab with or without alpelisib in patients with advanced BRAF-mutant colorectal cancer (BRAFm CRC) : phase 2 results

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  Effect of dose adjustment on the safety and efficacy of afatinib for EGFR mutation-positive lung adenocarcinoma : post hoc analyses of the randomized LUX-Lung 3 and 6 trials

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  A phase I, open-label study of pasireotide in patients with BRAF- and NRAS-wild type, unresectable and or metastatic melanoma

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  Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation

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  Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia

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  Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice

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  Radiosensitization by BRAF inhibitor therapy-mechanism and frequency of toxicity in melanoma patients

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  HJURP involvement in De Novo CenH3CENP-A and CENP-C recruitment

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  CEACAM1-3S drives melanoma cells into NK cell-mediated cytolysis and enhances patient survival

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  Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma : a multicentre, double-blind, phase 3 randomised controlled trial

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  Overall survival (OS) with afatinib (A) vs chemotherapy (CT) in patients (pts) with NSCLC harboring EGFR mutations (mut) : Subgroup analyses by race in LUX-Lung 3 (LL3) and LUX-Lung 6 (LL6)

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  Afatinib (A) versus chemotherapy (CT) for EGFR mutation-positive NSCLC patients (pts) aged ≥65 years : Subgroup analyses of LUX-Lung 3 (LL3) and LUX-Lung 6 (LL6)

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  Influence of dose adjustment on afatinib safety and efficacy in patients (pts) with advanced EGFR mutation-positive (EGFRm plus ) non-small cell lung cancer (NSCLC)

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  Afatinib (a) plus paclitaxel (p) following progression on a monotherapy in patients (pts) with metastatic non-small-cell lung cancer (nsclc) who previously benefited from erlotinib (e)/gefitinib (g) : a global randomised phase iii triallux-lung 5 (ll5)

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  Adaptation of the Hepatitis B Virus Core Protein to CD8+ T-Cell Selection Pressure

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  BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity

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  Reversible reconfiguration of DNA origami nanochambers monitored by single-molecule FRET

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  The (phospho) needle in the (MELT) haystack

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  Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3

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  Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans

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  Functional divergence of two secreted immune proteases of tomato

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  A molecular tweezer antagonizes seminal amyloids and HIV infection

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  NEMO : A phase 3 trial of binimetinib (MEK162) versus dacarbazine in patients with advanced NRAS-mutant melanoma who are untreated or have progressed on or after immunotherapy

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  Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma

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  Endothelial cells isolated from colorectal carcinoma exhibit tumor microenvironment-dependent plasticity allowing the identification of SPARCL1 as a novel endothelial cell quiescence factor

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  Alternative tumor suppressor mechanisms in lung carcinomas - modulation of senescence by growth factor-induced signaling

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  Telomerase activation by genomic rearrangements in high-risk neuroblastoma

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  Final biomarker analysis of the phase I study of the selective BRAF V600 inhibitor encorafenib (LGX818) combined with cetuximab with or without the α-specific PI3K inhibitor alpelisib (BYL719) in patients with advanced BRAF-mutant colorectal cancer

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  Complement Inhibition with Eculizumab in Patients with Cold Agglutinin Disease (CAD) : Results from a Prospective Phase II Trial (DECADE Trial)

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  Immunoglobulin M Heavy/Light Chain Pair Measurement Independently Predicts Clinical Outcome and Refines Prognostic Information Provided By Interim PET in Patients with Aggressive Lymphomas

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  Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): Final results of the multicentre, open-label, randomised, phase 3 trial

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  Genomic Classification of Cutaneous Melanoma

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  Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

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  Whole-genome fingerprint of the DNA methylome during human B cell differentiation

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  Progressive epigenetic programming during B cell maturation yields a continuum of clonal disease phenotypes with distinct etiologies in chronic lymphocytic leukemia

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  Recurrent CDKN1B (p27) mutations in hairy cell leukemia

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  Origins of major archaeal clades correspond to gene acquisitions from bacteria

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  Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia

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  International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

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  Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

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  Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria

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  The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

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  Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002) : a randomised, controlled, phase 2 trial

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  Conjugated Bilirubin Triggers Anemia by Inducing Erythrocyte Death

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  DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control

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  Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia

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  Analysis of varicella-zoster virus in temporal arteries biopsy positive and negative for giant cell arteritis

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  An Interbacterial NAD(P)⁺ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

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  Unveiling the Correlation between Nanometer-Thick Molecular Monolayer Sensitivity and Near-Field Enhancement and Localization in Coupled Plasmonic Oligomers

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  Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions

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  HLA-B*27 is protective against HCV genotype 1 and 3 and associated with targeting of distinct genotype-specific CD8(+) cell epitopes

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  T-cell responses to oncogenic Merkel cell polyomavirus proteins distinguish patients with Merkel cell carcinoma from healthy donors

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  Surrogate endpoints for overall survival in metastatic melanoma: A meta-analysis of randomised controlled trials

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  KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats

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  Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization

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  Hepatic intra-arterial versus intravenous fotemustine in patients with liver metastases from uveal melanoma (EORTC 18021) : A multicentric randomized trial

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  Functional and symptom impact of trametinib versus chemotherapy in BRAF V600E advanced or metastatic melanoma : Quality-of-life analyses of the METRIC study

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  Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanoma

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  Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans : A multicenter phase II DeCOG Trial with Long-Term Follow-Up

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  Circulating CD4+ T cells that produce IL4 or IL17 when stimulated by Melan-A but not by NY-ESO-1 have negative impacts on survival of patients with stage IV melanoma

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  Myeloid-derived suppressor cells predict survival of patients with advanced melanoma : Comparison with regulatory T cells and NY-ESO-1- or melan-A-specific T cells

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  Positron Emission Tomography (PET) Guided Therapy of Aggressive Lymphomas - a Randomized Controlled Trial Comparing Different Treatment Approaches Based on Interim PET Results (PETAL Trial)

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  Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3) : extended follow-up of a phase 3, randomised, open-label study

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  Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

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  Combined SNP Microarray Based Genomic Mapping and Next Generation Transcriptome Sequencing Confirms the Presence of Somatic STAT3 Mutations and Identifies Novel Chromosomal Imbalances and Candidate Genes in T Large Granular Lymphocytic Leukemia (T-LGL)

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  Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

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  Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p

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  Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas

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  Common variants at 12q15 and 12q24 are associated with infant head circumference

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  Improved survival with MEK inhibition in BRAF-mutated melanoma

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  Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection

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  Prevalence and dynamics of bcr-abl kinase domain mutations during imatinib treatment differ in patients with newly diagnosed and recurrent bcr-abl positive acute lymphoblastic leukemia

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  Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

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  Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer

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  Promoting brain remodelling and plasticity for stroke recovery : Therapeutic promise and potential pitfalls of clinical translation

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  Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis

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  Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling

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  Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

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  A Landscape of Driver Mutations in Melanoma

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  Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

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  Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with epcampositive relapsed or refractory advanced-stage breast cancer

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  Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma

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  Advances and perspectives in immunotherapy of melanoma

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  Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB) : A multicentre, open-label, phase 2 trial

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  LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

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  TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance - Forming modification

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  Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing

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  Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling

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  Small-molecule stabilization of protein-protein interactions : An underestimated concept in drug discovery?

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  The impact of plant-pathogen studies on medicinal drug discovery

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  Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosis

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  Melanoma genome sequencing reveals frequent PREX2 mutations

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  Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D

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  Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis

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  Hydroxyureas as noncovalent proteasome inhibitors

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  Brain natriuretic peptide (BNP) : A general mortality predictor in HIV-infected patients? - Results from the 5 year follow-up of the HIV-HEART trial

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  Efficient pharmacological prevention of the major side effects of cisplatin without affecting the antineoplastic effiacy in vivo

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  LUX-Lung 3 : Symptom and health-related quality of life results from a randomized phase III study in 1st-line advanced NSCLC patients harbouring EGFR mutations

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  Phase IB dose-escalation study of BEZ235 or BKM 120 in combination with paclitaxel (PTX) in patients with advanced solid tumors

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  Lux-LungG 3 : Afatinib versus cisplatin and pemetrexed in Japanese patients with adenocarcinoma of the lung harboring an EGFR mutation

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  Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations in Lux-Lung 3, a phase III trial of afatinib or cisplatin/pemetrexed EGFR mutation-positive lung cancer

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  Changes of peripheral alpha LPHA-Melanocortin stimulating hormone (alpha-MSH) in childhood craniopharyngioma patients in comparison with other forms of childhood obesity

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  Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain

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  Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors

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  MEK inhibition in BRAF-mutated melanoma

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  Why not the liver instead of the kidney?

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  Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes

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  BLUEPRINT to decode the epigenetic signature written in blood

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  Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants

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  The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia

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  The heterodimerization domains of MLL-FYRN and FYRC-are potential target structures in t(4;11) leukemia.

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  Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides

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  Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

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  Substrate induced remodeling of the active site regulates human HtrA1 activity

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  The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

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  Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma

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  miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples

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  High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma

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  Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans

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  Cleavage of cohesin rings coordinates the separation of centrioles and chromatids

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  Covalent Tethering of Protruding Arms for Addressable DNA Nanostructures

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  CD8+ T-Cell Response Promotes Evolution of Hepatitis C Virus Nonstructural Proteins

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  Nanoparticle size is a critical physicochemical determinant of the human blood plasma corona : a comprehensive quantitative proteomic analysis

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  HTRA proteases : regulated proteolysis in protein quality control

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  Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

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  Functionalization of DNA nanostructures with proteins

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  Comparison of PIK3CA Hot Spot Mutations in the Primary Tumor or Metastases with PIK3CA Mutations or PIK3CA Over-Expression in Circulating Tumor Cells of Metastatic Breast Cancer Patients under Sequential Palliative Therapy

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  G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands

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  Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections

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  Protein quality control in the bacterial periplasm

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  Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis

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  NPAT mutations in Hodgkin lymphoma

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  IL-IR/MyD88 Signalling Mediates Severity of UC-Like Pancolitis in TLR2/MDRIA Double Deficient Mice

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  Growth Factor Independence 1 (Gfi1) Regulates Cell-Fate Decision of the Bipotential Granulocytic-Monocytic Precursors Defined by Expression of CD48 As a New Marker

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  Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome

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  Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

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  Anthropogenic greenhouse gas contribution to flood risk in England and Wales in autumn 2000

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  Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair

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  Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk : evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients

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  Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma : A multicenter phase II DeCOG trial

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  A randomized controlled study in patients with newly diagnosed severe aplastic anemia receiving antithymocyte globulin (ATG), cyclosporine, with or without G-CSF : a study of the SAA Working Party of the European Group for Blood and Marrow Transplantation

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  Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer

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  Elucidation of the α-keto-aldehyde binding mechanism : A lead structure motif for proteasome inhibition

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  Vasoconstrictor Potential of Coronary Aspirate From Patients Undergoing Stenting of Saphenous Vein Aortocoronary Bypass Grafts and Its Pharmacological Attenuation

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  Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma

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  Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia

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  Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults

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  Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPC

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  Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

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  The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia

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  Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature

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  Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma

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  Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma

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  A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

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  Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

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  ERBB2 Induces an Antiapoptotic Expression Pattern of Bcl-2 Family Members in Node-Negative Breast Cancer

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  Ipilimumab monotherapy in patients with pretreated advanced melanoma : a randomised, double-blind, multicentre, phase 2, dose-ranging study

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  SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing

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  The use of calcium phosphate nanoparticles encapsulating toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation

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  Orthogonal Protein Decoration of DNA Origami

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  A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia

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  Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells

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  Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

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  The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma

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  Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

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  Mutations of CARD11 but not TNFAIP3 may activate the NF-κB pathway in primary CNS lymphoma

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