ZMB Member Florian Wirsdörfer

ZMB Member
Florian Wirsdörfer

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Dr. Florian Wirsdörfer portrait
© UKE

Dr. Florian Wirsdörfer

Junior Research Group

Immunomodulation

Institute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen

Research Overview

The junior research group "Immunmodulation" investigates the complex interplay between radiation-induced tissue damage, immune activation, and the development of therapy-associated side effects. A particular focus lies on the cellular and molecular mechanisms underlying radiation-induced lung toxicity, aiming to identify novel therapeutic targets that enable selective protection of normal tissue while maintaining effective tumor control. In addition, the group pursues translational research approaches focused on the identification of predictive biomarkers to systematically assess the risks and therapeutic potential of combined radio-immunotherapies and to improve patient stratification.

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Publications

    Journal articles

  • Herz, Andreas; Guberina, Maja; Pöttgen, Christoph; Gauler, Thomas; Ton, That Truong Mike; Fischedick, Gerrit; Kiwitt, Lars Oliver; Lübcke, Wolfgang; Hoffmann, Christian; Schuler, Martin; Metzenmacher, Martin; Schaarschmidt, Benedikt; Bos, Denise; Opitz, Marcel; Hautzel, Hubertus; Darwiche, Kaid; Bölükbas, Servet; Grapatsas, Konstantinos; Jendrossek, Verena; Gockeln, Lena; Wirsdörfer, Florian; Hetzel, Mario; Mladenov, Emil; Stuschke, Martin; Guberina, Nika
    The effect of durvalumab consolidation after definitive radiochemotherapy for non-operable stage III non-small cell lung cancer on the dose effect relation for therapy related pulmonary infiltrates as a risk factor for pneumonitis
    In: Translational Lung Cancer Research, Vol. 14, 2025, Nr. 6, pp. 2074 – 2088
    DOI (Open Access)
  • Gockeln, Lena; Wirsdörfer, Florian; Jendrossek, Verena
    CD73/adenosine dynamics in treatment-induced pneumonitis : balancing efficacy with risks of adverse events in combined radio-immunotherapies
    In: Frontiers in Cell and Developmental Biology, Vol. 12, 2024, 1471072
    DOI, Online Full Text (Open Access)
  • Guberina, Nika; Wirsdörfer, Florian; Stuschke, Martin; Jendrossek, Verena
    Combined radiation- and immune checkpoint-inhibitor-induced pneumonitis : The challenge to predict and detect overlapping immune-related adverse effects from evolving laboratory biomarkers and clinical imaging
    In: Neoplasia: An International Journal for Oncology Research, Vol. 39, 2023, 100892
    DOI (Open Access)
  • Martins Nascentes Melo, Luiza; Herrera-Rios, Dayana; Hinze, Daniel; Löffek, Stefanie; Oezel, Irem; Turiello, Roberta; Klein, Juliane; Leonardelli, Sonia; Westedt, Isa-Vanessa; Al-Matary, Yahya; Egea-Rodriguez, Sara; Brenzel, Alexandra; Bau, Maja; Sucker, Antje; Hadaschik, Eva; Wirsdörfer, Florian; Hanenberg, Helmut; Uhlenbrock, Niklas; Rauh, Daniel; Poźniak, Joanna; Rambow, Florian; Marine, Jean-Christophe; Effern, Maike; Glodde, Nicole; Schadendorf, Dirk; Jablonska, Jadwiga; Hölzel, Michael; Helfrich, Iris
    Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma
    In: Journal for ImmunoTherapy of Cancer, Vol. 11, 2023, Nr. 4, e004150
    DOI (Open Access)
  • Wenzek, Christina; Steinbach, Philine; Wirsdörfer, Florian; Sutter, Kathrin; Boehme, Julia D.; Geffers, Robert; Klopfleisch, Robert; Bruder, Dunja; Jendrossek, Verena; Buer, Jan; Westendorf, Astrid; Knuschke, Torben
    CD47 restricts antiviral function of alveolar macrophages during influenza virus infection
    In: iScience, Vol. 25, 2022, Nr. 12, 105540
    DOI (Open Access)
  • Meyer, Alina V.; Klein, Diana; de Leve, Simone; Szymonowicz, Klaudia; Stuschke, Martin; Robson, Simon C.; Jendrossek, Verena; Wirsdörfer, Florian
    Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity
    In: Frontiers in Oncology, Vol. 10, 2020, pp. 554883
    DOI, Online Full Text (Open Access)
  • de Leve, Simone; Wirsdörfer, Florian; Jendrossek, Verena
    Addendum: de Leve, S.; et al. The CD73/Ado System—A New Player in RT Induced Adverse Late Effects. Cancers 2019, 11, 1578
    In: Cancers, Vol. 11, 2019, Nr. 12, pp. 1898
    DOI (Open Access)
  • Wiesemann, Alina; Ketteler, Julia; Slama, Alexis; Wirsdörfer, Florian; Hager, Thomas; Röck, Katharina; Engel, Daniel Robert; Fischer, Jens W.; Aigner, Clemens; Jendrossek, Verena; Klein, Diana
    Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss
    In: Antioxidants and Redox Signaling, Vol. 30, 2019, Nr. 2, pp. 213 – 231
    DOI
  • de Leve, Simone; Wirsdörfer, Florian; Jendrossek, Verena
    Targeting the Immunomodulatory CD73/Adenosine System to Improve the Therapeutic Gain of Radiotherapy
    In: Frontiers in Immunology, Vol. 10, 2019, pp. 698
    DOI, Online Full Text (Open Access)
  • de Leve, Simone; Wirsdörfer, Florian; Jendrossek, Verena
    The CD73/Ado System - A New Player in RT Induced Adverse Late Effects
    In: Cancers, Vol. 11, 2019, Nr. 10, pp. 1578
    DOI, Online Full Text (Open Access)
  • Wirsdörfer, Florian; de Leve, Simone; Jendrossek, Verena
    Combining Radiotherapy and Immunotherapy in Lung Cancer : Can We Expect Limitations Due to Altered Normal Tissue Toxicity?
    In: International Journal of Molecular Sciences (IJMS), Vol. 20, 2018, Nr. 1, pp. 24
    DOI, Online Full Text (Open Access)
  • Hlouschek, Julian; Ritter, Violetta; Wirsdörfer, Florian; Klein, Diana; Jendrossek, Verena; Matschke, Johann
    Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
    In: Cancer Letters, Vol. 439, 2018, pp. 24 – 38
    DOI
  • De Leve, Simone; Wirsdörfer, Florian; Cappuccini, Federica; Schütze, Alexandra; Meyer, Alina V.; Röck, Katharina; Thompson, Linda F.; Fischer, Jens W.; Stuschke, Martin; Jendrossek, Verena
    Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of prefibrotic macrophage clusters in irradiated lungs
    In: The FASEB Journal, Vol. 31, 2017, Nr. 7, pp. 2869 – 2880
    DOI, Online Full Text (Open Access)
  • Klein, Diana; Steens, Jennifer; Wiesemann, Alina; Schulz, Florian; Kaschani, Farnusch; Röck, Katharina; Yamaguchi, Masahiro; Wirsdörfer, Florian; Kaiser, Markus; Fischer, Jens W.; Stuschke, Martin; Jendrossek, Verena
    Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression
    In: Antioxidants and Redox Signaling, Vol. 26, 2017, Nr. 11, pp. 563 – 582
    DOI (Open Access)
  • Wirsdörfer, Florian; Jendrossek, Verena
    Modeling DNA damage-induced pneumopathy in mice : insight from danger signaling cascades
    In: Radiation Oncology, Vol. 12, 2017, pp. 142
    DOI (Open Access)
  • Smirnov, Anna; Pohlmann, Stephanie; Nehring, Melanie; Ali, Shafaqat; Mann-Nüttel, Ritu; Scheu, Stefanie; Antoni, Anne-Charlotte; Hansen, Wiebke; Büettner, Manuela; Gardiasch, Miriam J.; Westendorf, Astrid; Wirsdörfer, Florian; Pastille, Eva; Dudda, Marcel; Flohe, Stefanie
    Sphingosine 1-Phosphate- and C-C Chemokine Receptor 2-Dependent Activation of CD4+ Plasmacytoid Dendritic Cells in the Bone Marrow Contributes to Signs of Sepsis-Induced Immunosuppression
    In: Frontiers in Immunology, Vol. 8, 2017, 1622
    DOI (Open Access)
  • Wirsdörfer, Florian; Bangen, Jörg-Martin; Pastille, Eva; Schmitz, Daniel; Flohé, Sascha; Schumak, Beatrix; Flohe, Stefanie
    Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge
    In: PLoS ONE, Vol. 11, 2016, Nr. 5, pp. e0155870
    DOI (Open Access)
  • Wirsdörfer, Florian; de Leve, Simone; Cappuccini, Federica; Eldh, Therese; Meyer, Alina V; Gau, Eva; Thompson, Linda F; Chen, Ning-Yuan; Karmouty-Quintana, Harry; Fischer, Ute; Kasper, Michael; Klein, Diana; Ritchey, Jerry W; Blackburn, Michael R; Westendorf, Astrid; Stuschke, Martin; Jendrossek, Verena
    Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis
    In: Cancer Research, Vol. 76, 2016, Nr. 10, pp. 3045 – 3056
    DOI (Open Access)
  • Wirsdörfer, Florian; Jendrossek, Verena
    The Role of Lymphocytes in Radiotherapy-Induced Adverse Late Effects in the Lung
    In: Frontiers in Immunology, Vol. 7, 2016, pp. 591
    DOI (Open Access)
  • Klein, Diana; Schmetter, Alexandra; Imsak, Roze; Wirsdörfer, Florian; Unger, Kristian; Jastrow, Holger; Stuschke, Martin; Jendrossek, Verena
    Therapy with multipotent mesenchymal stromal cells protects lungs from radiation-induced injury and reduces the risk of lung metastasis
    In: Antioxidants and Redox Signaling, Vol. 24, 2016, Nr. 2, pp. 53 – 69
    DOI
  • Pastille, Eva; Pohlmann, Stephanie; Wirsdörfer, Florian; Reib, Anna; Flohe, Stefanie
    A disturbed interaction with accessory cells upon opportunistic infection with Pseudomonas aeruginosa contributes to an impaired IFN-γ production of NK cells in the lung during sepsis-induced immunosuppression
    In: Innate Immunity, Vol. 21, 2015, Nr. 2, pp. 115 – 126
    DOI
  • Wirsdörfer, Florian; Bangen, Jörg-Martin; Pastille, Eva; Hansen, Wiebke; Flohe, Stefanie
    Breaking the co-operation between bystander T-cells and natural killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in mice
    In: Clinical Science, Vol. 128, 2015, Nr. 11, pp. 825 – 838
    DOI (Open Access)
  • Ring, Sabine; Pushkarevskaya, Anna; Schild, Hansjörg; Probst, Hans Christian; Jendrossek, Verena; Wirsdörfer, Florian; Ledent, Catherine; Robson, Simon Christopher; Enk, Alexander H.; Mahnke, Karsten
    Regulatory T Cell–Derived Adenosine Induces Dendritic Cell Migration through the Epac-Rap1 Pathway
    In: The Journal of Immunology (JI), Vol. 194, 2015, Nr. 8, pp. 3735 – 3744
    DOI
  • De Haan, Jacco Juri; Pastille, Eva; Wirsdörfer, Florian; Lubbers, Tim; Greve, Jan Willem M; Zhang, Yang; Buurman, Wim A.; Flohe, Stefanie
    Lipid-rich enteral nutrition improves the defense against an opportunistic infection during polymicrobial sepsis
    In: Shock, Vol. 41, 2014, Nr. 2, pp. 109 – 114
    DOI
  • Wirsdörfer, Florian; Cappuccini, Federica; Niazman, Musca; Leve, Simone de; Westendorf, Astrid; Lüdemann, Lutz; Stuschke, Martin; Jendrossek, Verena
    Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells
    In: Radiation Oncology, Vol. 9, 2014, Nr. 1, 98
    DOI (Open Access)
  • Wirsdörfer, Florian; Cappucini, F.; Drabczyk, M.; Stuschke, Martin; Hagemann, T.; Jendrossek, Verena
    Thorax irradiation triggers local and systemic immune changes
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics, Vol. 189, 2013, Nr. Suppl. 1, pp. 125 – 126
  • Friedrichs, Melanie; Wirsdöerfer, Florian; Flohe, Stefanie; Schneider, Sabine; Wülling, Manuela; Vortkamp, Andrea
    BMP signaling balances proliferation and differentiation of muscle satellite cell descendants.
    In: BMC Cell Biology, Vol. 12, 2011, 26
    DOI, Online Full Text (Open Access)
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