ZMB Member Manuela Wülling

ZMB Member
Manuela Wülling

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portrait photo of ZMB member Manuela Wülling

Dr. Manuela Wülling


Developmental Biology

Transcriptional and epigenetic control of endochondral ossification

Center of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

The main interest of the group are the transcriptional mechanisms that govern chondrocyte development and pathology. Dysregulation of chondrocyte proliferation and differentiation lead to shortened and malformed endochondral bones and the degenerative diseases of the connecting joints. Our goal is to decipher how transcriptional cascades interact to coordinate cell cycle progression and differentiation of skeletal cells. Epigenetic modifiers link chromatin structure to the transcriptional output. Changes in epigenetic profiles have been reported to affect pathological processes like osteoarthritis. Using next generation sequencing technologies, we are currently integrating epigenetic and transcriptional profiles to understand how alterations in chromatin structure and transcription factor binding affect skeletal development and disease.