Genetically induced skeletal malformations and degenerating bone diseases, like osteoarthritis and rheumatoid arthritis, represent major challenges of modern medicine. Both can result in severe pain, mobility restrictions and significantly impair the quality of human life. To identify the molecular basis of skeletal disorders and to pave the way for the development of targeted repair strategies we are investigating the mechanisms that regulate differentiation and growth of the skeletal elements during embryonic development and postnatal life.
We are concentrating our research on the differentiation of chondrocytes in the growth plate of endochondral bones, the formation of bone tumors and the development and maintenance of the articular cartilage in the joints.
- Signaling factors regulating chondrocyte differentiation
- Gene regulation and Chromatin modification
- Heparan sulfate: an extracellular regulator of growth factor signaling and cellular interactions
- Degenerating Joint Diseases: Osteoarthrosis