AG Ulf Dittmer
Experimentelle Virologie
Forschungsschwerpunkte
- Persistierende virale Infektionen
- Angeborene Immunität gegen Retroviren
- Grundlagen zellulärer und molekularer Immunabwehrmechanismen
- Immunregulation bei Retrovirus Infektionen
- Immuntherapie gegen retrovirale Infektionen und Virus-induzierte Tumoren
- Entwicklung von Impfstoffen gegen Retroviren
- Antivirale Aktivität von Interferonen
Retrovirale Infektionen
Trotz weltweit intensiver Forschung ist es bisher nicht gelungen, Impfstoffe gegen humanpathogene Retroviren, wie HTLV und HIV, zu entwickeln. Die klassischen Methoden der Impfstoffentwicklung gegen Viren sind bei Retroviren bisher weitestgehend fehlgeschlagen. Daher müssen neue Ansätze ermittelt werden, um erfolgreich Impfstoffe gegen Retroviren herstellen zu können. Wir verwenden ein Mausmodell, die Infektion von Mäusen mit dem „Friend Murine Leukemia Virus“ (FV), um grundlegende immunologische Mechanismen des Impfschutzes gegen Retroviren aufzuklären. Darüber hinaus untersuchen wir, welche Mediatoren des Immunsystems für die Kontrolle einer chronischen Infektion mit Retroviren wichtig sind. Die Erkenntnisse aus diesen Untersuchungen werden verwendet, um neue Immuntherapien und Impfstoffe gegen Retroviren zu entwickeln.
Arbeitsgruppe
Simone Schimmer, MTA
Tel.: +49 (0)201 723 3583
E-Mail: simone.schimmer@uni-due.de
Mohamed Saad, M.Sc.
Tel.: +49 (0)201 723 2875
E-Mail: Mohamed.Saad@uk-essen.de
Jeffrey Hastings, M.Sc.
Tel.: +49 (0)201 723 2721
E-Mail: jeffrey.hastings@uk-essen.de
Publikationen
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Amitriptyline potently neutralizes distinct SARS-CoV-2 variants including D614G, Omicron BA.5, and Omicron XBB.1In: Frontiers in Microbiology, Jg. 16, 2025, 1631947DOI, Online Volltext (Open Access)
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Body composition measurement and diabetes : A new perspective on development of antibodies after SARS-CoV-2 booster vaccinationIn: Journal of Diabetes and Metabolic Disorders, Jg. 24, 2025, Nr. 2, 250DOI (Open Access)
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Dietary lipid overload creates a suppressive environment that impedes the antiviral functions of NK cellsIn: iScience, Jg. 28, 2025, Nr. 5, 112396DOI (Open Access)
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Disease Burden of RSV Infection in Adult Patients in Comparison to Influenza Virus InfectionIn: Journal of Medical Virology, Jg. 97, 2025, Nr. 5, e70373DOI (Open Access)
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From Entry to Outbreak in a High School Setting : Clinical and Wastewater Surveillance of a Rare SARS-CoV-2 VariantIn: Viruses, Jg. 17, 2025, Nr. 4, 477DOI, Online Volltext (Open Access)
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Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responsesIn: Hepatology International, Jg. 19, 2025, Nr. 1, S. 93 – 105
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Iron improves the antiviral activity of NK cellsIn: Frontiers in Immunology, Jg. 15, 2025, 1526197DOI, Online Volltext (Open Access)
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Letales Dengue-Schock-Syndrom bei Reiserückkehrer mit Dengue-PrimärinfektionIn: Flugmedizin, Tropenmedizin, Reisemedizin (FTR), Jg. 32, 2025, Nr. 02, S. 61 – 63
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Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined with Peg-IFNα-2a as Treatment for Chronic Hepatitis DeltaIn: Liver International, Jg. 45, 2025, Nr. 2, e70008DOI (Open Access)
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Regulatory T cells suppress TLR9-induced formation of intrahepatic myeloid-cell aggregates for T cell population expansion in liverIn: Medical Microbiology and Immunology, Jg. 214, 2025, Nr. 1, 24
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A Variety of Mouse PYHIN Proteins Restrict Murine and Human RetrovirusesIn: Viruses, Jg. 16, 2024, Nr. 4, 493DOI (Open Access)
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Adult patients with severe respiratory syncytial virus infections in the emergency departmentIn: Medicine, Jg. 103, 2024, Nr. 39, e39265DOI (Open Access)
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Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 VariantsIn: Viruses, Jg. 16, 2024, Nr. 4, 545DOI (Open Access)
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Frequency of SARS-CoV-2 Infections among Healthcare Workers in Germany: 3-Year Follow-Up StudyIn: Infectious Disease Reports, Jg. 16, 2024, Nr. 4, S. 615 – 627DOI (Open Access)
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IFNα Subtypes in HIV Infection and ImmunityIn: Viruses, Jg. 16, 2024, Nr. 3, 364DOI, Online Volltext (Open Access)
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Immunogenicity of the Monovalent Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine in People Living with HIV (PLWH)In: Vaccines, Jg. 12, 2024, Nr. 7, 785DOI (Open Access)
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Influenza virus infection enhances tumour-specific CD8+ T-cell immunity, facilitating tumour controlIn: PLoS Pathogens, Jg. 20, 2024, Nr. 1, e1011982DOI (Open Access)
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Monitoring of hepatitis E virus in wastewater can identify clinically relevant variantsIn: Liver International, Jg. 44, 2024, Nr. 3, S. 637 – 643DOI (Open Access)
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PD-1 knockout on cytotoxic primary murine CD8+ T cells improves their motility in retrovirus infected miceIn: Frontiers in Immunology, Jg. 15, 2024, 1338218DOI, Online Volltext (Open Access)
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Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cellsIn: Cell Reports Medicine, Jg. 5, 2024, Nr. 4, 101483DOI (Open Access)
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Seasonal Patterns of Common Respiratory Viral Infections in Immunocompetent and Immunosuppressed PatientsIn: Pathogens, Jg. 13, 2024, Nr. 8, 704DOI, Online Volltext (Open Access)
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TLR9 dependent activation by inactivated parapoxvirus ovis (iPPVO) in murine bone marrow-derived dendritic cells is associated with specific strain-dependent dendritic cell subsetsIn: Journal of Innate Immunity, Jg. 16, 2024, Nr. 1, S. 354 – 366DOI, Online Volltext (Open Access)
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The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshiftingIn: Journal of Virology, Jg. 98, 2024, Nr. 7, e0053424
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UnCoVar : A reproducible and scalable workflow for transparent and robust virus variant calling and lineage assignment using SARS-CoV-2 as an exampleIn: BMC Genomics, Jg. 25, 2024, Nr. 1, 647DOI, Online Volltext (Open Access)
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From airport to school to hospital : the story of a rare SARS-CoV-2 virus variant importIn: Das Gesundheitswesen. Stuttgart: Thieme, Jg. 86, 2024, Nr. S02, S. S133 – S134
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A systematic comparison reveals dynamic differences in early adaptive immune responses of acute-resolving versus chronic HBV replicationIn: Journal of Medical Virology, Jg. 95, 2023, Nr. 3, e28670DOI (Open Access)
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Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMIIn: Heliyon, Jg. 9, 2023, Nr. 1, e12746DOI, Online Volltext (Open Access)
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COVID-19 vaccination in psoriasis patients receiving systemic treatment : A prospective single-center studyIn: Frontiers in Immunology, Jg. 14, 2023, S. 1107438DOI (Open Access)
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Cell-to-cell spread inhibiting antibodies constitute a correlate of protection against herpes simplex virus type 1 reactivations : A retrospective studyIn: Frontiers in Immunology, Jg. 14, 2023, 1143870DOI, Online Volltext (Open Access)
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Cytotoxic CD4⁺ T cells in chronic viral infections and cancerIn: Frontiers in Immunology, Jg. 14, 2023, 1271236DOI, Online Volltext (Open Access)
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Fatty acids are crucial to fuel NK cells upon acute retrovirus infectionIn: Frontiers in Immunology, Jg. 14, 2023, 1296355DOI, Online Volltext (Open Access)
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Generation of potentially inhibitory autoantibodies to ADAMTS13 in coronavirus disease 2019In: Scientific Reports, Jg. 13, 2023, Nr. 1, 10501DOI (Open Access)
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HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistanceIn: Clinical Cancer Research, Jg. 29, 2023, Nr. 15, S. 2894 – 2907
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Immune responses in COVID-19 patients during breakthrough infection with SARS-CoV-2 variants Delta, Omicron-BA.1 and Omicron-BA.5In: Frontiers in Immunology, Jg. 14, 2023, 1150667DOI, Online Volltext (Open Access)
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Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell folliclesIn: PLoS Pathogens, Jg. 19, 2023, Nr. 10, e1011725DOI (Open Access)
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Impact of low eGFR on the immune response against COVID-19In: Journal of Nephrology (JN), Jg. 36, 2023, Nr. 1, S. 199 – 202DOI (Open Access)
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Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patientsIn: Nature Communications, Jg. 14, 2023, Nr. 1, 2835DOI (Open Access)
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Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in IFITM3 on the Antibody Response after Vaccination against COVID-19In: Vaccines, Jg. 11, 2023, Nr. 7, 1257DOI (Open Access)
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Janus kinase-inhibition modulates hepatitis E virus infectionIn: Antiviral Research, Jg. 217, 2023, 105690DOI (Open Access)
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Long-Term Follow-Up after Adoptive Transfer of BK-Virus-Specific T Cells in Hematopoietic Stem Cell Transplant RecipientsIn: Vaccines, Jg. 11, 2023, Nr. 4, S. 845DOI, Online Volltext (Open Access)
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Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patientsIn: Frontiers in Immunology, Jg. 14, 2023, 1236374DOI, Online Volltext (Open Access)
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Patients with SARS-CoV-2-Induced Viral Sepsis Simultaneously Show Immune Activation, Impaired Immune Function and a Procoagulatory Disease StateIn: Vaccines, Jg. 11, 2023, Nr. 2, 435DOI (Open Access)
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Polymorphism of tmprss2 (rs12329760) and severity of COVID-19 in the Ukrainian population : ResponseIn: Acta Biomedica, Jg. 94, 2023, Nr. 2, e2023109
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Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian populationIn: Acta Biomedica, Jg. 94, 2023, Nr. 1, e2023030DOI (Open Access)
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Regulatory T cells suppress the motility of cytotoxic T cells in Friend retrovirus-infected miceIn: JCI Insight, Jg. 8, 2023, Nr. 13, e167482DOI, Online Volltext (Open Access)
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SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infectionIn: Virologica Sinica, Jg. 38, 2023, Nr. 4, S. 606 – 619DOI (Open Access)
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Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and PentamerIn: Immunity, Jg. 56, 2023, Nr. 11, S. 2602 – 2620.e10
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Targeted mutations in IFNα2 improve its antiviral activity against various virusesIn: mBio, Jg. 14, 2023, Nr. 6, e02357-23DOI, Online Volltext (Open Access)
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Upregulation of miRNA-200c during Disease Progression in COVID-19 PatientsIn: Journal of Clinical Medicine (JCM), Jg. 12, 2023, Nr. 1, 283DOI, Online Volltext (Open Access)
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Analyses of defined human cytomegalovirus-specific antibody effector functions in people living with human immunodeficiency virus
DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,In: HIV Medicine. Hoboken: Wiley-Blackwell, Jg. 24, 2023, Nr. 1, S. 48 – 49 -
Cellular and humoral immune response after SARS-CoV-2 vaccination in pediatric kidney recipients
12th Congress of the International Pediatric Transplant Association, March 25-28. 2028, Austin, USA,In: Pediatric Transplantation. Hoboken: Wiley, Jg. 27, 2023, Nr. 2, SI, S. 21 – 22 -
Distinct type I interferon subtypes differentially stimulate T cell responses in HIV1-infected individuals
DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,In: HIV Medicine. Hoboken: Wiley-Blackwell, Jg. 24, 2023, Nr. 1, S. 92 -
Effects of type I interferons on HIV latency
DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,In: HIV Medicine. Hoboken: Wiley-Blackwell, Jg. 24, 2023, Nr. S1, S. 82 -
False-positive HIV diagnosis post SARSCoV-2 infection : a case report
DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,In: HIV Medicine. Hoboken: Wiley-Blackwell, Jg. 24, 2023, Nr. Supplement 1, S. 90 -
HIV-1 gp120 polymorphisms A281T and M426R might influence the efficacy of fostemsavir in an HIV-1 LLV patient
DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,In: HIV Medicine. Hoboken: Wiley-Blackwell, Jg. 24, 2023, Nr. 1, S. 14 – 15 -
Individuals with weaker humoral response after second booster vaccination are prone to SARS-CoV-2 Omicron BA.5 infections
8th German Pharm-Tox Summit 2023, 06.-09.03.2023, Ulm,In: Naunyn-Schmiedeberg's Archives of Pharmacology. Berlin: Springer, Jg. 396, 2023, Nr. Supplement 1: 8th German Pharm-Tox Summit 2023 Abstracts of the 89. Jahrestagung der Deutschen Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT) in Zusammenarbeit mit der AGAH, S. S5DOI (Open Access) -
Cellular and Humoral Immune Response after Sars-Cov-2 Vaccination in Pediatric Kidney Recipients
American Transplant Congress 2023, ATC 2023 ; June 3 - 7, 2023, San Diego, CA, USA,In: American Journal of Transplantation. Amsterdam: Elsevier, Jg. 23, 2023, Nr. 6, Supplement 1: American Transplant Congress 2023 Abstracts, S. S1144 – S1145DOI (Open Access) -
CCL2 : a Chemokine Potentially Promoting Early Seeding of the Latent HIV ReservoirIn: mBio, Jg. 13, 2022, Nr. 5, e0189122DOI, Online Volltext (Open Access)
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COVID-19 vaccination in advanced skin cancer patients receiving systemic anticancer treatment : A prospective singlecenter study investigating seroconversion ratesIn: Frontiers in Oncology, Jg. 12, 2022, 879876DOI, Online Volltext (Open Access)
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Cellular and Humoral Immunity against Different SARS-CoV-2 Variants Is Detectable but Reduced in Vaccinated Kidney Transplant PatientsIn: Vaccines, Jg. 10, 2022, Nr. 8, 1348DOI (Open Access)
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Decline of Humoral Responses 6 Months after Vaccination with BNT162b2 (Pfizer–BioNTech) in Patients on HemodialysisIn: Vaccines, Jg. 10, 2022, Nr. 2, 327DOI, Online Volltext (Open Access)
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Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infectionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 119, 2022, Nr. 8, e2111600119DOI (Open Access)
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Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected IndividualsIn: Frontiers in Immunology, Jg. 13, 2022, 936918DOI, Online Volltext (Open Access)
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Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized miceIn: AIDS, Jg. 36, 2022, Nr. 3, S. 325 – 336
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Establishment and clinical validation of an in-cell-ELISA-based assay for the rapid quantification of Rabies virus neutralizing antibodiesIn: PLoS Neglected Tropical Diseases, Jg. 16, 2022, Nr. 5, e0010425DOI, Online Volltext (Open Access)
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GNB3 c.825c>T polymorphism influences T-cell but not antibody response following vaccination with the mRNA-1273 vaccineIn: Frontiers in Genetics, Jg. 13, 2022, 932043DOI, Online Volltext (Open Access)
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HBeAg Is Indispensable for Inducing Liver Sinusoidal Endothelial Cell Activation by Hepatitis B VirusIn: Frontiers in Cellular and Infection Microbiology, Jg. 12, 2022, 797915DOI, Online Volltext (Open Access)
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HBsAg isoform dynamics during NAP-based therapy of HBeAg-negative chronic HBV and HBV/HDV infectionIn: Hepatology Communications, Jg. 6, 2022, Nr. 8, S. 1870 – 1880DOI (Open Access)
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IFNα subtype-specific susceptibility of HBV in the course of chronic infectionIn: Frontiers in Immunology, Jg. 13, 2022, 1017753DOI (Open Access)
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Identification of herbal teas and their compounds eliciting antiviral activity against SARS-CoV-2 in vitroIn: BMC Biology (incorporating Journal of Biology), Jg. 20, 2022, Nr. 1, 264DOI, Online Volltext (Open Access)
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Immune Response in Moderate to Critical Breakthrough COVID-19 Infection After mRNA VaccinationIn: Frontiers in Immunology, Jg. 13, 2022, 816220DOI, Online Volltext (Open Access)
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Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral InfectionIn: Frontiers in Immunology, Jg. 12, 2022, 809774DOI, Online Volltext (Open Access)
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Individuals With Weaker Antibody Responses After Booster Immunization Are Prone to Omicron Breakthrough InfectionsIn: Frontiers in Immunology, Jg. 13, 2022, 907343DOI, Online Volltext (Open Access)
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Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis CIn: JCI Insight, Jg. 7, 2022, Nr. 2, e155432DOI (Open Access)
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Prevalence of Anti-Adeno-Associated Virus Serotype 9 Antibodies in Adult Patients with Spinal Muscular AtrophyIn: Human Gene Therapy, Jg. 33, 2022, Nr. 17-18, S. 968 – 976
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SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration stepsIn: Frontiers in Immunology, Jg. 13, 2022, 935800DOI (Open Access)
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The Course of Anti-HBc Antibodies over Time in Immunocompromised HostsIn: Vaccines, Jg. 10, 2022, Nr. 2, 137DOI (Open Access)
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The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell ResponsesIn: Frontiers in Virology, Jg. 2, 2022, 836291DOI, Online Volltext (Open Access)
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Evaluation of Hepatitis E Virus Infection during Jak Inhibitor Therapy in Autimmune Inflammatory Rheumatic DiseasesIn: Annals of the Rheumatic Diseases (ARD). London: BMJ Publishing Group, Jg. 81, 2022, Nr. Suppl. 1, S. 1832
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A combination of anti-pd-l1 treatment and therapeutic vaccination facilitates improved retroviral clearance via reactivation of highly exhausted t cellsIn: mBio, Jg. 12, 2021, Nr. 1, S. e02121 – 20DOI (Open Access)
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A model to identify individuals with a high probability of a SARS-CoV-2 infectionIn: Journal of Infection, Jg. 82, 2021, Nr. 3, S. e32 – e34DOI, Online Volltext (Open Access)
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A rapid test recognizing mucosal SARS-CoV-2-specific antibodies distinguishes prodromal from convalescent COVID-19In: iScience, Jg. 24, 2021, Nr. 10, 103194DOI (Open Access)
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ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19In: Pharmacogenetics and Genomics, Jg. 31, 2021, Nr. 8, S. 165 – 171DOI, Online Volltext (Open Access)
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Analysis of HBsAg Immunocomplexes and cccDNA Activity During and Persisting After NAP‐Based TherapyIn: Hepatology Communications, Jg. 5, 2021, Nr. 11, S. 1873 – 1887DOI (Open Access)
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Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairmentIn: mBio, Jg. 12, 2021, Nr. 2, S. e00085 – 21DOI (Open Access)
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Benefit of transaminase elevations in establishing functional cure of HBV infection during nap-based combination therapyIn: Journal of Viral Hepatitis, Jg. 28, 2021, Nr. 5, S. 817 – 825
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Cellular immunity in COVID-19 convalescents with PCR-confirmed infection but with undetectable SARS-CoV-2-Specific IgGIn: Emerging Infectious Diseases (EID), Jg. 27, 2021, Nr. 1, S. 122 – 129DOI (Open Access)
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Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World SettingIn: Frontiers in Immunology, Jg. 12, 2021, 802858DOI (Open Access)
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Common respiratory viral infections : Bilateral versus unilateral bronchoalveolar lavage versus endotracheal aspirationIn: Journal of Medical Virology, Jg. 93, 2021, Nr. 6, S. 3955 – 3959
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Comparable Environmental Stability and Disinfection Profiles of the Currently Circulating SARS-CoV-2 Variants of Concern B.1.1.7 and B.1.351In: The Journal of Infectious Diseases (JID), Jg. 224, 2021, Nr. 3, S. 420 – 424DOI, Online Volltext (Open Access)
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Comparison of Humoral and Cellular CMV Immunity in Patients Awaiting Kidney TransplantationIn: Diagnostics, Jg. 11, 2021, Nr. 9, 1688DOI, Online Volltext (Open Access)
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Convalescent plasma treatment of critically ill intensive care COVID-19 patientsIn: Transfusion, Jg. 61, 2021, Nr. 5, S. 1394 – 1403DOI (Open Access)
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Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 Patients One Year Post Symptom OnsetIn: Frontiers in Immunology, Jg. 12, 2021, 708523DOI, Online Volltext (Open Access)
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Delivery of toll-like receptor 3 ligand poly(I:C) to the liver by calcium phosphate nanoparticles conjugated with an F4/80 antibody exerts an anti-hepatitis B virus effect in a mouse modelIn: Acta Biomaterialia, Jg. 133, 2021, S. 297 – 307
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Disinfection of SARS-CoV-2 Contaminated Surfaces of Personal Items with UVC-LED Disinfection BoxesIn: Viruses, Jg. 13, 2021, Nr. 4, 598DOI, Online Volltext (Open Access)
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Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ SignalingIn: Hepatology, Jg. 73, 2021, Nr. 2, S. 486 – 502
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Generation of HBsAg-reactive T- and B-cells following HBV vaccination in serological non-responders under hemodialysis treatmentIn: European Journal of Immunology, Jg. 51, 2021, Nr. 5, S. 1278 – 1281DOI (Open Access)
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Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main ProteaseIn: Viruses, Jg. 13, 2021, Nr. 4, 609DOI, Online Volltext (Open Access)
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HBeAg induces liver sinusoidal endothelial cell activation to promote intrahepatic CD8 T cell immunity and HBV clearanceIn: Cellular & Molecular Immunology, Jg. 18, 2021, Nr. 11, S. 2572 – 2574DOI (Open Access)
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Hepatitis B virus particles activate B cells through the TLR2–MyD88–mTOR axisIn: Cell Death and Disease, Jg. 12, 2021, Nr. 1, 34DOI, Online Volltext (Open Access)
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Humoral response to SARS-CoV-2-vaccination with BNT162b2 (pfizer-biontech) in patients on hemodialysisIn: Vaccines, Jg. 9, 2021, Nr. 4, S. 360DOI, Online Volltext (Open Access)
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Impaired humoral response in renal transplant recipients to sars-cov-2 vaccination with bnt162b2 (Pfizer-biontech)In: Viruses, Jg. 13, 2021, Nr. 5, 756DOI, Online Volltext (Open Access)
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Long-term sars-cov-2 specific immunity is affected by the severity of initial covid-19 and patient ageIn: Journal of Clinical Medicine (JCM), Jg. 10, 2021, Nr. 19, 4606DOI, Online Volltext (Open Access)
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Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg lossIn: eBioMedicine, Jg. 69, 2021, 103464DOI (Open Access)
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Metabolic requirements of NK cells during the acute response against retroviral infectionIn: Nature Communications, Jg. 12, 2021, Nr. 1, 5376DOI, Online Volltext (Open Access)
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Natural Killer Cells Regulate the Maturation of Liver Sinusoidal Endothelial Cells Thereby Promoting Intrahepatic T‐Cell Responses in a Mouse ModelIn: Hepatology Communications, Jg. 5, 2021, Nr. 5, S. 865 – 881DOI (Open Access)
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Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal FluidIn: Immunity, Jg. 54, 2021, Nr. 1, S. 164DOI, Online Volltext (Open Access)
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Observational cohort study of neurological involvement among patients with SARS-CoV-2 infectionIn: Therapeutic Advances in Neurological Disorders, Jg. 14, 2021DOI, Online Volltext (Open Access)
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Occurrence of COVID-19 Symptoms During SARS-CoV-2 Infection Defines Waning of Humoral ImmunityIn: Frontiers in Immunology, Jg. 12, 2021, 722027DOI, Online Volltext (Open Access)
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Over 90% of clinical swabs used for SARS-CoV-2 diagnostics contain sufficient nucleic acid concentrationsIn: Journal of Medical Virology, Jg. 93, 2021, Nr. 5, S. 2848 – 2856DOI (Open Access)
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Pasteurization Inactivates SARS-CoV-2-Spiked Breast MilkIn: Pediatrics, Jg. 147, 2021, Nr. 1, S. e2020031690
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Performance of the LIAISON® SARS-CoV-2 Antigen Assay vs. SARS-CoV-2-RT-PCRIn: Pathogens, Jg. 10, 2021, Nr. 6, 658DOI, Online Volltext (Open Access)
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Persistent Control of Hepatitis B Virus and Hepatitis Delta Virus Infection Following REP 2139‐Ca and Pegylated Interferon Therapy in Chronic Hepatitis B Virus/Hepatitis Delta Virus CoinfectionIn: Hepatology Communications, Jg. 5, 2021, Nr. 2, S. 189 – 202DOI (Open Access)
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Poor clinical and virological outcome of nucleos(t)ide analogue monotherapy in HBV/HDV co-infected patientsIn: Medicine, Jg. 100, 2021, Nr. 28, e26571DOI (Open Access)
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Production of HIV-1 env-specific antibodies mediating innate immune functions depends on cognate interleukin-21-secreting CD4⁺T cellsIn: Journal of Virology, Jg. 95, 2021, Nr. 8, S. e02097DOI, Online Volltext (Open Access)
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Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonist in miceIn: European Journal of Immunology, Jg. 51, 2021, Nr. 2, S. 393 – 407DOI (Open Access)
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Rapid and Sensitive SERS-Based Lateral Flow Test for SARS-CoV2-Specific IgM/IgG AntibodiesIn: Analytical Chemistry, Jg. 93, 2021, Nr. 36, S. 12391 – 12399
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SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19In: Nature Communications, Jg. 12, 2021, Nr. 1, S. 1813DOI (Open Access)
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SARS-CoV-2 rapid antigen test : Fast-safe or dangerous? ; An analysis in the emergency department of an university hospitalIn: Journal of Medical Virology, Jg. 93, 2021, Nr. 9, Part-XIV, Special Issue, 2019 Novel Coronavirus, Origin, Evolution, Disease, Biology and Epidemiology, S. 5323 – 5327DOI (Open Access)
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SARS-CoV-2-IgG-Antikörperseroprävalenz bei Personal in der außerklinischen Bekämpfung der COVID-19-PandemieIn: Notfall und Rettungsmedizin, Jg. 26, 2021, Nr. 8, S. 593 – 601DOI (Open Access)
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SARS-CoV-2-specific humoral and cellular immunity in two renal transplants and two hemodialysis patients treated with convalescent plasmaIn: Journal of Medical Virology, Jg. 93, 2021, Nr. 5, S. 3047 – 3054DOI (Open Access)
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Sars-cov-2 seroprevalence in healthcare workers in Germany : A follow-up studyIn: International Journal of Environmental Research and Public Health = IJERPH, Jg. 18, 2021, Nr. 9, 4540DOI, Online Volltext (Open Access)
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Seasonality of non-sars, non-mers coronaviruses and the impact of meteorological factorsIn: Pathogens, Jg. 10, 2021, Nr. 2, S. 187DOI, Online Volltext (Open Access)
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