AG Zelinskyy

Forschungsschwerpunkte

  • Zytotoxische Virus-spezifische T-Zellen
  • Regulation von Virus-spezifischen T-Zellen
  • Checkpoint-Rezeptoren 
  • Regulatorische T-Zellen
  • Immuntherapie gegen retrovirale Infektionen und Virus-induzierte Tumoren

Aktivierte zytotoxische T-Zellen sind für die erfolgreiche Eliminierung Virus-infizierter Zellen und Tumoren erforderlich. Andererseits können zytotoxische Zellen gefährlich sein und immunvermittelte Pathologien verursachen. Verschiedene Regulationsmechanismen steuern gleichzeitig die Expansion und Aktivierung dieser Effektorzellen, um Virus-infizierte Zellen oder Tumorzellen zu eliminieren und dabei den Schaden in dem infizierten Organ zu minimieren.

Checkpoint-Rezeptoren, regulatorische T-Zellen (Treg) und MDSC (myeloid-derived suppressor cells) beeinflussen gleichzeitig die Expansion und die Funktionalität von zytotoxischen T-Zellen. Eine Entschlüsselung der Effekte einzelner regulatorischer Mechanismen ist nur in einem Tiermodell möglich. Daten von mit dem „Friend Murine Leukemia Virus“ (FV) infizierten Mäusen erlauben einen tiefen Einblick in verschiedene regulatorische Mechanismen bei akuten und chronischen antiviralen Antworten. Diese Kenntnisse liefern die Grundlagen für eine erfolgreiche antivirale Immuntherapie ähnlich den sehr erfolgreichen Behandlungen von Melanomen, Lungenkrebs und anderen malignen Erkrankungen mit auf Checkpoint-Rezeptoren gerichteten Therapien.

Arbeitsgruppe

Leiter

​​​Dr. rer. nat. Gennadiy Zelinskyy
Tel.: +49 (0)201 723 3541
E-Mail: gennadiy.zelinskyy@uni-due.de

Tanja Werner, BTA
Tel.: +49 (0)201 723 3583
E-Mail: tanja.werner@uni-due.de

Publikationen

    2025

    Artikel in Zeitschriften

  • Ozel, Irem; Sha, Guanyu; Będzińska, Agnieszka; Pylaeva, Ekaterina; Naumova, Yuliia; Thiel, Ilona; Antczak, Joanna; Squire, Anthony; Gunzer, Matthias; Zelinskyy, Gennadiy; Kürten, Cornelius; Lang, Stephan; Silvestre-Roig, Carlos; Kortylewski, Marcin; Granot, Zvi; Jablonska, Jadwiga
    Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8⁺ T cells
    In: Signal Transduction and Targeted Therapy, Jg. 10, 2025, Nr. 1, 279
    DOI (Open Access)

    • 2023

    Artikel in Zeitschriften

  • Stupia, Simone; Heeke, Christina; Brüggemann, Alicia; Zaremba-Montenari, Anne; Thier, Beatrice; Kretz, Julia; Sucker, Antje; Philip, Manuel; Zelinskyy, Gennadiy; Ferrone, Soldano; Rösch, Alexander; Horn, Susanne; Hadaschik, Eva; Schadendorf, Dirk; Trilling, Mirko; Dittmer, Ulf; Griewank, Klaus; Zhao, Fang; Paschen, Annette
    HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance
    In: Clinical Cancer Research, Jg. 29, 2023, Nr. 15, S. 2894 – 2907
    DOI
  • Westmeier, Jaana; Brochtrup, Annika; Paniskaki, Krystallenia; Karakoese, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Limmer, Andreas; Mittermüller, Daniela; Liu, Jia; Zheng, Xin; Koval, Tetiana; Kaidashev, Igor; Berger, Marc Moritz; Herbstreit, Frank; Brenner, Thorsten; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
    In: Frontiers in Immunology, Jg. 14, 2023, 1236374
    DOI, Online Volltext (Open Access)
  • Limmer, Andreas; Engler, Andrea; Kattner, Simone; Gregorius, Jonas; Pattberg, Kevin Thomas; Schulz, Rebecca; Schwab, Jansje; Roth, Johannes; Vogl, Thomas; Krawczyk, Adalbert; Witzke, Oliver; Zelinskyy, Gennadiy; Dittmer, Ulf; Brenner, Thorsten; Berger, Marc
    Patients with SARS-CoV-2-Induced Viral Sepsis Simultaneously Show Immune Activation, Impaired Immune Function and a Procoagulatory Disease State
    In: Vaccines, Jg. 11, 2023, Nr. 2, 435
    DOI (Open Access)
  • Izmailova, Olga; Shlykova, Oksana; Kabaliei, Alina; Vatsenko, Anastasia; Ivashchenko, Dmytro; Dudchenko, Maksym; Volianskyi, Andrii; Zelinskyy, Gennadiy; Koval, Tetiana; Dittmer, Ulf; Kaidashev, Igor
    Polymorphism of tmprss2 (rs12329760) and severity of COVID-19 in the Ukrainian population : Response
    In: Acta Biomedica, Jg. 94, 2023, Nr. 2, e2023109
    DOI
  • Izmailova, Olga; Shlykova, Oksana; Kabaliei, Alina; Vatsenko, Anastasia; Ivashchenko, Dmytro; Dudchenko, Maksym; Volianskyi, Andrii; Zelinskyy, Gennadiy; Koval, Tetiana; Dittmer, Ulf; Kaidashev, Igor
    Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population
    In: Acta Biomedica, Jg. 94, 2023, Nr. 1, e2023030
    DOI (Open Access)
  • Mittermüller, Daniela; Otto, Lucas; Long, Zoë; Kraus, Andreas; Beer, Alexander; Hasenberg, Anja; Zelinskyy, Gennadiy; Westmeier, Jaana; Hasenkrug, Kim J.; Dittmer, Ulf; Gunzer, Matthias
    Regulatory T cells suppress the motility of cytotoxic T cells in Friend retrovirus-infected mice
    In: JCI Insight, Jg. 8, 2023, Nr. 13, e167482
    DOI, Online Volltext (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Liu, Jing; Deng, Hui; Yang, Xuecheng; Wang, Hua; Feng, Xuemei; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Wang, Baoju; Yang, Dongliang; Zheng, Xin; Liu, Jia
    SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
    In: Virologica Sinica, Jg. 38, 2023, Nr. 4, S. 606 – 619
    DOI (Open Access)

    • 2022

    Artikel in Zeitschriften

  • David, Paul; Westmeier, Jaana; Drabczyk-Pluta, Malgorzata; Werner, Tanja; Ickler, Julia; Francois, Sandra; Bayer, Wibke; Sutter, Kathrin; Del Rio, Maria Luisa; Rodriguez-Barbosa, Jose-Ignacio; Dittmer, Ulf; Zelinskyy, Gennadiy
    The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell Responses
    In: Frontiers in Virology, Jg. 2, 2022, 836291
    DOI, Online Volltext (Open Access)

    • 2021

    Artikel in Zeitschriften

  • Knuschke, Torben; Kollenda, Sebastian; Wenzek, Christina; Zelinskyy, Gennadiy; Steinbach, Philine; Dittmer, Ulf; Buer, Jan; Epple, Matthias; Westendorf, Astrid
    A combination of anti-pd-l1 treatment and therapeutic vaccination facilitates improved retroviral clearance via reactivation of highly exhausted t cells
    In: mBio, Jg. 12, 2021, Nr. 1, S. e02121 – 20
    DOI (Open Access)
  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio, Jg. 12, 2021, Nr. 2, S. e00085 – 21
    DOI (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Deng, Hui; Wang, Hua; Feng, Xuemei; Quan, Xufeng; Wang, Xiaoyan; Li, Sumeng; Lu, Sihong; Yang, Xuecheng; Wang, Baoju; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Zheng, Xin; Liu, Jia
    Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
    In: Frontiers in Immunology, Jg. 12, 2021, 802858
    DOI (Open Access)

    • 2020

    Artikel in Zeitschriften

  • David, Paul; Drabczyk-Pluta, Malgorzata; Pastille, Eva; Knuschke, Torben; Werner, Tanja; Honke, Nadine; Megger, Dominik A.; Akhmetzyanova, Ilseyar; Shaabani, Namir; Eyking-Singer, Annette; Cario, Elke; Kershaw, Olivia; Gruber, Achim D.; Tenbusch, Matthias; Dietze, Kirsten; Trilling, Mirko; Liu, Jia; Schadendorf, Dirk; Streeck, Hendrik; Lang, Karl S.; Xie, Youhua; Zimmer, Lisa; Sitek, Barbara; Paschen, Annette; Westendorf, Astrid; Dittmer, Ulf; Zelinskyy, Gennadiy
    Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology
    In: PLoS Pathogens, Jg. 16, 2020, Nr. 3, e1008340
    DOI (Open Access)
  • Rodriguez-Barbosa, Jose-Ignacio; Azuma, Miyuki; Zelinskyy, Gennadiy; Perez-Simon, Jose-Antonio; del Rio, Maria-Luisa
    Critical role of PD-L1 expression on non-tumor cells rather than on tumor cells for effective anti-PD-L1 immunotherapy in a transplantable mouse hematopoietic tumor model
    In: Cancer Immunology, Immunotherapy, 2020
    DOI, Online Volltext (Open Access)
  • Cassetta, Luca; Bruderek, Kirsten; Skrzeczynska-Moncznik, Joanna; Osiecka, Oktawia; Hu, Xiaoying; Rundgren, Ida Marie; Lin, Ang; Santegoets, Kim; Horzum, Utku; Godinho-Santos, Ana; Zelinskyy, Gennadiy; Garcia-Tellez, Thalia; Bjelica, Sunčica; Taciak, Bartłomiej; Kittang, Astrid Olsnes; Höing, Benedikt; Lang, Stephan; Dixon, Michael; Müller, Verena; Utikal, Jochen Sven; Karakoç, Derya; Yilmaz, Kerim Bora; Górka, Emilia; Bodnar, Lubomir; Anastasiou, Olympia Evdoxia; Bourgeois, Christine; Badura, Robert; Kapinska-Mrowiecka, Monika; Gotic, Mirjana; Ter Laan, Mark; Kers-Rebel, Esther; Król, Magdalena; Santibañez, Juan Francisco; Müller-Trutwin, Michaela; Dittmer, Ulf; De Sousa, Ana Espada; Esendaǧli, Güneş; Adema, Gosse; Loré, Karin; Ersvær, Elisabeth; Umansky, Viktor; Pollard, Jeffrey W.; Cichy, Joanna; Brandau, Sven
    Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
    In: Journal for ImmunoTherapy of Cancer, Jg. 8, 2020, Nr. 2, S. e001223
    DOI (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio, Jg. 11, 2020, Nr. 5, S. 02243 – 02220
    DOI (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio, Jg. 11, 2020, Nr. 5, S. e02243 – 20
    DOI (Open Access)
  • Gu, Chenjian; Ming, Lijun; Fang, Yili; Liu, Xuejing; Zhang, Junqi; Zelinskyy, Gennadiy; Deng, Qiang; Liu, Jing; Xie, Youhua
    Restriction of exogenous DNA expression by SAMHD1
    In: Science Bulletin, Jg. 65, 2020, Nr. 7, S. 573 – 586
    DOI, Online Volltext

    • 2019

    Artikel in Zeitschriften

  • Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.
    Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
    In: FEMS Microbiology Reviews, Jg. 43, 2019, Nr. 5, S. 435 – 456
    DOI, Online Volltext (Open Access)
  • Dorhoi, Anca; Glaría, Estibaliz; Garcia-Tellez, Thalia; Nieuwenhuizen, Natalie E.; Zelinskyy, Gennadiy; Favier, Benoit; Singh, Anurag; Ehrchen, Jan; Gujer, Cornelia; Münz, Christian; Saraiva, Margarida; Sohrabi, Yahya; Sousa, Ana E.; Delputte, Peter; Müller-Trutwin, Michaela; Valledor, Annabel F.
    MDSCs in infectious diseases: regulation, roles, and readjustment
    In: Cancer Immunology, Immunotherapy, Jg. 68, 2019, Nr. 4, S. 673 – 685
    DOI (Open Access)
  • David, Paul; Megger, Dominik A.; Kaiser, Tamara; Werner, Tanja; Liu, Jia; Chen, Lieping; Sitek, Barbara; Dittmer, Ulf; Zelinskyy, Gennadiy
    The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8⁺ T Cells During an Acute Retroviral Infection
    In: Frontiers in Immunology, Jg. 10, 2019, 54
    DOI (Open Access)

    • 2018

    Artikel in Zeitschriften

  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications, Jg. 9, 2018, 2561
    DOI (Open Access)
  • Otto, Lucas; Zelinskyy, Gennadiy; Schuster, Marc; Dittmer, Ulf; Gunzer, Matthias
    Imaging of cytotoxic antiviral immunity while considering the 3R principle of animal research
    In: Journal of Molecular Medicine, Jg. 96, 2018, Nr. 3-4, S. 349 – 360
    DOI

    • 2017

    Artikel in Zeitschriften

  • Klein, Johanna C.; Moses, Katrin; Zelinskyy, Gennadiy; Sody, Simon; Buer, Jan; Lang, Stephan; Helfrich, Iris; Dittmer, Ulf; Kirschning, Carsten Jürgen; Brandau, Sven
    Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    In: Nature Communications, Jg. 8, 2017, S. 14600
    DOI (Open Access)
  • Teigler, Jeffrey E.; Zelinskyy, Gennadiy; Eller, Michael A.; Bolton, Diane L.; Marovich, Mary; Gordon, Alexander D.; Alrubayyi, Aljawharah; Alter, Galit; Robb, Merlin L.; Martin, Jeffrey N.; Deeks, Steven G.; Michael, Nelson L.; Dittmer, Ulf; Streeck, Hendrik
    Differential inhibitory receptor expression on T cells delineates functional capacities in chronic viral infection
    In: Journal of Virology, Jg. 91, 2017, Nr. 23, S. e01263 – 17
    DOI, Online Volltext (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports, Jg. 7, 2017, S. 7785
    DOI (Open Access)
  • Drabczyk-Pluta, Malgorzata; Werner, Tanja; Hoffmann, Daniel; Leng, Qibin; Chen, Lieping; Dittmer, Ulf; Zelinskyy, Gennadiy
    Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection
    In: Retrovirology, Jg. 14, 2017, 42
    DOI (Open Access)
  • Ma, Zhiyong; Liu, Jia; Wu, Weimin; Zhang, Ejuan; Zhang, Xiaoyong; Li, Qian; Zelinskyy, Gennadiy; Buer, Jan; Dittmer, Ulf; Kirschning, Carsten Jürgen; Lu, Mengji
    The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model
    In: Cellular & Molecular Immunology, Jg. 14, 2017, Nr. 12, S. 997 – 1008
    DOI (Open Access)

    • 2016

    Artikel in Zeitschriften

  • Akhmetzyanova, Ilseyar; Dittmer, Ulf; Brandau, Sven; Streeck, Hendrik; Dietze, Kirsten; Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Zelinskyy, Gennadiy
    CD137 agonist therapy can reprogram regulatory T cells into cytotoxic CD4+ T cells with antitumor activity
    In: The Journal of Immunology (JI), Jg. 196, 2016, Nr. 1, S. 484 – 492
    DOI (Open Access)
  • Shaabani, Namir; Duhan, Vikas; Khairnar, Vishal; Gassa, Asmae; Ferrer-Tur, Rita; Häussinger, Dieter; Recher, Mike; Zelinskyy, Gennadiy; Liu, Jia; Dittmer, Ulf; Trilling, Mirko; Scheu, Stefanie; Hardt, Cornelia; Lang, Philipp A; Honke, Nadine; Lang, Karl S.
    CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection
    In: Cell Death and Disease, Jg. 7, 2016, Nr. 11, e2446
    DOI (Open Access)

    • 2015

    Artikel in Zeitschriften

  • Akhmetzyanova, Ilseyar; Drabczyk, Malgorzata; Neff, C Preston; Gibbert, Kathrin; Dietze, Kirsten; Werner, Tanja; Liu, Jia; Chen, Lieping; Lang, Karl S.; Palmer, Brent E; Dittmer, Ulf; Zelinskyy, Gennadiy
    Correction: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing
    In: PLoS Pathogens, Jg. 11, 2015, Nr. 12, e1005364
    DOI (Open Access)
  • Akhmetzyanova, Ilseyar; Drabczyk, Malgorzata; Neff, C Preston; Gibbert, Kathrin; Dietze, Kirsten; Werner, Tanja; Liu, Jia; Chen, Lieping; Lang, Karl S.; Palmer, Brent E; Dittmer, Ulf; Zelinskyy, Gennadiy
    PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing
    In: PLoS Pathogens, Jg. 11, 2015, Nr. 10, e1005224
    DOI (Open Access)

    • 2014

    Artikel in Zeitschriften

  • Joedicke, Jara J.; Zelinskyy, Gennadiy; Dittmer, Ulf; Hasenkrug, Kim J.
    CD8+ T Cells Are Essential for Controlling Acute Friend Retrovirus Infection in C57BL/6 Mice
    In: Journal of Virology, Jg. 88, 2014, Nr. 9, S. 5200 – 5201
    DOI
  • Joedicke, Jara J.; Dietze, Kirsten; Zelinskyy, Gennadiy; Dittmer, Ulf
    The phenotype and activation status of regulatory T cells during Friend retrovirus infection
    In: Virologica Sinica, Jg. 29, 2014, Nr. 1, S. 48 – 60
    DOI

    • 2013

    Artikel in Zeitschriften

  • Manzke, Nora; Akhmetzyanova, Ilseyar; Hasenkrug, Kim J.; Trilling, Mirko; Zelinskyy, Gennadiy; Dittmer, Ulf
    CD4⁺ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8⁺ T cells
    In: Journal of Virology, Jg. 87, 2013, Nr. 11, S. 6306 – 6313
    DOI, Online Volltext
  • Dietze, Kirsten Katrin; Zelinskyy, Gennadiy; Liu, Jia; Kretschmer, Freya; Schimmer, Simone; Dittmer, Ulf
    Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8+ T Cells and Efficiently Reduces Chronic Retroviral Loads
    In: PLoS Pathogens, Jg. 9, 2013, Nr. 12, S. e1003798
    DOI (Open Access)
  • Zelinskyy, Gennadiy; Werner, Tanja; Dittmer, Ulf
    Natural regulatory T cells inhibit production of cytotoxic molecules in CD8+ T cells during low-level Friend retrovirus infection
    In: Retrovirology, Jg. 10, 2013, Nr. 1, 109
    DOI (Open Access)
  • Liu, Jia; Jiang, Min; Ma, Zhiyong; Dietze, Kirsten; Zelinskyy, Gennadiy; Yang, Dongliang; Dittmer, Ulf; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    TLR1/2 ligand-stimulated mouse liver endothelial cells secrete IL-12 and trigger CD8+ T cell immunity in vitro
    In: The Journal of Immunology (JI), Jg. 191, 2013, Nr. 12, S. 6178 – 6190
    DOI
  • Akhmetzyanova, Ilseyar; Zelinskyy, Gennadiy; Schimmer, Simone; Brandau, Sven; Altenhoff, Petra; Sparwasser, Tim; Dittmer, Ulf
    Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells
    In: Cancer Immunology, Immunotherapy, Jg. 62, 2013, Nr. 2, S. 257 – 271
    DOI

    • 2011

    Artikel in Zeitschriften

  • Dietze, Kirsten; Zelinskyy, Gennadiy; Gibbert, Kathrin; Schimmer, Simone; Francois, Sandra; Myers, Lara; Sparwasser, Tim; Hasenkrug, Kim J.; Dittmer, Ulf
    Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8⁺ T cells and reduces chronic retroviral set points
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 108, 2011, Nr. 6, S. 2420 – 2425
    DOI (Open Access)
  • Zelinskyy, Gennadiy; Myers, Lara; Dietze, Kirsten; Gibbert, Kathrin; Roggendorf, Michael; Liu, Jia; Lu, Mengji; Kraft, Anke R.; Teichgräber, Volker; Hasenkrug, Kim J.; Dittmer, Ulf
    Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
    In: The Journal of Immunology (JI), Jg. 187, 2011, Nr. 7, S. 3730 – 3737
    DOI

    • 2010

    Artikel in Zeitschriften

  • Nair, Savita R.; Zelinskyy, Gennadiy; Shimmer, Simone; Gerlach, Nicole; Kassiotis, George; Dittmer, Ulf; Schimmer, S.
    Mechanisms of control of acute Friend virus infection by CD4⁺ T helper cells and their functional impairment by regulatory T cells
    In: Journal of General Virology, Jg. 91, 2010, Nr. 2, S. 440 – 451
    DOI
  • Gibbert, Kathrin; Dietze, Kirsten; Zelinskyy, Gennadiy; Lang, Karl S.; Barchet, Winfried; Kirschning, Carsten Jürgen; Dittmer, Ulf
    Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease
    In: The Journal of Immunology (JI), Jg. 185, 2010, Nr. 10, S. 6179 – 6189
    DOI (Open Access)

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