AG Mirko Trilling

Virale Immunevasionsmechanismen

Forschungsschwerpunkte

  • Cytomegalovirale Immunevasion
  • Interferone und pro-inflammatorische Cytokine
  • Jak-STAT Signalwege
  • Virolyse
  • Latenz-assoziierte Genprodukte
  • Virale Mutationsraten

Projekt

Cytomegaloviren sind prototypische Vertreter der β-Subgruppe der Herpesviren, deren wichtigste Mitglieder das humane Cytomegalovirus (CMV; HCMV; HHV-5) und das murine Cytomegalovirus (MCMV, Murid herpesvirus 1) sind. Wie alle Herpesviren, etablieren auch Cytomegaloviren nach der Primärinfektion eine lebenslange Latenz, die nach stressreichen Phasen oder durch Beeinträchtigungen des Immunsystems zu einer Reaktivierung der Viren führen kann. Dies löst wiederkehrende Infektionen aus und ermöglicht eine Übertragung auf neue Wirte. Die Mehrheit der humanen Population ist latent mit HCMV infiziert. Symptome löst die HCMV-Infektion jedoch meist nur bei Individuen aus, deren Immunsystem unterentwickelt oder beeinträchtigt ist.
Üblicherweise kommt es nach Virusinfektionen zu einer Immunreaktion, die im Erfolgsfall zu der Elimination des Virus und einer anschließenden Immunität gegenüber dem gleichen Virus führt. Bei Herpesviren ist dies jedoch nicht der Fall. Herpesviren besitzen die Fähigkeit, sich dem Immunsystem des Wirts zu entziehen und eine sterile Immunität abzuwenden. Sie haben im Laufe der Evolution unzählige molekulare Maßnahmen entwickelt, um die meisten (alle?) relevanten Immunfunktionen des Wirts zu umgehen. Wir untersuchen diese viralen Immunevasionsmechanismen mit dem Ziel, spezifische pharmakologische Wirkstoffe zu finden, die die Funktion dieser viralen Proteine blockieren, dem Immunsystem so seine Aktivität gegenüber Herpesviren zurückgeben und dem Patienten helfen, sich selbst zu helfen. Da die Genome von Herpesviren gezielt genetisch modifiziert werden können, stellen Virusmutanten, denen Immunevasionsgene fehlen, darüber hinaus interessante Kandidaten für potentielle Lebendimpfstoffe und Vakzinvektoren dar. Außerdem sind herpesvirale Proteine sehr präzise molekulare Werkzeuge für die Grundlagenforschung, mit denen zelluläre Prozesse gezielt moduliert und blockiert werden können, um grundsätzliche Erkenntnisse über die Zelle bzw. das Immunsystem zu gewinnen.

Arbeitsgruppe

Leiter

Prof. Dr. rer. nat. Mirko Trilling
Tel.: +49 (0)201 723 83830
E-Mail: mirko.trilling@uni-due.de
Link to ORCID
Link to PUBMED

Dr. rer. nat. Vu Thuy Khanh Le-Trilling
Tel.: +49 (0)201 723 83830
E-Mail: khanh.le@uk-essen.de
Link to ORCID
Link to PUBMED

​Katschinski Benjamin 162x205
​Benjamin Katschinski, B. Sc., BTA
​​Tel.: +49 (0)201 723 3057
E-Mail: benjamin.katschinski@uk-essen.de
 

Fit To Size 162x205 Robin Klingen
Tel.: +49 (0)201 723 3094

​Fit To Size 162x205Lara Schöler
Tel.: +49 (0)201 723 3094
E-Mail: LaraMaria.Schoeler@uk-essen.de

 

Fit To Size 162x205Corinna Siegmund, M. Sc.
Tel.: +49 (0)201 723 3022
E-Mail: Corinna.Siegmund@uk-essen.de

​Kerstin Wohlgemuth 162x205pixel
Kerstin Wohlgemuth, BTA
Tel.: +49 (0)201 723 3067
E-Mail: kerstin.wohlgemuth@uk-essen.de

Alumni

M. Sc. Alan Herman
M. Sc. Yulia Alejandra Flores Martinez
Dr. rer. nat. Sebastian Howe
Dr. rer. nat. Christine Landsberg
Dr. med. Jassin Rashidi Alavijeh
Dr. rer. nat. Tanja Becker
Dr. rer. nat. Andreja Jagnjić
Dr. rer. nat. Meike Rückborn
Dr. rer. nat. Mareike Eilbrecht

Publikationen

    2025

    Artikel in Zeitschriften

  • Chan, Junned; Rubio, Julian Gonzalez; Lancaster-Jones, Oscar O’Dwyer; Verma, Yashasvi; Büchter, Charlotte; Jockenhoevel, Stefan; De Laporte, Laura; Trilling, Mirko; Thiebes, Anja Lena; Campos, Daniela Duarte
    Integrating three-dimensional printing and bioprinting technologies to develop a stretchable in vitro model of the human airway
    In: Bio-design and Manufacturing, Jg. 8, 2025, Nr. 4, S. 595 – 608
    DOI (Open Access)
  • Maassen, Fabienne; Le-Trilling, Vu Thuy Khanh; Betke, Luisa; Bracht, Thilo; Siegmund, Corinna; Bayer, Malte; Katschinski, Benjamin; Belter, Antonia; Becker, Tanja; Mennerich, Denise; Voigt, Sebastian; Frappier, Lori; Sitek, Barbara; Fleischhauer, Katharina; Trilling, Mirko
    The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA
    In: eLife, Jg. 14, 2025, e96414
    DOI, Online Volltext (Open Access)

    • 2024

    Artikel in Zeitschriften

  • Mao, Binli; Le-Trilling, Vu Thuy Khanh; Tang, Haihuan; Hu, Jie; Schmitz, Mona S.; Barbet, Kimberly; Xu, Dan; Wei, Zhen; Guo, Beinu; Mennerich, Denise; Yao, Chun; Liu, Jinxin; Li, Zhenghan; Wan, Yushun; Zhang, Xiaoyong; Wang, Kai; Tang, Ni; Yu, Zebo; Trilling, Mirko; Lin, Yong
    Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin
    In: Virus Research, Jg. 350, 2024, 199485
    DOI (Open Access)
  • Rohn, Hana; Elischer, Fynn; Larbig, Louisa; Jansen, Sarah; Schramm, Sabine; Otte, Mona; Konik, Margarethe; Paniskaki, Krystallenia; Weber, Peter; Reinold, Johanna; Gäckler, Anja; Krawczyk, Adalbert; Wilde, Benjamin; Trilling, Mirko; Michita, Rafael T.; Möhlendick, Birte; Siffert, Winfried; Brenner, Thorsten; Dinse, Hannah; Skoda, Eva M.; Horn, Peter; Witzke, Oliver; Rebmann, Vera
    Influence of HLA-G 3′ Untranslated Region Haplotypes and SNP +3422 Gene Variants as Host Genetic Factors on the Outcomes of SARS-CoV-2 Infection During Acute and Post-Acute Phases in a German Cohort
    In: HLA: Immune Response Genetics (Human Leukocyte Antigens), Jg. 104, 2024, Nr. 6, e15799
    DOI (Open Access)
  • Gerke, Carolin; Bauersfeld, Liane; Schirmeister, Ivo; Mireisz, Chiara Noemi-Marie; Oberhardt, Valerie; Mery, Lea; Wu, Di; Jürges, Christopher Sebastian; Spaapen, Robbert M.; Mussolino, Claudio; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Dölken, Lars; Paster, Wolfgang; Erhard, Florian; Hofmann, Maike; Schlosser, Andreas; Hengel, Hartmut; Momburg, Frank; Halenius, Anne
    Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning
    In: eLife, Jg. 13, 2024, e85560
    DOI (Open Access)
  • Thomas, Alexander; Battenfeld, Thomas; Kraiselburd, Ivana; Anastasiou, Olympia; Dittmer, Ulf; Dörr, Ann-Kathrin; Dörr, Adrian; Elsner, Carina; Gosch, Jule; Le-Trilling, Vu Thuy Khanh; Magin, Simon; Scholtysik, René; Yilmaz, Pelin; Trilling, Mirko; Schöler, Lara; Köster, Johannes; Meyer, Folker
    UnCoVar : A reproducible and scalable workflow for transparent and robust virus variant calling and lineage assignment using SARS-CoV-2 as an example
    In: BMC Genomics, Jg. 25, 2024, Nr. 1, 647
    DOI, Online Volltext (Open Access)

    • 2023

    Artikel in Zeitschriften

  • Anastasiou, Olympia E.; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    A simple algorithm based on initial Ct values predicts the duration to SARS-CoV-2 negativity and allows more efficient test-to-release and return-to-work schedules
    In: Diagnostic Microbiology and Infectious Disease, Jg. 106, 2023, Nr. 3, 115949
    DOI, Online Volltext (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Ebel, Jana‐Fabienne; Baier, Franziska; Wohlgemuth, Kerstin; Pfeifer, Kai Robin; Mookhoek, Aart; Krebs, Philippe; Determann, Madita; Katschinski, Benjamin; Adamczyk, Alexandra; Lange, Erik; Klopfleisch, Robert; Lange, Christian; Sokolova, Viktoriya; Trilling, Mirko; Westendorf, Astrid
    Acute cytomegalovirus infection modulates the intestinal microbiota and targets intestinal epithelial cells
    In: European Journal of Immunology, Jg. 53, 2023, Nr. 2, 2249940
    DOI, Online Volltext (Open Access)
  • Holtkamp, Caroline; Schöler, Lara; Anastasiou, Olympia E.; Brune, Bastian; Fessmann, Kai; Elsner, Carina; Möhlendick, Birte; Ciuciulkaite, Ieva; Dudda, Marcel; Trilling, Mirko; Dittmer, Ulf; Spors, Jörg; Le-Trilling, Vu Thuy Khanh
    Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMI
    In: Heliyon, Jg. 9, 2023, Nr. 1, e12746
    DOI, Online Volltext (Open Access)
  • Alt, Mira; Wolf, Susanne; van de Sand, Lukas; Dittrich, Robin; Tertel, Tobias; Brochhagen, Leonie; Dirks, Miriam; Aufderhorst, Ulrich Wilhelm; Thümmler, Laura; Otte, Mona; Rainer, Kordula; Dittmer, Ulf; Giebel, Bernd; Trilling, Mirko; Heilingloh, Christiane Silke; Lotfi, Ramin; Roggendorf, Michael; Witzke, Oliver; Krawczyk, Adalbert
    Cell-to-cell spread inhibiting antibodies constitute a correlate of protection against herpes simplex virus type 1 reactivations : A retrospective study
    In: Frontiers in Immunology, Jg. 14, 2023, 1143870
    DOI, Online Volltext (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Maaßen, Fabienne; Katschinski, Benjamin; Hengel, Hartmut; Trilling, Mirko
    Deletion of the non-adjacent genes UL148 and UL148D impairs human cytomegalovirus-mediated TNF receptor 2 surface upregulation
    In: Frontiers in Immunology, Jg. 14, 2023, 1170300
    DOI, Online Volltext (Open Access)
  • Stupia, Simone; Heeke, Christina; Brüggemann, Alicia; Zaremba-Montenari, Anne; Thier, Beatrice; Kretz, Julia; Sucker, Antje; Philip, Manuel; Zelinskyy, Gennadiy; Ferrone, Soldano; Rösch, Alexander; Horn, Susanne; Hadaschik, Eva; Schadendorf, Dirk; Trilling, Mirko; Dittmer, Ulf; Griewank, Klaus; Zhao, Fang; Paschen, Annette
    HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance
    In: Clinical Cancer Research, Jg. 29, 2023, Nr. 15, S. 2894 – 2907
    DOI
  • Unterberg, M.; Ehrentraut, S.F.; Bracht, T.; Wolf, A.; Haberl, Helge; von Busch, A.; Rump, K.; Ziehe, D.; Bazzi, M.; Thon, P.; Sitek, B.; Marcus, K.; Bayer, M.; Schork, K.; Eisenacher, M.; Ellger, B.; Oswald, D.; Wappler, F.; Defosse, J.; Henzler, D.; Köhler, T.; Zarbock, A.; Putensen, C.P.; Schewe, J.C.; Frey, U.H.; Anft, M.; Babel, N.; Steinmann, E.; Brüggemann, Y.; Trilling, Mirko; Schlüter, A.; Nowak, H.; Adamzik, Michael; Rahmel, T.; Koos, B.
    Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
    In: Critical Care: The Online Intensive Care Journal, Jg. 27, 2023, Nr. 1, 417
    DOI (Open Access)
  • Westmeier, Jaana; Brochtrup, Annika; Paniskaki, Krystallenia; Karakoese, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Limmer, Andreas; Mittermüller, Daniela; Liu, Jia; Zheng, Xin; Koval, Tetiana; Kaidashev, Igor; Berger, Marc Moritz; Herbstreit, Frank; Brenner, Thorsten; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
    In: Frontiers in Immunology, Jg. 14, 2023, 1236374
    DOI, Online Volltext (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Jagnjić, Andreja; Brizić, Ilija; Eilbrecht, Mareike; Wohlgemuth, Kerstin; Rožmanić, Carmen; Herdman, Alan; Hoffmann, Katja; Westendorf, Astrid M.; Hengel, Hartmut; Jonjić, Stipan; Trilling, Mirko
    Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus
    In: npj Vaccines, Jg. 8, 2023, Nr. 1, 8
    DOI, Online Volltext (Open Access)
  • Specka, Michael; Kröckert, Tobias; Trilling, Mirko; Bonnet, Udo; Schifano, Fabrizio; Scherbaum, Norbert
    Opiate maintenance patients’ attitudes and self-reported adherence to protective measures against SARS-CoV-2 infections
    In: Frontiers in Psychiatry, Jg. 14, 2023, 1254053
    DOI, Online Volltext (Open Access)
  • Rohn, Hana; Schramm, Sabine; Pansikaki, Krystallenia; Jansen, Sarah; Hendriks, Celina; Platte, Maximilian; Konik, Margarethe; Dolff, Sebastian; Wilde, Benjamin; Kordelas, Lambros; Trilling, Mirko; Krawczyk, Adalbert; Horn, Peter; Witzke, Oliver; Rebmann, Vera
    Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients
    In: Human Immunology, Jg. 84, 2023, Nr. 8, S. 393 – 400
    DOI (Open Access)
  • Di Vito, Clara; Coianiz, Nicolò; Calvi, Michela; Terzoli, Sara; Zaghi, Elisa; Puccio, Simone; Frigo, Alessandro; Mariotti, Jacopo; De Philippis, Chiara; Mannina, Daniele; Sarina, Barbara; Mineri, Rossana; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Castagna, Luca; Bramanti, Stefania; Santoro, Armando; Mavilio, Domenico
    Persistence of KIRⁿeg NK cells after haploidentical hematopoietic stem cell transplantation protects from human cytomegalovirus infection/reactivation
    In: Frontiers in Immunology, Jg. 14, 2023, 1266051
    DOI (Open Access)
  • Gonzalez-Rubio, Julian; Le-Trilling, Vu Thuy Khanh; Baumann, Lea; Cheremkhina, Maria; Kubiza, Hannah; Luengen, Anja E.; Reuter, Sebastian; Taube, Christian; Ruetten, Stephan; Duarte Campos, Daniela; Cornelissen, Christian G.; Trilling, Mirko; Thiebes, Anja Lena
    SARS-CoV-2 particles promote airway epithelial differentiation and ciliation
    In: Frontiers in Bioengineering and Biotechnology, Jg. 11, 2023, 1268782
    DOI (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Liu, Jing; Deng, Hui; Yang, Xuecheng; Wang, Hua; Feng, Xuemei; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Wang, Baoju; Yang, Dongliang; Zheng, Xin; Liu, Jia
    SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
    In: Virologica Sinica, Jg. 38, 2023, Nr. 4, S. 606 – 619
    DOI (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Banchenko, Sofia; Paydar, Darius; Leipe, Pia Madeleine; Binting, Lukas; Lauer, Simon; Graziadei, Andrea; Klingen, Robin; Gotthold, Christine; Bürger, Jörg; Bracht, Thilo; Sitek, Barbara; Lebbink, Robert Jan; Malyshkina, Anna; Mielke, Thorsten; Rappsilber, Juri; Spahn, Christian; Voigt, Sebastian; Trilling, Mirko; Schwefel, David
    Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor
    In: The EMBO Journal, Jg. 42, 2023, Nr. 5, e112351
    DOI (Open Access)
  • Karakoese, Zehra; Le-Trilling, Vu Thuy Khanh; Schuhenn, Jonas; Francois, Sandra; Lu, Mengji; Liu, Jia; Trilling, Mirko; Hoffmann, Daniel; Dittmer, Ulf; Sutter, Kathrin
    Targeted mutations in IFNα2 improve its antiviral activity against various viruses
    In: mBio, Jg. 14, 2023, Nr. 6, e02357-23
    DOI, Online Volltext (Open Access)
  • Vollmer-Raschdorf, Stephanie; Rashidi-Alavijeh, Jassin; Voigt, Sebastian; Hengel, Hartmut; Borchardt, Benjamin; Huzly, Daniela; Hüßler, Eva-Maria; In der Schmitten, Jürgen; Halenius, Anne; Willuweit, Katharina; Botzenhardt, Suzan; Trilling, Mirko; Boettler, Tobias; Dehnen, Dorothea
    Tiza-Titre increase and enhanced immunity through an adjuvanted, recombinant herpes zoster subunit vaccine in patients with liver cirrhosis and post-liver transplantation : A study protocol for a prospective cohort study
    In: BMJ Open, Jg. 13, 2023, Nr. 11, e074461
    DOI, Online Volltext (Open Access)

    • Abstracts

  • Schoeler, Lara; Le-Trilling, Vu Thuy Khanh; Dittmer, Ulf; Esser, Stefan; Trilling, Mirko; HIV HEART AGEING Study
    Analyses of defined human cytomegalovirus-specific antibody effector functions in people living with human immunodeficiency virus
    DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,
    In: HIV Medicine. Hoboken: Wiley-Blackwell, Jg. 24, 2023, Nr. 1, S. 48 – 49
  • Schmidt, Teresa; Rohn, Hana; Trilling, Mirko; Agkatsev, Sarina; Oster, Christoph; Kleinschnitz, Christoph; Sure, Ulrich; Stuschke, Martin; Scheffler, Björn; Kebir, Sied; Glas, Martin
    Immunogenicity of an additional dose of covid-19 vaccine in fully vaccinated patients with glioma to evaluate new national vaccination guidelines : a prospective cohort study
    In: Neuro-Oncology. Oxford: Oxford University Press, Jg. 25, 2023, Nr. Suppl. 5, S. v63 – v64
    DOI

    • Poster / Posterbeiträge

  • Pfeifer, Kai Robin; Ebel, Jana-Fabienne; Trilling, Mirko; Le-Trilling, Vu Thuy Khanh; Westendorf, Astrid
    Cytomegalovirus infection aggravates intestinal inflammation during colitis and impairs the convalescence of the intestinal niche
    Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI) ; 26-29 September, 2023, Strasbourg, France,
    In: European Journal of Immunology. Hoboken: Wiley, Jg. 53, 2023, Nr. S2, Special issue: Abstracts: Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), 26–29 September, 2023, Strasbourg, France, S. 354
    DOI (Open Access)

    • 2022

    Artikel in Zeitschriften

  • Wang, Xiaoyan; Kerkmann, Leonie; Hetzel, Mario; Windmann, Sonja; Trilling, Mirko; Zhang, Wenli; Ehrhardt, Anja; Bayer, Wibke
    Analysis of the Prevalence of Binding and Neutralizing Antibodies against 39 Human Adenovirus Types in Student Cohorts Reveals Low-Prevalence Types and a Decline in Binding Antibody Levels during the SARS-CoV-2 Pandemic
    In: Journal of Virology, Jg. 96, 2022, Nr. 22, e0113322
    DOI
  • Schuhenn, Jonas; Meister, Toni Luise; Todt, Daniel; Bracht, Thilo; Schork, Karin; Billaud, Jean-Noel; Elsner, Carina; Heinen, Natalie; Karakoese, Zehra; Haid, Sibylle; Kumar, Sriram; Brunotte, Linda; Eisenacher, Martin; Di, Yunyun; Lew, Jocelyne; Falzarano, Darryl; Chen, Jieliang; Yuan, Zhenghong; Pietschmann, Thomas; Wiegmann, Bettina; Uebner, Hendrik; Taube, Christian; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Krawczyk, Adalbert; Ludwig, Stephan; Sitek, Barbara; Steinmann, Eike; Dittmer, Ulf; Lavender, Kerry J.; Sutter, Kathrin; Pfaender, Stephanie
    Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 119, 2022, Nr. 8, e2111600119
    DOI (Open Access)
  • Dehnen, Dorothea; Dehnen, Katja; Trilling, Mirko; Fiedler, Melanie; Drexler, Julia; Goralski, Marcel; Le-Trilling, Vu Thuy Khanh; Schöler, Lara; Jöckel, Karl-Heinz; Heßbrügge, Martina
    Discrepancy between frequent occurrence of COVID-19-like symptoms and low seroconversion rates among healthcare workers
    In: Journal of Medical Virology, Jg. 94, 2022, Nr. 3: Special Issue on New coronavirus (2019‐nCoV or SARS‐CoV‐2) and the outbreak of the respiratory illness (COVID‐19): Part‐XVIII, S. 951 – 957
    DOI (Open Access)
  • Rohn, Hana; Lang, Cordula; Schramm, Sabine; Heinemann, Falko M.; Trilling, Mirko; Gäckler, Anja; Witzke, Oliver; Horn, Peter; Rebmann, Vera
    Effect of HLA-G5 Immune Checkpoint Molecule on the Expression of ILT-2, CD27, and CD38 in Splenic B cells
    In: Journal of Immunology Research, Jg. 2022, 2022, 4829227
    DOI, Online Volltext (Open Access)
  • Schöler, Lara; Le-Trilling, Vu Thuy Khanh; Dittmer, Ulf; Fiedler, Melanie; Trilling, Mirko
    Establishment and clinical validation of an in-cell-ELISA-based assay for the rapid quantification of Rabies virus neutralizing antibodies
    In: PLoS Neglected Tropical Diseases, Jg. 16, 2022, Nr. 5, e0010425
    DOI, Online Volltext (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Mennerich, Denise; Schuler, Corinna; Sakson, Roman; Lill, Julia K.; Kasarla, Siva Swapna; Kopczynski, Dominik; Loroch, Stefan; Flores-Martinez, Yulia; Katschinski, Benjamin; Wohlgemuth, Kerstin; Gunzer, Matthias; Meyer, Folker; Phapale, Prasad; Dittmer, Ulf; Sickmann, Albert; Trilling, Mirko
    Identification of herbal teas and their compounds eliciting antiviral activity against SARS-CoV-2 in vitro
    In: BMC Biology (incorporating Journal of Biology), Jg. 20, 2022, Nr. 1, 264
    DOI, Online Volltext (Open Access)
  • Turki, Amin T.; Tsachakis-Muck, Nikolaos; Leserer, Saskia; Crivello, Pietro; Liebregts, Tobias; Betke, Luisa; Alashkar, Ferras; Leimkuhler, Nils B.; Trilling, Mirko; Fleischhauer, Katharina; Beelen, Dietrich
    Impact of CMV reactivation on relapse of acute myeloid leukemia after HCT is dependent on disease stage and ATG
    In: Blood Advances, Jg. 6, 2022, Nr. 1, S. 28 – 36
    DOI (Open Access)
  • Möhlendick, Birte; Čiučiulkaitė, Ieva; Elsner, Carina; Anastasiou, Olympia E.; Trilling, Mirko; Wagner, Bernd; Zwanziger, Denise; Jöckel, Karl-Heinz; Dittmer, Ulf; Siffert, Winfried
    Individuals With Weaker Antibody Responses After Booster Immunization Are Prone to Omicron Breakthrough Infections
    In: Frontiers in Immunology, Jg. 13, 2022, 907343
    DOI, Online Volltext (Open Access)
  • Mao, Binli; Le-Trilling, Vu Thuy Khanh; Wang, Kai; Mennerich, Denise; Hu, Jie; Zhao, Zhenyu; Zheng, Jiaxin; Deng, Yingying; Katschinski, Benjamin; Xu, Shilei; Zhang, Guiji; Cai, Xuefei; Hu, Yuan; Wang, Jianwei; Lu, Mengji; Huang, Ailong; Tang, Ni; Trilling, Mirko; Lin, Yong
    Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro
    In: Emerging Microbes & Infections, Jg. 11, 2022, Nr. 1, S. 483 – 497
    DOI, Online Volltext (Open Access)

    • Abstracts

  • Betke, Luisa; Crivello, Pietro; Maassen, Fabienne; Schuler, Corinna; Arrieta-Bolaños, Thuja; Arrieta-Bolaños, Esteban; Doelken, Lars; Erhard, Florian; Trilling, Mirko; Fleischhauer, Katharina
    HLA-DP-restricted immunity to human cytomegalovirus is directed against a variety of viral proteins, and modulated by its 84-87 DEAV/GGPM polymorphism
    Joint 35th European Immunogenetics and Histocompatibility Conference; May 17–20, 2022; Amsterdam, the Netherlands,
    In: HLA: Immune Response Genetics (Human Leukocyte Antigens). Hoboken: Wiley-Blackwell - STM, Jg. 99, 2022, Nr. 5, SI, S. 427 – 428

    • Poster / Posterbeiträge

  • Rohn, Hana; Lang, Cordula; Schramm, Sabine; Heinemann, Falko M.; Trilling, Mirko; Gäckler, Anja; Witzke, Oliver; Horn, Peter A.; Rebmann, Vera
    The influence of HLA-G5 on expression of differentiation markers on splenic B cells
    Joint 35th European Immunogenetics and Histocompatibility Conference; May 17–20, 2022; Amsterdam, the Netherlands,
    In: HLA: Immune Response Genetics (Human Leukocyte Antigens). Hoboken: Wiley-Blackwell - STM, Jg. 99, 2022, Nr. 5, SI, S. 547 – 548

    • 2021

    Artikel in Zeitschriften

  • Krempe, Friederike; Schöler, Lara; Katschinski, Benjamin; Herrmann, Anke; Anastasiou, Olympia E.; Elsner, Carina; Roß, R. Stefan; Scholz, Friedrich; Dittmer, Ulf; Miethe, Peter; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    A rapid test recognizing mucosal SARS-CoV-2-specific antibodies distinguishes prodromal from convalescent COVID-19
    In: iScience, Jg. 24, 2021, Nr. 10, 103194
    DOI (Open Access)
  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio, Jg. 12, 2021, Nr. 2, S. e00085 – 21
    DOI (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Deng, Hui; Wang, Hua; Feng, Xuemei; Quan, Xufeng; Wang, Xiaoyan; Li, Sumeng; Lu, Sihong; Yang, Xuecheng; Wang, Baoju; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Zheng, Xin; Liu, Jia
    Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
    In: Frontiers in Immunology, Jg. 12, 2021, 802858
    DOI (Open Access)
  • Leserer, Saskia; Bayraktar, Evren; Trilling, Mirko; Bogdanov, Rashit; Arrieta-Bolaños, Esteban; Tsachakis-Mück, Nikolaos; Crivello, Pietro; Koldehoff, Michael; Maaßen, Fabienne; Roß, Rudolf Stefan; Fleischhauer, Katharina; Beelen, Dietrich; Turki, Amin T.
    Cytomegalovirus kinetics after hematopoietic cell transplantation reveal peak titers with differential impact on mortality, relapse and immune reconstitution
    In: American Journal of Hematology, Jg. 96, 2021, Nr. 4, S. 436 – 445
    DOI (Open Access)
  • Xiang, Tiandan; Liang, Boyun; Fang, Yaohui; Lu, Sihong; Li, Sumeng; Wang, Hua; Li, Huadong; Yang, Xiaoli; Shen, Shu; Zhu, Bin; Wang, Baoju; Wu, Jun; Liu, Jia; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Trilling, Mirko; Deng, Fei; Zheng, Xin
    Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 Patients One Year Post Symptom Onset
    In: Frontiers in Immunology, Jg. 12, 2021, 708523
    DOI, Online Volltext (Open Access)
  • Trilling, Mirko
    Erratum to: Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants
    In: Basic Research in Cardiology, Jg. 116, 2021, Nr. 1, 43
    DOI (Open Access)
  • Zhou, Li; He, Rui; Fang, Peining; Li, Mengqi; Yu, Haisheng; Wang, Qiming; Yu, Yi; Wang, Fubing; Zhang, Yi; Chen, Aidong; Peng, Nanfang; Lin, Yong; Zhang, Rui; Trilling, Mirko; Bröring, Ruth; Lu, Mengji; Zhu, Ying; Liu, Shi
    Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition
    In: Nature Communications, Jg. 12, 2021, Nr. 1, S. 98
    DOI (Open Access)
  • Kolb, Philipp; Hoffmann, Katja; Sievert, Annika; Reinhard, Henrike; Mercé-Maldonado, Eva; Le-Trilling, Vu Thuy Khanh; Halenius, Anne; Gütle, Dominique; Hengel, Hartmut
    Human cytomegalovirus antagonizes activation of fcγ receptors by distinct and synergizing modes of igg manipulation
    In: eLife, Jg. 10, 2021, S. e63877
    DOI (Open Access)
  • Konik, Margarethe; Lindemann, Monika; Zettler, Markus; Meller, Lara; Dolff, Sebastian; Rebmann, Vera; Horn, Peter; Dittmer, Ulf; Krawczyk, Adalbert; Schipper, Leonie; Trilling, Mirko; Anastasiou, Olympia Evdoxia; Schwarzkopf, Sina; Thümmler, Laura; Taube, Christian; Schöbel, Christoph; Brenner, Thorsten; Skoda, Eva-Maria; Wilde, Benjamin; Gäckler, Anja; Witzke, Oliver; Rohn, Hana
    Long-term sars-cov-2 specific immunity is affected by the severity of initial covid-19 and patient age
    In: Journal of Clinical Medicine (JCM), Jg. 10, 2021, Nr. 19, 4606
    DOI, Online Volltext (Open Access)
  • Flores-Martínez, Yulia Alejandra; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    Nedd8-activating enzyme is a druggable host dependency factor of human and mouse cytomegalovirus
    In: Viruses, Jg. 13, 2021, Nr. 8, 1610
    DOI, Online Volltext (Open Access)
  • Wu, Jun; Liang, Bo-Yun; Fang, Yao-Hui; Wang, Hua; Yang, Xiao-Li; Shen, Shu; Chen, Liang-Kai; Li, Su-Meng; Lu, Si-Hong; Xiang, Tian-Dan; Liu, Jia; Le-Trilling, Vu Thuy Khanh; Lu, Mengji; Yang, Dong-Liang; Deng, Fei; Dittmer, Ulf; Trilling, Mirko; Zheng, Xin
    Occurrence of COVID-19 Symptoms During SARS-CoV-2 Infection Defines Waning of Humoral Immunity
    In: Frontiers in Immunology, Jg. 12, 2021, 722027
    DOI, Online Volltext (Open Access)
  • Klingen, Robin L.; Katschinski, Benjamin; Anastasiou, Olympia E.; Roß, Rudolf Stefan; Dittmer, Ulf; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    Over 90% of clinical swabs used for SARS-CoV-2 diagnostics contain sufficient nucleic acid concentrations
    In: Journal of Medical Virology, Jg. 93, 2021, Nr. 5, S. 2848 – 2856
    DOI (Open Access)
  • Huang, Hongming; Rückborn, Meike; Le-Trilling, Vu Thuy Khanh; Zhu, Dan; Yang, Shangqing; Zhou, Wenqing; Yang, Xuecheng; Feng, Xuemei; Lu, Yinping; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Trilling, Mirko; Liu, Jia
    Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonist in mice
    In: European Journal of Immunology, Jg. 51, 2021, Nr. 2, S. 393 – 407
    DOI (Open Access)
  • Cherneha, Maxim; Korth, Johannes; Kaulfuß, Meike; Trilling, Mirko; Widera, Marek; Rohn, Hana; Dolff, Sebastian; Babel, Nina; Hörning, Andre; Kribben, Andreas; Witzke, Oliver
    Reactivations of Latent Viral Infections Are Associated with an Increased Thr389 p70S6k Phosphorylation in Peripheral Lymphocytes of Renal Transplant Recipients
    In: Viruses, Jg. 13, 2021, Nr. 3, 424
    DOI, Online Volltext (Open Access)
  • Wu, Jun; Liang, Boyun; Chen, Cunrong; Wang, Hua; Fang, Yaohui; Shen, Shu; Yang, Xiaoli; Wang, Baoju; Chen, Liangkai; Chen, Qi; Wu, Yang; Liu, Jia; Yang, Xuecheng; Li, Wei; Zhu, Bin; Zhou, Wenqing; Wang, Huan; Li, Sumeng; Lu, Sihong; Liu, Di; Li, Huadong; Krawczyk, Adalbert; Lu, Mengji; Yang, Dongliang; Deng, Fei; Dittmer, Ulf; Trilling, Mirko; Zheng, Xin
    SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
    In: Nature Communications, Jg. 12, 2021, Nr. 1, S. 1813
    DOI (Open Access)
  • Korth, Johannes; Wilde, Benjamin; Dolff, Sebastian; Frisch, Jasmin; Jahn, Michael; Krawczyk, Adalbert; Trilling, Mirko; Schipper, Leonie; Cordes, Sebastian; Ross, Birgit; Lindemann, Monika; Kribben, Andreas; Dittmer, Ulf; Witzke, Oliver; Herrmann, Anke; Anastasiou, Olympia Evdoxia
    Sars-cov-2 seroprevalence in healthcare workers in Germany : A follow-up study
    In: International Journal of Environmental Research and Public Health = IJERPH, Jg. 18, 2021, Nr. 9, 4540
    DOI, Online Volltext (Open Access)
  • Zou, Shi; Du, Yanqin; Huang, Shunmei; Chen, Mingfa; Yang, Xiaoli; Li, Sumeng; Chen, Yingshan; Han, Meihong; Li, Jia; Yu, Qing; Littwitz-Salomon, Elisabeth; Huang, Hongming; Trilling, Mirko; Liu, Shi; Pei, Rongjuan; Liu, Jia; Wang, Baoju; Zheng, Xin; Lu, Mengji; Dittmer, Ulf; Sun, Shuilin; Yang, Dongliang; Wu, Jun
    Simultaneous or Prior Activation of Intrahepatic Type I Interferon Signaling Leads to Hepatitis B Virus Persistence in a Mouse Model
    In: Journal of Virology, Jg. 95, 2021, Nr. 24, e00034-21
    DOI, Online Volltext (Open Access)
  • Zaghi, Elisa; Calvi, Michela; Puccio, Simone; Spata, Gianmarco; Terzoli, Sara; Peano, Clelia; Roberto, Alessandra; De Paoli, Federica; van Beek, Jasper J.P.; Mariotti, Jacopo; De Philippis, Chiara; Sarina, Barbara; Mineri, Rossana; Bramanti, Stefania; Santoro, Armando; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Marcenaro, Emanuela; Castagna, Luca; Di Vito, Clara; Lugli, Enrico; Mavilio, Domenico
    Single-cell profiling identifies impaired adaptive NK cells expanded after HCMV reactivation in haploidentical HSCT
    In: JCI Insight, Jg. 6, 2021, Nr. 12, e146973
    DOI (Open Access)
  • Seidel, Einat; Dassa, Liat; Schuler, Corinna; Oiknine-Djian, Esther; Wolf, Dana G.; Le-Trilling, Vu Thuy Khanh; Mandelboim, Ofer; Stanton, Richard James
    The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele : MICA*008, to evade NK cell-mediated killing
    In: PLoS Pathogens, Jg. 17, 2021, Nr. 5, S. e1008807
    DOI (Open Access)
  • Zhao, Zhenyu; Lu, Kefeng; Mao, Binli; Liu, Shi; Trilling, Mirko; Huang, Ailong; Lu, Mengji; Lin, Yong
    The interplay between emerging human coronavirus infections and autophagy
    In: Emerging Microbes & Infections, Jg. 10, 2021, Nr. 1, S. 196 – 205
    DOI, Online Volltext (Open Access)
  • Bormann, Maren; Alt, Mira; Schipper, Leonie; van de Sand, Lukas; Le-Trilling, Vu Thuy Khanh; Rink, Lydia; Heinen, Natalie; Madel, Rabea Julia; Otte, Mona; Wuensch, Korbinian; Heilingloh, Christiane Silke; Mueller, Thorsten; Dittmer, Ulf; Elsner, Carina; Pfaender, Stephanie; Trilling, Mirko; Witzke, Oliver; Krawczyk, Adalbert
    Turmeric root and its bioactive ingredient curcumin effectively neutralize sars-cov-2 in vitro
    In: Viruses, Jg. 13, 2021, Nr. 10, 1914
    DOI, Online Volltext (Open Access)

    • Abstracts

  • Thier, B.; Such, L.; Peller, V.; Schwamborn, M.; Sucker, A.; Coch, C.; Schadendorf, Dirk; Griewank, Klaus; Trilling, Mirko; Zhao, F.; Paschen, Annette
    Interferon-independent enhancement of melanoma cell immunogenicity by RIG-I activation
    47th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) Virtual, March 04‐06, 2021,
    In: Experimental Dermatology. Hoboken: Wiley, Jg. 30, 2021, Nr. 3, S. E78

    • 2020

    Artikel in Zeitschriften

  • Wang, Shichuan; Trilling, Mirko; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2
    In: Virologica Sinica, 2020
    DOI (Open Access)
  • Schöler, Lara; Le-Trilling, Vu Thuy Khanh; Eilbrecht, Mareike; Mennerich, Denise; Anastasiou, Olympia E.; Krawczyk, Adalbert; Herrmann, Anke; Dittmer, Ulf; Trilling, Mirko
    A Novel In-Cell ELISA Assay Allows Rapid and Automated Quantification of SARS-CoV-2 to Analyze Neutralizing Antibodies and Antiviral Compounds
    In: Frontiers in Immunology, Jg. 11, 2020, S. 573526
    DOI, Online Volltext (Open Access)
  • David, Paul; Drabczyk-Pluta, Malgorzata; Pastille, Eva; Knuschke, Torben; Werner, Tanja; Honke, Nadine; Megger, Dominik A.; Akhmetzyanova, Ilseyar; Shaabani, Namir; Eyking-Singer, Annette; Cario, Elke; Kershaw, Olivia; Gruber, Achim D.; Tenbusch, Matthias; Dietze, Kirsten; Trilling, Mirko; Liu, Jia; Schadendorf, Dirk; Streeck, Hendrik; Lang, Karl S.; Xie, Youhua; Zimmer, Lisa; Sitek, Barbara; Paschen, Annette; Westendorf, Astrid; Dittmer, Ulf; Zelinskyy, Gennadiy
    Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology
    In: PLoS Pathogens, Jg. 16, 2020, Nr. 3, e1008340
    DOI (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio, Jg. 11, 2020, Nr. 5, S. 02243 – 02220
    DOI (Open Access)
  • Rohn, Hana; Schwich, Esther; Tomoya Michita, Rafael; Schramm, Sabine; Dolff, Sebastian; Gäckler, Anja; Korth, Johannes; Heinemann, Falko M.; Wilde, Benjamin; Trilling, Mirko; Horn, Peter; Kribben, Andreas; Witzke, Oliver; Rebmann, Vera
    HLA-G 3′ untranslated region gene variants are promising prognostic factors for BK polyomavirus replication and acute rejection after living-donor kidney transplant
    In: Human Immunology, Jg. 81, 2020, Nr. 4, S. 141 – 146
    DOI
  • Heilingloh, Christiane Silke; Lull, Christopher; Kleiser, Elissa; Alt, Mira; Schipper, Leonie; Witzke, Oliver; Trilling, Mirko; Eis-Hübinger, Anna-Maria; Dittmer, Ulf; Krawczyk, Adalbert
    Herpes Simplex Virus Type 2 Is More Difficult to Neutralize by Antibodies Than Herpes Simplex Virus Type 1
    In: Vaccines, Jg. 8, 2020, Nr. 3, S. 478
    DOI, Online Volltext (Open Access)
  • Lübke, Maren; Spalt, Stefanie; Kowalewski, Daniel J.; Zimmermann, Cosima; Bauersfeld, Liane; Nelde, Annika; Bichmann, Leon; Marcu, Ana; Peper, Janet Kerstin; Kohlbacher, Oliver; Walz, Juliane S.; Le-Trilling, Vu Thuy Khanh; Hengel, Hartmut; Rammensee, Hans-Georg; Stevanović, Stefan; Halenius, Anne
    Identification of HCMV-derived T cell epitopes in seropositive individuals through viral deletion models
    In: Journal of Experimental Medicine (JEM), Jg. 217, 2020, Nr. 3, S. e20191164
    DOI (Open Access)
  • Trilling, Mirko
    Im Rennen der Roten Königin : Evolutionäres Wettrüsten zwischen Herpesviren und ihren Wirten
    In: Unikate: Berichte aus Forschung und Lehre, 2020, Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, S. 62 – 69
    DOI, Online Volltext (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio, Jg. 11, 2020, Nr. 5, S. e02243 – 20
    DOI (Open Access)
  • Yu, Haisheng; Li, Menqui; He, Rui; Fang, Peining; Wang, Qiming; Yi, Yu; Wang, Fubing; Zhou, Li; Zhang, Yi; Chen, Aidong; Peng, Nanfang; Liu, Dan; Trilling, Mirko; Bröring, Ruth; Wiemer, Erik A.C.; Lu, Mengji; Zhu, Ying; Liu, Shi
    Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity
    In: Hepatology, Jg. 72, 2020, Nr. 2, S. 518 – 534
    DOI
  • Eilbrecht, Mareike; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    Mouse Cytomegalovirus M34 Encodes a Non-essential, Nuclear, Early-Late Expressed Protein Required for Efficient Viral Replication
    In: Frontiers in Cellular and Infection Microbiology, Jg. 10, 2020, 171
    DOI, Online Volltext (Open Access)
  • Liu, Jia; Zheng, Xin; Tong, Qiaoxia; Li, Wei; Wang, Baoju; Sutter, Kathrin; Trilling, Mirko; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang
    Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV
    In: Journal of Medical Virology, Jg. 92, 2020, Nr. 5, S. 491 – 494
    DOI, Online Volltext (Open Access)
  • Heilingloh, Christiane Silke; Aufderhorst, Ulrich Wilhelm; Schipper, Leonie; Dittmer, Ulf; Witzke, Oliver; Yang, Dongliang; Zheng, Xin; Sutter, Kathrin; Trilling, Mirko; Alt, Mira; Steinmann, Eike; Krawczyk, Adalbert
    Susceptibility of SARS-CoV-2 to UV irradiation
    In: American Journal of Infection Control, Jg. 48, 2020, Nr. 10, S. 1273 – 1275
    DOI, Online Volltext (Open Access)
  • Such, Lina; Zhao, Fang; Liu, Derek; Thier, Beatrice; Le-Trilling, Vu Thuy Khanh; Sucker, Antje; Coch, Christoph; Pieper, Natalia; Howe, Sebastian; Bhat, Hilal; Kalkavan, Halime; Ritter, Cathrin; Brinkhaus, Robin; Ugurel, Selma; Köster, Johannes; Seifert, Ulrike; Dittmer, Ulf; Schuler, Martin; Lang, Karl S.; Kufer, Thomas A.; Hartmann, Gunther; Becker, Jürgen; Horn, Susanne; Ferrone, Soldano; Liu, David; Van Allen, Eliezer M.; Schadendorf, Dirk; Griewank, Klaus; Trilling, Mirko; Paschen, Annette
    Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy
    In: The Journal of Clinical Investigation (JCI), Jg. 130, 2020, Nr. 8, S. 4266 – 4281
    DOI, Online Volltext (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Becker, Tanja; Nachshon, Aharon; Stern-Ginossar, Noam; Schöler, Lara; Voigt, Sebastian; Hengel, Hartmut; Trilling, Mirko
    The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity
    In: Cell Reports, Jg. 30, 2020, Nr. 7, S. 2248 – 2260.e5
    DOI (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    Ub to no good : How cytomegaloviruses exploit the ubiquitin proteasome system
    In: Virus Research, Jg. 281, 2020, S. 197938
    DOI

    • Abstracts

  • Thier, B.; Such, L.; Schwamborn, M.; Sucker, A.; Coch, C.; Schadendorf, Dirk; Griewank, Klaus; Trilling, Mirko; Zhao, F.; Paschen, Annette
    RIG-I activation enhances melanoma immunogenicity and improves anti-tumor T cell responses in combination with anti-PD-1 immune checkpoint blocking antibodies
    In: Journal for ImmunoTherapy of Cancer. London: BMJ, Jg. 8, 2020, Nr. Suppl. 2, S. A3
    DOI (Open Access)
  • Thier, Beatrice; Such, Lina; Sucker, Antje; Coch, Carla; Hartmann, G.; Schadendorf, Dirk; Griewank, Klaus; Trilling, Mirko; Zhao, F.; Paschen, Annette
    Tumorzell‐intrinsiche Aktivierung des Immunrezeptors RIG‐I in Kombination mit Immun‐Checkpoint‐Blockade verbessert anti‐Tumor T‐Zellantworten
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 18, 2020, Nr. Suppl. 2: Special Issue: Abstractband anlässlich des 30. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 09.–12. September 2020, S. FV18
    DOI (Open Access)

    • 2019

    Artikel in Zeitschriften

  • Becker, Tanja; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    Cellular Cullin RING Ubiquitin Ligases : Druggable Host Dependency Factors of Cytomegaloviruses
    In: International Journal of Molecular Sciences (IJMS), Jg. 20, 2019, Nr. 7, S. 1636
    DOI, Online Volltext (Open Access)
  • Zimmermann, Cosima; Kowalewski, Daniel; Bauersfeld, Liane; Hildenbrand, Andreas; Gerke, Carolin; Schwarzmüller, Magdalena; Le-Trilling, Vu Thuy Khanh; Stevanovic, Stefan; Hengel, Hartmut; Momburg, Frank; Halenius, Anne
    HLA-B locus products resist degradation by the human cytomegalovirus immunoevasin US11
    In: PLoS Pathogens, Jg. 15, 2019, Nr. 9, S. e1008040
    DOI (Open Access)
  • Rohn, Hana; Michita, Rafael Tomoya; Schramm, Sabine; Dolff, Sebastian; Gäckler, Anja; Korth, Johannes; Heinemann, Falko M.; Wilde, Benjamin; Trilling, Mirko; Horn, Peter; Kribben, Andreas; Witzke, Oliver; Rebmann, Vera
    HLA-E Polymorphism Determines Susceptibility to BK Virus Nephropathy after Living-Donor Kidney Transplant
    In: Cells, Jg. 8, 2019, Nr. 8, S. 847
    DOI, Online Volltext (Open Access)
  • Bongard, Nadine; Le-Trilling, Vu Thuy Khanh; Malyshkina, Anna; Rückborn, Meike; Wohlgemuth, Kerstin; Wensing, Ina; Windmann, Sonja; Dittmer, Ulf; Trilling, Mirko; Bayer, Wibke
    Immunization with a murine cytomegalovirus based vector encoding retrovirus envelope confers strong protection from Friend retrovirus challenge infection
    In: PLoS Pathogens, Jg. 15, 2019, Nr. 9, e1008043
    DOI (Open Access)
  • Winkler, Roni; Gillis, Ella; Lasman, Lior; Safra, Modi; Geula, Shay; Soyris, Clara; Nachshon, Aharon; Tai-Schmiedel, Julie; Friedman, Nehemya; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Mandelboim, Michal; Hanna, Jacob H.; Schwartz, Schraga; Stern-Ginossar, Noam
    Publisher Correction : m6A modification controls the innate immune response to infection by targeting type I interferons
    In: Nature Immunology, Jg. 20, 2019, Nr. 2, S. 243
    DOI (Open Access)
  • Winkler, Roni; Gillis, Ella; Lasman, Lior; Safra, Modi; Geula, Shay; Soyris, Clara; Nachshon, Aharon; Tai-Schmiedel, Julie; Friedman, Nehemya; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Mandelboim, Michal; Hanna, Jacob H.; Schwartz, Schraga; Stern-Ginossar, Noam
    m⁶A modification controls the innate immune response to infection by targeting type I interferons
    In: Nature Immunology, Jg. 20, 2019, S. 173 – 183
    DOI

    • Abstracts

  • Leserer, Saskia; Bayraktar, Erva; Tsachakis-Mück, Nikolaus; Koldehoff, Michael; Trilling, Mirko; Fleischhauer, Katharina; Beelen, Dietrich; Turki, Amin T.
    Cytomegalovirus reactivation kinetics as predictors of survival and relapse after allogeneic cell transplantation for hematologic malignancies
    Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 11. - 14. Oktober 2019, Berlin, Germany,
    In: Oncology Research and Treatment. Basel: Karger, Jg. 42, 2019, Nr. Supplement 4: Abstracts, S. 203
    DOI (Open Access)

    • 2018

    Artikel in Zeitschriften

  • Landsberg, Christine D.; Megger, Dominik A.; Hotter, Dominik; Rückborn, Meike U.; Eilbrecht, Mareike; Rashidi-Alavijeh, Jassin; Howe, Sebastian; Heinrichs, Stefan; Sauter, Daniel; Sitek, Barbara; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx
    In: Frontiers in Immunology, Jg. 9, 2018, S. 2978
    DOI (Open Access)
  • Khosa, Sakshi; Scholz, Romy; Schwarz, Christian; Trilling, Mirko; Hengel, Hartmut; Jaeger, Karl-Erich; Smits, Sander H.J.; Schmitt, Lutz
    An A/U-rich enhancer region is required for high-level protein secretion through the HlyA type I secretion system
    In: Applied and Environmental Microbiology, Jg. 84, 2018, Nr. 1, S. e01163 – 17
    DOI (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Wohlgemuth, Kerstin; Rückborn, Meike U.; Jagnjic, Andreja; Maaßen, Fabienne; Timmer, Lejla; Katschinski, Benjamin; Trilling, Mirko
    STAT2-Dependent immune responses ensure host survival despite the presence of a potent viral antagonist
    In: Journal of Virology, Jg. 92, 2018, Nr. 14, S. e00296 – 18.
    DOI (Open Access)
  • Guberina, Hana; Da Silva Nardi, Fabiola; Michita, Rafael Tomoya; Dolff, Sebastian; Bienholz, Anja; Heinemann, Falko M.; Wilde, Benjamin; Trilling, Mirko; Horn, Peter; Kribben, Andreas; Witzke, Oliver; Rebmann, Vera
    Susceptibility of HLA-E*01:03 Allele Carriers to Develop Cytomegalovirus Replication After Living-Donor Kidney Transplantation
    In: The Journal of Infectious Diseases (JID), Jg. 217, 2018, Nr. 12, S. 1918 – 1922
    DOI (Open Access)
  • Rohn, Hana; Tomoya Michita, Rafael; Schwich, Esther; Dolff, Sebastian; Gäckler, Anja; Horn, Peter; Kribben, Andreas; Trilling, Mirko; Le-Trilling, Vu Thuy Khanh; Wilde, Benjamin; Korth, Johannes; Heinemann, Falko M.; Witzke, Oliver; Rebmann, Vera
    The Donor Major Histocompatibility Complex Class I Chain-Related Molecule A Allele rs2596538 G Predicts Cytomegalovirus Viremia in Kidney Transplant Recipients
    In: Frontiers in Immunology, Jg. 9, 2018, S. 917
    DOI, Online Volltext (Open Access)
  • Dassa, Liat; Seidel, Einat; Oiknine-Djian, Esther; Yamin, Rachel; Wolf, Dana G.; Le-Trilling, Vu Thuy Khanh; Mandelboim, Ofer
    The human cytomegalovirus protein UL148A downregulates the NK cell-activating ligand MICA to avoid NK cell attack
    In: Journal of Virology, Jg. 92, 2018, Nr. 17, S. e00162 – 18
    DOI, Online Volltext (Open Access)
  • Shinde, Prashant V.; Xu, Haifeng C.; Maney, Sathish Kumar; Kloetgen, Andreas; Namineni, Sukumar; Zhuang, Yuan; Honke, Nadine; Shaabani, Namir; Bellora, Nicolas; Doerrenberg, Mareike; Trilling, Mirko; Pozdeev, Vitaly I.; van Rooijen, Nico; Scheu, Stefanie; Pfeffer, Klaus; Crocker, Paul R.; Tanaka, Masato; Duggimpudi, Sujitha; Knolle, Percy; Heikenwalder, Mathias; Ruland, Jürgen; Mak, Tak W.; Brenner, Dirk; Pandyra, Aleksandra A.; Hoell, Jessica I.; Borkhardt, Arndt; Häussinger, Dieter; Lang, Karl S.; Lang, Philipp A.
    Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection
    In: Journal of Virology, Jg. 92, 2018, Nr. 3, S. e01637 – 17
    DOI (Open Access)

    • Abstracts

  • Guberina, H.; Nardi, F. D.; Michita, R. T.; Dolff, Sebastian; Gackler, A.; Heinemann, Falko M.; Wilde, Benjamin; Trilling, Mirko; Horn, Peter; Kribben, Andreas; Witzke, Oliver; Rebmann, Vera
    Impact of HLA-E*01:03 allele carrier status and NKG2C allele deletion on the risk of CMV infection after renal transplantation
    In: HLA: Immune Response Genetics (Human Leukocyte Antigens). Hoboken: Wiley-Blackwell - STM, Jg. 91, 2018, Nr. 5, S. 345 – 345
    DOI

    • Poster / Posterbeiträge

  • Grosche, L.; Drassner, C.; Muehl-Zuerbes, P.; Kamm, L.; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Steinkasserer, A.; Heilingloh, C.
    Human cytomegalovirus interferes with dendritic cell adhesion and migration via the proteasomal degradation of the cytohesin-1 interacting protein
    15th International Symposium on Dendritic Cells, 10–14 June 2018, Aachen, Germany,
    In: European Journal of Immunology. Hoboken: Wiley, Jg. 48, 2018, Nr. Suppl. 1, S. 103 – 104
    DOI (Open Access)

    • 2017

    Artikel in Zeitschriften

  • Sucker, Antje; Zhao, Fang; Pieper, Natalia; Heeke, Christina; Maltaner, Raffaela; Stadtler, Nadine; Real, Birgit; Bielefeld, Nicola; Howe, Sebastian; Weide, Benjamin; Gutzmer, Ralf; Utikal, Jochen; Loquai, Carmen; Gogas, Helen; Klein-Hitpaß, Ludger; Zeschnigk, Michael; Westendorf, Astrid; Trilling, Mirko; Horn, Susanne; Schilling, Bastian; Schadendorf, Dirk; Griewank, Klaus; Paschen, Annette
    Acquired IFNγ 3 resistance impairs anti-Tumor immunity and gives rise to T-cell-resistant melanoma lesions
    In: Nature Communications, Jg. 8, 2017, 15440
    DOI (Open Access)
  • Ahci, Müberra; Stempelmann, Karin; Buttkereit, Ulrike; Crivello, Pietro; Trilling, Mirko; Heinold, Andreas; Steckel, Nina Kristin; Koldehoff, Michael; Horn, Peter; Beelen, Dietrich; Fleischhauer, Katharina
    Clinical utility of quantitative PCR for chimerism and engraftment monitoring after allogeneic stem cell transplantation for hematologic malignancies
    In: Biology of Blood and Marrow Transplantation, Jg. 23, 2017, Nr. 10, S. 1658 – 1668
    DOI
  • Megger, Dominik A; Philipp, Jos; Le-Trilling, Vu Thuy Khanh; Sitek, Barbara; Trilling, Mirko
    Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression.
    In: Frontiers in Immunology, Jg. 14, 2017, Nr. 8, 1139
    DOI (Open Access)
  • Guberina, H.; Silva, F. D.; Michita, R. T.; Dolff, Sebastian; Bienholz, A.; Heinemann, Falko M.; Wilde, Benjamin; Trilling, Mirko; Horn, Peter; Kribben, Andreas; Witzke, Oliver; Rebmann, Vera
    HLA-E Allelic Genotype Impacts on Occurrence of CMV Infection After Living Renal Transplantation
    In: Transplant International, Jg. 30, 2017, Nr. Suppl. 4 SI, S. 7 Abstract V024
    DOI
  • Grosche, Linda; Draßner, Christina; Mühl-Zürbes, Petra; Kamm, Lisa; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Steinkasserer, Alexander; Heilingloh, Christiane S.
    Human cytomegalovirus-induced degradation of CYTIP modulates dendritic cell adhesion and migration
    In: Frontiers in Immunology, Jg. 8, 2017, 461
    DOI (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    Mouse newborn cells allow highly productive mouse cytomegalovirus replication, constituting a novel convenient primary cell culture system
    In: PLoS ONE, Jg. 12, 2017, Nr. 3, e0174695
    DOI (Open Access)
  • Guberina, Hana; Michita, Rafael Tomoya; Dolff, Sebastian; Bienholz, Anja; Trilling, Mirko; Heinemann, Falko M.; Horn, Peter; Kribben, Andreas; Witzke, Oliver; Rebmann, Vera
    Recipient HLA-G +3142 CC genotype and concentrations of soluble HLA-G impact on occurrence of CMV infection after living-donor kidney transplantation
    In: International Journal of Molecular Sciences (IJMS), Jg. 18, 2017, Nr. 11, S. 2338
    DOI, Online Volltext (Open Access)

    • 2016

    Artikel in Zeitschriften

  • Schupp, Anna-Kathrin; Trilling, Mirko; Rattay, Stephanie; Le-Trilling, Vu Thuy Khanh; Haselow, Katrin; Stindt, Jan; Zimmermann, Albert; Häussinger, Dieter; Hengel, Hartmut; Graf, Dirk
    Bile Acids Act as Soluble Host Restriction Factors Limiting Cytomegalovirus Replication in Hepatocytes
    In: Journal of Virology, Jg. 90, 2016, Nr. 15, S. 6686 – 6698
    DOI (Open Access)
  • Le-Trilling, Vu Thuy Khanh; Megger, Dominik A.; Katschinski, Benjamin; Landsberg, Christine D.; Rückborn, Meike U.; Tao, Sha; Krawczyk, Adalbert; Bayer, Wibke; Drexler, Ingo; Tenbusch, Matthias; Sitek, Barbara; Trilling, Mirko
    Broad and potent antiviral activity of the NAE inhibitor MLN4924
    In: Scientific Reports, Jg. 6, 2016, 19977
    DOI (Open Access)
  • Shaabani, Namir; Duhan, Vikas; Khairnar, Vishal; Gassa, Asmae; Ferrer-Tur, Rita; Häussinger, Dieter; Recher, Mike; Zelinskyy, Gennadiy; Liu, Jia; Dittmer, Ulf; Trilling, Mirko; Scheu, Stefanie; Hardt, Cornelia; Lang, Philipp A; Honke, Nadine; Lang, Karl S.
    CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection
    In: Cell Death and Disease, Jg. 7, 2016, Nr. 11, e2446
    DOI (Open Access)
  • Yamin, Rachel; Lecker, Laura S.M.; Weisblum, Yiska; Vitenshtein, Alon; Le-Trilling, Vu Thuy Khanh; Wolf, Dana G.; Mandelboim, Ofer
    HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2
    In: Cell Reports, Jg. 15, 2016, Nr. 7, S. 1542 – 1553
    DOI (Open Access)
  • Corrales-Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Falcone, Valeria; Zimmermann, Albert; Adams, Ortwin; Santibanez, Sabine; Hengel, Hartmut
    Highly individual patterns of virus-immune IgG effector responses in humans
    In: Medical Microbiology and Immunology, Jg. 205, 2016, Nr. 5, S. 409 – 424
    DOI (Open Access)
  • Lavender, Kerry J.; Gibbert, Kathrin; Peterson, Karin E.; Van Dis, Erik; Francois, Sandra; Woods, Tyson; Messer, Ronald J.; Gawanbacht, Ali; Müller, Janis A.; Münch, Jan; Phillips, Katie; Race, Brent; Harper, Michael S.; Guo, Kejun; Lee, Eric J.; Trilling, Mirko; Hengel, Hartmut; Piehler, Jacob; Verheyen, Jens; Wilson, Cara C.; Santiago, Mario L.; Hasenkrug, Kim J.; Dittmer, Ulf
    Interferon alpha subtype-specific suppression of HIV-1 infection in vivo
    In: Journal of Virology, Jg. 90, 2016, Nr. 13, S. 6001 – 6013
    DOI (Open Access)
  • Ehlting, Christian; Trilling, Mirko; Tiedje, Christopher; Le-Trilling, Vu Thuy Khanh; Albrecht, Ute; Kluge, Stefanie; Zimmermann, Albert; Graf, Dirk; Gaestel, Matthias; Hengel, Hartmut; Häussinger, Dieter; Bode, Johannes Georg
    MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections
    In: Journal of Hepatology, Jg. 64, 2016, Nr. 2, S. 380 – 389
    DOI
  • Donnarumma, Tiziano; Young, George R; Merkenschlager, Julia; Eksmond, Urszula; Bongard, Nadine; Nutt, Stephen L; Boyer, Claude; Dittmer, Ulf; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Bayer, Wibke; Kassiotis, George
    Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus
    In: Cell Reports, Jg. 17, 2016, Nr. 6, S. 1571 – 1583
    DOI (Open Access)

    • Abstracts

  • Beelen, Dietrich; Bujor, L. V.; Stempelmann, K.; Fiedler, Melanie; Crivello, P.; Trilling, Mirko; Dittmer, Ulf; Ditschkowski, Markus; Fleischhauer, Katharina
    Early Replication of Human Cytomegalovirus (HCMV) is associated with a reduced risk of hematologic relapse in myeloid neoplasias after matched Unrelated Stem Cell Transplantation (HSCT) in an anti-thymocyte-globuline dependent manner
    In: Oncology Research and Treatment. Basel: Karger, Jg. 39, 2016, Nr. Suppl. 3, S. 312 – 313
    DOI

    • 2015

    Artikel in Zeitschriften

  • Le-Trilling, Vu Thuy Khanh; Trilling, Mirko
    Attack, parry and riposte : Molecular fencing between the innate immune system and human herpesviruses
    In: Tissue Antigens, Jg. 86, 2015, Nr. 1, S. 1 – 13
    DOI
  • Seidel, Einat; Le, Vu Thuy Khanh; Bar-On, Yotam; Tsukerman, Pinchas; Enk, Jonatan; Yamin, Rachel; Stein, Nathan; Schmiedel, Dominik; Djian, Esther Oiknine; Weisblum, Yiska; Tirosh, Boaz; Stastny, Peter; Wolf, Dana G.; Hengel, Hartmut; Mandelboim, Ofer
    Dynamic co-evolution of host and pathogen : HCMV downregulates the prevalent allele MICA*008 to escape elimination by NK cells
    In: Cell Reports, Jg. 10, 2015, Nr. 6, S. 968 – 982
    DOI (Open Access)
  • Wu, Weimin; Dietze, Kirsten; Gibbert, Kathrin; Lang, Karl S.; Trilling, Mirko; Yan, Huimin; Wu, Jun; Yang, Dongliang; Lu, Mengji; Roggendorf, Michael; Dittmer, Ulf; Liu, Jia
    TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection
    In: Scientific Reports, Jg. 5, 2015, 10501
    DOI, Online Volltext (Open Access)
  • Rattay, Stephanie; Trilling, Mirko; Megger, Dominik A.; Sitek, Barbara; Meyer, Helmut E.; Hengel, Hartmut; Le-Trilling, Vu Thuy Khanh
    The canonical immediate early 3 gene product pIE611 of mouse cytomegalovirus is dispensable for viral replication but mediates transcriptional and posttranscriptional regulation of viral gene products
    In: Journal of Virology, Jg. 89, 2015, Nr. 16, S. 8590 – 8598
    DOI (Open Access)
  • Tirosh, Osnat; Cohen, Yifat; Shitrit, Alina; Shani, Odem; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Friedlander, Gilgi; Tanenbaum, Marvin; Stern-Ginossar, Noam
    The transcription and translation landscapes during human cytomegalovirus infection reveal novel host-pathogen interactions
    In: PLoS Pathogens, Jg. 11, 2015, Nr. 11, e1005288
    DOI (Open Access)

    • 2014

    Artikel in Zeitschriften

  • Trilling, Mirko; Le, Vu Thuy Khanh; Rashidi-Alavijeh, Jassin; Katschinski, Benjamin; Scheller, Jürgen; Rose-John, Stefan; Androsiac, Gabriela Elena; Jonjic, Stipan; Poli, Valeria; Pfeffer, Klaus; Hengel, Hartmut
    "Activated" STAT proteins : a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells
    In: The Journal of Immunology (JI), Jg. 192, 2014, Nr. 1, S. 447 – 458
    DOI (Open Access)
  • Zimmermann, Albert; Hauka, Sebastian; Maywald, Marco; Le, Vu Thuy Khanh; Schmidt, Silvia K.; Däubener, Walter; Hengel, Hartmut
    Checks and balances between human cytomegalovirus replication and indoleamine-2,3- dioxygenase
    In: Journal of General Virology, Jg. 95, 2014, S. 659 – 670
    DOI
  • Corrales-Aguilar, Eugenia; Trilling, Mirko; Hunold, Katja; Fiedler, Manuela; Le, Vu Thuy Khanh; Reinhard, Henrike; Ehrhardt, Katrin; Mercé-Maldonado, Eva; Aliyev, Enver; Zimmermann, Albert; Johnson, David C; Hengel, Hartmut
    Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III
    In: PLoS Pathogens, Jg. 10, 2014, Nr. 5, e1004131
    DOI (Open Access)
  • Rölle, Alexander; Pollmann, Julia; Ewen, Eva Maria; Le, Vu Thuy Khanh; Halenius, Anne; Hengel, Hartmut; Cerwenka, Adelheid
    IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion
    In: The Journal of Clinical Investigation (JCI), Jg. 124, 2014, Nr. 12, S. 5305 – 5316
    DOI
  • Keil, Eric; Finkenstädt, David; Wufka, Christian; Trilling, Mirko; Liebfried, Pia; Strobl, Birgit; Müller, Mathias; Pfeffer, Klaus
    Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation
    In: Blood, Jg. 123, 2014, Nr. 4, S. 520 – 529
    DOI
  • Döring, Marius; Lessin, Irina; Frenz, Theresa; Spanier, Julia; Kessler, Annett; Tegtmeyer, Pia; Daǧ, Franziska; Thiel, Nadine; Trilling, Mirko; Lienenklaus, Stefan; Weiß, Siegfried B.; Scheu, Stefanie; Messerle, Martin; Čičin-Šain, Luka; Hengel, Hartmut; Kalinke, Ulrich
    M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells
    In: Journal of Virology, Jg. 88, 2014, Nr. 23, S. 13638 – 13650
    DOI
  • Nachmani, Daphna; Zimmermann, Albert; Oiknine Dijan, Esther; Weisblum, Yiska; Livneh, Yoav; Le, Vu Thuy Khanh; Galun, Eithan; Horejsi, Vaclav; Isakov, Ofer; Shomron, Noam; Wolf, Dana G.; Hengel, Hartmut; Mandelboim, Ofer
    MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells
    In: PLoS Pathogens, Jg. 10, 2014, Nr. 2, e1003963
    DOI (Open Access)

    • 2013

    Artikel in Zeitschriften

  • Corrales-Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Mercé-Maldonado, Eva; Widera, Marek; Schaal, Heiner; Zimmermann, Albert; Mandelboim, Ofer; Hengel, Hartmut
    A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors
    In: Journal of Immunological Methods, Jg. 387, 2013, Nr. 1-2, S. 21 – 35
    DOI
  • Manzke, Nora; Akhmetzyanova, Ilseyar; Hasenkrug, Kim J.; Trilling, Mirko; Zelinskyy, Gennadiy; Dittmer, Ulf
    CD4⁺ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8⁺ T cells
    In: Journal of Virology, Jg. 87, 2013, Nr. 11, S. 6306 – 6313
    DOI, Online Volltext
  • Bayer, Wibke; Trilling, Mirko; Timm, Jörg; Dittmer, Ulf
    Das überlistete Immunsystem : Viren tricksen das Immunsystem aus, um chronische Infektionen zu etablieren
    In: Unikate: Berichte aus Forschung und Lehre, 2013, Nr. 44: Medizin : 50 Jahre Universitätsklinikum Essen, S. 32 – 41
    DOI, Online Volltext (Open Access)
  • Schleker, Sylvia; Trilling, Mirko
    Data-warehousing of protein-protein interactions indicates that pathogens preferentially target hub and bottleneck proteins
    In: Frontiers in Microbiology, Jg. 4, 2013, S. 51
    DOI
  • Trilling, Mirko; Bellora, Nicolás; Rutkowski, Andrzej J.; De Graaf, Miranda; Dickinson, Paul; Robertson, Kevin; Prazeres Da Costa, Olivia; Ghazal, Peter; Friedel, Caroline C.; Albà, M. Mar; Dölken, Lars
    Deciphering the modulation of gene expression by type i and II interferons combining 4sU-tagging, translational arrest and in silico promoter analysis
    In: Nucleic Acids Research, Jg. 41, 2013, Nr. 17, S. 8107 – 8125
    DOI (Open Access)

    • Abstracts

  • Francois, Sandra; Berendes, Christopher; Trilling, Mirko; Dittmer, Ulf; Piehler, Jacob; Gibbert, Kathrin
    Antiviral and immunomodulatory activity of different human interferon-α subtypes during chronic viral infections
    In: Cytokine. Amsterdam: Elsevier, Jg. 63, 2013, Nr. 3, S. 262 – 263
    DOI

    • 2012

    Artikel in Zeitschriften

  • Honke, Nadine; Shaabani, Namir; Cadeddu, Giuseppe; Sorg, Ursula R.; Zhang, Dong-Er; Trilling, Mirko; Klingel, Karin; Sauter, Martina; Kandolf, Reinhard; Gailus, Nicole; Van Rooijen, Nico; Burkart, Christoph; Baldus, Stephan E.; Grusdat, Melanie; Löhning, Max; Hengel, Hartmut; Pfeffer, Klaus; Tanaka, Masato; Häussinger, Dieter; Recher, Mike; Lang, Philipp A.; Lang, Karl S.
    Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus
    In: Nature Immunology, Jg. 13, 2012, Nr. 1, S. 51 – 57
    DOI
  • Gibbert, Kathrin; Joedicke, Jara J.; Meryk, Andreas; Trilling, Mirko; Francois, Sandra; Duppach, Janine; Kraft, Anke; Lang, Karl S.; Dittmer, Ulf
    Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral Infection
    In: PLoS Pathogens, Jg. 8, 2012, Nr. 8, S. e1002868
    DOI, Online Volltext (Open Access)
  • Trilling, Mirko; Le, Vu Thuy Khanh; Hengel, Hartmut
    Interplay between CMVs and interferon signaling : Implications for pathogenesis and therapeutic intervention
    In: Future Microbiology, Jg. 7, 2012, Nr. 11, S. 1269 – 1282
    DOI

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