ZMB Member Shirley Knauer

Shirley Knauer

Prof. Dr. Shirley Knauer

Phone +49 201 183 4987
Fax   +49 201 183 6053
Email

Fakultät für Biologie
Room S05 T04 B27
Universität Duisburg-Essen
45117 Essen

Department

Molekularbiologie II

Research Overview
 

Our research interests focus on molecular and translational clinical oncology as well as on the biomedical transfer of the compiled results. They aim on a detailed understanding of the regulation of nucleo-cytoplasmic transport processes, their impact on malignant transformation in cancer development, the discovery of novel therapeutic targets as well as the establishment of novel drug-screening assays.

Current projects concentrate on the molecular and pathophysiological function of the "Inhibitor of Apoptosis" protein Survivin, which is attributed a decisive role in the development of cancer and other diseases.

Using corroborating experimental approaches including microinjection experiments, flourescence as well as confocal microscopy, we could demonstrate that Survivin is actively exported from the cell nucleus. This transport process was not only a prerequisite for protection of cancer cells against radio- and chemotherapy by Survivin, but also plays a causal role in the treatment response of cancer patients. Therefore, targeted interference with the nuclear export of survivin by molecular decoys seems to be a highly promising innovative strategy to impede growth and therapy resistance of cancer cells. Additionally, the detailed functional characterisation of the anti-apoptotic protein Survivin and its cellular transport activity led to novel groundbreaking insights concerning the essential involvement of transport receptors in mitotic processes.

Lade den Film...

Interview with Professor Knauer as part of a video introducing the Centre for Medical Biotechnology (ZMB).

WAZ, 01.08.2017

Die Suche nach der Zauberkugel

Shirley Knauer erforscht in Essen neuartige Wege, den Krebs zu bekämpfen

ZMB Research Programme

Prof. Shirley Knauer participates in the ZMB research programme Oncology.

DFG Collaborative Research Centre 1093 Supramolecular Chemistry on Proteins

B5: Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands

SWR 2 Impuls - Podcast

Nano-Antibiotika gegen resistente Keime

Forscher setzen auf sehr kleine Wirkstoffe, die man gezielt einsetzen kann. Das Verfahren könnte den Kampf gegen die Keime entscheidend voranbringen.

Podcast aus der Mediathek von SWR 2 Impuls, Sendung vom 10.01.2019 (Audio von Peter Kolakowski, mit Shirley Knauer und Cecilia Vallet)

Press Releases

Laborjournal online, 14.08.2018 Gut getarnt

Beide sind klein, unauffällig und ubiquitär. Wenn sich Schimmelpilz-Sporen und Nanopartikel zusammentun, kann der Pilz sogar ungesehen die Immunpolizei passieren.

Artikel im Laborjournal online zur Publiaktion:

Westmeier D, Solouk-Saran D, Vallet C, Siemer S, Docter D, Götz H, Männ L, Hasenberg A, Hahlbrock A, Erler K, Reinhardt C, Schilling O, Becker S, Gunzer M, Hasenberg M, Knauer SK, Stauber RH. Nanoparticle decoration impacts airborne fungal pathobiology. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7087-7092.