Neutrophil granulopoiesis and mobilization

Neutrophil granulocytes are indispensable in the fight against many infectious diseases, the absence of these cells can lead to severe infection courses up to death. Interestingly, the presence of neutrophils in tumor tissue is often associated with a poor prognosis for the patient, since these neutrophils for example promote the formation of new blood vessels and thus tumor growth. The formation of neutrophil granulocytes from haematopoietic stem cells and their subsequent maturation takes place mainly in long bones. Under normal conditions, just a constant new formation of cells takes place there, but in case of infection or tumor disease, production is greatly increased and large amounts of neutrophils are released into the blood circulation. The aim of this project is to investigate which factors or cells influence granulopoiesis, i.e. the formation and maturation of neutrophil granulocytes, in the case of a tumor disease in the bone marrow and via which mechanisms the neutrophil granulocytes are ultimately recruited from the bone marrow into the blood circulation. Modern microscopy methods such as intravital 2-photon microscopy and light sheet microscopy are used for this purpose.

Researcher

  • Dr. Anja Hasenberg