Neutrophil functions in metastatic melanoma

Unraveling the phenotypic coevolution of melanoma cells and neutrophils fostering metastasis and therapy resistance.

Tumor-associated neutrophils (TAN) constitute a significant part of the immunological infiltrate in solid tumors. TANs are equipped with an enormous functional heterogeneity. However, the molecular mechanisms behind this diverse functionality are not understood. Hence it remains impossible to modulate TANs for the improvement of tumor therapy. Therefore, this project will investigate TAN during the development of metastasizing melanoma thereby making use of unique experimental systems as well as primary patient material.


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