Interaction of neutrophils with gut microbiota shapes
In this DFG project, Dr. Singh wants to understand the impact of intestinal microbiota on the activation of neutrophils and find ways to reduce their neurotoxic functions. Neutrophils are present in high numbers in the human blood and shown to be the first invaders to the injured brain. The molecular signals that can derive neutrophil activation are not yet completely elusive. Moreover, the therapies targeting neutrophil invasion and their neurotoxic functions are not yet available. The purpose of Dr. Singh’s DFG project is to shed further light on these questions.